Water leaching of As2O3 from metallurgical dust containing various metals was investigated,serving the purpose of dearsenization and simultaneous metal enrichment especially for indium.Effects of leaching temperature,...Water leaching of As2O3 from metallurgical dust containing various metals was investigated,serving the purpose of dearsenization and simultaneous metal enrichment especially for indium.Effects of leaching temperature,liquid/solid ratio(LSR)and leaching time were studied.It was found that the initial dissolution was very fast but was then so inhibited by the increasingly dissolved As2O3,which makes it difficult to saturate enough arsenic in the leaching solution or in leaching out all the soluble arsenic with excess dosage of water within acceptable time(120 min).Only about 73%of As2O3 was extracted under the optimal conditions investigated.Two-step leaching showed similar trends and was thus unnecessary for improving As2O3 extraction.These observations could reasonably be accounted for the reversibility of the dissolution reaction.Kinetically,the leaching was described satisfactorily by the semi-empirical Avrami model with the apparent activation energy of 36.08 kJ/mol.The purity of the obtained product As2O3 could reach 98.7%,while the indium could be enriched in the leaching residue without loss.展开更多
Objective To observe the apoptosis of osteosarcoma MG-63 cells induced by As2O3 and to explore its possible mechanisms. Methods The flowcytometric analysis and transmission electronmicroscope were performed to investi...Objective To observe the apoptosis of osteosarcoma MG-63 cells induced by As2O3 and to explore its possible mechanisms. Methods The flowcytometric analysis and transmission electronmicroscope were performed to investigate the inducing apoptosis and inhibitative of As2O3 on osteosarcoma MG-63 cells. In order to study mechanism of apoptosis in MG-63 cells treated with As2 O3, microarray was performed. The down-regulated gene was confirmed by RT-PCR, Northern-blotting. Results After treated with As2O3, hypodiploid peak before G0/G1 phase was observed in MG-63 cells through FCM analysis. Loss of microvilli, condensation and fragmentation of nuclear chromatin, condensation of cytoplasmic organelles, dilatation of the endoplasmic reticulum shrinkage of cells and alterations in cell membranes and apoptosis bodies which were observed in MG-63 cells treated with As2O3 by transmission electronmicroscope. The results of microarray show that As2 O3 induced MG-63 cell apoptosis involves down-regulation of IEX-1 and the down-regulated gene is confirmed by RT-PCR and Northern-blotting.Conclusion The results show that As2 O3 selectively inhibits growth of the solid tumor MG-63 cells by triggering apoptosis and indicates MG-63 induced by As2O3 cell apoptosis may through the IEX-1 pathway.展开更多
The neutral zinc sulfate solution obtained from hydrometallurgical process of Angouran zinc concentrate has cadmium, nickel and cobalt impurities, that must be purified before electrowinning. Therefore, cadmium and ni...The neutral zinc sulfate solution obtained from hydrometallurgical process of Angouran zinc concentrate has cadmium, nickel and cobalt impurities, that must be purified before electrowinning. Therefore, cadmium and nickel are usually cemented out by addition of zinc dust and remained nickel and cobalt cemented out at second stage with zinc powder and arsenic trioxide. In this research, a new approach is described for determination of effective parameters and optimization of zinc electrolyte hot purification process using statistical design of experiments. The Taguchi method based on orthogonal array design（OAD） has been used to arrange the experimental runs. The experimental conditions involved in the work are as follows： the temperature range of 70-90 ℃ for reaction temperature（T）, 30-90 min for reaction time（t）, 2-4 g/L for zinc powder mass concentration（M）, one to five series for zinc dust particle size distributions（S1-S5）, and 0.1-0.5 g/L（C） for arsenic trioxide mass concentration. Optimum conditions for hot purification obtained in this work are T4（85 ℃）, t4=75 min, M4=3.5 g/L, S4（Serie 4）, and C2=0.2 g/L.展开更多
A novel spherical tremella-like Sb2O3 was prepared by using metal-organic frameworks(MOFs)method under a mild liquid-phase reaction condition,and was further employed as an anode material for lithium-ion batteries(LIB...A novel spherical tremella-like Sb2O3 was prepared by using metal-organic frameworks(MOFs)method under a mild liquid-phase reaction condition,and was further employed as an anode material for lithium-ion batteries(LIBs).The effect of reaction temperature and time on morphologies of Sb2O3 was studied.The results from SEM and TEM demonstrate that the tremella-like Sb2O3 architecture are composed of numerous nanosheets with high specific surface area.When the tremella-like Sb2O3 was used as LIBs anode,the discharge and charge capacities can achieve 724 and 446 mA·h/g in the first cycle,respectively.Moreover,the electrode retains an impressive high capacity of 275 mA·h/g even after 50 cycles at 20 mA/g,indicating that the material is extremely promising for application in LIBs.展开更多
In the past two decades,target-based therapies achieve the great success in adult leukemia.Two typical examples are the applications of all-trans retinoic acid(ATRA)/arsenic trioxide(ATO)and specific tyrosine kinase i...In the past two decades,target-based therapies achieve the great success in adult leukemia.Two typical examples are the applications of all-trans retinoic acid(ATRA)/arsenic trioxide(ATO)and specific tyrosine kinase inhibitor imatinib respectively in acute promyelocytic leukemia(APL)and chronic myeloid leukemia(CML).These successful clinical practices originated from our understanding on展开更多
基金Project(51874356)supported by the National Natural Science Foundation of China
文摘Water leaching of As2O3 from metallurgical dust containing various metals was investigated,serving the purpose of dearsenization and simultaneous metal enrichment especially for indium.Effects of leaching temperature,liquid/solid ratio(LSR)and leaching time were studied.It was found that the initial dissolution was very fast but was then so inhibited by the increasingly dissolved As2O3,which makes it difficult to saturate enough arsenic in the leaching solution or in leaching out all the soluble arsenic with excess dosage of water within acceptable time(120 min).Only about 73%of As2O3 was extracted under the optimal conditions investigated.Two-step leaching showed similar trends and was thus unnecessary for improving As2O3 extraction.These observations could reasonably be accounted for the reversibility of the dissolution reaction.Kinetically,the leaching was described satisfactorily by the semi-empirical Avrami model with the apparent activation energy of 36.08 kJ/mol.The purity of the obtained product As2O3 could reach 98.7%,while the indium could be enriched in the leaching residue without loss.
文摘Objective To observe the apoptosis of osteosarcoma MG-63 cells induced by As2O3 and to explore its possible mechanisms. Methods The flowcytometric analysis and transmission electronmicroscope were performed to investigate the inducing apoptosis and inhibitative of As2O3 on osteosarcoma MG-63 cells. In order to study mechanism of apoptosis in MG-63 cells treated with As2 O3, microarray was performed. The down-regulated gene was confirmed by RT-PCR, Northern-blotting. Results After treated with As2O3, hypodiploid peak before G0/G1 phase was observed in MG-63 cells through FCM analysis. Loss of microvilli, condensation and fragmentation of nuclear chromatin, condensation of cytoplasmic organelles, dilatation of the endoplasmic reticulum shrinkage of cells and alterations in cell membranes and apoptosis bodies which were observed in MG-63 cells treated with As2O3 by transmission electronmicroscope. The results of microarray show that As2 O3 induced MG-63 cell apoptosis involves down-regulation of IEX-1 and the down-regulated gene is confirmed by RT-PCR and Northern-blotting.Conclusion The results show that As2 O3 selectively inhibits growth of the solid tumor MG-63 cells by triggering apoptosis and indicates MG-63 induced by As2O3 cell apoptosis may through the IEX-1 pathway.
文摘The neutral zinc sulfate solution obtained from hydrometallurgical process of Angouran zinc concentrate has cadmium, nickel and cobalt impurities, that must be purified before electrowinning. Therefore, cadmium and nickel are usually cemented out by addition of zinc dust and remained nickel and cobalt cemented out at second stage with zinc powder and arsenic trioxide. In this research, a new approach is described for determination of effective parameters and optimization of zinc electrolyte hot purification process using statistical design of experiments. The Taguchi method based on orthogonal array design（OAD） has been used to arrange the experimental runs. The experimental conditions involved in the work are as follows： the temperature range of 70-90 ℃ for reaction temperature（T）, 30-90 min for reaction time（t）, 2-4 g/L for zinc powder mass concentration（M）, one to five series for zinc dust particle size distributions（S1-S5）, and 0.1-0.5 g/L（C） for arsenic trioxide mass concentration. Optimum conditions for hot purification obtained in this work are T4（85 ℃）, t4=75 min, M4=3.5 g/L, S4（Serie 4）, and C2=0.2 g/L.
基金Project(51674114)supported by the National Natural Science Foundation of ChinaProject(2019JJ40069)supported by the Natural Science Foundation of Hunan Province,ChinaProject(16K025)supported by the Key Laboratory of the Education Department of Hunan Province,China
文摘A novel spherical tremella-like Sb2O3 was prepared by using metal-organic frameworks(MOFs)method under a mild liquid-phase reaction condition,and was further employed as an anode material for lithium-ion batteries(LIBs).The effect of reaction temperature and time on morphologies of Sb2O3 was studied.The results from SEM and TEM demonstrate that the tremella-like Sb2O3 architecture are composed of numerous nanosheets with high specific surface area.When the tremella-like Sb2O3 was used as LIBs anode,the discharge and charge capacities can achieve 724 and 446 mA·h/g in the first cycle,respectively.Moreover,the electrode retains an impressive high capacity of 275 mA·h/g even after 50 cycles at 20 mA/g,indicating that the material is extremely promising for application in LIBs.
文摘In the past two decades,target-based therapies achieve the great success in adult leukemia.Two typical examples are the applications of all-trans retinoic acid(ATRA)/arsenic trioxide(ATO)and specific tyrosine kinase inhibitor imatinib respectively in acute promyelocytic leukemia(APL)and chronic myeloid leukemia(CML).These successful clinical practices originated from our understanding on
