Abstract：Aim To investigate the effect of hydrogen-rich saline on arterial thrombosis in sinoaortic denervatted （SAD） rats. Methods Rats were divided randomly into Sham group, SAD group, SAD ＋ hydrogen-rich saline...Abstract：Aim To investigate the effect of hydrogen-rich saline on arterial thrombosis in sinoaortic denervatted （SAD） rats. Methods Rats were divided randomly into Sham group, SAD group, SAD ＋ hydrogen-rich saline （5 mL · kg^-1 · d^-1） group and SAD ＋ hydrogen-rich saline （10 mL · kg^-1 · d^-1） group. Four weeks after Sham or SAD operation, rats were given intraperitoneally normal saline or hydrogen-rich saline for 4 weeks. Carotid artery thrombosis was induced by 30% ferric chloride. Time till occlusion was measured by Laser Doppler Flowme- try. Results When compared with the Sham group, time till occlusion was significantly shorter in SAD group. Moreover, platelet aggregation, platelet adhesion to collagen and the level of ROS and malondialdehyde （MDA） in plasma and Ca2＋ in platelets were significantly raised. The level of NO and SOD in plasma and NO in platelet were significantly reduced. When compared with the SAD group, time till occlusion in hydrogen-rich saline group group was significantly prolonged. Platelet aggregation, adhesion, the level of ROS, MDA and Ca2＋ were significantly re- duced, whereas the level of NO and SOD in plasma and NO in platelets were significantly higher. Conclusion Hydrogen-rich saline might improve arterial thrombosis in SAD rats through inhibition of platelet activation and oxi- dative stress.展开更多
Background and Objective Previous reports from PANDA III trial had proven that BuMA biodegradable polymer(BP)sirolimus-elutingstents(SES),with faster drug eluting rate and polymer absorption kinetics,was non-inferior ...Background and Objective Previous reports from PANDA III trial had proven that BuMA biodegradable polymer(BP)sirolimus-elutingstents(SES),with faster drug eluting rate and polymer absorption kinetics,was non-inferior to the Excel SES in an all-comers population for 1-year target lesion failure(TLF),with a lower incidence of stent thrombosis(ST).The aim of the present study was to perform a safety evaluation of BuMA SES in the complex patient and lesion subgroup.展开更多
Utilizing a reliable, reproducible arterial inversiongraft thrombosis model, comparison of intraarterial VSwith intravenous heparin delivery in maintaining micro-vascular patency has been finished, concentrated on the...Utilizing a reliable, reproducible arterial inversiongraft thrombosis model, comparison of intraarterial VSwith intravenous heparin delivery in maintaining micro-vascular patency has been finished, concentrated on thestudy of the effective mechanism of heparin. Vesselpatency, complication rate and representative electromi-croscopy section of the AIG were studied. Patency inthe intraarterial group is 90% (26/29) as compared to50% (12/26) in the intravenous delivery group(P【0.05).Scanning electromicroscopy showed a significant absenceof dense fibrin deposition and decrease in the numberof aggregated platelets in the intra-arterial perfusedAIG. The results of the present study indicate that thesmall dose of heparin through the artery is still effectivein maintaining the vessel pateney. Furthermore, in alarge, carefully controlled series, the complication ratewas low.展开更多
文摘Abstract：Aim To investigate the effect of hydrogen-rich saline on arterial thrombosis in sinoaortic denervatted （SAD） rats. Methods Rats were divided randomly into Sham group, SAD group, SAD ＋ hydrogen-rich saline （5 mL · kg^-1 · d^-1） group and SAD ＋ hydrogen-rich saline （10 mL · kg^-1 · d^-1） group. Four weeks after Sham or SAD operation, rats were given intraperitoneally normal saline or hydrogen-rich saline for 4 weeks. Carotid artery thrombosis was induced by 30% ferric chloride. Time till occlusion was measured by Laser Doppler Flowme- try. Results When compared with the Sham group, time till occlusion was significantly shorter in SAD group. Moreover, platelet aggregation, platelet adhesion to collagen and the level of ROS and malondialdehyde （MDA） in plasma and Ca2＋ in platelets were significantly raised. The level of NO and SOD in plasma and NO in platelet were significantly reduced. When compared with the SAD group, time till occlusion in hydrogen-rich saline group group was significantly prolonged. Platelet aggregation, adhesion, the level of ROS, MDA and Ca2＋ were significantly re- duced, whereas the level of NO and SOD in plasma and NO in platelets were significantly higher. Conclusion Hydrogen-rich saline might improve arterial thrombosis in SAD rats through inhibition of platelet activation and oxi- dative stress.
文摘Background and Objective Previous reports from PANDA III trial had proven that BuMA biodegradable polymer(BP)sirolimus-elutingstents(SES),with faster drug eluting rate and polymer absorption kinetics,was non-inferior to the Excel SES in an all-comers population for 1-year target lesion failure(TLF),with a lower incidence of stent thrombosis(ST).The aim of the present study was to perform a safety evaluation of BuMA SES in the complex patient and lesion subgroup.
文摘Utilizing a reliable, reproducible arterial inversiongraft thrombosis model, comparison of intraarterial VSwith intravenous heparin delivery in maintaining micro-vascular patency has been finished, concentrated on thestudy of the effective mechanism of heparin. Vesselpatency, complication rate and representative electromi-croscopy section of the AIG were studied. Patency inthe intraarterial group is 90% (26/29) as compared to50% (12/26) in the intravenous delivery group(P【0.05).Scanning electromicroscopy showed a significant absenceof dense fibrin deposition and decrease in the numberof aggregated platelets in the intra-arterial perfusedAIG. The results of the present study indicate that thesmall dose of heparin through the artery is still effectivein maintaining the vessel pateney. Furthermore, in alarge, carefully controlled series, the complication ratewas low.
