Objective To investigate the changes of perioperative serum levels of interleukin-6(IL-6), C-reactive protein (CRP), and cortisol, as well as gastric intramucosal pH (pHi) and plasma lactate, aiming to compare systemi...Objective To investigate the changes of perioperative serum levels of interleukin-6(IL-6), C-reactive protein (CRP), and cortisol, as well as gastric intramucosal pH (pHi) and plasma lactate, aiming to compare systemic changes and tissue perfusion during colorectal and orthopaedic surgical procedures. Methods Twenty patients were randomly assigned to two groups, 10 cases of operation on vertebral canal, 10 cases of colorectal radical operation.Venous blood was drawn at 1 day before operation, 2, 4, and 6 hours following skin incision, and 1 day after operation, in order to measure serum IL-6, CRP, and cortisol.pHi and plasma lactate were also measured at the same time points.Results Serum concentrations of IL-6 and cortisol increased gradually following operation, reaching the peak value at 6 hours from the beginning of operation.CRP was not detectable until the first day after operation.Peak concentration of IL-6 had positive relationship with CRP.These variables changed more significantly in colorectal group than that in orthopaedic group (P<0.05).pHi decreased gradually, reaching the lowest level at 4 hours from the beginning of operation, and to more extent in colorectal group than that in orthopaedic group (P<0.05).Conclusion IL-6 may reflect tissue damage more sensitively than CRP.Colorectal surgery might induce systemic disorder to more extent, in terms of immuno-endocrinal aspect as well as tissue perfusion, reflected with pHi.展开更多
目的分析改良Miccoli术式甲状腺腺叶切除术中运用膜解剖技术的出血量及出血部位对患者手术时间及术后并发症的影响。方法选择运用膜解剖技术完成改良MIiccoli术式单侧甲状腺腺叶加峡部切除加中央区淋巴结清扫术(CLND)的单侧甲状腺乳头...目的分析改良Miccoli术式甲状腺腺叶切除术中运用膜解剖技术的出血量及出血部位对患者手术时间及术后并发症的影响。方法选择运用膜解剖技术完成改良MIiccoli术式单侧甲状腺腺叶加峡部切除加中央区淋巴结清扫术(CLND)的单侧甲状腺乳头癌患者125例,采用脑棉片浸染实验估算术中出血量(分为术中出血量<1.0 mL或≥1.0 mL者),术中出血量≥1.0 mL者再根据出血部位发生率分为危险区出血和非危险区出血,比较其手术时间和术后并发症(暂时性喉返神经损伤、生化型甲状旁腺功能减退)。结果125例患者中术中出血量<1.0 mL 84例(67.2%)、出血量≥1.0 mL 41例(32.8%),其手术时间分别为(59.8±4.9)、(81.1±8.2)min,二者比较P<0.05;其术后发生暂时性喉返神经损伤分别为2例(2.4%)、6例(14.6%),二者比较P<0.05;其术后发生生化型甲状旁腺功能减退分别为14例(16.7%)、8例(19.5%),二者比较P>0.05。术中出血量≥1.0 mL者危险区出血36例、非危险区出血5例,其手术时间分别为(82.1±8.3)、(73.9±1.7)min(P<0.05),其术后暂时性喉返神经损伤、生化型甲状旁腺功能减退发生率比较P均>0.05。结论膜解剖技术用于单侧甲状腺乳头癌患者改良Miccoli术式甲状腺腺叶切除术,术中出血量控制在1.0 mL以内并避免危险区出血可以缩短手术时间、减少术后并发症的发生。展开更多
Objective.T o assess the viability of surgical procedures on gynecologic malignant patients o f70years age and older.Methods.Between September1,1983to June30,1 999,57gynecologic malignant patients aged70years and olde...Objective.T o assess the viability of surgical procedures on gynecologic malignant patients o f70years age and older.Methods.Between September1,1983to June30,1 999,57gynecologic malignant patients aged70years and older were treated by surgical procedures.A retrospective study was perf ormed.All patients were analyzed for preexisting medical conditions,length of hospital stay,morbidi-ty,and mortality.Results.Thirty-four patients had a n extensive surgical procedure,while a local surgical procedure was done in23 patients.Forty-one patientshad one or more preexisting medical i llnesses.Minor surgical morbidity occurred in24patientsand majo r surgical morbidity occurred in6patients.There were no differen ces in the types of surgical procedures,mean hospital stay,preexisting medical illness and postoperative complications between the two groups of patients70 to75year older and over age75.The major postoperative complications all occ urred in the extensive surgical procedure group that were higher as compared wit h local operation and postoperative mean stay was also significant-ly length in former group.Conclusions.The extensive surgical procedure can be performed fo r elderly patients with gynecologic malignances.Careful preoperative evaluatio n,monitoring,and meticulous postoperative care are vital to the success.展开更多
文摘Objective To investigate the changes of perioperative serum levels of interleukin-6(IL-6), C-reactive protein (CRP), and cortisol, as well as gastric intramucosal pH (pHi) and plasma lactate, aiming to compare systemic changes and tissue perfusion during colorectal and orthopaedic surgical procedures. Methods Twenty patients were randomly assigned to two groups, 10 cases of operation on vertebral canal, 10 cases of colorectal radical operation.Venous blood was drawn at 1 day before operation, 2, 4, and 6 hours following skin incision, and 1 day after operation, in order to measure serum IL-6, CRP, and cortisol.pHi and plasma lactate were also measured at the same time points.Results Serum concentrations of IL-6 and cortisol increased gradually following operation, reaching the peak value at 6 hours from the beginning of operation.CRP was not detectable until the first day after operation.Peak concentration of IL-6 had positive relationship with CRP.These variables changed more significantly in colorectal group than that in orthopaedic group (P<0.05).pHi decreased gradually, reaching the lowest level at 4 hours from the beginning of operation, and to more extent in colorectal group than that in orthopaedic group (P<0.05).Conclusion IL-6 may reflect tissue damage more sensitively than CRP.Colorectal surgery might induce systemic disorder to more extent, in terms of immuno-endocrinal aspect as well as tissue perfusion, reflected with pHi.
文摘目的分析改良Miccoli术式甲状腺腺叶切除术中运用膜解剖技术的出血量及出血部位对患者手术时间及术后并发症的影响。方法选择运用膜解剖技术完成改良MIiccoli术式单侧甲状腺腺叶加峡部切除加中央区淋巴结清扫术(CLND)的单侧甲状腺乳头癌患者125例,采用脑棉片浸染实验估算术中出血量(分为术中出血量<1.0 mL或≥1.0 mL者),术中出血量≥1.0 mL者再根据出血部位发生率分为危险区出血和非危险区出血,比较其手术时间和术后并发症(暂时性喉返神经损伤、生化型甲状旁腺功能减退)。结果125例患者中术中出血量<1.0 mL 84例(67.2%)、出血量≥1.0 mL 41例(32.8%),其手术时间分别为(59.8±4.9)、(81.1±8.2)min,二者比较P<0.05;其术后发生暂时性喉返神经损伤分别为2例(2.4%)、6例(14.6%),二者比较P<0.05;其术后发生生化型甲状旁腺功能减退分别为14例(16.7%)、8例(19.5%),二者比较P>0.05。术中出血量≥1.0 mL者危险区出血36例、非危险区出血5例,其手术时间分别为(82.1±8.3)、(73.9±1.7)min(P<0.05),其术后暂时性喉返神经损伤、生化型甲状旁腺功能减退发生率比较P均>0.05。结论膜解剖技术用于单侧甲状腺乳头癌患者改良Miccoli术式甲状腺腺叶切除术,术中出血量控制在1.0 mL以内并避免危险区出血可以缩短手术时间、减少术后并发症的发生。
文摘Objective.T o assess the viability of surgical procedures on gynecologic malignant patients o f70years age and older.Methods.Between September1,1983to June30,1 999,57gynecologic malignant patients aged70years and older were treated by surgical procedures.A retrospective study was perf ormed.All patients were analyzed for preexisting medical conditions,length of hospital stay,morbidi-ty,and mortality.Results.Thirty-four patients had a n extensive surgical procedure,while a local surgical procedure was done in23 patients.Forty-one patientshad one or more preexisting medical i llnesses.Minor surgical morbidity occurred in24patientsand majo r surgical morbidity occurred in6patients.There were no differen ces in the types of surgical procedures,mean hospital stay,preexisting medical illness and postoperative complications between the two groups of patients70 to75year older and over age75.The major postoperative complications all occ urred in the extensive surgical procedure group that were higher as compared wit h local operation and postoperative mean stay was also significant-ly length in former group.Conclusions.The extensive surgical procedure can be performed fo r elderly patients with gynecologic malignances.Careful preoperative evaluatio n,monitoring,and meticulous postoperative care are vital to the success.
