A chiral cinchona alkaloid derivative, which can be recovered and reused in asymmetric dihydroxylation (AD) reaction, was easily prepared from 1,4-dichlorophthalazine by two steps. The total yield is 87.4%. Applicatio...A chiral cinchona alkaloid derivative, which can be recovered and reused in asymmetric dihydroxylation (AD) reaction, was easily prepared from 1,4-dichlorophthalazine by two steps. The total yield is 87.4%. Application of this ligand to the AD reaction of six olefins afforded corresponding chiral diols in 92%～98% and 86%～99% ee. After the catalytic reaction, the ligand can be got by filtration from diethyl ether and reused for five runs with good yields and excellent enantioseletivity unchanged.展开更多
文摘A chiral cinchona alkaloid derivative, which can be recovered and reused in asymmetric dihydroxylation (AD) reaction, was easily prepared from 1,4-dichlorophthalazine by two steps. The total yield is 87.4%. Application of this ligand to the AD reaction of six olefins afforded corresponding chiral diols in 92%～98% and 86%～99% ee. After the catalytic reaction, the ligand can be got by filtration from diethyl ether and reused for five runs with good yields and excellent enantioseletivity unchanged.
