The current single-atom catalysts(SACs)for medicine still suffer from the limited active site density.Here,we develop a synthetic method capable of increasing both the metal loading and mass-specific activity of SACs ...The current single-atom catalysts(SACs)for medicine still suffer from the limited active site density.Here,we develop a synthetic method capable of increasing both the metal loading and mass-specific activity of SACs by exchanging zinc with iron.The constructed iron SACs(h^(3)-FNC)with a high metal loading of 6.27 wt%and an optimized adjacent Fe distance of~4 A exhibit excellent oxidase-like catalytic performance without significant activity decay after being stored for six months and promising antibacterial effects.Attractively,a“density effect”has been found at a high-enough metal doping amount,at which individual active sites become close enough to interact with each other and alter the electronic structure,resulting in significantly boosted intrinsic activity of single-atomic iron sites in h^(3)-FNCs by 2.3 times compared to low-and medium-loading SACs.Consequently,the overall catalytic activity of h^(3)-FNC is highly improved,with mass activity and metal mass-specific activity that are,respectively,66 and 315 times higher than those of commercial Pt/C.In addition,h^(3)-FNCs demonstrate efficiently enhanced capability in catalyzing oxygen reduction into superoxide anion(O_(2)·^(−))and glutathione(GSH)depletion.Both in vitro and in vivo assays demonstrate the superior antibacterial efficacy of h^(3)-FNCs in promoting wound healing.This work presents an intriguing activity-enhancement effect in catalysts and exhibits impressive therapeutic efficacy in combating bacterial infections.展开更多
Reactive oxygen species(ROS)plays important roles in living organisms.While ROS is a double-edged sword,which can eliminate drug-resistant bacteria,but excessive levels can cause oxidative damage to cells.A core–shel...Reactive oxygen species(ROS)plays important roles in living organisms.While ROS is a double-edged sword,which can eliminate drug-resistant bacteria,but excessive levels can cause oxidative damage to cells.A core–shell nanozyme,Ce O_(2)@ZIF-8/Au,has been crafted,spontaneously activating both ROS generating and scavenging functions,achieving the multifaceted functions of eliminating bacteria,reducing inflammation,and promoting wound healing.The Au Nanoparticles(NPs)on the shell exhibit high-efficiency peroxidase-like activity,producing ROS to kill bacteria.Meanwhile,the encapsulation of Ce O_(2) core within ZIF-8 provides a seal for temporarily limiting the superoxide dismutase and catalase-like activities of Ce O_(2) nanoparticles.Subsequently,as the ZIF-8 structure decomposes in the acidic microenvironment,the Ce O_(2) core is gradually released,exerting its ROS scavenging activity to eliminate excess ROS produced by the Au NPs.These two functions automatically and continuously regulate the balance of ROS levels,ultimately achieving the function of killing bacteria,reducing inflammation,and promoting wound healing.Such innovative ROS spontaneous regulators hold immense potential for revolutionizing the field of antibacterial agents and therapies.展开更多
在我国科学技术迅速发展的今天,移动机器人的智能程度在不断提升。同步定位与建图(Simultaneous Localization and Mapping,SLAM)算法是移动机器人自主导航实现的前提与关键。文章在ROS系统基础上分析了基于滤波器与基于图优化方法的SLA...在我国科学技术迅速发展的今天,移动机器人的智能程度在不断提升。同步定位与建图(Simultaneous Localization and Mapping,SLAM)算法是移动机器人自主导航实现的前提与关键。文章在ROS系统基础上分析了基于滤波器与基于图优化方法的SLAM算法原理,利用基于Jetson Nano硬件平台的移动机器人进行SLAM算法建图。文章针对建图中产生的地图错位漂移等问题进行研究讨论,分析得出Cartographer算法可在室内复杂环境下构建出误差低、精度高的2D栅格地图,验证了该算法在室内环境较其他算法的优异性,为移动机器人在室内SLAM建图提供更可靠的解决方案。展开更多
如何准确对岩体分级是深埋地下工程的一个难题。针对单一岩体评价模型存在误判的问题,提出了Random Over Sampler (ROS)改进机器学习算法集成权重岩体质量评价方法。采用ROS算法对类别非均衡样本进行采样处理,经SVM、KNN、NB、DT、RBF...如何准确对岩体分级是深埋地下工程的一个难题。针对单一岩体评价模型存在误判的问题,提出了Random Over Sampler (ROS)改进机器学习算法集成权重岩体质量评价方法。采用ROS算法对类别非均衡样本进行采样处理,经SVM、KNN、NB、DT、RBF、RF、LDA、LightGBM、XGBoost和GradientBoosting计算得到初步分级结果。将每一个分类器作为一个指标,确定每一个分类器的权重,建立ROS与机器学习算法的集成权重岩体质量评价模型,得到综合判别结果,大大降低了单一模型误判率。基于ROS改进机器学习算法集成权重提高了岩体质量评价模型的准确率,为岩体质量评价提供一种新的方法。展开更多
基金supported by the National Key Research and Development Program of China(Grant No.2022YFB3804500)the National Natural Science Foundation of China(Grant No.52202352,22335006)+4 种基金the Shanghai Municipal Health Commission(Grant No.20224Y0010)the CAMS Innovation Fund for Medical Sciences(Grant No.2021-I2M-5-012)the Basic Research Program of Shanghai Municipal Government(Grant No.21JC1406000)the Fundamental Research Funds for the Central Universities(Grant No.22120230237,2023-3-YB-11,22120220618)the Basic Research Program of Shanghai Municipal Government(23DX1900200).
文摘The current single-atom catalysts(SACs)for medicine still suffer from the limited active site density.Here,we develop a synthetic method capable of increasing both the metal loading and mass-specific activity of SACs by exchanging zinc with iron.The constructed iron SACs(h^(3)-FNC)with a high metal loading of 6.27 wt%and an optimized adjacent Fe distance of~4 A exhibit excellent oxidase-like catalytic performance without significant activity decay after being stored for six months and promising antibacterial effects.Attractively,a“density effect”has been found at a high-enough metal doping amount,at which individual active sites become close enough to interact with each other and alter the electronic structure,resulting in significantly boosted intrinsic activity of single-atomic iron sites in h^(3)-FNCs by 2.3 times compared to low-and medium-loading SACs.Consequently,the overall catalytic activity of h^(3)-FNC is highly improved,with mass activity and metal mass-specific activity that are,respectively,66 and 315 times higher than those of commercial Pt/C.In addition,h^(3)-FNCs demonstrate efficiently enhanced capability in catalyzing oxygen reduction into superoxide anion(O_(2)·^(−))and glutathione(GSH)depletion.Both in vitro and in vivo assays demonstrate the superior antibacterial efficacy of h^(3)-FNCs in promoting wound healing.This work presents an intriguing activity-enhancement effect in catalysts and exhibits impressive therapeutic efficacy in combating bacterial infections.
基金supported by the Natural Science Foundation of Fujian Province of China(No.2022J01043)China Scholarship Council(201806315005 and 201703170071).
文摘Reactive oxygen species(ROS)plays important roles in living organisms.While ROS is a double-edged sword,which can eliminate drug-resistant bacteria,but excessive levels can cause oxidative damage to cells.A core–shell nanozyme,Ce O_(2)@ZIF-8/Au,has been crafted,spontaneously activating both ROS generating and scavenging functions,achieving the multifaceted functions of eliminating bacteria,reducing inflammation,and promoting wound healing.The Au Nanoparticles(NPs)on the shell exhibit high-efficiency peroxidase-like activity,producing ROS to kill bacteria.Meanwhile,the encapsulation of Ce O_(2) core within ZIF-8 provides a seal for temporarily limiting the superoxide dismutase and catalase-like activities of Ce O_(2) nanoparticles.Subsequently,as the ZIF-8 structure decomposes in the acidic microenvironment,the Ce O_(2) core is gradually released,exerting its ROS scavenging activity to eliminate excess ROS produced by the Au NPs.These two functions automatically and continuously regulate the balance of ROS levels,ultimately achieving the function of killing bacteria,reducing inflammation,and promoting wound healing.Such innovative ROS spontaneous regulators hold immense potential for revolutionizing the field of antibacterial agents and therapies.
文摘在我国科学技术迅速发展的今天,移动机器人的智能程度在不断提升。同步定位与建图(Simultaneous Localization and Mapping,SLAM)算法是移动机器人自主导航实现的前提与关键。文章在ROS系统基础上分析了基于滤波器与基于图优化方法的SLAM算法原理,利用基于Jetson Nano硬件平台的移动机器人进行SLAM算法建图。文章针对建图中产生的地图错位漂移等问题进行研究讨论,分析得出Cartographer算法可在室内复杂环境下构建出误差低、精度高的2D栅格地图,验证了该算法在室内环境较其他算法的优异性,为移动机器人在室内SLAM建图提供更可靠的解决方案。
文摘如何准确对岩体分级是深埋地下工程的一个难题。针对单一岩体评价模型存在误判的问题,提出了Random Over Sampler (ROS)改进机器学习算法集成权重岩体质量评价方法。采用ROS算法对类别非均衡样本进行采样处理,经SVM、KNN、NB、DT、RBF、RF、LDA、LightGBM、XGBoost和GradientBoosting计算得到初步分级结果。将每一个分类器作为一个指标,确定每一个分类器的权重,建立ROS与机器学习算法的集成权重岩体质量评价模型,得到综合判别结果,大大降低了单一模型误判率。基于ROS改进机器学习算法集成权重提高了岩体质量评价模型的准确率,为岩体质量评价提供一种新的方法。
