A stochastic epidemic model with two age groups is established in this study,in which the susceptible(S),the exposed(E),the infected(I),the hospitalized(H)and the recovered(R)are involved within the total population,t...A stochastic epidemic model with two age groups is established in this study,in which the susceptible(S),the exposed(E),the infected(I),the hospitalized(H)and the recovered(R)are involved within the total population,the aging rates between two age groups are set to be constant.The existence-and-uniqueness of global positive solution is firstly showed.Then,by constructing several appropriate Lyapunov functions and using the high-dimensional Itô’s formula,the sufficient conditions for the stochastic extinction and stochastic persistence of the exposed individuals and the infected individuals are obtained.The stochastic extinction indicator and the stochastic persistence indicator are less-valued expressions compared with the basic reproduction number.Meanwhile,the main results of this study are modified into multi-age groups.Furthermore,by using the surveillance data for Fujian Provincial Center for Disease Control and Prevention,Fuzhou COVID-19 epidemic is chosen to carry out the numerical simulations,which show that the age group of the population plays the vital role when studying infectious diseases.展开更多
Objective:While age has been recognized as a noteworthy factor in preoperative graft selection,the correlation between age and hamstring autograft diameter has been the subject of continued debate within the scientifi...Objective:While age has been recognized as a noteworthy factor in preoperative graft selection,the correlation between age and hamstring autograft diameter has been the subject of continued debate within the scientific community.This study aimed to explore the correlation between the diameter of autologous tendon grafts and age in anterior cruciate ligament reconstruction(ACLR).Methods:A retrospective review of 388 patients who underwent arthroscopic ACLR with hamstring autografts was performed.Patients were grouped by age to analyze differences in hamstring autograft dia-meter and tendon cross-sectional area(CSA).We explored the correlations between age and graft diameter and between age and the CSA of the popliteal tendon while controlling for the influence of other pertinent variables.Results:Compared with female patients,male patients presented significantly greater autograft diameters and hamstring tendon CSAs(P<0.05).Notably,graft diameter and hamstring tendon CSA varied significantly across different age groups(P<0.05);patients aged>32 years were substantially more likely to have a graft diameter exceeding 8 mm and a CSA surpassing 18.5 mm^(2) than their≤32-year-old counterparts were(P<0.05).Conclusion:This study revealed that graft diameter varies across different age groups,with age independently influencing graft diameter.展开更多
旨在探究影响猪达100 kg体重日龄(age at 100 kg,AGE)和达100 kg体重平均日增重(average daily gain at 100 kg,ADG)的候选基因。本研究采集了来自大白、长白和杜洛克3个品种的共计4593头健康成年猪的耳组织作为试验材料,其中公猪2563头...旨在探究影响猪达100 kg体重日龄(age at 100 kg,AGE)和达100 kg体重平均日增重(average daily gain at 100 kg,ADG)的候选基因。本研究采集了来自大白、长白和杜洛克3个品种的共计4593头健康成年猪的耳组织作为试验材料,其中公猪2563头,母猪2030头。通过记录猪只的日龄和体重,计算校正AGE和ADG。通过酚氯仿法提取样品DNA,利用“中芯一号”50K SNP芯片对样本进行基因分型,并对质控后的SNPs进行基因型填充,将SNPs位点数从4万填充至800万。随后,利用GEMMA混合线性模型对AGE和ADG性状进行填充前后的全基因组关联分析,使用BEDTools在显著位点上、下游1 Mb范围查找候选基因。同时,结合PigGTEx中的34个组织的表达量数量性状位点数据,使用R软件进行共定位分析,挖掘与GWAS信号共享同一因果变异的基因,通过GWAS和共定位分析,确定AGE和ADG性状的候选基因。GWAS分析结果显示,AGE与ADG性状的显著SNP为1号染色体上的1_270827213。在该位点上、下游1 Mb范围内,共鉴定到32个基因。共定位分析结果显示,对于AGE性状,有10个基因的eQTL信号与GWAS信号共定位。对于ADG性状,有11个基因的eQTL信号与GWAS信号共定位。最终,确定了CRAT、GPR 107和USP 20这3个基因作为AGE的候选基因,确定了CRAT、GPR107、USP20、FNBP1、PTGES和HMCN 2这6个基因作为ADG的候选基因。本研究为猪品种改良提供了分子标记,对猪生长相关性状功能基因挖掘奠定基础。展开更多
基金Supported by National Natural Science Foundation of China(61911530398,12231012)Consultancy Project by the Chinese Academy of Engineering(2022-JB-06,2023-JB-12)+3 种基金the Natural Science Foundation of Fujian Province of China(2021J01621)Special Projects of the Central Government Guiding Local Science and Technology Development(2021L3018)Royal Society of Edinburgh(RSE1832)Engineering and Physical Sciences Research Council(EP/W522521/1).
文摘A stochastic epidemic model with two age groups is established in this study,in which the susceptible(S),the exposed(E),the infected(I),the hospitalized(H)and the recovered(R)are involved within the total population,the aging rates between two age groups are set to be constant.The existence-and-uniqueness of global positive solution is firstly showed.Then,by constructing several appropriate Lyapunov functions and using the high-dimensional Itô’s formula,the sufficient conditions for the stochastic extinction and stochastic persistence of the exposed individuals and the infected individuals are obtained.The stochastic extinction indicator and the stochastic persistence indicator are less-valued expressions compared with the basic reproduction number.Meanwhile,the main results of this study are modified into multi-age groups.Furthermore,by using the surveillance data for Fujian Provincial Center for Disease Control and Prevention,Fuzhou COVID-19 epidemic is chosen to carry out the numerical simulations,which show that the age group of the population plays the vital role when studying infectious diseases.
基金This work was supported by the Fundamental Research Funds for the Central Universities(WK9110000143)the USTC Research Funds of the Double First-Class Initiative(YD9110002060)the Health Research Program of Anhui(AHWJ2022b060)。
文摘Objective:While age has been recognized as a noteworthy factor in preoperative graft selection,the correlation between age and hamstring autograft diameter has been the subject of continued debate within the scientific community.This study aimed to explore the correlation between the diameter of autologous tendon grafts and age in anterior cruciate ligament reconstruction(ACLR).Methods:A retrospective review of 388 patients who underwent arthroscopic ACLR with hamstring autografts was performed.Patients were grouped by age to analyze differences in hamstring autograft dia-meter and tendon cross-sectional area(CSA).We explored the correlations between age and graft diameter and between age and the CSA of the popliteal tendon while controlling for the influence of other pertinent variables.Results:Compared with female patients,male patients presented significantly greater autograft diameters and hamstring tendon CSAs(P<0.05).Notably,graft diameter and hamstring tendon CSA varied significantly across different age groups(P<0.05);patients aged>32 years were substantially more likely to have a graft diameter exceeding 8 mm and a CSA surpassing 18.5 mm^(2) than their≤32-year-old counterparts were(P<0.05).Conclusion:This study revealed that graft diameter varies across different age groups,with age independently influencing graft diameter.
