C.P.E巴赫(Carl Philipp Emanuel Bach,1714~1788)上承巴洛克时代下启古典主义风格,无论在古钢琴奏鸣曲还是交响曲等体裁的创作上,都无疑是位举足轻重的人物。他作为柏林歌曲乐派的代表人物,一生创作了近300首德文歌曲,奠定了18世纪德...C.P.E巴赫(Carl Philipp Emanuel Bach,1714~1788)上承巴洛克时代下启古典主义风格,无论在古钢琴奏鸣曲还是交响曲等体裁的创作上,都无疑是位举足轻重的人物。他作为柏林歌曲乐派的代表人物,一生创作了近300首德文歌曲,奠定了18世纪德文歌曲写作手法,并推动了19世纪艺术歌曲的发展。以其一生的三部大型歌曲集为叙述重点,论述其德文歌曲创作的几个阶段,分析其歌曲特点,进而阐释与探析18世纪德文歌曲的写作风格。展开更多
C.P.E.巴赫不仅是腓特烈大帝的伴奏师、一位卓越的理论家,这位J.S.巴赫的次子更是一名极具创造力和美感的作曲家。
杰出的音乐历史学家查尔斯·伯尼（Charles Burney）博士曾两次游历欧洲,为他那本旷世巨作《音乐通史》（A General...C.P.E.巴赫不仅是腓特烈大帝的伴奏师、一位卓越的理论家,这位J.S.巴赫的次子更是一名极具创造力和美感的作曲家。
杰出的音乐历史学家查尔斯·伯尼（Charles Burney）博士曾两次游历欧洲,为他那本旷世巨作《音乐通史》（A General History of Music）寻找一手资料。其中最有意思的就是在1772年去汉堡拜见卡尔·菲利普·埃马努埃尔·巴赫（Carl Philipp Emanuel Bach,即C.P.E.巴赫）。展开更多
Selenium nanoparticles(SeNPs)have been demonstrated potential for use in diseases associated with oxidative stress.Functionalized SeNPs with lower toxicity and higher biocompatibility could bring better therapeutic ac...Selenium nanoparticles(SeNPs)have been demonstrated potential for use in diseases associated with oxidative stress.Functionalized SeNPs with lower toxicity and higher biocompatibility could bring better therapeutic activity and clinical application value.Herein,this work was conducted to investigate the protective effect of Pleurotus tuber-regium polysaccharide-protein complex funtionnalized SeNPs(PTR-SeNPs)against acetaminophen(APAP)-induced oxidative injure in HepG2 cells and C57BL/6J mouse liver.Further elucidation of the underlying molecular mechanism,in particular their modulation of Nrf2 signaling pathway was also performed.The results showed that PTR-SeNPs could significantly ameliorate APAP-induced oxidative injury as evidenced by a range of biochemical analysis,histopathological examination and immunoblotting study.PTR-SeNPs could hosphorylate and activate PKCδ,depress Keap1,and increase nuclear accumulation of Nrf2,resulting in upregulation of GCLC,GCLM,HO-1 and NQO-1 expression.Besides,PTR-SeNPs suppressed the biotransformation of APAP to generate intracellular ROS through CYP 2E1 inhibition,restoring the mitochondrial morphology.Furthermore,the protective effect of PTR-SeNPs against APAP induced hepatotoxicity was weakened as Nrf2 was depleted in vivo,indicating the pivotal role of Nrf2 signaling pathway in PTR-SeNPs mediated hepatoprotective efficacy.Being a potential hepatic protectant,PTR-SeNPs could serve as a new source of selenium supplement for health-promoting and biomedical applications.展开更多
文摘C.P.E巴赫(Carl Philipp Emanuel Bach,1714~1788)上承巴洛克时代下启古典主义风格,无论在古钢琴奏鸣曲还是交响曲等体裁的创作上,都无疑是位举足轻重的人物。他作为柏林歌曲乐派的代表人物,一生创作了近300首德文歌曲,奠定了18世纪德文歌曲写作手法,并推动了19世纪艺术歌曲的发展。以其一生的三部大型歌曲集为叙述重点,论述其德文歌曲创作的几个阶段,分析其歌曲特点,进而阐释与探析18世纪德文歌曲的写作风格。
文摘C.P.E.巴赫不仅是腓特烈大帝的伴奏师、一位卓越的理论家,这位J.S.巴赫的次子更是一名极具创造力和美感的作曲家。
杰出的音乐历史学家查尔斯·伯尼（Charles Burney）博士曾两次游历欧洲,为他那本旷世巨作《音乐通史》（A General History of Music）寻找一手资料。其中最有意思的就是在1772年去汉堡拜见卡尔·菲利普·埃马努埃尔·巴赫（Carl Philipp Emanuel Bach,即C.P.E.巴赫）。
基金financially supported by National Natural Science Foundation of China(81700524)Natural Science Foundation of Fujian Province(2022J01866)from Fujian Provincial Department of Science and Technology+1 种基金Key Project of Fujian University of Traditional Chinese Medicine(X2021019)Collaborative Innovation and Platform Establishment Project of Department of Science and Technology of Guangdong Province(2019A050520003)。
文摘Selenium nanoparticles(SeNPs)have been demonstrated potential for use in diseases associated with oxidative stress.Functionalized SeNPs with lower toxicity and higher biocompatibility could bring better therapeutic activity and clinical application value.Herein,this work was conducted to investigate the protective effect of Pleurotus tuber-regium polysaccharide-protein complex funtionnalized SeNPs(PTR-SeNPs)against acetaminophen(APAP)-induced oxidative injure in HepG2 cells and C57BL/6J mouse liver.Further elucidation of the underlying molecular mechanism,in particular their modulation of Nrf2 signaling pathway was also performed.The results showed that PTR-SeNPs could significantly ameliorate APAP-induced oxidative injury as evidenced by a range of biochemical analysis,histopathological examination and immunoblotting study.PTR-SeNPs could hosphorylate and activate PKCδ,depress Keap1,and increase nuclear accumulation of Nrf2,resulting in upregulation of GCLC,GCLM,HO-1 and NQO-1 expression.Besides,PTR-SeNPs suppressed the biotransformation of APAP to generate intracellular ROS through CYP 2E1 inhibition,restoring the mitochondrial morphology.Furthermore,the protective effect of PTR-SeNPs against APAP induced hepatotoxicity was weakened as Nrf2 was depleted in vivo,indicating the pivotal role of Nrf2 signaling pathway in PTR-SeNPs mediated hepatoprotective efficacy.Being a potential hepatic protectant,PTR-SeNPs could serve as a new source of selenium supplement for health-promoting and biomedical applications.
