Objective To observe the correlations of chest CT quantitative parameters in patients with acute exacerbation of chronic obstructive pulmonary disease(AECOPD)with blood eosinophil(EOS)level.Methods Chest CT data of 16...Objective To observe the correlations of chest CT quantitative parameters in patients with acute exacerbation of chronic obstructive pulmonary disease(AECOPD)with blood eosinophil(EOS)level.Methods Chest CT data of 162 AECOPD patients with elevated eosinophils were retrospectively analyzed.The patients were divided into low EOS group(n=105)and high EOS group(n=57)according to the absolute counting of blood EOS.The quantitative CT parameters,including the number of whole lung bronchi and the volume of blood vessels,low-attenuation area percentage(LAA%)of whole lung,of left/right lung and each lobe of lung,as well as the luminal diameter(LD),wall thickness(WT),wall area(WA)and WA percentage of total bronchial cross-section(WA%)of grade 3 to 8 bronchi were compared between groups.Spearman correlations were performed to analyze the correlations of quantitative CT parameters with blood EOS level.Results LAA%of the whole lung,of the left/right lung and each lobe of lung,as well as of the upper lobe of right lung LD grade 4,middle lobe of right lung WT grade 5,upper lobe of right lung WA grade 4,middle lobe of right lung WA grade 5 and lower lobe of left lung WA grade 3 in low EOS group were all higher than those in high EOS group(all P<0.05).Except for the upper lobe of right lung LD grade 4,the above quantitative CT indexes being significant different between groups were all weakly and negatively correlated with blood EOS level(r=-0.335 to-0.164,all P<0.05).Conclusion Chest CT quantitative parameters of AECOPD patients were correlated with blood EOS level,among which LAA%,a part of WT and WA were all weakly negatively correlated with blood EOS level.展开更多
文摘Objective To observe the correlations of chest CT quantitative parameters in patients with acute exacerbation of chronic obstructive pulmonary disease(AECOPD)with blood eosinophil(EOS)level.Methods Chest CT data of 162 AECOPD patients with elevated eosinophils were retrospectively analyzed.The patients were divided into low EOS group(n=105)and high EOS group(n=57)according to the absolute counting of blood EOS.The quantitative CT parameters,including the number of whole lung bronchi and the volume of blood vessels,low-attenuation area percentage(LAA%)of whole lung,of left/right lung and each lobe of lung,as well as the luminal diameter(LD),wall thickness(WT),wall area(WA)and WA percentage of total bronchial cross-section(WA%)of grade 3 to 8 bronchi were compared between groups.Spearman correlations were performed to analyze the correlations of quantitative CT parameters with blood EOS level.Results LAA%of the whole lung,of the left/right lung and each lobe of lung,as well as of the upper lobe of right lung LD grade 4,middle lobe of right lung WT grade 5,upper lobe of right lung WA grade 4,middle lobe of right lung WA grade 5 and lower lobe of left lung WA grade 3 in low EOS group were all higher than those in high EOS group(all P<0.05).Except for the upper lobe of right lung LD grade 4,the above quantitative CT indexes being significant different between groups were all weakly and negatively correlated with blood EOS level(r=-0.335 to-0.164,all P<0.05).Conclusion Chest CT quantitative parameters of AECOPD patients were correlated with blood EOS level,among which LAA%,a part of WT and WA were all weakly negatively correlated with blood EOS level.
文摘目的研究以涤痰汤为基础,随证加减化裁方治疗慢性阻塞性肺疾病(chronic obstructive pulmonary disease,COPD)合并肺部感染的临床疗效及对血清白介素-6(interleukin-6,IL-6)、干扰素γ(interferon gamma,IFN-γ)及肿瘤坏死因子-α(tumor necrosis factor-α,TNF-α)水平的影响。方法纳入2022年1月—2023年6月医院收治的124例慢性阻塞性肺疾病合并肺部感染患者,采用随机数字表法分为研究组(62例)和对照组(62例)。对照组采用西医常规治疗,研究组在常规治疗的基础上联合涤痰汤化裁方治疗。对比两组治疗后的临床疗效、中医证候积分、血气指标血氧分压(partial pressure of oxygen,PaO_(2))、血氧饱和度(oxygen saturation of blood,SaO_(2))、动脉血二氧化碳分压(partial pressure of arterial blood carbon dioxide,PaCO_(2))水平、肺功能第一秒用力呼气量(forced expiratory volume in the first second,FEV_(1))、最大自主通气量(maximalvoluntaryventilation,MVV)、用力肺活量(forced vital capacity,FVC)、第一秒用力呼气量与用力肺活量的比值(FEV_(1)/FVC)水平、促炎因子IL-6、IFN-γ及TNF-α水平。结果两组患者治疗前各项肺功能检测指标、血气指标、中医证候积分、血清IL-6、IFN-γ及TNF-α差异均无统计学意义(P>0.05)。治疗后,研究组患者的总有效率为96.77%高于对照组的87.10%(P<0.05);研究组患者治疗后的中医证候积分值小于对照组(P<0.05);两组患者治疗后的血气指标如PaO_(2)、SaO_(2)均升高、PaCO_(2)均降低,且研究组改善更明显(P<0.05);两组患者治疗后的肺功能指标如FEV_(1)、MVV、FVC、FEV_(1)/FVC均升高,且研究组改善更明显(P<0.05);两组患者治疗后血清IL-6、IFN-γ及TNF-α水平均降低,且研究组改善更明显,差异具有统计学意义(P<0.05)。结论涤痰汤化裁方治疗慢性阻塞性肺疾病合并肺部感染有较高的疗效,其能改善患者肺功能、缓解临床症状及降低血清IL-6、IFN-γ及TNF-α水平。
