This study presents a significant advancement in the vibration analysis of functionally graded sandwich plates with auxetic cores by introducing a general viscoelastic foundation model that more accurately reflects th...This study presents a significant advancement in the vibration analysis of functionally graded sandwich plates with auxetic cores by introducing a general viscoelastic foundation model that more accurately reflects the complex interactions between the plate and the foundation.The novelty of this study is that the proposed viscoelastic foundation model incorporates elastic and damping effects in both the Winkler and Pasternak layers.To develop the theoretical framework for this analysis,the higher-order shear deformation theory is employed,while Hamilton's principle is used to derive the governing equations of motion.The closed-form solution is used to determine the damped vibration behaviors of the sandwich plates.The precision and robustness of the proposed mathematical model are validated through several comparison studies with existing numerical results.A detailed parametric study is conducted to investigate the influence of various parameters,including the elastic and damping coefficients of the foundation,the material gradation,and the properties of the auxetic core on the vibration behavior of the plates.The numerical results provide new insights into the vibration characteristics of sandwich plates with auxetic cores resting on viscoelastic foundation,highlighting the significant role of the two damping coefficients and auxetic cores in the visco-vibration behavior of the plates.展开更多
Plum blossom pile is a new type of special-shaped pile, which is proposed based on the principle of maximum perimeter with the same cross-sectional area. To advance this technique, primarily for the design of plum blo...Plum blossom pile is a new type of special-shaped pile, which is proposed based on the principle of maximum perimeter with the same cross-sectional area. To advance this technique, primarily for the design of plum blossom piles, it is important to investigate the skin friction behavior of plum blossom pile foundations precluding any straightforward constitutive model. In this work, an analytic method dependent on the cross-sectional geometry and the vertical shearing effects is proposed by means of equilibrium analysis to calculate the effective vertical stress in the surrounding soil, the skin friction/negative skin friction, and the axial force/dragload of a plum blossom pile. Additionally, the curves of skin friction of piles are investigated with the same conditions. The results show that the curves of skin friction of piles deduced according to the developed analytic method agree well with the FEM results and related literature solution, which validates the solution. The axial force of the pile decreases with the increase of the shear action coefficient in the buried depth direction under the vertical concentrated load when considering the vertical shearing effects on the pile-soil interfaces.展开更多
A GC-NCI-MS method was developed for the determination of chlorfenapyr residues in eggplant and soil sample.The sample was extracted by the mixture solvent of acetone-dichloromethane(4 ∶3,by volume),and cleaned up by...A GC-NCI-MS method was developed for the determination of chlorfenapyr residues in eggplant and soil sample.The sample was extracted by the mixture solvent of acetone-dichloromethane(4 ∶3,by volume),and cleaned up by chromatographic column of aluminum oxide-graphitized carbon black.The analysis of extract was performed by gas chromatography-negative chemical ionization-mass spectrometry(GC-NCI-MS).The recoveries of chlorfenapyr at the spiked concentration levels of 0.1,1.0,10.0 mg/kg were 100%-116% for eggplant sample with RSD of 2.0%-6.2%,and 83%-116% for the soil sample with RSD of 1.1%-4.5%,respectively.展开更多
文本分类是信息检索的关键问题之一.提取更多的可信反例和构造准确高效的分类器是PU(positive and unlabeled)文本分类的两个重要问题.然而,在现有的可信反例提取方法中,很多方法提取的可信反例数量较少,构建的分类器质量有待提高.分别...文本分类是信息检索的关键问题之一.提取更多的可信反例和构造准确高效的分类器是PU(positive and unlabeled)文本分类的两个重要问题.然而,在现有的可信反例提取方法中,很多方法提取的可信反例数量较少,构建的分类器质量有待提高.分别针对这两个重要步骤提供了一种基于聚类的半监督主动分类方法.与传统的反例提取方法不同,利用聚类技术和正例文档应与反例文档共享尽可能少的特征项这一特点,从未标识数据集中尽可能多地移除正例,从而可以获得更多的可信反例.结合SVM主动学习和改进的Rocchio构建分类器,并采用改进的TFIDF(term frequency inverse document frequency)进行特征提取,可以显著提高分类的准确度.分别在3个不同的数据集中测试了分类结果(RCV1,Reuters-21578,20 Newsgoups).实验结果表明,基于聚类寻找可信反例可以在保持较低错误率的情况下获取更多的可信反例,而且主动学习方法的引入也显著提升了分类精度.展开更多
Six massive ores in the Jinchuan deposit were dated by Re-Os technique. The Os concentrations and isotopic ratios were determined by N-TIMS, while Re and Pt concentrations were determined by ICP-MS. The samples gave a...Six massive ores in the Jinchuan deposit were dated by Re-Os technique. The Os concentrations and isotopic ratios were determined by N-TIMS, while Re and Pt concentrations were determined by ICP-MS. The samples gave an isochron age of (852±25) Ma with an initial 187Os/188Os ratio of 0.255 ± 0.014. A 7-point Pt-Os isochrone gives an age of (870±38) Ma with an initial 186Os/188Os ratio of 0.119 84±0.000 27.展开更多
The article presents some major researches concerning the concept of backwash effect of language testing; analyses both the positive and negative effects and their implications in EFL classrooms; then provides some su...The article presents some major researches concerning the concept of backwash effect of language testing; analyses both the positive and negative effects and their implications in EFL classrooms; then provides some suggested ways to be followed when creating positive backwash effects on teaching and learning.展开更多
The effects of a fine water mist environment in a semi-confined blast chamber on the chemical and thermodynamic processes following detonation of a 20 g PE4 explosive charge have been investigated.The effects were qua...The effects of a fine water mist environment in a semi-confined blast chamber on the chemical and thermodynamic processes following detonation of a 20 g PE4 explosive charge have been investigated.The effects were quantified by the analysis of pressure profiles recorded where several parameters including arrival time of the shock at the sensors, peak overpressures, specific impulse of the positive phase, period of the negative phase and the specific impulse of the multiple reflections were quantified.The effect of the fine water mist on the arrival time, peak pressures and the specific impulse of the positive phase agrees with previous findings in literature. In this paper, the focus is on the implications of the fine water mist on the negative phase and the impulse of multiple pressure reflections. The period of the negative phase was found to have increased by 40% and with higher negative peak pressure in the mist condition compared to the atmospheric condition. The activities of the multiple pressure reflections were found to have decreased considerably, both in number and in amplitude leading to lower impulses(by about 60%) for the water mist conditions.展开更多
OBJECTIVE To discover a small molecule targeting ULK1-modulated cell death of triple negative breast cancer and exploreits potential mechanisms.METHODS ULK1 expression was analyzed by The Cancer Genome Atlas(TCGA)anal...OBJECTIVE To discover a small molecule targeting ULK1-modulated cell death of triple negative breast cancer and exploreits potential mechanisms.METHODS ULK1 expression was analyzed by The Cancer Genome Atlas(TCGA)analysis and tissue microarray(TMA)analysis.ULK1agonist was designed by using in silico screening,as well as modified by chemical synthesis and screened by kinase and anti-proliferative activities.The amino acid residues that key to the activation site of LYN-1604 were determined by site-directed mutagenesis,as well as in vitro kinase assay and ADP-Glo kinase assay.The mechanisms of LYN-1604 induced cell death were investigated by fluorescence microscope,western blotting,flow cytometry analysis,immunocytochemistry,as well as si RNA and GFP-m RFP-LC3 plasmid transfections.Potential ULK1 interactors were discovered by performing comparative microarray analysis and the therapeutic effect of LYN-1604 was assessed by xenograft breast cancer mouse model.RESULTS We found that ULK1 was remarkably downregulated in breast cancer tissue samples,especial y in triple negative breast cancer(TNBC).32 candidate smal molecules were synthesized,and we discovered a small molecule named LYN-1604 as the best candidate ULK1agonist.Additionally,we identified that three amino acid residues(LYS50,LEU53 and TYR89)were key to the activation site of LYN-1604 and ULK1.Subsequently,we demonstrated that LYN-1604 could induce autophagy-associated cell death via ULK complex(ULK1-m ATG13-FIP200-ATG101)in MDA-MB-231 cells.We also found that LYN-1604 induced cell death involved in ATF3,RAD21 and caspase 3,accompanied with autophagy and apoptosis.Moreover,we demonstrated that LYN-1604 had a good therapeutic potential on TNBC by targeting ULK1-modulated cell death in vivo.CONCLUSION We discovered a small molecule(LYN-1604)has therapeutic potential by targeting ULK1-modulated cell death associated with autophagy and apoptosis of TNBC in vitro and in vivo,which could be utilized as a new anti-TNBC drug candidate.展开更多
A simplified approach was proposed to analyze the negative skin friction calculation of special-shaped pile considering pile-soil interaction under surcharge. Based on the concentric cylinder shearing theory, consider...A simplified approach was proposed to analyze the negative skin friction calculation of special-shaped pile considering pile-soil interaction under surcharge. Based on the concentric cylinder shearing theory, considering the changes of pile shape(such as, taper angle and diameters of pile base, etc.), the load-transfer of special-shaped pile was built. The accuracy of the developed simplified approach was verified by numerical simulation model with the same condition. Then, the influence factors, such as, taper angles, the diameter of pile base, surcharge, and pile-soil interface parameters were analyzed and discussed. The results show that the developed simplified approach can calculate NSF of special-shaped pile under surcharge effectively. A limited parametric study indicates that in many practical situations special-shaped piles(such as belled wedge pile shown in this work) offer a design option that is more economical than traditional uniform cross-section piles.展开更多
Focusing on data imbalance and intraclass variation,an improved pedestrian detection with a cascade of complex peer AdaBoost classifiers is proposed.The series of the AdaBoost classifiers are learned greedily,along wi...Focusing on data imbalance and intraclass variation,an improved pedestrian detection with a cascade of complex peer AdaBoost classifiers is proposed.The series of the AdaBoost classifiers are learned greedily,along with negative example mining.The complexity of classifiers in the cascade is not limited,so more negative examples are used for training.Furthermore,the cascade becomes an ensemble of strong peer classifiers,which treats intraclass variation.To locally train the AdaBoost classifiers with a high detection rate,a refining strategy is used to discard the hardest negative training examples rather than decreasing their thresholds.Using the aggregate channel feature(ACF),the method achieves miss rates of 35%and 14%on the Caltech pedestrian benchmark and Inria pedestrian dataset,respectively,which are lower than that of increasingly complex AdaBoost classifiers,i.e.,44%and 17%,respectively.Using deep features extracted by the region proposal network(RPN),the method achieves a miss rate of 10.06%on the Caltech pedestrian benchmark,which is also lower than 10.53%from the increasingly complex cascade.This study shows that the proposed method can use more negative examples to train the pedestrian detector.It outperforms the existing cascade of increasingly complex classifiers.展开更多
Ballistic missile defense system (BMDS) is important for its special role in ensuring national security and maintaining strategic balance. Research on modeling and simulation of the BMDS beforehand is essential as dev...Ballistic missile defense system (BMDS) is important for its special role in ensuring national security and maintaining strategic balance. Research on modeling and simulation of the BMDS beforehand is essential as developing a real one requires lots of manpower and resources. BMDS is a typical complex system for its nonlinear, adaptive and uncertainty characteristics. The agent-based modeling method is well suited for the complex system whose overall behaviors are determined by interactions among individual elements. A multi-agent decision support system (DSS), which includes missile agent, radar agent and command center agent, is established based on the studies of structure and function of BMDS. Considering the constraints brought by radar, intercept missile, offensive missile and commander, the objective function of DSS is established. In order to dynamically generate the optimal interception plan, the variable neighborhood negative selection particle swarm optimization (VNNSPSO) algorithm is proposed to support the decision making of DSS. The proposed algorithm is compared with the standard PSO, constriction factor PSO (CFPSO), inertia weight linear decrease PSO (LDPSO), variable neighborhood PSO (VNPSO) algorithm from the aspects of convergence rate, iteration number, average fitness value and standard deviation. The simulation results verify the efficiency of the proposed algorithm. The multi-agent DSS is developed through the Repast simulation platform and the constructed DSS can generate intercept plans automatically and support three-dimensional dynamic display of missile defense process.展开更多
A new type of lead-based porous anode in zinc electrowinning was prepared by negative pressure infiltration. The anodic polarization potential and corrosion rate were studied and compared with those of traditional fia...A new type of lead-based porous anode in zinc electrowinning was prepared by negative pressure infiltration. The anodic polarization potential and corrosion rate were studied and compared with those of traditional fiat anodes （Pb-0.8%Ag） used in industry. The anode corrosion rate was determined by anode actual current density and microstructure. The results show that the anodic oxygen evolution potential decreases first and then increases with the decrease of pore diameter. The anodic potential decreases to the lowest value of 1.729 V at the pore diameter of 1.25-1.60 mm. The porous anode can decrease its actual current density and thus decrease the anodic corrosion rate. When the pore diameter is 1.60-2.00 mm, the anodic relative corrosion rate reaches the lowest value of 52.1%.展开更多
基金the funding of the Deanship of Graduate Studies and Scientific Research,Jazan University,Saudi Arabia,through project number:RG24-M027.
文摘This study presents a significant advancement in the vibration analysis of functionally graded sandwich plates with auxetic cores by introducing a general viscoelastic foundation model that more accurately reflects the complex interactions between the plate and the foundation.The novelty of this study is that the proposed viscoelastic foundation model incorporates elastic and damping effects in both the Winkler and Pasternak layers.To develop the theoretical framework for this analysis,the higher-order shear deformation theory is employed,while Hamilton's principle is used to derive the governing equations of motion.The closed-form solution is used to determine the damped vibration behaviors of the sandwich plates.The precision and robustness of the proposed mathematical model are validated through several comparison studies with existing numerical results.A detailed parametric study is conducted to investigate the influence of various parameters,including the elastic and damping coefficients of the foundation,the material gradation,and the properties of the auxetic core on the vibration behavior of the plates.The numerical results provide new insights into the vibration characteristics of sandwich plates with auxetic cores resting on viscoelastic foundation,highlighting the significant role of the two damping coefficients and auxetic cores in the visco-vibration behavior of the plates.
基金Project(52325905) supported by the National Natural Science Foundation of ChinaProjects(DJ-HXGG-2023-04, DJHXGG-2023-16) supported by the Key Technology Research Projects of Power China。
文摘Plum blossom pile is a new type of special-shaped pile, which is proposed based on the principle of maximum perimeter with the same cross-sectional area. To advance this technique, primarily for the design of plum blossom piles, it is important to investigate the skin friction behavior of plum blossom pile foundations precluding any straightforward constitutive model. In this work, an analytic method dependent on the cross-sectional geometry and the vertical shearing effects is proposed by means of equilibrium analysis to calculate the effective vertical stress in the surrounding soil, the skin friction/negative skin friction, and the axial force/dragload of a plum blossom pile. Additionally, the curves of skin friction of piles are investigated with the same conditions. The results show that the curves of skin friction of piles deduced according to the developed analytic method agree well with the FEM results and related literature solution, which validates the solution. The axial force of the pile decreases with the increase of the shear action coefficient in the buried depth direction under the vertical concentrated load when considering the vertical shearing effects on the pile-soil interfaces.
文摘A GC-NCI-MS method was developed for the determination of chlorfenapyr residues in eggplant and soil sample.The sample was extracted by the mixture solvent of acetone-dichloromethane(4 ∶3,by volume),and cleaned up by chromatographic column of aluminum oxide-graphitized carbon black.The analysis of extract was performed by gas chromatography-negative chemical ionization-mass spectrometry(GC-NCI-MS).The recoveries of chlorfenapyr at the spiked concentration levels of 0.1,1.0,10.0 mg/kg were 100%-116% for eggplant sample with RSD of 2.0%-6.2%,and 83%-116% for the soil sample with RSD of 1.1%-4.5%,respectively.
文摘文本分类是信息检索的关键问题之一.提取更多的可信反例和构造准确高效的分类器是PU(positive and unlabeled)文本分类的两个重要问题.然而,在现有的可信反例提取方法中,很多方法提取的可信反例数量较少,构建的分类器质量有待提高.分别针对这两个重要步骤提供了一种基于聚类的半监督主动分类方法.与传统的反例提取方法不同,利用聚类技术和正例文档应与反例文档共享尽可能少的特征项这一特点,从未标识数据集中尽可能多地移除正例,从而可以获得更多的可信反例.结合SVM主动学习和改进的Rocchio构建分类器,并采用改进的TFIDF(term frequency inverse document frequency)进行特征提取,可以显著提高分类的准确度.分别在3个不同的数据集中测试了分类结果(RCV1,Reuters-21578,20 Newsgoups).实验结果表明,基于聚类寻找可信反例可以在保持较低错误率的情况下获取更多的可信反例,而且主动学习方法的引入也显著提升了分类精度.
文摘Six massive ores in the Jinchuan deposit were dated by Re-Os technique. The Os concentrations and isotopic ratios were determined by N-TIMS, while Re and Pt concentrations were determined by ICP-MS. The samples gave an isochron age of (852±25) Ma with an initial 187Os/188Os ratio of 0.255 ± 0.014. A 7-point Pt-Os isochrone gives an age of (870±38) Ma with an initial 186Os/188Os ratio of 0.119 84±0.000 27.
文摘The article presents some major researches concerning the concept of backwash effect of language testing; analyses both the positive and negative effects and their implications in EFL classrooms; then provides some suggested ways to be followed when creating positive backwash effects on teaching and learning.
文摘The effects of a fine water mist environment in a semi-confined blast chamber on the chemical and thermodynamic processes following detonation of a 20 g PE4 explosive charge have been investigated.The effects were quantified by the analysis of pressure profiles recorded where several parameters including arrival time of the shock at the sensors, peak overpressures, specific impulse of the positive phase, period of the negative phase and the specific impulse of the multiple reflections were quantified.The effect of the fine water mist on the arrival time, peak pressures and the specific impulse of the positive phase agrees with previous findings in literature. In this paper, the focus is on the implications of the fine water mist on the negative phase and the impulse of multiple pressure reflections. The period of the negative phase was found to have increased by 40% and with higher negative peak pressure in the mist condition compared to the atmospheric condition. The activities of the multiple pressure reflections were found to have decreased considerably, both in number and in amplitude leading to lower impulses(by about 60%) for the water mist conditions.
基金supported by National Natural Science Foundation of China(81402496,81673455and 81602627)China Postdoctoral Special Science Foundation(2017T100704)China Postdoctoral Science Foundation(2015M580794)
文摘OBJECTIVE To discover a small molecule targeting ULK1-modulated cell death of triple negative breast cancer and exploreits potential mechanisms.METHODS ULK1 expression was analyzed by The Cancer Genome Atlas(TCGA)analysis and tissue microarray(TMA)analysis.ULK1agonist was designed by using in silico screening,as well as modified by chemical synthesis and screened by kinase and anti-proliferative activities.The amino acid residues that key to the activation site of LYN-1604 were determined by site-directed mutagenesis,as well as in vitro kinase assay and ADP-Glo kinase assay.The mechanisms of LYN-1604 induced cell death were investigated by fluorescence microscope,western blotting,flow cytometry analysis,immunocytochemistry,as well as si RNA and GFP-m RFP-LC3 plasmid transfections.Potential ULK1 interactors were discovered by performing comparative microarray analysis and the therapeutic effect of LYN-1604 was assessed by xenograft breast cancer mouse model.RESULTS We found that ULK1 was remarkably downregulated in breast cancer tissue samples,especial y in triple negative breast cancer(TNBC).32 candidate smal molecules were synthesized,and we discovered a small molecule named LYN-1604 as the best candidate ULK1agonist.Additionally,we identified that three amino acid residues(LYS50,LEU53 and TYR89)were key to the activation site of LYN-1604 and ULK1.Subsequently,we demonstrated that LYN-1604 could induce autophagy-associated cell death via ULK complex(ULK1-m ATG13-FIP200-ATG101)in MDA-MB-231 cells.We also found that LYN-1604 induced cell death involved in ATF3,RAD21 and caspase 3,accompanied with autophagy and apoptosis.Moreover,we demonstrated that LYN-1604 had a good therapeutic potential on TNBC by targeting ULK1-modulated cell death in vivo.CONCLUSION We discovered a small molecule(LYN-1604)has therapeutic potential by targeting ULK1-modulated cell death associated with autophagy and apoptosis of TNBC in vitro and in vivo,which could be utilized as a new anti-TNBC drug candidate.
基金Projects(51278170,U1134207)supported by the National Natural Science Foundation of ChinaProject(B13024)supported by the Program of Introducing Talents of Discipline to Universities,China
文摘A simplified approach was proposed to analyze the negative skin friction calculation of special-shaped pile considering pile-soil interaction under surcharge. Based on the concentric cylinder shearing theory, considering the changes of pile shape(such as, taper angle and diameters of pile base, etc.), the load-transfer of special-shaped pile was built. The accuracy of the developed simplified approach was verified by numerical simulation model with the same condition. Then, the influence factors, such as, taper angles, the diameter of pile base, surcharge, and pile-soil interface parameters were analyzed and discussed. The results show that the developed simplified approach can calculate NSF of special-shaped pile under surcharge effectively. A limited parametric study indicates that in many practical situations special-shaped piles(such as belled wedge pile shown in this work) offer a design option that is more economical than traditional uniform cross-section piles.
基金Project(2018AAA0102102)supported by the National Science and Technology Major Project,ChinaProject(2017WK2074)supported by the Planned Science and Technology Project of Hunan Province,China+1 种基金Project(B18059)supported by the National 111 Project,ChinaProject(61702559)supported by the National Natural Science Foundation of China。
文摘Focusing on data imbalance and intraclass variation,an improved pedestrian detection with a cascade of complex peer AdaBoost classifiers is proposed.The series of the AdaBoost classifiers are learned greedily,along with negative example mining.The complexity of classifiers in the cascade is not limited,so more negative examples are used for training.Furthermore,the cascade becomes an ensemble of strong peer classifiers,which treats intraclass variation.To locally train the AdaBoost classifiers with a high detection rate,a refining strategy is used to discard the hardest negative training examples rather than decreasing their thresholds.Using the aggregate channel feature(ACF),the method achieves miss rates of 35%and 14%on the Caltech pedestrian benchmark and Inria pedestrian dataset,respectively,which are lower than that of increasingly complex AdaBoost classifiers,i.e.,44%and 17%,respectively.Using deep features extracted by the region proposal network(RPN),the method achieves a miss rate of 10.06%on the Caltech pedestrian benchmark,which is also lower than 10.53%from the increasingly complex cascade.This study shows that the proposed method can use more negative examples to train the pedestrian detector.It outperforms the existing cascade of increasingly complex classifiers.
文摘Ballistic missile defense system (BMDS) is important for its special role in ensuring national security and maintaining strategic balance. Research on modeling and simulation of the BMDS beforehand is essential as developing a real one requires lots of manpower and resources. BMDS is a typical complex system for its nonlinear, adaptive and uncertainty characteristics. The agent-based modeling method is well suited for the complex system whose overall behaviors are determined by interactions among individual elements. A multi-agent decision support system (DSS), which includes missile agent, radar agent and command center agent, is established based on the studies of structure and function of BMDS. Considering the constraints brought by radar, intercept missile, offensive missile and commander, the objective function of DSS is established. In order to dynamically generate the optimal interception plan, the variable neighborhood negative selection particle swarm optimization (VNNSPSO) algorithm is proposed to support the decision making of DSS. The proposed algorithm is compared with the standard PSO, constriction factor PSO (CFPSO), inertia weight linear decrease PSO (LDPSO), variable neighborhood PSO (VNPSO) algorithm from the aspects of convergence rate, iteration number, average fitness value and standard deviation. The simulation results verify the efficiency of the proposed algorithm. The multi-agent DSS is developed through the Repast simulation platform and the constructed DSS can generate intercept plans automatically and support three-dimensional dynamic display of missile defense process.
基金Project(2007SK2009) supported by the Science and Technology Research Project of Hunan Province, China
文摘A new type of lead-based porous anode in zinc electrowinning was prepared by negative pressure infiltration. The anodic polarization potential and corrosion rate were studied and compared with those of traditional fiat anodes （Pb-0.8%Ag） used in industry. The anode corrosion rate was determined by anode actual current density and microstructure. The results show that the anodic oxygen evolution potential decreases first and then increases with the decrease of pore diameter. The anodic potential decreases to the lowest value of 1.729 V at the pore diameter of 1.25-1.60 mm. The porous anode can decrease its actual current density and thus decrease the anodic corrosion rate. When the pore diameter is 1.60-2.00 mm, the anodic relative corrosion rate reaches the lowest value of 52.1%.
