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Boosted Lithium-Ion Transport Kinetics in n-Type Siloxene Anodes Enabled by Selective Nucleophilic Substitution of Phosphorus
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作者 Se In Kim Woong-Ju Kim +1 位作者 Jin Gu Kang Dong-Wan Kim 《Nano-Micro Letters》 SCIE EI CAS CSCD 2024年第10期618-637,共20页
Doped two-dimensional(2D)materials hold significant promise for advancing many technologies,such as microelectronics,optoelectronics,and energy storage.Herein,n-type 2D oxidized Si nanosheets,namely n-type siloxene(n-... Doped two-dimensional(2D)materials hold significant promise for advancing many technologies,such as microelectronics,optoelectronics,and energy storage.Herein,n-type 2D oxidized Si nanosheets,namely n-type siloxene(n-SX),are employed as Li-ion battery anodes.Via thermal evaporation of sodium hypophosphite at 275℃,P atoms are effectively incorporated into siloxene(SX)without compromising its 2D layered morphology and unique Kautsky-type crystal structure.Further,selective nucleophilic substitution occurs,with only Si atoms being replaced by P atoms in the O_(3)≡Si-H tetrahedra.The resulting n-SX possesses two delocalized electrons arising from the presence of two electron donor types:(i)P atoms residing in Si sites and(ii)H vacancies.The doping concentrations are varied by controlling the amount of precursors or their mean free paths.Even at 2000 mA g^(-1),the n-SX electrode with the optimized doping concentration(6.7×10^(19) atoms cm^(-3))delivers a capacity of 594 mAh g^(-1) with a 73%capacity retention after 500 cycles.These improvements originate from the enhanced kinetics of charge transport processes,including electronic conduction,charge transfer,and solid-state diffusion.The approach proposed herein offers an unprecedented route for engineering SX anodes to boost Li-ion storage. 展开更多
关键词 Li-ion battery Two-dimensional n-type siloxene Doping mechanism KINETICS
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Noticeable positive Doppler effect on optical bistability in an N-type active Raman gain atomic system 被引量:2
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作者 常增光 钮月萍 +1 位作者 张敬涛 龚尚庆 《Chinese Physics B》 SCIE EI CAS CSCD 2012年第11期280-284,共5页
We theoretically investigate the Doppler effect on optical bistability in an N-type active Raman gain atomic system inside an optical ring cavity. It is shown that the Doppler effect can greatly enhance the dispersion... We theoretically investigate the Doppler effect on optical bistability in an N-type active Raman gain atomic system inside an optical ring cavity. It is shown that the Doppler effect can greatly enhance the dispersion and thus create the bistable behaviour or greatly increase the bistable region, which has been known as the positive Doppler effect on optical bistability. In addition, we find that a positive Doppler effect can change optical bistability from the hybrid dispersion-gain type to a dispersive type. 展开更多
关键词 positive Doppler effect optical bistability n-type atomic system active Raman gain
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Analytical Descriptions of Magnetic Properties and Magnetoresistance in n-Type HgCr_2Se_4 被引量:2
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作者 林朝镜 石友国 李永庆 《Chinese Physics Letters》 SCIE CAS CSCD 2016年第7期157-160,共4页
We present a detailed investigation of magnetic properties of colossal magnetoresistance material HgCr2Se4. While spontaneous magnetization and zero-field magnetic susceptibility are found to follow asymptotic scaling... We present a detailed investigation of magnetic properties of colossal magnetoresistance material HgCr2Se4. While spontaneous magnetization and zero-field magnetic susceptibility are found to follow asymptotic scaling laws for a narrow range of temperatures near the critical point, two methods with connections to the renormalization group theory provide analytical descriptions of the magnetic properties for much wider temperature ranges. Based on this, an analytical formula is obtained for the temperature dependence of the low field magnetoresistance in the paramagnetic phase. 展开更多
关键词 of on de is ET Analytical Descriptions of Magnetic Properties and Magnetoresistance in n-type HgCr2Se4 in for
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New CMOS compatible super-junction LDMOST with n-type buried layer 被引量:1
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作者 段宝兴 张波 李肇基 《Chinese Physics B》 SCIE EI CAS CSCD 2007年第12期3754-3759,共6页
A new super-junction lateral double diffused MOSFET (LDMOST) structure is designed with n-type charge compensation layer embedded in the p^--substrate near the drain to suppress substrate-assisted depletion effect t... A new super-junction lateral double diffused MOSFET (LDMOST) structure is designed with n-type charge compensation layer embedded in the p^--substrate near the drain to suppress substrate-assisted depletion effect that results from the compensating charges imbalance between the pillars in the n-type buried layer. A high electric field peak is introduced in the surface by the pn junction between the p^--substrate and n-type buried layer, which given rise to a more uniform surface electric field distribution by modulation effect. The effect of reduced bulk field (REBULF) is introduced to improve the vertical breakdown voltage by reducing the high bulk electric field around the drain, The new structure features high breakdown voltage, low on-resistance and charges balance in the drift region due to n-type buried layer. 展开更多
关键词 super-junction LDMOST n-type buried layer REBULF breakdown voltage
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Uniaxial stress influence on lattice,band gap and optical properties of n-type ZnO:first-principles calculations 被引量:1
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作者 Yang Ping Li Pei +4 位作者 Zhang Li-Qiang Wang Xiao-Liang Wang Huan Song Xi-Fu Xie Fang-Wei 《Chinese Physics B》 SCIE EI CAS CSCD 2012年第1期399-403,共5页
The lattice, the band gap and the optical properties of n-type ZnO under uniaxial stress are investigated by first- principles calculations. The results show that the lattice constants change linearly with stress. Ban... The lattice, the band gap and the optical properties of n-type ZnO under uniaxial stress are investigated by first- principles calculations. The results show that the lattice constants change linearly with stress. Band gaps are broadened linearly as the uniaxial compressive stress increases. The change of band gap for n-type ZnO comes mainly from the contribution of stress in the c-axis direction, and the reason for band gap of n-type ZnO changing with stress is also explained. The calculated results of optical properties reveal that the imaginary part of the dielectric function decreases with the increase of uniaxial compressive stress at low energy. However, when the energy is higher than 4.0 eV, the imaginary part of the dielectric function increases with the increase of stress and a blueshift appears. There are two peaks in the absorption spectrum in an energy range of 4.0-13.0 eV. The stress coefficient of the band gap of n-type ZnO is larger than that of pure ZnO, which supplies the theoretical reference value for the modulation of the band gap of doped ZnO. 展开更多
关键词 uniaxial stress FIRST-PRINCIPLES optical properties n-type ZnO
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Hot-Carrier Effects on Total Dose Irradiated 65 nm n-Type Metal-Oxide-Semiconductor Field-Effect Transistors 被引量:1
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作者 郑齐文 崔江维 +3 位作者 周航 余德昭 余学峰 郭旗 《Chinese Physics Letters》 SCIE CAS CSCD 2016年第7期117-119,共3页
The influence of total dose irradiation on hot-carrier reliability of 65 nm n-type metal-oxide-semiconductor field- effect transistors (nMOSFETs) is investigated. Experimental results show that hot-carrier degradati... The influence of total dose irradiation on hot-carrier reliability of 65 nm n-type metal-oxide-semiconductor field- effect transistors (nMOSFETs) is investigated. Experimental results show that hot-carrier degradations on ir- radiated narrow channel nMOSFETs are greater than those without irradiation. The reason is attributed to radiation-induced charge trapping in shallow trench isolation (STI). The electric field in the pinch-off region of the nMOSFET is enhanced by radiation-induced charge trapping in STI, resulting in a more severe hot-carrier effect. 展开更多
关键词 of NM in Hot-Carrier Effects on Total Dose Irradiated 65 nm n-type Metal-Oxide-Semiconductor Field-Effect Transistors STI on IS
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Recent development of n-type thermoelectric materials based on conjugated polymers 被引量:1
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作者 Bin Meng Jun Liu Lixiang Wang 《Nano Materials Science》 CAS CSCD 2021年第2期113-123,共11页
Thermoelectric(TE)materials based on conjugated polymers have received much attention due to their great advantages of solution processibility,light weight,flexibility,and low thermal conductivity.These advantages mak... Thermoelectric(TE)materials based on conjugated polymers have received much attention due to their great advantages of solution processibility,light weight,flexibility,and low thermal conductivity.These advantages make them potential candidates for large-area,low-cost and low-power TE applications.Both efficient p-type and n-type conjugated polymers with high and comparable thermoelectric performance are required for practical TE applications.However,due to the inefficient n-doping efficiency and unstable electron transport of most n-type conjugated polymers,the TE performance of n-type polymers is much poorer than that of their p-type counterparts,impeding the development of polymer TE materials.Great efforts have been made to address the low ndoping efficiency and TE performance of n-type polymers,including the chemical modification of traditional ntype polymers,the design of new n-type conjugated polymers,and the development of more efficient n-dopants,as well as doping engineering.Nowadays,the TE performance of n-type polymers has been greatly improved,indicating a bright future for polymer TE materials.In this review,we summarize the recent progress made on ntype polymer TE materials,mainly focusing on the structure-performance relationships based on promising n-type polymers for TE applications.This review aims to provide some guidelines for future material design. 展开更多
关键词 Polymer thermoelectrics n-type polymers N-DOPING CONDUCTIVITY Power facto
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n-type ZnS used as electron transport material in organic light-emitting diodes
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作者 杜鹏 张希清 +2 位作者 孙学柏 姚志刚 王永生 《Chinese Physics B》 SCIE EI CAS CSCD 2006年第6期1370-1373,共4页
This paper reports on the n-type ZnS used as electron transport layer for the organic light-emitting diodes (OLEDs). The naphthyl-substituted benzidine derivative (NPB) and tris (8-hydroxyquinoline) aluminium (... This paper reports on the n-type ZnS used as electron transport layer for the organic light-emitting diodes (OLEDs). The naphthyl-substituted benzidine derivative (NPB) and tris (8-hydroxyquinoline) aluminium (Alq3) are used as the hole transport layer and the emitting layer respectively. The insertion of the n-type ZnS layer enhances the electron injection in the OLEDs. The study was carried out on OLEDs of structures: indium-tin-oxide (ITO)/NPB/Alq3/ZnS/LiF/AL, ITO/NPB/Alq3/LiF/AL and ITO/NPB/Alq3/AL. The luminance and efficiency of the device containing this electron transport layer are increased significantly over those obtained from conventional devices due to better carrier balance. 展开更多
关键词 OLEDS n-type ZnS electron transport layer LUMINANCE efficiency
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Boron implanted emitter for n-type silicon solar cell
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作者 梁鹏 韩培德 +1 位作者 范玉洁 邢宇鹏 《Chinese Physics B》 SCIE EI CAS CSCD 2015年第3期447-452,共6页
The effects of ion doses on the properties of boron implanted Si for n-type solar cell application were investigated with doses ranging from 5×10^14cm^-2 to 2×10^15cm^-2 and a subsequent two-step annealing p... The effects of ion doses on the properties of boron implanted Si for n-type solar cell application were investigated with doses ranging from 5×10^14cm^-2 to 2×10^15cm^-2 and a subsequent two-step annealing process in a tube furnace.With the help of the TCAD process simulation tool, knowledge on diffusion kinetics of dopants and damage evolution was obtained by fitting SIMS measured boron profiles. Due to insufficient elimination of the residual damage, the implanted emitter was found to have a higher saturation current density(J0e) and a poorer crystallographic quality. Consistent with this observation, V oc, J sc, and the efficiency of the all-implanted p^+–n–n^+solar cells followed a decreasing trend with an increase of the implantation dose. The obtained maximum efficiency was 19.59% at a low dose of 5×10^14cm^-2. The main efficiency loss under high doses came not only from increased recombination of carriers in the space charge region revealed by double-diode parameters of dark I–V curves, but also from the degraded minority carrier diffusion length in the emitter and base evidenced by IQE data. These experimental results indicated that clusters and dislocation loops had appeared at high implantation doses, which acted as effective recombination centers for photogenerated carriers. 展开更多
关键词 boron implanted emitter n-type silicon clusters and dislocation loops saturation current density
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Experimental Investigation of the Electromagnetically Induced-Absorption-Like Effect for an N-Type Energy Level in a Rubidium BEC
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作者 Khan Sadiq Nawaz Cheng-Dong Mi +2 位作者 Liang-Chao Chen Peng-Jun Wang Jing Zhang 《Chinese Physics Letters》 SCIE CAS CSCD 2019年第4期15-18,共4页
We study the electromagnetically induced-absorption-like(EIA-like) effect for an n-type system in an ^(87)Rb Bose–Einstein condensate(BEC) using the absorption imaging technique for coupling and driving lasers operat... We study the electromagnetically induced-absorption-like(EIA-like) effect for an n-type system in an ^(87)Rb Bose–Einstein condensate(BEC) using the absorption imaging technique for coupling and driving lasers operating at the D_1 and D_2 lines of ^(87)Rb. The coherent effect is probed by measuring the number of atoms remaining after the BEC is exposed to strong driving fields and a weak probe field. The absorption imaging technique accurately reveals the EIA-like effect of the n-type system. This coherent effect in an n-type system is useful for optical storage, tunable optical switching, and so on. 展开更多
关键词 87Rb Bose–Einstein CONDENSATE lasers n-type system
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N-type core-shell heterostructured Bi2S3@Bi nanorods/polyaniline hybrids for stretchable thermoelectric generator
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作者 Lu Yang Chenghao Liu +3 位作者 Yalong Wang Pengcheng Zhu Yao Wang Yuan Deng 《Chinese Physics B》 SCIE EI CAS CSCD 2022年第2期73-79,共7页
With the growing need on distributed power supply for portable electronics,energy harvesting from environment becomes a promising solution.Organic thermoelectric(TE)materials have advantages in intrinsic flexibility a... With the growing need on distributed power supply for portable electronics,energy harvesting from environment becomes a promising solution.Organic thermoelectric(TE)materials have advantages in intrinsic flexibility and low thermal conductivity,thus hold great prospect in applications as a flexible power generator from dissipated heat.Nevertheless,the weak electrical transport behaviors of organic TE materials have severely impeded their development.Moreover,compared with p-type organic TE materials,stable and high-performance n-type counterparts are more difficult to obtain.Here,we developed a n-type polyaniline-based hybrid with core-shell heterostructured Bi;S;@Bi nanorods as fillers,showing a Seebeck coefficient-159.4μV/K at room temperature.Further,a couple of n/p legs from the PANI-based hybrids were integrated into an elastomer substrate forming a stretchable thermoelectric generator(TEG),whose function to output stable voltages responding to temperature differences has been demonstrated.The in situ output performance of the TEG under stretching could withstand up to 75%elongation,and stability test showed little degradation over a one-month period in the air.This study provides a promising strategy to develop stable and high thermopower organic TEGs harvesting heat from environment as long-term power supply. 展开更多
关键词 polyaniline-based hybrids thermoelectric properties n-type stretchable electronics
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Nonlinear optical properties in n-type quadrupleδ-doped GaAs quantum wells
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作者 Humberto Noverola-Gamas Luis Manuel Gaggero-Sager Outmane Oubram 《Chinese Physics B》 SCIE EI CAS CSCD 2022年第4期348-351,共4页
The effects of the interlayer distance on the nonlinear optical properties of n-type quadrupleδ-doped GaAs quantum well were theoretically investigated.Particularly,the absorption coefficient and the relative refract... The effects of the interlayer distance on the nonlinear optical properties of n-type quadrupleδ-doped GaAs quantum well were theoretically investigated.Particularly,the absorption coefficient and the relative refraction index change were determined.In the effective mass approach and within the framework of the Thomas-Fermi theory,the Schrodinger equation was resolved.Thereby,the subband energy levels and their respective wave functions were calculated.The variations in the nonlinear optical properties were determined by using the density matrix solutions.The achieved results demonstrate that the interlayer distance causes optical red-shift on nonlinear optical properties.Therefore,it can be deduced that the suitably chosen interlayer distance can be used to tune optical properties within the infrared spectrum region in optoelectronic devices such as far-infrared photo-detectors,high-speed electronic-optical modulators,and infrared lasers. 展开更多
关键词 DELTA-DOPING n-type GaAs layers electronic structure non-linear optical properties
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Anomalous Channel Length Dependence of Hot-Carrier-Induced Saturation Drain Current Degradation in n-Type MOSFETs
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作者 张春伟 刘斯扬 +7 位作者 孙伟锋 周雷雷 张艺 苏巍 张爱军 刘玉伟 胡久利 何骁伟 《Chinese Physics Letters》 SCIE CAS CSCD 2015年第8期193-195,共3页
The dependencies of hot-carrier-induced degradations on the effective channel length Lch,eff are investigated for n-type metal-oxide-semiconductor field effect transistor (MOSFETs). Our experiments find that, with d... The dependencies of hot-carrier-induced degradations on the effective channel length Lch,eff are investigated for n-type metal-oxide-semiconductor field effect transistor (MOSFETs). Our experiments find that, with decreasing Lch,eff, the saturation drain current (Iasat ) degradation is unexpectedly alleviated. The further study demonstrates that the anomalous Lch,eff dependence of Idsat degradation is induced by the increasing influence of the substrate current degradation on the lazar degradation with Lch,eff reducing. 展开更多
关键词 Anomalous Channel Length Dependence of Hot-Carrier-Induced Saturation Drain Current Degradation in n-type MOSFETs
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Spin Dynamics in Ferromagnet/10-nm-Thick N-Type GaAs Quantum Well Junctions
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作者 纪晓晨 申超 +2 位作者 吴元军 鲁军 郑厚植 《Chinese Physics Letters》 SCIE CAS CSCD 2017年第11期61-65,共5页
Spin dynamics in several different types of ferromagnetic metal (FM)/10-nm-thick n-type GaAs quantum well (QW) junctions is studied by means of time-resolved Kerr rotation measurements. Compared with the MnGa/insi... Spin dynamics in several different types of ferromagnetic metal (FM)/10-nm-thick n-type GaAs quantum well (QW) junctions is studied by means of time-resolved Kerr rotation measurements. Compared with the MnGa/insitu doped lO-nm-thick n-type GaAs QW junction, the spin lifetime of the MnGa/modulation-doped 10-nm-thick n-type GaAs QW junction is shorter by a factor of 6, consistent with the D'yakonov Perel' spin relaxation mechanism. Meanwhile, compared with the spin lifetime of the MnAs/in-situ doped 10-nm-thick n-type GaAs QW junction, the MnGa/in-situ doped 10-nm-thick n-type GaAs QW junction is of a spin lifetime longer by a factor of 4.2. The later observation is well explained by the Rashba effect in the presence of structure inversion asymmetry, which acts directly on photo-excited electron spins. We demonstrate that MnGa-like FM/in-situ doped 10-nm-thick n-type GaAs QW junctions, which possess relatively low interfaciai potential barriers, are able to provide long spin lifetimes. 展开更多
关键词 Spin Dynamics in Ferromagnet/10-nm-Thick n-type GaAs Quantum Well Junctions
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n^(+)/n^(-)型硅衬底扩散片X_(jn+)理论分析与测试方法优化
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作者 张现磊 李立谦 +1 位作者 周涛 张志林 《半导体技术》 CAS 北大核心 2025年第1期39-45,共7页
n型衬底扩散片扩散深度(X_(jn+))是n^(+)/n^(-)型硅衬底扩散片最重要的参数之一,X_(jn+)的理论计算对磷扩散生产和X_(jn+)测试具有重要的指导意义。但现有扩散理论计算结果与实验数据差异较大,需更精准的计算方法。通过实验对X_(jn+)的... n型衬底扩散片扩散深度(X_(jn+))是n^(+)/n^(-)型硅衬底扩散片最重要的参数之一,X_(jn+)的理论计算对磷扩散生产和X_(jn+)测试具有重要的指导意义。但现有扩散理论计算结果与实验数据差异较大,需更精准的计算方法。通过实验对X_(jn+)的测试与理论计算结果进行对比分析,引入了修正系数k_(n)与k_(p),得到理论计算与测试结果吻合的X_(jn+)计算方法。并根据修正后的计算方法对染色法测试X_(jn+)进行了优化。新的X_(jn+)计算方法得到的结果与测试结果差异小于2%,可用于指导生产,且优化后的X_(jn+)测试方法更加便捷。 展开更多
关键词 衬底扩散片 扩散系数修正 协同扩散 n型衬底扩散片扩散深度(X_(jn+))计算 X_(jn+)测试方法优化
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不同髋关节置换术式治疗老年髋关节骨折内固定失败患者的临床效果及对髋关节功能的影响
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作者 潘恒 宋雄英 李公 《临床误诊误治》 2025年第3期67-72,共6页
目的比较不同髋关节置换术式治疗老年髋关节骨折内固定失败患者的临床效果。方法回顾性分析2012年1月至2022年1月收治的老年髋关节骨折内固定失败患者80例的临床资料,根据手术方案分为对照组39例和观察组41例。对照组采用半髋关节置换术... 目的比较不同髋关节置换术式治疗老年髋关节骨折内固定失败患者的临床效果。方法回顾性分析2012年1月至2022年1月收治的老年髋关节骨折内固定失败患者80例的临床资料,根据手术方案分为对照组39例和观察组41例。对照组采用半髋关节置换术,观察组采用全髋关节置换术。比较2组临床指标、Harris髋关节评分、临床疗效、骨代谢生化指标[骨碱性磷酸酶(BALP)、骨钙素、Ⅰ型前胶原氨基端原肽(PⅠNP)以及抗酒石酸性磷酸酶(TRACP-5b)],统计2组术后并发症发生情况。结果80例患者均成功完成手术及随访,随访时间(6.16±0.38)个月。观察组手术时间、下床活动时间长于对照组,术中失血量多于对照组(P<0.05)。随着术后时间延长,2组Harris髋关节评分呈上升趋势,且术后1、3、6个月,观察组高于对照组(P<0.05)。术后6个月,观察组总优良率[95.12%(39/41)]高于对照组[79.49%(31/39)],差异有统计学意义(P<0.05)。术后6个月,2组BALP、骨钙素、PⅠNP水平升高,TRACP-5b水平降低,且观察组BALP、骨钙素、PⅠNP水平高于对照组,TRACP-5b水平低于对照组(P<0.05,P<0.01)。2组并发症发生率比较差异无统计学意义(P>0.05)。结论全髋关节置换术治疗老年髋关节骨折内固定失败患者较半髋关节置换术临床疗效显著、骨代谢能力更佳,且不增加并发症发生风险。 展开更多
关键词 关节成形术 置换 髋关节骨折内固定失败 Harris髋关节评分 骨碱性磷酸酶 骨钙素 Ⅰ型前胶原氨基端原肽 抗酒石酸性磷酸酶 手术后并发症
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山地光伏组件安装工艺及运维关键技术研究
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作者 唐勇 程普 +2 位作者 孙航 王炜贵 孙浩杰 《工程建设与设计》 2025年第2期113-115,共3页
对山地光伏组件的安装工艺和运维关键技术进行深入研究,阐述了山地光伏组件的特性和应用,分析了N型、轻质光伏组件的安装技术,包括场景选择和关键技术,以提高光伏系统在山地地区的效率和可靠性。
关键词 N型光伏组件 轻质光伏组件 场景选择 安装技术 运维关键技术
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沙库巴曲缬沙坦钠对扩张型心肌病心衰患者NT-proBNP、CgA水平及心功能指标的影响研究
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作者 邝光华 周宇明 《中国实用医药》 2025年第1期1-5,共5页
目的研究扩张型心肌病(DCM)心力衰竭(心衰,HF)患者使用沙库巴曲缬沙坦钠治疗后对氨基末端B型利钠肽前体(NT-proBNP)、嗜铬粒蛋白A(CgA)和心功能指标的影响。方法选取60例DCM心衰患者作为观察组,根据随机双盲法将观察组患者分为A组与B组,... 目的研究扩张型心肌病(DCM)心力衰竭(心衰,HF)患者使用沙库巴曲缬沙坦钠治疗后对氨基末端B型利钠肽前体(NT-proBNP)、嗜铬粒蛋白A(CgA)和心功能指标的影响。方法选取60例DCM心衰患者作为观察组,根据随机双盲法将观察组患者分为A组与B组,各30例;另选取同期30例健康体检者作为对照组。对照组不进行任何治疗,观察组给予利尿剂、强心剂和硝酸酯类等常规药物治疗,在此基础上A组行培哚普利治疗,B组行沙库巴曲缬沙坦钠治疗。比较观察组与对照组、A组与B组的临床基本资料,观察组治疗前与对照组的CgA、NT-proBNP水平,A组与B组治疗前后的血清指标(CgA和NT-proBNP)和心功能指标[左室射血分数(LVEF)、左室收缩末期容积(LVESV)和左室舒张末期容积(LVEDV)]。结果观察组与对照组、A组与B组的年龄、性别、体质量指数(BMI)、总胆固醇(TC)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)、空腹血糖(FPG)、收缩压、舒张压比较差异无统计学意义(P>0.05)。对照组CgA、NT-proBNP水平低于观察组及观察组美国纽约心脏病学会(NYHA)分级Ⅱ、Ⅲ、Ⅳ级患者(P<0.05);观察组NYHA分级Ⅳ级患者CgA、NT-proBNP水平高于Ⅲ、Ⅱ级患者,且NYHA分级Ⅲ级患者CgA、NT-proBNP水平高于Ⅱ级患者(P<0.05)。治疗后,A组的LVEF(31.49±2.52)%明显低于B组的(33.79±3.11)%(P<0.05);B组的NT-proBNP(1534.20±1249.31)pg/ml、CgA(164.20±76.57)ng/ml、LVEDV(159.23±23.75)ml和LVESV(109.06±14.84)ml均明显低于A组的(2139.35±1032.66)pg/ml、(213.10±100.17)ng/ml、(176.52±38.17)ml、(129.26±27.68)ml(P<0.05)。观察组NT-proBNP与LVESV、LVEDV呈正相关(r=0.701、0.706,P<0.01),与LVEF呈负相关(r=-0.390,P<0.01);CgA与LVEF呈负相关(r=-0.649,P<0.01),与LVESV和LVEDV呈正相关(r=0.569、0.585,P<0.01);NT-proBNP与CgA呈正相关(r=0.602,P<0.01)。结论DCM心衰患者使用沙库巴曲缬沙坦钠治疗可有效改善心功能和降低CgA水平的表达,值得临床推广使用。 展开更多
关键词 沙库巴曲缬沙坦钠 扩张型心肌病 心力衰竭 氨基末端B型利钠肽前体 嗜铬粒蛋白A 心功能指标 左室射血分数
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托拉塞米联合不同剂量螺内酯对慢性射血分数降低的心力衰竭患者的影响
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作者 荆珍 《河南医学研究》 2025年第1期139-143,共5页
目的分析托拉塞米联合不同剂量螺内酯对慢性射血分数降低性心力衰竭(HFrEF)患者的影响。方法选取灵宝市第一人民医院2018年3月至2020年7月接收的150例HFrEF患者作为研究对象,均接受托拉塞米治疗,应用随机数表法分为3组,小剂量组(50例)... 目的分析托拉塞米联合不同剂量螺内酯对慢性射血分数降低性心力衰竭(HFrEF)患者的影响。方法选取灵宝市第一人民医院2018年3月至2020年7月接收的150例HFrEF患者作为研究对象,均接受托拉塞米治疗,应用随机数表法分为3组,小剂量组(50例)患者使用10 mg螺内酯治疗,中剂量组(50例)使用20 mg螺内酯治疗,大剂量组(50例)使用40 mg螺内酯治疗。观察3组治疗前、治疗3个月后心功能指标、氨基末端脑钠肽前体(NT-proBNP)、炎症因子水平及治疗有效率、不良反应发生情况。结果治疗前3组左心室射血分数(LVEF)、左室舒张末内径(LVEDD)、左室收缩末内径(LVESD)水平及6分钟步行距离差异无统计学意义(P>0.05),治疗后3组LVEF、LVEDD、LVESD水平及6分钟步行距离比较,差异有统计学意义(P<0.05),且治疗后LVEF水平及6分钟步行距离均高于治疗前,中剂量组高于小剂量组、大剂量组,治疗后LVEDD、LVESD水平低于治疗前,中剂量组低于小剂量组、大剂量组。治疗前3组NT-proBNP、肿瘤坏死因子α(TNF-α)、超敏C反应蛋白(hs-CRP)水平差异无统计学意义(P>0.05),治疗后3组NT-proBNP、TNF-α、hs-CRP水平比较,差异有统计学意义(P<0.05),且治疗后低于治疗前,中剂量组低于小剂量组、大剂量组。小剂量组不良反应发生率(6.00%)低于大剂量组(20.00%)(P<0.05),但小剂量组与中剂量组(10.00%)差异无统计学意义(P>0.05)。中剂量组总有效率(94.00%)高于小剂量组(78.00%)、大剂量组(76.00%)(P<0.05)。结论与10、40 mg剂量的螺内酯相比,20 mg螺内酯联合托拉塞米改善HFrEF患者心功能的效果最好,减轻炎症反应,10 mg螺内酯不良反应发生风险最低,但20 mg不良反应发生风险在可控范围内,使用20 mg螺内酯治疗总体疗效最高。 展开更多
关键词 慢性心力衰竭 射血分数降低 螺内酯剂量 N末端B型钠尿肽
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慢性心力衰竭患者血清HMGB1水平变化及其与病情和预后的关系
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作者 张丹 成威 +1 位作者 高彦琳 戎李 《山东医药》 2025年第1期6-9,14,共5页
目的观察慢性心力衰竭(CHF)患者血清高迁移率族蛋白B1(HMGB1)水平变化,探讨其与患者病情严重程度及预后的关系。方法选取CHF患者200例作为CHF组,同期健康体检者20例为对照组。采用ELISA法检测血清HMGB1水平;根据美国纽约心脏病学会(NYHA... 目的观察慢性心力衰竭(CHF)患者血清高迁移率族蛋白B1(HMGB1)水平变化,探讨其与患者病情严重程度及预后的关系。方法选取CHF患者200例作为CHF组,同期健康体检者20例为对照组。采用ELISA法检测血清HMGB1水平;根据美国纽约心脏病学会(NYHA)的心功能分级方法,将CHF患者按病情严重程度分级;随访24个月,记录患者出院后发生恶性心律失常、心源性死亡和全因死亡等重大不良心血管事件(MACE)的情况。采用受试者工作特征(ROC)曲线及曲线下面积(AUC)分析血清HMGB1对CHF患者预后不良的预测价值;Kaplan-Meier生存曲线分析血清HMGB1高表达和低表达患者的预后差异。结果CHF组血清HMGB1水平高于对照组(P<0.05)。200例CHF患者中NYHA心功能分级Ⅱ级41例、Ⅲ级99例、Ⅳ级60例;CHF患者血清N末端B型利钠肽前体(NT-proBNP)、HMGB1水平均随NYHA心功能分级的提升而升高(P均<0.05)。随访24个月,200例CHF患者中发生MACE 65例、未发生MACE 135例;发生MACE的CHF患者血清NT-ProBNP、HMGB1水平均高于未发生MACE的患者(P均<0.05)。ROC曲线分析结果显示,血清HMGB1、血清NT-ProBNP预测CHF患者发生MACE的AUC分别为0.752、0.772,两者联合预测CHF患者发生MACE的AUC为0.863。Kaplan-Merier生存曲线分析结果显示,血清HMGB1高、低水平的CHF患者预后不良发生率分别为67.50%、35.50%,HMGB1高水平者预后不良发生率高于HMGB1低水平者(P<0.05)。结论CHF患者血清HMGB1水平升高,且与患者的病情严重程度有关,其与血清NT-ProBNP联合检测有助于提高预测患者预后的准确性。 展开更多
关键词 慢性心力衰竭 高迁移率族蛋白B1 N末端B型利钠肽前体 重大不良心血管事件
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