In order to develop novel antitumor d rugs,1,5-bis(2-hydroxybenzylidene)-thiocarbohydrazide(HL)and its Ag ?Complex([Ag2L]·NO3)have been prepared and characterize d by elemental analysis,IR,UV,1 H NMR and molar co...In order to develop novel antitumor d rugs,1,5-bis(2-hydroxybenzylidene)-thiocarbohydrazide(HL)and its Ag ?Complex([Ag2L]·NO3)have been prepared and characterize d by elemental analysis,IR,UV,1 H NMR and molar conductance,respectively.The inhibitory effects of them on five tumor cell lines,including HL-60,Bel-7402,EJ,HCT-8and A431 have been measured by using MTT(Dimethoxyneotetrazolium)colorimetric assay and SRB(Sulforhodamine B)assay.The result indicated that the Ag Complex has str onger inhibitory effect on the five t umor cell lines than the ligand,especially showed very stro ng effect on HL-60cell and Bel-7402c ell.When the exposure concentration of the complex was 10-5mol·L-1,The inhibitory rate is over 96%.展开更多
N,N′-ethidenedi(2-hydroxy 4 methoxy benzophenone imine acetal)was synthesized and characterized by the melting point,elemental analysis,UV,IR,MS and 1H NMR.The result of XRD proved that it belonged to the monoclinic ...N,N′-ethidenedi(2-hydroxy 4 methoxy benzophenone imine acetal)was synthesized and characterized by the melting point,elemental analysis,UV,IR,MS and 1H NMR.The result of XRD proved that it belonged to the monoclinic system.Its lattice parameters were:a=1.1018nm,b=1.5730nm,c=1.8858nm,β=93.50°.The schiff base has a strong absorption ability to absorb the UV-A and UV-B,and bears antibacterial activity of many bacterial.展开更多
文摘In order to develop novel antitumor d rugs,1,5-bis(2-hydroxybenzylidene)-thiocarbohydrazide(HL)and its Ag ?Complex([Ag2L]·NO3)have been prepared and characterize d by elemental analysis,IR,UV,1 H NMR and molar conductance,respectively.The inhibitory effects of them on five tumor cell lines,including HL-60,Bel-7402,EJ,HCT-8and A431 have been measured by using MTT(Dimethoxyneotetrazolium)colorimetric assay and SRB(Sulforhodamine B)assay.The result indicated that the Ag Complex has str onger inhibitory effect on the five t umor cell lines than the ligand,especially showed very stro ng effect on HL-60cell and Bel-7402c ell.When the exposure concentration of the complex was 10-5mol·L-1,The inhibitory rate is over 96%.
文摘N,N′-ethidenedi(2-hydroxy 4 methoxy benzophenone imine acetal)was synthesized and characterized by the melting point,elemental analysis,UV,IR,MS and 1H NMR.The result of XRD proved that it belonged to the monoclinic system.Its lattice parameters were:a=1.1018nm,b=1.5730nm,c=1.8858nm,β=93.50°.The schiff base has a strong absorption ability to absorb the UV-A and UV-B,and bears antibacterial activity of many bacterial.
