Objective Heart failure(HF)is divided into two types:Heart failure with reduced ejection fraction(HFrEF)and heart failure with preserved ejection fraction(HFpEF).The latter always results in diastolic dysfunction,char...Objective Heart failure(HF)is divided into two types:Heart failure with reduced ejection fraction(HFrEF)and heart failure with preserved ejection fraction(HFpEF).The latter always results in diastolic dysfunction,characterized by changes in mechanical properties.The objective of this study is to build a finite element(FE)model of HFpEF and analyze diastolic and systolic function in rats.Methods Ten Dahl salt-sensitive rats were fed either a low-salt(LS)(n=5)or highsalt(HS)(n=5)diet beginning at 7 weeks of age and scanned by ultrasonic machine at 14 weeks of age.A non-linear FE model of the left ventricle(LV)was built from cardiac echo images at end-diastole and passive material properties of the LV were prescribed using Fung’s transversely isotropic constitutive law.Fiber angles of the endocardium and epicardium were prescribed as 53°°and-52°,respectively,with respect to the circumferential direction and varied linearly through the LV wall.The method developed by Krishnamurthywas used to determine the unloaded geometry to estimate the Fung passive material parameters.LV end-diastolic pressure(EDP)was determined from the measured pressure waves and applied to the endocardium at the unloaded geometry to simulate passive filling.Active material properties of the LV were prescribed using Guccione’s time-varying elastance model and maximum isometric tension was scaled to match the measured peak systolic pressure.The finite element model was then coupled to the Windkessel model,whose parameters were adjusted to the measured hemodynamics.Results Measured LVEDPs of LS and HS rats were 4.9±3.4 mmHg and 13.2±5.4 mmHg(P-0.030 8),respectively.End-diastolic Cauchy stress along the fiber direction for LS rats was significantly lower than for HS rats(0.91±0.60 kPa vs 3.00±0.63 kPa,P=0.001 4)and there was a similar trend in end-diastolic Green Strain along the fiber direction(0.058±0.003 vs 0.072±0.010,P=0.012 8,Figure 1b),as well.There was no distinctive difference between end-systolic Cauchy stress along the fiber direction for LS rats and HS rats(17.2±4.3 kPa vs 17.2±5.5 kPa,P=0.991 9)but end-systolic Green Strain along the fiber direction for LS rats was significantly higher than for HS rats(-0. 108±0.017 vs-0.065±0.024,negative sign represents direction).Conclusions For rats with HFpEF,it is the elevated LVEDP that induces the increase in end-diastolic stress and strain,thereby leading to diastolic dysfunction.Because of the preserved ejection fraction,HFpEF has less effect on systolic function.展开更多
Addressing the issues of significant entry settlement and severe mining pressure manifestations in the conventional 121 approach,an innovative N00 approach is proposed.By comparing the mining process and entry formati...Addressing the issues of significant entry settlement and severe mining pressure manifestations in the conventional 121 approach,an innovative N00 approach is proposed.By comparing the mining process and entry formation process of different approaches,the characteristics of entry roof settlement evolution under different approaches are obtained.The N00 approach,which incorporates roof cutting and NPR cable support,optimizes the mining and entry formation process to reduce the settlement phase of entry roof,decreases the settlement of entry roof,and enhances the steadiness of entry roof.The N00 approach modifies the entry roof structure through roof cutting and establishes a hydraulic support load mechanics model for the mining panel to derive the theoretical load pressure formula for the N00 approach’s hydraulic support.Compared with the conventional 121 approach,the pressure on the N00 approach’s hydraulic support is reduced.Empirical data obtained through field monitoring demonstrate that the N00 approach has reduced the roof settlement of the entry and weakened the mining pressure manifestation at the mining panel,achieving the goal of protecting the entry and mining panel.展开更多
Sexism not only exists in the society, but is also reflected in English language. Although language can’t determine thought, in some sense, it does influence people’s views. In order to remind people of the harsh fa...Sexism not only exists in the society, but is also reflected in English language. Although language can’t determine thought, in some sense, it does influence people’s views. In order to remind people of the harsh fact and rectify the phenomenon, the author, by illustration and contrast, lists the manifestations of sexism in English, analyzes the causes and appeals to all the people for their contribution to the solution.展开更多
The structure and shape of a cotton shrub aredetermined in result of combining theirelements:length and amount internodes of amain stem and fruit brunches,amount and shapeof leaf blades.Some lines of genetic collectio...The structure and shape of a cotton shrub aredetermined in result of combining theirelements:length and amount internodes of amain stem and fruit brunches,amount and shapeof leaf blades.Some lines of genetic collectionhave been crossed between each other for展开更多
To analyze the influence of movement in shallow-buried working faces with large mining heights on mine pressure manifestation, the key stratum at a working face was categorised using the 1313 top-coal caving face with...To analyze the influence of movement in shallow-buried working faces with large mining heights on mine pressure manifestation, the key stratum at a working face was categorised using the 1313 top-coal caving face with super great mining height under cover as a case study. The research combined theoretical analysis, field measurement, and numerical simulation to analyze the influencing mechanism of key stratum. Moreover, the research results were verified by numerical simulation and indicate that the sub-key stratum is prone to be broken to form a "cantilever beam" structure rather than a stable hinged structure during the excavation of working faces with super great mining heights. When the "cantilever beam" structure is unstable, a low pressure will occur on the working face, and the overlying strata will subside simultaneously with the sub-key stratum to induce the breakage of the primary key stratum: the breakage will further trigger the periodic breakage of sub-key stratum, causing a greater load on the working face. Finally, steps, and strength of weighting in the working face vary to be great or small alternatively. This is the main reason explaining why the 1313 working face shows strong mine pressure manifestation. The results provide theoretical and practical experience for forecasting and controlling mine pressure manifestation.展开更多
基金supported by the National Natural Science Foundation of China ( 11732001)
文摘Objective Heart failure(HF)is divided into two types:Heart failure with reduced ejection fraction(HFrEF)and heart failure with preserved ejection fraction(HFpEF).The latter always results in diastolic dysfunction,characterized by changes in mechanical properties.The objective of this study is to build a finite element(FE)model of HFpEF and analyze diastolic and systolic function in rats.Methods Ten Dahl salt-sensitive rats were fed either a low-salt(LS)(n=5)or highsalt(HS)(n=5)diet beginning at 7 weeks of age and scanned by ultrasonic machine at 14 weeks of age.A non-linear FE model of the left ventricle(LV)was built from cardiac echo images at end-diastole and passive material properties of the LV were prescribed using Fung’s transversely isotropic constitutive law.Fiber angles of the endocardium and epicardium were prescribed as 53°°and-52°,respectively,with respect to the circumferential direction and varied linearly through the LV wall.The method developed by Krishnamurthywas used to determine the unloaded geometry to estimate the Fung passive material parameters.LV end-diastolic pressure(EDP)was determined from the measured pressure waves and applied to the endocardium at the unloaded geometry to simulate passive filling.Active material properties of the LV were prescribed using Guccione’s time-varying elastance model and maximum isometric tension was scaled to match the measured peak systolic pressure.The finite element model was then coupled to the Windkessel model,whose parameters were adjusted to the measured hemodynamics.Results Measured LVEDPs of LS and HS rats were 4.9±3.4 mmHg and 13.2±5.4 mmHg(P-0.030 8),respectively.End-diastolic Cauchy stress along the fiber direction for LS rats was significantly lower than for HS rats(0.91±0.60 kPa vs 3.00±0.63 kPa,P=0.001 4)and there was a similar trend in end-diastolic Green Strain along the fiber direction(0.058±0.003 vs 0.072±0.010,P=0.012 8,Figure 1b),as well.There was no distinctive difference between end-systolic Cauchy stress along the fiber direction for LS rats and HS rats(17.2±4.3 kPa vs 17.2±5.5 kPa,P=0.991 9)but end-systolic Green Strain along the fiber direction for LS rats was significantly higher than for HS rats(-0. 108±0.017 vs-0.065±0.024,negative sign represents direction).Conclusions For rats with HFpEF,it is the elevated LVEDP that induces the increase in end-diastolic stress and strain,thereby leading to diastolic dysfunction.Because of the preserved ejection fraction,HFpEF has less effect on systolic function.
基金Project(2022XDHZ12)supported by the Lvliang Technology Project,ChinaProjects(8232056,2232080)supported by the Beijing Natural Science Foundation,ChinaProject([2020]3008)supported by the Science and Technology Projects in Guizhou Province,China。
文摘Addressing the issues of significant entry settlement and severe mining pressure manifestations in the conventional 121 approach,an innovative N00 approach is proposed.By comparing the mining process and entry formation process of different approaches,the characteristics of entry roof settlement evolution under different approaches are obtained.The N00 approach,which incorporates roof cutting and NPR cable support,optimizes the mining and entry formation process to reduce the settlement phase of entry roof,decreases the settlement of entry roof,and enhances the steadiness of entry roof.The N00 approach modifies the entry roof structure through roof cutting and establishes a hydraulic support load mechanics model for the mining panel to derive the theoretical load pressure formula for the N00 approach’s hydraulic support.Compared with the conventional 121 approach,the pressure on the N00 approach’s hydraulic support is reduced.Empirical data obtained through field monitoring demonstrate that the N00 approach has reduced the roof settlement of the entry and weakened the mining pressure manifestation at the mining panel,achieving the goal of protecting the entry and mining panel.
文摘Sexism not only exists in the society, but is also reflected in English language. Although language can’t determine thought, in some sense, it does influence people’s views. In order to remind people of the harsh fact and rectify the phenomenon, the author, by illustration and contrast, lists the manifestations of sexism in English, analyzes the causes and appeals to all the people for their contribution to the solution.
文摘The structure and shape of a cotton shrub aredetermined in result of combining theirelements:length and amount internodes of amain stem and fruit brunches,amount and shapeof leaf blades.Some lines of genetic collectionhave been crossed between each other for
基金Project(2015-29)supported by Jiangsu Distinguished Professor,ChinaProject(BRA2015311)supported by the Jiangsu Province Fourth 333 Engineering,China
文摘To analyze the influence of movement in shallow-buried working faces with large mining heights on mine pressure manifestation, the key stratum at a working face was categorised using the 1313 top-coal caving face with super great mining height under cover as a case study. The research combined theoretical analysis, field measurement, and numerical simulation to analyze the influencing mechanism of key stratum. Moreover, the research results were verified by numerical simulation and indicate that the sub-key stratum is prone to be broken to form a "cantilever beam" structure rather than a stable hinged structure during the excavation of working faces with super great mining heights. When the "cantilever beam" structure is unstable, a low pressure will occur on the working face, and the overlying strata will subside simultaneously with the sub-key stratum to induce the breakage of the primary key stratum: the breakage will further trigger the periodic breakage of sub-key stratum, causing a greater load on the working face. Finally, steps, and strength of weighting in the working face vary to be great or small alternatively. This is the main reason explaining why the 1313 working face shows strong mine pressure manifestation. The results provide theoretical and practical experience for forecasting and controlling mine pressure manifestation.
