Despite significant progress in cancer research during the past decades,yet there are no major breakthroughs that can be translated into major benefits for the general public in terms of treatment or therapy for the c...Despite significant progress in cancer research during the past decades,yet there are no major breakthroughs that can be translated into major benefits for the general public in terms of treatment or therapy for the complex neoplastic diseases,especially for the malignant solid tumors.This depressing but indisputable fact leads to a call for new ideas to target tumor metastasis by editors of Nature Medicine<sup>[1]</sup>.The real problems are that the fundamental issues of transformation and malignancy in vivo are poorly understood.In a recent review on cancer,展开更多
Over the past 10 years adoptive immunotherapieshave been developed for cancer treatment. Cytotoxic Tlymphocytes (CTL) play a major role in host antitumorimmune response. The perforin and Fas ligand (Fas-L)pathways whi...Over the past 10 years adoptive immunotherapieshave been developed for cancer treatment. Cytotoxic Tlymphocytes (CTL) play a major role in host antitumorimmune response. The perforin and Fas ligand (Fas-L)pathways which were two major mechanisms are res-ponsible for tumor cell death by CTLs. A major obstacleto the application of adoptive imunotherapy in thetreatment of human malignancy has been the inability展开更多
With deep research into apoptosis recently,malignancy has been recognized to result not only fromenhanced cell proliferation but also from decreasedphysiological programmed cell death (apoptosis).Interleukin-l β conv...With deep research into apoptosis recently,malignancy has been recognized to result not only fromenhanced cell proliferation but also from decreasedphysiological programmed cell death (apoptosis).Interleukin-l β converting enzyme (ICE) gene, ahomologue of the Caenorhabiditis elegans ce1l death geneced-3, has been identified as a key inducer of apoptosis inmammalian cells. However, no study of ICE genetherapy on cancer has been reported up to now. Weconstructed recombinant retroviral vectors with展开更多
Genotype of IgH, TCRγ and TCR δ gene rearrangement in 42 cases of malignant lymphoproliferative disorders were studied by using polymerase chain reaction (PCR) technique. The results suggested that among the 23 case...Genotype of IgH, TCRγ and TCR δ gene rearrangement in 42 cases of malignant lymphoproliferative disorders were studied by using polymerase chain reaction (PCR) technique. The results suggested that among the 23 cases, in which malignant cells expressed B-lineage cell surface markers, 20 showed IgH gene rearrangement and 11 had TCRγ gene rearrangement and / or TCRδ gene deletion. All the 11 cases expressed T-lineage cell differentiation antigens were found to have TCRγand TCRδ gene rearrangement or deletion and only one had IgH gene rearrangement. Double rearrangements of IgH and TCRγ genes were detected in all the 3 cases of T and B double-phenotype ALL. In the cases malignant cells did not express any lineage specific antigens while 4/5 had TCRγ gene rearrangement but all failed in IgH gene rearrangement. The relation of cellular differentiation origin and rearrangement of antigen receptor genes with clinical manifestations was discussed.展开更多
基金supported by the funds from Huazhong University of Science and TechnologyUS NIH grant GM072744
文摘Despite significant progress in cancer research during the past decades,yet there are no major breakthroughs that can be translated into major benefits for the general public in terms of treatment or therapy for the complex neoplastic diseases,especially for the malignant solid tumors.This depressing but indisputable fact leads to a call for new ideas to target tumor metastasis by editors of Nature Medicine<sup>[1]</sup>.The real problems are that the fundamental issues of transformation and malignancy in vivo are poorly understood.In a recent review on cancer,
文摘Over the past 10 years adoptive immunotherapieshave been developed for cancer treatment. Cytotoxic Tlymphocytes (CTL) play a major role in host antitumorimmune response. The perforin and Fas ligand (Fas-L)pathways which were two major mechanisms are res-ponsible for tumor cell death by CTLs. A major obstacleto the application of adoptive imunotherapy in thetreatment of human malignancy has been the inability
文摘With deep research into apoptosis recently,malignancy has been recognized to result not only fromenhanced cell proliferation but also from decreasedphysiological programmed cell death (apoptosis).Interleukin-l β converting enzyme (ICE) gene, ahomologue of the Caenorhabiditis elegans ce1l death geneced-3, has been identified as a key inducer of apoptosis inmammalian cells. However, no study of ICE genetherapy on cancer has been reported up to now. Weconstructed recombinant retroviral vectors with
文摘Genotype of IgH, TCRγ and TCR δ gene rearrangement in 42 cases of malignant lymphoproliferative disorders were studied by using polymerase chain reaction (PCR) technique. The results suggested that among the 23 cases, in which malignant cells expressed B-lineage cell surface markers, 20 showed IgH gene rearrangement and 11 had TCRγ gene rearrangement and / or TCRδ gene deletion. All the 11 cases expressed T-lineage cell differentiation antigens were found to have TCRγand TCRδ gene rearrangement or deletion and only one had IgH gene rearrangement. Double rearrangements of IgH and TCRγ genes were detected in all the 3 cases of T and B double-phenotype ALL. In the cases malignant cells did not express any lineage specific antigens while 4/5 had TCRγ gene rearrangement but all failed in IgH gene rearrangement. The relation of cellular differentiation origin and rearrangement of antigen receptor genes with clinical manifestations was discussed.
