The interaction of tetracyline-Pt(Ⅱ)complex with DNA was studied.The studies on absorption spectrum and electrochemistry indicate that the interaction of tetracyline with DNA is not obvious.After tetracycline interac...The interaction of tetracyline-Pt(Ⅱ)complex with DNA was studied.The studies on absorption spectrum and electrochemistry indicate that the interaction of tetracyline with DNA is not obvious.After tetracycline interact with Pt(Ⅱ)to form complex,the complex can interact with calf thymus DNA by way of intercalation.And the formation of tetracyline-Pt(Ⅱ)complex could be affected by the pH value of the sulotion.展开更多
Reaction of the non-substituted/substituted unsymmetric pinene-derived complex[Pt(N^C^N')Cl]with the aryl isocyanide 2,6-dimethylphenyl isocyanide(CNXyl)afforded a mixture of two isomeric species:the ionic complex...Reaction of the non-substituted/substituted unsymmetric pinene-derived complex[Pt(N^C^N')Cl]with the aryl isocyanide 2,6-dimethylphenyl isocyanide(CNXyl)afforded a mixture of two isomeric species:the ionic complex[Pt(κ^(3)-N^C^N')(CNXyl)]Cl([A]Cl)and the molecular complex[Pt(κ^(2)-N^C^N')(CNXyl)Cl](B).Isomer B was almost the dominating product.The structures of the isomer B derivatives bearing-CF_(3)and-Cl substituents on the pyridine ring of the pinene moiety(5B and 7B,respectively)have been confirmed by single-crystal X-ray diffraction,revealing a slightly distorted square planar geometry with trans-N_(N^C^N'),CNR configuration(The terminal N atom of theκ^(2)-N^C^N'ligand is trans to the isocyanide ligand CNXyl.).Isomer B is thermodynamically more stable,as confirmed by theoretical calculations.CCDC:2416415,5B;2416414,7B.展开更多
文摘The interaction of tetracyline-Pt(Ⅱ)complex with DNA was studied.The studies on absorption spectrum and electrochemistry indicate that the interaction of tetracyline with DNA is not obvious.After tetracycline interact with Pt(Ⅱ)to form complex,the complex can interact with calf thymus DNA by way of intercalation.And the formation of tetracyline-Pt(Ⅱ)complex could be affected by the pH value of the sulotion.
文摘Reaction of the non-substituted/substituted unsymmetric pinene-derived complex[Pt(N^C^N')Cl]with the aryl isocyanide 2,6-dimethylphenyl isocyanide(CNXyl)afforded a mixture of two isomeric species:the ionic complex[Pt(κ^(3)-N^C^N')(CNXyl)]Cl([A]Cl)and the molecular complex[Pt(κ^(2)-N^C^N')(CNXyl)Cl](B).Isomer B was almost the dominating product.The structures of the isomer B derivatives bearing-CF_(3)and-Cl substituents on the pyridine ring of the pinene moiety(5B and 7B,respectively)have been confirmed by single-crystal X-ray diffraction,revealing a slightly distorted square planar geometry with trans-N_(N^C^N'),CNR configuration(The terminal N atom of theκ^(2)-N^C^N'ligand is trans to the isocyanide ligand CNXyl.).Isomer B is thermodynamically more stable,as confirmed by theoretical calculations.CCDC:2416415,5B;2416414,7B.
