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Low velocity impact studies of E-glass/epoxy composite laminates at different thicknesses and temperatures 被引量:5
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作者 T.Sreekantha Reddy P.Rama Subba Reddy Vemuri Madhu 《Defence Technology(防务技术)》 SCIE EI CAS CSCD 2019年第6期897-904,共8页
Low velocity impact experiments were carried out on E-glass/epoxy composite laminates having varying thicknesses at sub zero and elevated temperatures using hemi spherical steel impactor of 16 mm diameter with impact ... Low velocity impact experiments were carried out on E-glass/epoxy composite laminates having varying thicknesses at sub zero and elevated temperatures using hemi spherical steel impactor of 16 mm diameter with impact energies in the rage of 50-150 J.The performance of the laminates was assessed in terms of energy absorption,maximum displacement,peak force and failure behaviour.Results indicated that the effect of temperature on energy absorption of the laminate is negligible although the laminates are embrittling at sub zero temperatures.However it has influence on failure behaviour and displacement.Peak force has increased linearly with increase in laminate thickness from 5 to 10 mm.However it got reduced by 25% when temperature was increased from-20℃ to 100℃,Based on experimental results,laminate perforation energies were predicted using curve fitting equations.Statistical analysis was carried out using Taguchi method to identify the global effects of various parameters on laminate performance and confirmed that the laminate thickness has significant influence as compared to temperature,for the studied range. 展开更多
关键词 laminates Glass fibres Impact behaviour DELAMINATION
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Ballistic penetration damages of hybrid plain-woven laminates with carbon,Kevlar and UHMWPE fibers in different stacking sequences 被引量:3
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作者 Zhi-yong Li You-song Xue +1 位作者 Bao-zhong Sun Bo-hong Gu 《Defence Technology(防务技术)》 SCIE EI CAS CSCD 2023年第8期23-38,共16页
Hybrid composite materials combine different fibers in preform and take advantages of different mechanical behaviors for improving ballistic impact damage tolerances.Here we report ballistic impact damages of plain-wo... Hybrid composite materials combine different fibers in preform and take advantages of different mechanical behaviors for improving ballistic impact damage tolerances.Here we report ballistic impact damages of plain-woven laminates with different hybrids and stacking sequences.Three kinds of hybrid laminates,i.e.,carbon/Kevlar,carbon/ultra-high molecular weight polyethylene(UHMWPE),and UHMWPE/Kevlar,had been prepared and tested in ballistic penetration with fragment simulating projectiles(FSP).The residual velocities of the projectiles and impact damage morphologies of the laminates have been obtained to show impact energy absorptions for the different hybrid schemes.A microstructural model of the hybrid laminates had also been established to show impact damage mechanisms with finite element analysis(FEA).We found that the UHMWPE/Kevlar hybrid laminates with Kevlar layers as the front face have the highest energy absorption capacity,followed by the carbon/Kevlar hybrid laminates with carbon layers as the front face.The main damage modes are fiber breakages,matrix crack and interlayer delamination.The ballistic damage evolutions from the FEA results show that the major damage is shear failure for front layers,while tension failure for the back layers.We expect that the ballistic impact performance could be improved from the different hybrid schemes. 展开更多
关键词 Hybrid laminates Ballistic impact damages Energy absorption Finite element analysis(FEA)
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Real-time prediction of projectile penetration to laminates by training machine learning models with finite element solver as the trainer 被引量:2
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作者 Pushkar Wadagbalkar G.R.Liu 《Defence Technology(防务技术)》 SCIE EI CAS CSCD 2021年第1期147-160,共14页
Studies on ballistic penetration to laminates is complicated,but important for design effective protection of structures.Experimental means of study is expensive and can often be dangerous.Numerical simulation has bee... Studies on ballistic penetration to laminates is complicated,but important for design effective protection of structures.Experimental means of study is expensive and can often be dangerous.Numerical simulation has been an excellent supplement,but the computation is time-consuming.Main aim of this thesis was to develop and test an effective tool for real-time prediction of projectile penetrations to laminates by training a neural network and a decision tree regression model.A large number of finite element models were developed;the residual velocities of projectiles from finite element simulations were used as the target data and processed to produce sufficient number of training samples.Study focused on steel 4340tpolyurea laminates with various configurations.Four different 3D shapes of the projectiles were modeled and used in the training.The trained neural network and decision tree model was tested using independently generated test samples using finite element models.The predicted projectile velocity values using the trained machine learning models are then compared with the finite element simulation to verify the effectiveness of the models.Additionally,both models were trained using a published experimental data of projectile impacts to predict residual velocity of projectiles for the unseen samples.Performance of both the models was evaluated and compared.Models trained with Finite element simulation data samples were found capable to give more accurate predication,compared to the models trained with experimental data,because finite element modeling can generate much larger training set,and thus finite element solvers can serve as an excellent teacher.This study also showed that neural network model performs better with small experimental dataset compared to decision tree regression model. 展开更多
关键词 Finite element simulations Machine learning Neural networks Impact analysis Protective laminates PROJECTILE Decision tree
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Suppression of thermal postbuckling and nonlinear panel flutter motions of variable stiffness composite laminates using piezoelectric actuators 被引量:2
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作者 TAO Ji-xiao YI Sheng-hui +1 位作者 DENG Ya-jie HE Xiao-qiao 《Journal of Central South University》 SCIE EI CAS CSCD 2021年第12期3757-3777,共21页
Variable stiffness composite laminates(VSCLs)are promising in aerospace engineering due to their designable material properties through changing fiber angles and stacking sequences.Aiming to control the thermal postbu... Variable stiffness composite laminates(VSCLs)are promising in aerospace engineering due to their designable material properties through changing fiber angles and stacking sequences.Aiming to control the thermal postbuckling and nonlinear panel flutter motions of VSCLs,a full-order numerical model is developed based on the linear quadratic regulator(LQR)algorithm in control theory,the classical laminate plate theory(CLPT)considering von Kármán geometrical nonlinearity,and the first-order Piston theory.The critical buckling temperature and the critical aerodynamic pressure of VSCLs are parametrically investigated.The location and shape of piezoelectric actuators for optimal control of the dynamic responses of VSCLs are determined through comparing the norms of feedback control gain(NFCG).Numerical simulations show that the temperature field has a great effect on aeroelastic tailoring of VSCLs;the curvilinear fiber path of VSCLs can significantly affect the optimal location and shape of piezoelectric actuator for flutter suppression;the unstable panel flutter and the thermal postbuckling deflection can be suppressed effectively through optimal design of piezoelectric patches. 展开更多
关键词 active control finite element method linear quadratic regulator algorithm nonlinear flutter thermal postbuckling variable stiffness composite laminates
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Evaluation of stiffness in a cellulose fiber reinforced epoxy laminates for structural applications:Experimental and finite element analysis 被引量:1
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作者 Furkan Ahmad Pramendra Kumar Bajpai 《Defence Technology(防务技术)》 SCIE EI CAS CSCD 2018年第4期278-286,共9页
Natural fiber composites have been proved to have the ability to replace the synthetic fiber composites in many structural applications. Unprecedented growth in the field of computational techniques has opened the doo... Natural fiber composites have been proved to have the ability to replace the synthetic fiber composites in many structural applications. Unprecedented growth in the field of computational techniques has opened the doors of analysis and simulation of composite materials under various environment.Modelling and simulation using various available softwares saves a lot of time and resources. In the present work, an attempt has been made to analyze the tensile behavior of jute fiber reinforced epoxy based polymer composite materials using the student version of commercially available finite element code Siemens PLM NX 10.0. In most of the structural applications, materials are required to have enough stiffness to resist the shape deformation under normal loading conditions. Therefore, emphasis is given to the load-deformation behavior of the developed composites. A 3-dimensional model of the test specimen was developed using ply-stacking method and the strain-stress values were verified by the available literature. The model showed a good agreement between the experimental and software results. Effect of ply angle, fiber percentage, fiber type, number of layers and weft fiber angle on the stiffness of laminate have been studied. 展开更多
关键词 Finite element ANALYSIS JUTE FIBER Polymer composite Ply-stacking WEFT FIBER angle laminates ANALYSIS
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Multi-stage penetration characteristics of thick ultra-high molecular weight polyethylene laminates 被引量:1
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作者 Ming-jin Cao Li Chen +2 位作者 Rong-zheng Xu Si-jia Liu Qin Fang 《Defence Technology(防务技术)》 SCIE EI CAS CSCD 2023年第9期101-110,共10页
To further reveal the failure mechanisms of thick ultra-high molecular weight polyethylene(UHMWPE)laminates,field firing tests were conducted for 10-,20-,and 30-mm thick laminates against 12.7-mm calibre wedge-shaped ... To further reveal the failure mechanisms of thick ultra-high molecular weight polyethylene(UHMWPE)laminates,field firing tests were conducted for 10-,20-,and 30-mm thick laminates against 12.7-mm calibre wedge-shaped fragment simulated projectiles at high velocities between 450 and 1200 m/s.The ballistic performance,deformation process,and staged failure characteristics of the laminates with different thicknesses were compared and analysed.The results demonstrate that the ballistic limits of the UHMWPE laminates increase almost linearly with laminate thickness.The 10-mm thick laminate generally experiences two-stage failure characteristics,whereas three-staged failure occurs in the 20-and 30-mm thick laminates and the progressive delamination is evident.The energy limit concept representing the maximum energy absorption efficiency and the idea of reuse of the thick UHMWPE laminates are proposed in this study.The findings of this research will be useful in the design of flexible and effective UHMWPE-based protective equipment. 展开更多
关键词 UHMWPE laminates Ballistic limit Thickness Mechanism Energy limit
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Lagged strain of laminates in RC beams strengthened with fiber-reinforced polymer 被引量:5
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作者 贺学军 周朝阳 +1 位作者 李毅卉 徐玲 《Journal of Central South University of Technology》 EI 2007年第3期431-435,共5页
Based on the theory of concrete structure, a new expression was derived for lagged strain of fiber-reinforced polymer (FLIP) laminates in reinforced concrete (RC) beams strengthened with FRP. The influence of diff... Based on the theory of concrete structure, a new expression was derived for lagged strain of fiber-reinforced polymer (FLIP) laminates in reinforced concrete (RC) beams strengthened with FRP. The influence of different preloaded states and nonlinear stress-strain relationship of compressed concrete were both taken into account in this approach. Then a simplified expression was given by ignoring tensile resistance of concrete. Comparison of analytical predictions with experimental results indicates satisfactory accuracy of the procedures. The errors are less than 8% and 10% respectively when the tensile resistance of concrete is or not considered. While the maximum error of existing procedures is up to 60%. 展开更多
关键词 reinforced concrete beam: bonded laminates strengthening: lagged strain: nreloaded state
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Residual Characteristic of High-Velocity Steel Fragments Penetrating UHMWPE FRP Laminates
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作者 王晓强 朱锡 梅志远 《Defence Technology(防务技术)》 SCIE EI CAS 2010年第1期54-58,共5页
The mechanical performance of ultra-high molecular weight polyethylene fiber (UHMWPE) and its composites were proposed. Penetrated properties of different thicknesses UHMWPE FRP laminates (URP) impacted by 3.3g cubic ... The mechanical performance of ultra-high molecular weight polyethylene fiber (UHMWPE) and its composites were proposed. Penetrated properties of different thicknesses UHMWPE FRP laminates (URP) impacted by 3.3g cubic high velocity fragments were studied. According to the ballistic experimental results and theoretical analysis, the linear relation between ballistic limit vBL and area density AD was confirmed. The relative parameters of showing experientially residual velocity vr were expressed by the function of AD. In the end, versatile experiential expression between vr and AD was found. Prediction of vr and vBL using obtained expressions under the above stated condition of impacting URP was consistent with the experimentaled results. Consequently, the two experiential relations can be used to predict the residual velocity and ballistic limit of cubic high velocity fragments impacting URP. The residual characteristic of high-velocity steel fragments penetrating UHMWPE FRP laminates can be more exactly forecasted by the two derived experiential formulas. 展开更多
关键词 mechanics of explosion UHMWPE fiber laminates ballistic testing residual velocity
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Mechanical property of single-bolted composite laminates 被引量:1
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作者 王富生 王佩艳 +2 位作者 姬尧尧 刘志强 岳珠峰 《Journal of Central South University》 SCIE EI CAS 2014年第2期466-471,共6页
In order to investigate the effects of different geometrical parameters and pretightening loads on failure mode and bearing strength,a large number of single-bolted T300/QY8911 composite laminates were tested under st... In order to investigate the effects of different geometrical parameters and pretightening loads on failure mode and bearing strength,a large number of single-bolted T300/QY8911 composite laminates were tested under static tension load.Box-plot was used to extract the singular testing values of bearing strength and effective statistical values were obtained.T-test method of independent samples was used to study how much pretightening loads influence bearing strength.The results show that the geometrical parameters,such as ratios of width to hole diameter(w/d) and edge distance to hole diameter(e/d),remarkably influence failure mode and bearing strength.Net-section failure will occur when w/d is smaller than 4,and shear-out failure will occur when e/d is smaller than 2.Bearing failure or bearing and shear-out combined failure will occur when w/d is greater than 4 and e/d is greater than 2.There is an optimal combination of geometrical parameters to achieve the highest bearing strength.For most of specimens,pretightening loads do not explicitly influence bearing strength. 展开更多
关键词 single-bolted composite laminate geometrical parameter pretightening load singular testing values T-test method of independent samples
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Fatigue life prediction and experiment research for composite laminates with circular hole 被引量:1
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作者 齐红宇 温卫东 孙联文 《Journal of Central South University of Technology》 2004年第1期19-22,共4页
Based on the fatigue prediction model of exponential function and Whitney-Nuismer(WN) criterion of static strength for the composite material laminate with a circular hole, the stress correct factor ( β ) was put for... Based on the fatigue prediction model of exponential function and Whitney-Nuismer(WN) criterion of static strength for the composite material laminate with a circular hole, the stress correct factor ( β ) was put forward and a new fatigue prediction model for composite material laminate was set up. T300/KH304, which is recently studied and is a high capability composite material, was used as the raw material. In order to gain the factor β , the fatigue experiments of the laminates with holes in different diameters and the same ratio of width to diameter were conducted. The fatigue analysis and tests of the laminates with a hole 5 mm in diameter are carried out at different stress levels, and the results meet the engineering requirement. The simple, prompt and practical method is provided for the prediction of S-N curve of composite laminate with a circular hole. 展开更多
关键词 composite material FATIGUE Whitney-Nuismer criterion laminate with a hole
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Mechanical and impact behaviour of titanium-based fiber metal laminates reinforced with kevlar and jute fibers under various stacking configurations
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作者 V.Subramanian K.Logesh +1 位作者 Renjin J.Bright P.Hariharasakthisudhan 《Defence Technology(防务技术)》 2025年第11期19-30,共12页
The mechanical behaviour of Titanium-based Fiber Metal Laminates(FMLs)reinforced with Kevlar,Jute and the novel woven(Kevlar+Jute)fiber mat were evaluated through tensile,flexural,Charpy impact,and drop-weight tests.T... The mechanical behaviour of Titanium-based Fiber Metal Laminates(FMLs)reinforced with Kevlar,Jute and the novel woven(Kevlar+Jute)fiber mat were evaluated through tensile,flexural,Charpy impact,and drop-weight tests.The FMLs were fabricated with various stacking configurations(2/1,3/2,4/3,and 5/4)to examine their influence on mechanical properties.Kevlar-reinforced laminates consistently demonstrated superior tensile and flexural strengths,with the highest tensile strength of 772 MPa observed in the 3/2 configuration,attributed to Kevlar's excellent load-bearing capacity.Jute-reinforced laminates exhibited lower performance due to poor bonding and early delamination,while the FMLs reinforced with woven(Kevlar+Jute)fiber mat achieved a balance between mechanical strength and cost-effectiveness by attaining a tensile strength of 718 MPa in the 3/2 configuration.Impact energy absorption results revealed that Kevlar-reinforced FMLs provided the highest energy absorption under Charpy tests,reaching 13.5 J in the 3/2 configuration.The 4/3 configu ration exhibited superior resistance under drop-weight impacts,absorbing 104.7 J of energy.Failure analysis using SEM revealed key mechanisms such as fiber debonding,delamination,and fiber pull-out,with increased severity observed in laminates with a higher number of fiber-epoxy layers,especially in the 5/4 configuration.This study highlights the potential of Kevlar-Jute hybrid fiber-reinforced FMLs for applications requiring high mechanical performance and impact resistance.Future research should explore advanced surface treatments and the environmental durability of these laminates for aerospace and automotive applications. 展开更多
关键词 Titanium-based fiber metal laminates(FMLs) Kevlar-jute hybrid fibers Mechanical properties Stacking configuration Drop-weight test
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槲皮素对微重力引起骨髓间充质干细胞衰老的影响研究 被引量:5
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作者 杨玉田 轩莹莹 +6 位作者 高玉海 王龙飞 唐汉琴 马智慧 李亮 武艺 陈克明 《中国药理学通报》 CAS CSCD 北大核心 2024年第1期38-45,共8页
目的 研究槲皮素对微重力作用下建立的骨髓间充质干细胞衰老模型的影响。方法 用3D回转仪构造骨髓间充质干细胞衰老模型,给予细胞槲皮素后进行相关蛋白检测、氧化指标检测对药物抗衰老作用进行评估研究。结果 与对照组相比微重力组细胞... 目的 研究槲皮素对微重力作用下建立的骨髓间充质干细胞衰老模型的影响。方法 用3D回转仪构造骨髓间充质干细胞衰老模型,给予细胞槲皮素后进行相关蛋白检测、氧化指标检测对药物抗衰老作用进行评估研究。结果 与对照组相比微重力组细胞的衰老相关蛋白p21、p16、p53、RB的表达显著性上升、细胞周期蛋白Cyclin D1、核纤层蛋白lamin B1表达显著下降,差异具有统计学意义(P<0.05)。并且微重力组细胞线粒体膜电位明显下降(P<0.05),细胞ROS蓄积量明显上升(P<0.05),SOD含量明显下降(P<0.05),MDA含量明显上升(P<0.05)。相较于微重力组细胞,槲皮素组细胞的衰老相关蛋白p21、p16、p53、RB的表达显著性下降、细胞周期蛋白cyclin D1、核纤层蛋白lamin B1表达显著上升,差异具有统计学意义(P<0.05)。并且槲皮素组细胞线粒体膜电位明显上升(P<0.05),细胞ROS蓄积量明显下降(P<0.05),SOD含量明显上升(P<0.05),MDA含量明显下降(P<0.05)。结论 槲皮素可抗氧化、保护线粒体功能、保护细胞周期正常进行,从而延缓微重力导致的骨髓间充质干细胞衰老。 展开更多
关键词 微重力 衰老 骨髓间充质干细胞 槲皮素 氧化应激 lamin B1 线粒体
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Study of damage behavior and repair effectiveness of patch repaired carbon fiber laminate under quasi-static indentation loading
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作者 Alok Kumar Chinmaya Kumar Sahoo A.Arockiarajan 《Defence Technology(防务技术)》 SCIE EI CAS CSCD 2024年第4期29-41,共13页
Damage caused due to low-velocity impacts in composites leads to substantial deterioration in their residual strength and eventually provokes structural failure.This work presents an experimental investigation on the ... Damage caused due to low-velocity impacts in composites leads to substantial deterioration in their residual strength and eventually provokes structural failure.This work presents an experimental investigation on the effects of different patch and parent laminate stacking sequences on the enhancement of impact strength of Carbon Fiber Reinforced Polymers(CFRP)composites by utilising the adhesively bonded external patch repair technique.Damage evolution study is also performed with the aid of Acoustic Emission(AE).Two different quasi-isotropic configurations were selected for the parent laminate,viz.,[45°/45°/0°/0°]s and[45°/0°/45°/0°]s.Quasi Static Indentation(QSI)test was performed on both the pristine laminates,and damage areas were detected by using the C-scan inspection technique.Damaged laminates were repaired by using a single-sided patch of two different configurations,viz.,[45°/45°/45°/45°]and[45°/0°/0°/45°],and employing a circular plug to fill the damaged hole.Four different combinations of repaired laminates with two configurations of each parent and patch laminate were produced,which were further subjected to the QSI test.The results reveal the effectiveness of the repair method,as all the repaired laminates show higher impact resistance compared to the respective pristine laminates.Patches of[45°/0°/0°/45°]configuration when repaired by taking[45°/45°/0°/0°]s and[45°/0°/45°/0°]s as parents exhibited 68%and 73%higher peak loads,respectively,than the respective pristine laminates.Furthermore,parent and patch of configuration[45°/0°/45°/0°]s and[45°/0°/0°/45°],respectively,attain the highest peak load,whereas[45°/45°/0°/0°]s and[45°/45°/45°/45°]combinations possess the most gradual decrease in the load. 展开更多
关键词 Carbon fiber reinforced polymers(CFRP) Quasi-isotropic laminate Quasi static indentation(QSI) Acoustic emission(AE) Composite repair
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VEGF和miR-205及靶蛋白Ezrin和LaminA/C在卵巢癌中的表达及意义 被引量:23
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作者 周君 刘海玲 +3 位作者 陈亦乐 文继舫 李龙 吴晓英 《中南大学学报(医学版)》 CAS CSCD 北大核心 2014年第2期142-150,共9页
目的:分析血管内皮生长因子(vascular endothelial growth factor,VEGF),miR-205,Ezrin,Lamin A/C在卵巢癌组织中的表达及意义。方法:采用酶联免疫吸附测定(enzyme-linked immunosorbent assay,ELISA)检测卵巢癌患者和正常女性血清中VEG... 目的:分析血管内皮生长因子(vascular endothelial growth factor,VEGF),miR-205,Ezrin,Lamin A/C在卵巢癌组织中的表达及意义。方法:采用酶联免疫吸附测定(enzyme-linked immunosorbent assay,ELISA)检测卵巢癌患者和正常女性血清中VEGF的含量;免疫组织化学检测上皮性卵巢癌组织、卵巢良性肿瘤组织和正常卵巢组织中血管内皮细胞生长因子受体-1(vascular endothelial cell growth factor receptor-1,VEGFR-1),VEGFR-2,Ezrin,Lamin A/C蛋白的表达情况和CD31所标记的微血管密度(microvessel density,MVD);采用荧光定量PCR方法检测卵巢上皮性癌组织、卵巢良性肿瘤组织和正常卵巢组织中miR-205,Ezrin和Lamin A/C的相对表达量。结果:VEGF在上皮性卵巢癌患者血清中的表达水平为(116.10±11.94),高于正常女性(40.04±4.97,P<0.05);VEGFR-1和VEGFR-2在卵巢上皮性癌组织中的阳性表达率分别为75.9%和91.4%,高于卵巢良性肿瘤组织和正常卵巢组织中的阳性表达率(P<0.05),VEGFR-1和VEGFR-2在卵巢良性肿瘤组织和正常卵巢组织中的表达差异无统计学意义(P>0.05);MVD在上皮性卵巢癌组织中的计数为(7.56±0.51),高于正常卵巢组织(1.22±0.56,P<0.05),MVD在卵巢良性肿瘤组织和正常卵巢组织中的表达差异无统计学意义(P>0.05);miR-205在上皮性卵巢癌组织中的相对表达量为(0.106±0.035),高于正常卵巢组织中的相对表达量(0.0007±0.0005,P<0.05),miR-205在卵巢良性肿瘤组织中的相对表达量为(0.0002±0.0003),高于正常卵巢癌组织中的相对表达量,但差异无统计学意义(P>0.05);免疫组织化学结果显示:Ezrin和Lamin A/C在上皮性卵巢癌组织中的阳性表达率分别为51.7%和60.3%,低于卵巢良性肿瘤组织和正常卵巢组织中的阳性表达率(P<0.05),Ezrin和Lamin A/C在卵巢良性肿瘤组织和正常卵巢组织中的表达差异无统计学意义(P>0.05);RT-PCR结果显示:Ezrin和Lamin A/C在上皮性卵巢癌组织中的相对表达量低于正常卵巢组织中的相对表达量(P<0.05);Ezrin和Lamin A/C在卵巢良性组织中的相对表达量高于在上皮性卵巢癌组织,但差异无统计学意义(P>0.05)。结论:VEGF在上皮性卵巢癌患者血清中表达上调;miR-205在上皮性卵巢癌组织中表达上调;差异蛋白Ezrin和Lamin A/C在上皮性卵巢癌组织中表达下调,提示VEGF和miR-205及靶蛋白Ezrin和Lamin A/C与卵巢癌的侵袭、转移相关。 展开更多
关键词 miR-205 VEGF 卵巢癌 EZRIN LAMIN A/C 侵袭
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益气除痰方降低肺癌Caspase 6、Lamin B1表达诱导细胞凋亡的机制 被引量:7
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作者 李舒 王淑美 +1 位作者 杨洋博君 刘启欧 《中成药》 CAS CSCD 北大核心 2016年第3期683-686,共4页
目的研究益气除痰方对肺癌A549裸鼠移植瘤天冬氨酸特异性半胱氨酸蛋白酶6(Caspase 6)及核纤层蛋白B1(Lamin B1)表达的影响。方法选用BALB/c裸小鼠40只,将肺癌A549细胞悬液接种于小鼠背侧皮下建立肺癌模型,接种第7天将小鼠随机分为5组,... 目的研究益气除痰方对肺癌A549裸鼠移植瘤天冬氨酸特异性半胱氨酸蛋白酶6(Caspase 6)及核纤层蛋白B1(Lamin B1)表达的影响。方法选用BALB/c裸小鼠40只,将肺癌A549细胞悬液接种于小鼠背侧皮下建立肺癌模型,接种第7天将小鼠随机分为5组,即模型组(生理盐水组),顺铂注射液组(0.002 g/kg),益气除痰方低、高剂量组(3.0、6.0 g/kg),联合用药组(3.0 g/kg益气除痰方+0.002 g/kg顺铂),每组8只。中药灌胃,每天1次连用21 d;顺铂注射液腹腔注射,每天1次,连用7 d。干预第22天,处死所有小鼠,测量瘤体质量、体积,并采用免疫组化及RT-PCR法检测肿瘤组织中Caspase 6、Lamin B1的表达。结果益气除痰方高剂量组和联合用药组肿瘤体积、肿瘤质量明显下降,免疫组织化学法及RT-PCR法检测结果显示,肿瘤组织中Caspase 6、Lamin B1的表达均降低,与模型组比较,差异有显著性(P<0.01);联合用药组与顺铂注射液组比较,差异有显著性(P<0.05)结论益气除痰方可抑制小鼠A549肺癌,与化疗药物联用有一定的增效作用,其机制可能与通过降低Caspase 6Lamin B1的表达诱导细胞凋亡有关。 展开更多
关键词 益气除痰方 肺癌 CASPASE 6 LAMIN B1 细胞凋亡
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Lamin B1在邻苯二甲酸二丁酯致大鼠尿道下裂发生中的表达变化 被引量:3
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作者 魏云飞 常俊锴 +1 位作者 冯宁翰 张炜 《南京医科大学学报(自然科学版)》 CAS CSCD 北大核心 2010年第7期928-931,共4页
目的:利用邻苯二甲酸二丁酯(di-n-butyl phthalate,DBP)胚胎晚期暴露导致SD胎鼠尿道下裂发生的动物模型,验证Lamin B1在尿道下裂与正常胎鼠阴茎中的差异表达,以进一步探讨尿道下裂的发生机制。方法:妊娠14~18天SD雌鼠20只,随机分为2组... 目的:利用邻苯二甲酸二丁酯(di-n-butyl phthalate,DBP)胚胎晚期暴露导致SD胎鼠尿道下裂发生的动物模型,验证Lamin B1在尿道下裂与正常胎鼠阴茎中的差异表达,以进一步探讨尿道下裂的发生机制。方法:妊娠14~18天SD雌鼠20只,随机分为2组,实验组和对照组分别给予DBP800mg/(kg·d)和大豆油2ml/d灌胃,孕期第19天剖宫产后记录雄性胎鼠肛门和生殖器之间的距离(AGD)、出生体重(BW)及尿道下裂发生数,取雄性胎鼠阴茎,运用免疫印迹法和免疫组织化学方法分析Lamin B1的表达情况。结果:实验组AGD/BW与对照组相比有显著性差异(P<0.05);尿道下裂发生率为40%;Lamin B1在对照组的相对表达量为0.923±0.013(n=10),实验组为0.593±0.014(n=10),差异有统计学意义(P<0.05);Lamin B1主要定位于尿道上皮细胞,对照组染色强度明显强于实验组。结论:DBP灌胃期间改变了尿道组织中Lamin B1的表达,影响了细胞迁移和尿生殖褶的融合,这可能是尿道下裂发生的原因之一。 展开更多
关键词 LAMIN B1 邻苯二甲酸二丁酯 尿道下裂 阴茎
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Texture evaluation in AZ31/AZ31 multilayer and AZ31/AA5068 laminar composite during accumulative roll bonding 被引量:3
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作者 Pankaj Kumar Aviral Madhup +1 位作者 Prasad RKalvala Satyam Suwas 《Defence Technology(防务技术)》 SCIE EI CAS CSCD 2020年第3期514-519,共6页
This article presents the texture development of magnesium AZ31 alloy in the accumulative roll bonded(ARB) AZ31/AZ31 multilayer and AZ31/AA5086 laminate composite.The comparative study demonstrates that the texture ev... This article presents the texture development of magnesium AZ31 alloy in the accumulative roll bonded(ARB) AZ31/AZ31 multilayer and AZ31/AA5086 laminate composite.The comparative study demonstrates that the texture evolution in AZ31 in a multilayer system is strongly influenced by the interfaces.A typical basal texture of AZ31 has been observed in AZ31/AZ31 multilayer with texture intensity increased with the rolling deformation.Presence of AZ31/AA5086 interface in the laminate composite leads to a tilted basal texture along the rolling direction(RD) in AZ31 alloy.The texture intensity of composite increased initially with rolling reduction and weakened at the higher rolling strain.Weakening of texture in AZ31 during the laminate processing at higher strain has been attributed to the development of wavy interfaces in AZ31/AA5086 laminate. 展开更多
关键词 Accumulative roll bonding Defence application AZ31 alloy TEXTURE COMPOSITE laminates
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Crashworthiness performance of hybrid kenaf/glass fiber reinforced epoxy tube on winding orientation effect under quasi-static compression load 被引量:5
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作者 A.B.M.Supian S.M.Sapuan +2 位作者 M.Y.M.Zuhri E.S.Zainudin H.H.Ya 《Defence Technology(防务技术)》 SCIE EI CAS CSCD 2020年第5期1051-1061,共11页
This research was aimed to study the effect winding orientation on the crashworthiness performance of hybrid tube.The specimens tested under quasi-static compression load involve of three winding parameters(q?30,45a... This research was aimed to study the effect winding orientation on the crashworthiness performance of hybrid tube.The specimens tested under quasi-static compression load involve of three winding parameters(q?30,45and 70)of hybrid kenaf/glass fiber reinforced epoxy and glass fiber reinforced epoxy as contrast specimen.The automated filament winding technique has been used in fabrication of hybrid and non-hybrid composite tube and crashworthiness performance was investigated experimentally.The effects of winding orientation on energy absorption capabilities and crashworthiness characteristic were investigated through quasi-static compression load and the result are compared with the glass fiber composite tube to justify the capability of hybrid natural/synthetic as energy absorption application.Hybridized samples proved to enhancing the progressive crushing capability as combination of local buckling,delaminate and brittle fracturing as progressive crushing modes.In the view of winding orientation aspect,the results of high winding orientation of hybrid composite tube elevated the crush load efficiency,specific energy absorption and energy absorption capability compared to glass composite tube(GFRP).The hybrid kenaf/glass composite tube with high winding orientation showed the best winding orientation to enhance the energy absorber characteristics as energy absorption application. 展开更多
关键词 composite LAMINATE WINDING
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Corrosion damage evolution and mechanical properties of carbon fiber reinforced aluminum laminate 被引量:5
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作者 WU Xin-tong ZHAN Li-hua +3 位作者 HUANG Ming-hui ZHAO Xing WANG Xun ZHAO Guo-qing 《Journal of Central South University》 SCIE EI CAS CSCD 2021年第3期657-668,共12页
Fiber metal laminates(FMLs),a kind of lightweight material with excellent comprehensive performance,have been successfully applied in aerospace.FMLs reinforced with carbon fiber have better mechanical properties than ... Fiber metal laminates(FMLs),a kind of lightweight material with excellent comprehensive performance,have been successfully applied in aerospace.FMLs reinforced with carbon fiber have better mechanical properties than those with glass or aramid fiber.However,carbon fiber binding metal may lead to galvanic corrosion which limits its application.In this paper,electrochemical methods,optical microscope and scanning electron microscope were used to analyze the corrosion evolution of carbon fiber reinforced aluminum laminate(CARALL)in corrosive environment and explore anti-corrosion ways to protect CARALL.The results show that the connection between carbon fiber and aluminum alloy changes electric potential,causing galvanic corrosion.The galvanic corrosion will obviously accelerate CARALL corroded in solution,leading to a 72.1%decrease in interlaminar shear strength,and the crevice corrosion has a greater impact on CARALL resulting in delamination.The reduction of interlaminar shear strength has a similar linear relationship with the corrosion time.In addition,the adhesive layers between carbon fiber and aluminum alloy cannot protect CARALL,while side edge protection can effectively slow down corrosion rate.Therefore,the exposed edges should be coated with anti-corrosion painting.CARALL has the potential to be used for aerospace components. 展开更多
关键词 carbon fiber reinforced aluminum laminate galvanic corrosion ELECTROCHEMISTRY interlaminar shear strength aluminum alloy
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Development of cost effective personnel armour through structural hybridization 被引量:4
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作者 P.Rama Subba Reddy T.Sreekantha Reddy +2 位作者 I.Srikanth Juhi Kushwaha V.Madhu 《Defence Technology(防务技术)》 SCIE EI CAS CSCD 2020年第6期1089-1097,共9页
The objective of the present study is to develop cost effective thermoplastic hybrid laminate using Dyneema®HB50 and Tensylon®HSBD 30A through structural hybridization method.Laminates having 20 mm thickness... The objective of the present study is to develop cost effective thermoplastic hybrid laminate using Dyneema®HB50 and Tensylon®HSBD 30A through structural hybridization method.Laminates having 20 mm thickness were fabricated and subjected to 7.6239 mm mild steel core projectile with an impact velocity of 730±10 ms1.Parameters such as energy absorption,back face deformation and rate of back face deformation were measured as a function of hybridization ratio.It was observed that hybrid laminate with 50:50 ratio(w/w)of Tensylon®and Dyneema®with Tensylon®as front face showed 200%more energy absorption when compared to 100%Tensylon®laminate and showed equal energy absorption as that of expensive 100%Dyneema®laminate.Moreover,hybrid laminate with TD50:50 ratio showed 40%lower in terms of final back face deformation than Dyneema®laminate.Rate of back face deformation was also found to be slow for hybrid laminate as compared to Dyneema®laminate.Dynamic mechanical analysis showed that,Tensylon®laminate has got higher stiffness and lower damping factor than Dyneema®and hybrid laminates.The interface between Tensylon®and Dyneema®layers was found to be separating during the penetration process due to the poor interfacial bonding.Failure behaviour of laminates for different hybridization ratios were studied by sectioning the impacted laminates.It was observed that,the Tensylon®laminate has undergone shear cutting of fibers as major failure mode whereas the hybrid laminate showed shear cutting followed by tensile stretching,fiber pull out and delamination.These inputs are highly useful for body armour applications to design cost effective armour with enhanced performance. 展开更多
关键词 Dyneema® Tensylon® Hybrid laminate Ballistic impact Energy absorption Back face signature
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