Efficient and eco-friendly disinfection of air-borne human respiratory RNA viruses is pursued in both public environment and portable usage.The AlGaN-based deep ultraviolet(DUV)light-emission diode(LED)has high practi...Efficient and eco-friendly disinfection of air-borne human respiratory RNA viruses is pursued in both public environment and portable usage.The AlGaN-based deep ultraviolet(DUV)light-emission diode(LED)has high practical potentials because of its advantages of variable wavelength,rapid sterilization,environmental protection,and miniaturization.Therefore,whether the emission wavelength has effects on the disinfection as well as whether the device is feasible to sterilize various respiratory RNA viruses under portable conditions is crucial.Here,we fabricate AlGaN-based DUV LEDs with different wavelength on high-temperature-annealed(HTA)AlN/Sapphire templates and investigate the inactivation effects for several respiratory RNA viruses.The AlN/AlGaN superlattices are employed between the template and upper n-AlGaN to release the strong compressive stress(SCS),improving the crystal quality and interface roughness.DUV LEDs with the wavelength of 256,265,and 278 nm,corresponding to the light output power of 6.8,9.6,and 12.5 mW,are realized,among which the 256 nm-LED shows the most potent inactivation effect in human respiratory RNA viruses,including SARS-CoV-2,influenza A virus(IAV),and human parainfluenza virus(HPIV),at a similar light power density(LPD)of~0.8 mW/cm2 for 10 s.These results will contribute to the advanced DUV LED application of disinfecting viruses with high potency and broad spectrum in a portable and eco-friendly use.展开更多
The clinical data of 3 patients with rhabdomyolysis(RM)caused by different viral infections were retrospectively reviewed.The diagnoses were established according to the clinical symptoms,physical signs,myocardial enz...The clinical data of 3 patients with rhabdomyolysis(RM)caused by different viral infections were retrospectively reviewed.The diagnoses were established according to the clinical symptoms,physical signs,myocardial enzymes,and muscle biopsy.Case 1 was a 11-year-old boy with influenza A virus infection,whose major symptoms were fever,cough and myalgia.After the treatment of active anti-virus,hydration,and alkalinization,the patient completely recovered.Case 2 was a 10-year-old girl with Epstein-Barr(EB)virus infection who had significant musculoskeletal pain and muscle weakness symptoms with significantly elevated serum creatine kinase.After active hydration and anti-infective treatment,the patient s condition returned to normal.Case 3 was a 15-year・old boy with human cytomegalovirus infection,whose symptoms were mainly repeated fever,accompanied by myalgia and facial edema.Antibacterial therapy was ineffective,and the disease progressed with respiratory muscle weakness and multiple organ injuries.After antiviral treatment,respiratory support and hemofiltration,the symptoms relieved and patient recovered without sequela.With literature review,we believe that although influenza virus,Epstein-Barr virus and cytomegalovirus rarely cause RM in children,it should be attached attention to.With early diagnosis and treatment,the prognosis is favorable.展开更多
基金supports from the National Key R&D Program of China(2022YFB3605001)National Natural Science Foundation of China(62121005,62004196,61725403,31922004,and 61827813)+2 种基金Youth Innovation Promotion Association of Chinese Academy of Sciences(2023223)Young Elite Scientist Sponsorship Program by CAST(YESS20200182)Innovation Team Project from the Hubei Province(2020CFA015).
文摘Efficient and eco-friendly disinfection of air-borne human respiratory RNA viruses is pursued in both public environment and portable usage.The AlGaN-based deep ultraviolet(DUV)light-emission diode(LED)has high practical potentials because of its advantages of variable wavelength,rapid sterilization,environmental protection,and miniaturization.Therefore,whether the emission wavelength has effects on the disinfection as well as whether the device is feasible to sterilize various respiratory RNA viruses under portable conditions is crucial.Here,we fabricate AlGaN-based DUV LEDs with different wavelength on high-temperature-annealed(HTA)AlN/Sapphire templates and investigate the inactivation effects for several respiratory RNA viruses.The AlN/AlGaN superlattices are employed between the template and upper n-AlGaN to release the strong compressive stress(SCS),improving the crystal quality and interface roughness.DUV LEDs with the wavelength of 256,265,and 278 nm,corresponding to the light output power of 6.8,9.6,and 12.5 mW,are realized,among which the 256 nm-LED shows the most potent inactivation effect in human respiratory RNA viruses,including SARS-CoV-2,influenza A virus(IAV),and human parainfluenza virus(HPIV),at a similar light power density(LPD)of~0.8 mW/cm2 for 10 s.These results will contribute to the advanced DUV LED application of disinfecting viruses with high potency and broad spectrum in a portable and eco-friendly use.
基金Fund supported by the National Natural Science Foundation of China(81770026)Natural Science Foundation of Jilin Province(20180101157JC).
文摘The clinical data of 3 patients with rhabdomyolysis(RM)caused by different viral infections were retrospectively reviewed.The diagnoses were established according to the clinical symptoms,physical signs,myocardial enzymes,and muscle biopsy.Case 1 was a 11-year-old boy with influenza A virus infection,whose major symptoms were fever,cough and myalgia.After the treatment of active anti-virus,hydration,and alkalinization,the patient completely recovered.Case 2 was a 10-year-old girl with Epstein-Barr(EB)virus infection who had significant musculoskeletal pain and muscle weakness symptoms with significantly elevated serum creatine kinase.After active hydration and anti-infective treatment,the patient s condition returned to normal.Case 3 was a 15-year・old boy with human cytomegalovirus infection,whose symptoms were mainly repeated fever,accompanied by myalgia and facial edema.Antibacterial therapy was ineffective,and the disease progressed with respiratory muscle weakness and multiple organ injuries.After antiviral treatment,respiratory support and hemofiltration,the symptoms relieved and patient recovered without sequela.With literature review,we believe that although influenza virus,Epstein-Barr virus and cytomegalovirus rarely cause RM in children,it should be attached attention to.With early diagnosis and treatment,the prognosis is favorable.
