Flexible electronics are transforming our lives by making daily activities more convenient.Central to this innovation are field-effect transistors(FETs),valued for their efficient signal processing,nanoscale fabricati...Flexible electronics are transforming our lives by making daily activities more convenient.Central to this innovation are field-effect transistors(FETs),valued for their efficient signal processing,nanoscale fabrication,low-power consumption,fast response times,and versatility.Graphene,known for its exceptional mechanical properties,high electron mobility,and biocompatibility,is an ideal material for FET channels and sensors.The combination of graphene and FETs has given rise to flexible graphene field-effect transistors(FGFETs),driving significant advances in flexible electronics and sparked a strong interest in flexible biomedical sensors.Here,we first provide a brief overview of the basic structure,operating mechanism,and evaluation parameters of FGFETs,and delve into their material selection and patterning techniques.The ability of FGFETs to sense strains and biomolecular charges opens up diverse application possibilities.We specifically analyze the latest strategies for integrating FGFETs into wearable and implantable flexible biomedical sensors,focusing on the key aspects of constructing high-quality flexible biomedical sensors.Finally,we discuss the current challenges and prospects of FGFETs and their applications in biomedical sensors.This review will provide valuable insights and inspiration for ongoing research to improve the quality of FGFETs and broaden their application prospects in flexible biomedical sensing.展开更多
Ammonium level in body fluids serves as one of the critical biomarkers for healthcare,especially those relative to liver diseases.The continuous and real-time monitoring in both invasive and noninvasive manners is hig...Ammonium level in body fluids serves as one of the critical biomarkers for healthcare,especially those relative to liver diseases.The continuous and real-time monitoring in both invasive and noninvasive manners is highly desired,while the ammonium concentrations vary largely in different body fluids.Besides,the sensing reliability based on ion-selective biosensors can be significantly interfered by potassium ions.To tackle these challenges,a flexible and biocompatible sensing patch for wireless ammonium level sensing was reported with an ultrawide linear range for universal body fluids including blood,tears,saliva,sweat and urine.The as-prepared biocompatible sensors deliver a reliable sensitivity of 58.7 mV decade-1 in the range of 1-100 mM and a desirable selectivity coefficient of 0.11 in the interference of potassium ions,attributed to the cross-calibration within the sensors array.The sensor’s biocompatibility was validated by the cell growth on the sensor surface(>80%),hemolysis rates(<5%),negligible cellular inflammatory responses and weight changes of the mice with implanted sensors.Such biocompatible sensors with ultrawide linear range and desirable selectivity open up new possibility of highly compatible biomarker analysis via different body fluids in versatile approaches.展开更多
目的比较学龄前儿童不同间隔时间序贯植入双侧人工耳蜗术后听觉效果。方法选取2022年2月~2023年5月在本院诊治的45例13~68个月学龄前儿童,按序贯植入的间隔时间分为双侧人工耳蜗序贯植入1组(sequential bilateral cochlear implantation...目的比较学龄前儿童不同间隔时间序贯植入双侧人工耳蜗术后听觉效果。方法选取2022年2月~2023年5月在本院诊治的45例13~68个月学龄前儿童,按序贯植入的间隔时间分为双侧人工耳蜗序贯植入1组(sequential bilateral cochlear implantation I,SBCI1)10例(间隔<12个月)、SBCI2组23例(间隔12~23个月)及SBCI3组12例(间隔24~36个月),分别在首次人工耳蜗植入时(T_(0))、对侧耳蜗植入时(T_(1))及双侧耳蜗植入1年后(T_(2)),采用父母版言语空间特性量表(the speech,spatial and qualities of hearing scale-parent’s version,SSQ-P)、儿童听力/口语评估家长问卷(parents’evaluation of aural/oral performance of children,PEACH)及言语可懂度分级问卷(SIR)评估患儿听觉康复效果。结果①双侧人工耳蜗植入1年后(T_(2)),3组儿童的听觉能力相近(P>0.05)。②双侧人工耳蜗植入1年后(T_(2)),3组儿童的听觉能力较对侧人工耳蜗植入时(T_(1))显著改善;对侧耳蜗植入时(T_(1)),3组儿童的听觉能力较首次植入时(T_(0))显著改善(P<0.01)。③T_(0)~T_(1)期间,SBCI2、SBCI3组的SSQ-P、PEACH得分增长水平高于SBCI1组;SBCI3组SIR得分增长水平显著高于SBCI1组(P<0.01)。T_(1)~T_(2)期间,SBCI1组的SSQ-P得分增长水平高于SBCI2,SBCI2组高于SBCI3组;SBCI1、SBCI2组PEACH得分增长水平显著高于SBCI3组(P<0.01)。结论学龄前儿童不同间隔时间序贯植入双侧人工耳蜗术后短期听觉能力相近,但植入间隔时间越短的患儿获得听觉效果增益越早,应合理制订康复计划,促进患儿全面康复。展开更多
基金supported by the National Key R&D Plan of China(Grant No.2023YFB3210400)the National Natural Science Foundation of China(No.62174101)+2 种基金the Major Scientific and Technological Innovation Project of Shandong Province(2021CXGC010603)the Fundamental Research Funds of Shandong University(2020QNQT001)Collaborative Innovation Center of Technology and Equipment for Biological Diagnosis and Therapy in Universities of Shandong,Collaborative Innovation Center of Technology and Equipment for Biological Diagnosis and Therapy in Universities of Shandong,the Natural Science Foundation of Qingdao-Original exploration project(No.24-4-4-zrjj-139-jch).
文摘Flexible electronics are transforming our lives by making daily activities more convenient.Central to this innovation are field-effect transistors(FETs),valued for their efficient signal processing,nanoscale fabrication,low-power consumption,fast response times,and versatility.Graphene,known for its exceptional mechanical properties,high electron mobility,and biocompatibility,is an ideal material for FET channels and sensors.The combination of graphene and FETs has given rise to flexible graphene field-effect transistors(FGFETs),driving significant advances in flexible electronics and sparked a strong interest in flexible biomedical sensors.Here,we first provide a brief overview of the basic structure,operating mechanism,and evaluation parameters of FGFETs,and delve into their material selection and patterning techniques.The ability of FGFETs to sense strains and biomolecular charges opens up diverse application possibilities.We specifically analyze the latest strategies for integrating FGFETs into wearable and implantable flexible biomedical sensors,focusing on the key aspects of constructing high-quality flexible biomedical sensors.Finally,we discuss the current challenges and prospects of FGFETs and their applications in biomedical sensors.This review will provide valuable insights and inspiration for ongoing research to improve the quality of FGFETs and broaden their application prospects in flexible biomedical sensing.
基金supported by the National Natural Science Foundation of China(62201243)Natural Science Foundation of Guangdong Province(2022A1515011928)+2 种基金Shenzhen Science and Technology Program(Grant No.RCYX20231211090432060,JSGGZD20220822095600001)Postgraduate Scientific Research Innovation Project of Hunan Province(CX20231306)the technical support from the Southern University of Science and Technology Core Research Facilities(SUSTech CRF)。
文摘Ammonium level in body fluids serves as one of the critical biomarkers for healthcare,especially those relative to liver diseases.The continuous and real-time monitoring in both invasive and noninvasive manners is highly desired,while the ammonium concentrations vary largely in different body fluids.Besides,the sensing reliability based on ion-selective biosensors can be significantly interfered by potassium ions.To tackle these challenges,a flexible and biocompatible sensing patch for wireless ammonium level sensing was reported with an ultrawide linear range for universal body fluids including blood,tears,saliva,sweat and urine.The as-prepared biocompatible sensors deliver a reliable sensitivity of 58.7 mV decade-1 in the range of 1-100 mM and a desirable selectivity coefficient of 0.11 in the interference of potassium ions,attributed to the cross-calibration within the sensors array.The sensor’s biocompatibility was validated by the cell growth on the sensor surface(>80%),hemolysis rates(<5%),negligible cellular inflammatory responses and weight changes of the mice with implanted sensors.Such biocompatible sensors with ultrawide linear range and desirable selectivity open up new possibility of highly compatible biomarker analysis via different body fluids in versatile approaches.
文摘目的比较学龄前儿童不同间隔时间序贯植入双侧人工耳蜗术后听觉效果。方法选取2022年2月~2023年5月在本院诊治的45例13~68个月学龄前儿童,按序贯植入的间隔时间分为双侧人工耳蜗序贯植入1组(sequential bilateral cochlear implantation I,SBCI1)10例(间隔<12个月)、SBCI2组23例(间隔12~23个月)及SBCI3组12例(间隔24~36个月),分别在首次人工耳蜗植入时(T_(0))、对侧耳蜗植入时(T_(1))及双侧耳蜗植入1年后(T_(2)),采用父母版言语空间特性量表(the speech,spatial and qualities of hearing scale-parent’s version,SSQ-P)、儿童听力/口语评估家长问卷(parents’evaluation of aural/oral performance of children,PEACH)及言语可懂度分级问卷(SIR)评估患儿听觉康复效果。结果①双侧人工耳蜗植入1年后(T_(2)),3组儿童的听觉能力相近(P>0.05)。②双侧人工耳蜗植入1年后(T_(2)),3组儿童的听觉能力较对侧人工耳蜗植入时(T_(1))显著改善;对侧耳蜗植入时(T_(1)),3组儿童的听觉能力较首次植入时(T_(0))显著改善(P<0.01)。③T_(0)~T_(1)期间,SBCI2、SBCI3组的SSQ-P、PEACH得分增长水平高于SBCI1组;SBCI3组SIR得分增长水平显著高于SBCI1组(P<0.01)。T_(1)~T_(2)期间,SBCI1组的SSQ-P得分增长水平高于SBCI2,SBCI2组高于SBCI3组;SBCI1、SBCI2组PEACH得分增长水平显著高于SBCI3组(P<0.01)。结论学龄前儿童不同间隔时间序贯植入双侧人工耳蜗术后短期听觉能力相近,但植入间隔时间越短的患儿获得听觉效果增益越早,应合理制订康复计划,促进患儿全面康复。
