Background High-risk infants refer to newborns exposed to high-risk factors in the prenatal, natal or postnatal period. High-risk infants are at high risk of developmental retardation, and early identification of deve...Background High-risk infants refer to newborns exposed to high-risk factors in the prenatal, natal or postnatal period. High-risk infants are at high risk of developmental retardation, and early identification of developmental abnormalities plays a vital role in improving high-risk infants' quality of life.Aims To describe the neurodevelopment of high-risk infants aged less than 1 year old, and to analyse the incidences and influencing factors of neurodevelopmental abnormalities in order to provide a basis for neurodevelopment monitoring and management of highrisk infants.Methods High-risk infants born between January 2016 and December 2016 in the maternity and infant health hospitals of three districts in Shanghai were followed up.The Gesell Developmental Scale was used to assess the neurodevelopmental level at the time of recruitment(0-2 months) and at 9 months. Univariate and multivariate analyses of the influencing factors were conducted.Results 484 high-risk infants(male 51 %, female 49%)with an average gestation age of 36.5±2.2 weeks were recruited. At the time of recruitment, the average age was2.1(0.8) months, and the developmental quotient(DQ)scores of full-term high-risk infants in motor(t=3.542,p=0.001), cognitive(t=3.125, p=0.002), language(t=3.189, p=0.002) and social(t=3.316, p=0.001) areas were higher than those of preterm infants. The incidences of developmental abnormalities of full-term high-risk infants in motor(χ~2 =9.452, p=0.002), cognitive(χ~2=6.258, p=0.012), language(χ~2 =12.319, p =0.001) and social(χ~2 =6.811, p=0.009) areas were lower than the preterm infants. At 9 months, there was no difference in the DQ scores and incidences of developmental abnormalities in four areas between full-term and preterm high-risk infants, and the incidence of developmental abnormalities was around 10%.Conclusion The incidence of neurodevelopmental abnormalities in high-risk infants aged less than 1 year old is high. Preterm birth and parental bad habits are significant factors affecting the neurodevelopment.Monitoring and early interventions help to improve highrisk infants' neurodevelopment.展开更多
Infant intestinal microbiome is closely linked with health and risk of disease. Bifidobacterium are important components of the infant gut and are known to confer various health effects on the host. However, few studi...Infant intestinal microbiome is closely linked with health and risk of disease. Bifidobacterium are important components of the infant gut and are known to confer various health effects on the host. However, few studies have described the precise composition and dynamics of early infant gut bifidobacterial communities. Thus, this was a pilot study aiming to describe the developmental trajectories and temporal dynamics of bifidobacterial communities in infants before 6 months of age. A total of 28 fecal samples from 4 infants(GF, ZZ, QM, TN, respectively)were collected and analyzed after 5, 15, 30, 60, 90, 120, 150, and 180 days of birth by a bifidobacteria-target method(based on single-molecule real-time sequencing of partial bifidobacterial rpsK genes)in conjunction with droplet digital polymerase chain reaction(ddPCR). The infant fecal microbiota comprised a total of 11 bifidobacterial species, including 4 major species, i.e., B. dentium(37.35%), B. catenulatum(32.04%), B. breve(22.24%), and B. animalis(8.02%). The infant microbiota showed highly individualized developmental trajectories. The leading species for GF was B. catenulatum, with a relatively stable developmental trajectory. In ZZ, B. breve was enriched, and the developmental trajectory was rather fluctuating. The most abundant species for QM and TN was B. dentium. The developmental trajectory of B. dentium in QM showed a trend of gradual decrease, whereas an opposite trend was seen in samples of TN. The results of ddPCR confirmed large variations in quantities of bifidobacteria between infants and suggested discordances in temporal dynamics of bifidobacterial communities during the first half year of infancy. In conclusion, our results suggested that the early infant gut bifidobacterial microbiota was highly complex and temporal dynamics, with individualized developmental trajectories, which should be considered in future research of infant gut microbiota.展开更多
Preterm birth is associated with abnormal brain structure.However,the underlying microstructural properties of cerebral cortical differences in infants born very preterm(VPT,<32 GW)and moderately-late preterm(MLPT,...Preterm birth is associated with abnormal brain structure.However,the underlying microstructural properties of cerebral cortical differences in infants born very preterm(VPT,<32 GW)and moderately-late preterm(MLPT,32-37 GW)at term-equivalent age(TEA)relative to full-term(FT)neonates were rarely explored.To achieve this,we use neurite orientation dispersion and density imaging(NODDI)and the method of gray matter-based spatial statistics(GBSS).33 VPT infants,40 MLPT infants)and 69 FT neonates with no evidence of local lesions on conventional MRI adopted from dHCP database were included in this study.By extracting the core voxels of cerebral cortex from the 142 individuals in the standard space,we compared the differences between preterm groups and FT group voxel-wisely.展开更多
This study presents a danger estimation system to prevent accidents among infants. A video camera positioned above the infant＇s crib captures video. The proposed system can monitor the behavior of infants aged zero t...This study presents a danger estimation system to prevent accidents among infants. A video camera positioned above the infant＇s crib captures video. The proposed system can monitor the behavior of infants aged zero to six months. If there is a change in behavior or any other unusual occurrence, the system alerts the person responsible to attend to the baby immediately. The proposed system operates in three phases, which are foreground color model （FC model） construction, infant detection, and degree of danger analysis. During FC model construction, the foreground color histogram is created iteratively; the background image does not have to be constructed first. A motion-history image （MHI） is also obtained based on the motion of the infant. The color and motion information supplied by the FC model and the MHI are combined to detect the infant, who is regarded as the foreground object in the input frame. Moreover, six features of infant behavior are extracted from the detected infant to measure the degree of danger faced by the infant, and the result is used to warn the baby-sitter if needed. Experimental results show that the proposed method is robust and efficient.展开更多
Probiotics exert beneficial effects on the host.This study aimed to investigate whether maternally ingested Lacticaseibacillus rhamnosus Probio-M9 during pregnancy could access and colonize the infant gut.This study r...Probiotics exert beneficial effects on the host.This study aimed to investigate whether maternally ingested Lacticaseibacillus rhamnosus Probio-M9 during pregnancy could access and colonize the infant gut.This study recruited one pregnant woman,who ingested Probio-M9 daily from 35 weeks of gestation to delivery.Feces of the mother-infant pair were regularly collected from one month before delivery to 6 months of infant's age for metagenomic sequencing.Probio-M9 genomes were mappable to all infant fecal samples,suggesting the ingested probiotics could be vertically transmitted from mother to infant.Infant-or mother-specific differential metabolic pathways were found between the maternal and infant's gut microbiome,implicating apparent differences in the intestinal metagenomic potential/function between the mother and the infant.In conclusion,maternal ingestion of Probio-M9 during the final weeks of gestation could deliver to the infant gut.The findings provided novel insights into shaping infant's gut microbiota.展开更多
Infant formula(IF)based on cow milk and goat milk is a substitute food for infants who are underfed with human milk.In our previous study,we reported the composition and physicochemical stability of IF based on milk f...Infant formula(IF)based on cow milk and goat milk is a substitute food for infants who are underfed with human milk.In our previous study,we reported the composition and physicochemical stability of IF based on milk from cows and goats and a combination of both milks.Here,we investigated the effects of these 3 IFs on intestinal immunity and short-chain fatty acid production(SCFAs)using human microbiota-associated(HMA)mice and selected human milk as a positive control.The results showed that goat milk-based IF is associated with a functional immune advantage,due to the rise in the levels of immune-related cytokines interleukin(IL)-2 and IL-10,decreased levels of intestinal permeability markers D-lactic acid and endotoxin,and increased mRNA levels of intestinal tight junction proteins occludin and claudin.In addition,the intestine of mice fed with goat milk-based IF contained 12.06μmol/g acetate,2.42μmol/g propionate,and 1.72μmol/g butyrate,which reached 69%,79%,and 60%of the levels in human milk,respectively.Our results indicate that goat milk-based IF improves intestinal immune function and promotes the production of intestinal SCFAs.展开更多
The paper introduces babbling and its general features, summarizing the studies on it in the past several decades.Though it is widely believed that babbling is a natural process of maturation and share some universal ...The paper introduces babbling and its general features, summarizing the studies on it in the past several decades.Though it is widely believed that babbling is a natural process of maturation and share some universal features, the more recent researches show babbling is influenced by the ambient linguistic environment and shows a close match with the characteristics of the first language. Therefore, babbling has a language-specific feature even in the early stage.展开更多
基金funded by the'Three-Year Action Plan for Strengthening the Public Health System in Shanghai(2015-2017)–Management of High-risk infants with Multidisciplinary Cooperation',project number:GWIV-19
文摘Background High-risk infants refer to newborns exposed to high-risk factors in the prenatal, natal or postnatal period. High-risk infants are at high risk of developmental retardation, and early identification of developmental abnormalities plays a vital role in improving high-risk infants' quality of life.Aims To describe the neurodevelopment of high-risk infants aged less than 1 year old, and to analyse the incidences and influencing factors of neurodevelopmental abnormalities in order to provide a basis for neurodevelopment monitoring and management of highrisk infants.Methods High-risk infants born between January 2016 and December 2016 in the maternity and infant health hospitals of three districts in Shanghai were followed up.The Gesell Developmental Scale was used to assess the neurodevelopmental level at the time of recruitment(0-2 months) and at 9 months. Univariate and multivariate analyses of the influencing factors were conducted.Results 484 high-risk infants(male 51 %, female 49%)with an average gestation age of 36.5±2.2 weeks were recruited. At the time of recruitment, the average age was2.1(0.8) months, and the developmental quotient(DQ)scores of full-term high-risk infants in motor(t=3.542,p=0.001), cognitive(t=3.125, p=0.002), language(t=3.189, p=0.002) and social(t=3.316, p=0.001) areas were higher than those of preterm infants. The incidences of developmental abnormalities of full-term high-risk infants in motor(χ~2 =9.452, p=0.002), cognitive(χ~2=6.258, p=0.012), language(χ~2 =12.319, p =0.001) and social(χ~2 =6.811, p=0.009) areas were lower than the preterm infants. At 9 months, there was no difference in the DQ scores and incidences of developmental abnormalities in four areas between full-term and preterm high-risk infants, and the incidence of developmental abnormalities was around 10%.Conclusion The incidence of neurodevelopmental abnormalities in high-risk infants aged less than 1 year old is high. Preterm birth and parental bad habits are significant factors affecting the neurodevelopment.Monitoring and early interventions help to improve highrisk infants' neurodevelopment.
基金supported by the National Natural Science Foundation of China (31972083)the Natural Science Foundation of Inner Mongolia Autonomous Region (2020ZD12)+2 种基金the Inner Mongolia Science and Technology Major Projects (2021ZD0014)the Inner Mongolia Science & Technology Planning Project (2022YFSJ0017)China Agriculture Research System of MOF and MARA。
文摘Infant intestinal microbiome is closely linked with health and risk of disease. Bifidobacterium are important components of the infant gut and are known to confer various health effects on the host. However, few studies have described the precise composition and dynamics of early infant gut bifidobacterial communities. Thus, this was a pilot study aiming to describe the developmental trajectories and temporal dynamics of bifidobacterial communities in infants before 6 months of age. A total of 28 fecal samples from 4 infants(GF, ZZ, QM, TN, respectively)were collected and analyzed after 5, 15, 30, 60, 90, 120, 150, and 180 days of birth by a bifidobacteria-target method(based on single-molecule real-time sequencing of partial bifidobacterial rpsK genes)in conjunction with droplet digital polymerase chain reaction(ddPCR). The infant fecal microbiota comprised a total of 11 bifidobacterial species, including 4 major species, i.e., B. dentium(37.35%), B. catenulatum(32.04%), B. breve(22.24%), and B. animalis(8.02%). The infant microbiota showed highly individualized developmental trajectories. The leading species for GF was B. catenulatum, with a relatively stable developmental trajectory. In ZZ, B. breve was enriched, and the developmental trajectory was rather fluctuating. The most abundant species for QM and TN was B. dentium. The developmental trajectory of B. dentium in QM showed a trend of gradual decrease, whereas an opposite trend was seen in samples of TN. The results of ddPCR confirmed large variations in quantities of bifidobacteria between infants and suggested discordances in temporal dynamics of bifidobacterial communities during the first half year of infancy. In conclusion, our results suggested that the early infant gut bifidobacterial microbiota was highly complex and temporal dynamics, with individualized developmental trajectories, which should be considered in future research of infant gut microbiota.
文摘Preterm birth is associated with abnormal brain structure.However,the underlying microstructural properties of cerebral cortical differences in infants born very preterm(VPT,<32 GW)and moderately-late preterm(MLPT,32-37 GW)at term-equivalent age(TEA)relative to full-term(FT)neonates were rarely explored.To achieve this,we use neurite orientation dispersion and density imaging(NODDI)and the method of gray matter-based spatial statistics(GBSS).33 VPT infants,40 MLPT infants)and 69 FT neonates with no evidence of local lesions on conventional MRI adopted from dHCP database were included in this study.By extracting the core voxels of cerebral cortex from the 142 individuals in the standard space,we compared the differences between preterm groups and FT group voxel-wisely.
基金supported by the National Science Council,Taiwan under Contract No.NSC98-2221-E-003-014-MY2 and NSC99-2631-S-003-002
文摘This study presents a danger estimation system to prevent accidents among infants. A video camera positioned above the infant＇s crib captures video. The proposed system can monitor the behavior of infants aged zero to six months. If there is a change in behavior or any other unusual occurrence, the system alerts the person responsible to attend to the baby immediately. The proposed system operates in three phases, which are foreground color model （FC model） construction, infant detection, and degree of danger analysis. During FC model construction, the foreground color histogram is created iteratively; the background image does not have to be constructed first. A motion-history image （MHI） is also obtained based on the motion of the infant. The color and motion information supplied by the FC model and the MHI are combined to detect the infant, who is regarded as the foreground object in the input frame. Moreover, six features of infant behavior are extracted from the detected infant to measure the degree of danger faced by the infant, and the result is used to warn the baby-sitter if needed. Experimental results show that the proposed method is robust and efficient.
基金supported by Science and Technology Major Projects of Inner Mongolia Autonomous Region(2021ZD0014)。
文摘Probiotics exert beneficial effects on the host.This study aimed to investigate whether maternally ingested Lacticaseibacillus rhamnosus Probio-M9 during pregnancy could access and colonize the infant gut.This study recruited one pregnant woman,who ingested Probio-M9 daily from 35 weeks of gestation to delivery.Feces of the mother-infant pair were regularly collected from one month before delivery to 6 months of infant's age for metagenomic sequencing.Probio-M9 genomes were mappable to all infant fecal samples,suggesting the ingested probiotics could be vertically transmitted from mother to infant.Infant-or mother-specific differential metabolic pathways were found between the maternal and infant's gut microbiome,implicating apparent differences in the intestinal metagenomic potential/function between the mother and the infant.In conclusion,maternal ingestion of Probio-M9 during the final weeks of gestation could deliver to the infant gut.The findings provided novel insights into shaping infant's gut microbiota.
基金supported by “Hundred, Thousand and Ten Thousand” Science and Technology Major Special Project of Heilongjiang Province:Dairy Products and Meat Processing (2020ZX07B01-2-1)Chinese Nutrition Society-Feihe Physique Nutrition and Health Research Fund (CNS-Feihe2020A37)+3 种基金Young Elite Scientist Sponsorship Program by CAST (YESS20200271)the National Natural Science Foundation of China (32101919)the National Key Research and Development Program of China (2021YFD2100404-04)Young Teachers Start-Up Fund of Beijing Technology and Business University (19008022139)
文摘Infant formula(IF)based on cow milk and goat milk is a substitute food for infants who are underfed with human milk.In our previous study,we reported the composition and physicochemical stability of IF based on milk from cows and goats and a combination of both milks.Here,we investigated the effects of these 3 IFs on intestinal immunity and short-chain fatty acid production(SCFAs)using human microbiota-associated(HMA)mice and selected human milk as a positive control.The results showed that goat milk-based IF is associated with a functional immune advantage,due to the rise in the levels of immune-related cytokines interleukin(IL)-2 and IL-10,decreased levels of intestinal permeability markers D-lactic acid and endotoxin,and increased mRNA levels of intestinal tight junction proteins occludin and claudin.In addition,the intestine of mice fed with goat milk-based IF contained 12.06μmol/g acetate,2.42μmol/g propionate,and 1.72μmol/g butyrate,which reached 69%,79%,and 60%of the levels in human milk,respectively.Our results indicate that goat milk-based IF improves intestinal immune function and promotes the production of intestinal SCFAs.
文摘The paper introduces babbling and its general features, summarizing the studies on it in the past several decades.Though it is widely believed that babbling is a natural process of maturation and share some universal features, the more recent researches show babbling is influenced by the ambient linguistic environment and shows a close match with the characteristics of the first language. Therefore, babbling has a language-specific feature even in the early stage.
