Critical care medicine focuses on understanding the pathophysiological mechanisms and treatment approaches for life-threatening conditions,including sepsis,severe trauma/burns,hemorrhagic shock,heatstroke,and acute pa...Critical care medicine focuses on understanding the pathophysiological mechanisms and treatment approaches for life-threatening conditions,including sepsis,severe trauma/burns,hemorrhagic shock,heatstroke,and acute pancreatitis,all of which have high incidence rates.These conditions are primarily characterized by acute multi-organ dysfunction,with sudden onset,severe illness,and high mortality rates.Additionally,critical care treatment demands substantial medical resources,imposing significant economic burdens on patients’families and society.In recent years,critical care medicine has achieved notable progress,especially in multidisciplinary integration with immunology-based fields.Collaboration across disciplines has not only accelerated advancements in critical care but also propelled the rapid development of modern immunology.This paper provides an overview and assessment of the cross-disciplinary fusion between critical care medicine and immunology,exploring how these fields related extensions mutually enhance each other.It further analyzes China’s potential to become a global leader in this area within the next 5 to 10 years.展开更多
The immune checkpoint blockade has revolutionized cancer treatment.However,not all cancer types are susceptible to this therapy.Even in melanoma,one of the best scenario,about half of the patients do not respond to im...The immune checkpoint blockade has revolutionized cancer treatment.However,not all cancer types are susceptible to this therapy.Even in melanoma,one of the best scenario,about half of the patients do not respond to immune checkpoint blockade.Since CD8+T cell is the main driving force behind cancer elimination,then having a complete and competent T cell repertoire to cover all possible cancer antigens expressed by cancer cells should be a determining factor to the success of this therapy.Conversely,if there are'holes'in patients’T cell repertoire and/or'weak spots'manifested as functional dysregulation or exhaustion on T cells specific to a set of cancer antigens that dominantly expressed by cancer cells,cancer immune escape is inevitable.However,these two types of cancer immune escape might need different treatment strategies:the first group with'holes'in the T cell repertoire,whether the'holes'are taking on a form of missing T cells to cover these cancer antigens or missing high-affinity TCRs that are known to be more sensitive to antigen stimulation,would be benefited from TCR re-directed adoptive cell transfer(ACT)therapy;the other group with T cell repertoire'weak spots'would be benefited from immune checkpoint blockade alone or in combination with additional stimulatory factors such as cytokines and peptide vaccine.In the past decade,we have developed several tools to profile the T cell repertoire from T cell receptor diversity to T cell receptor affinity to high-throughput linking antigen specificity to single T cell receptor sequences in large scale.In this talk,I will first introduce these tools and then give examples on how we use them to answer some of the fundamental questions in systems immunology with a focus on cancer immunology,which in turn help us design new therapeutics immune engineering.展开更多
Food Science and Human Wellness(FSHW ISSN:2213-4530,CN 10-1750/TS)publishes original research papers demonstrating the latest advancement of multidisciplinary subjects related to food science and human health.Topics m...Food Science and Human Wellness(FSHW ISSN:2213-4530,CN 10-1750/TS)publishes original research papers demonstrating the latest advancement of multidisciplinary subjects related to food science and human health.Topics may include but not limited to:nutriology,biochemistry,microbiology,immunology and toxicology.展开更多
Food Science and Human Wellness(FSHW ISSN:2213-4530,CN 10-1750/TS)publishes original research papers demonstrating the latest advancement of multidisciplinary subjects related to food science and human health.Topics m...Food Science and Human Wellness(FSHW ISSN:2213-4530,CN 10-1750/TS)publishes original research papers demonstrating the latest advancement of multidisciplinary subjects related to food science and human health.Topics may include but not limited to:nutriology,biochemistry,microbiology,immunology and toxicology.展开更多
Food Science and Human Wellness(FSHW ISSN:2213-4530,CN 10-1750/TS)publishes original research papers demonstrating the latest advancement of multidisciplinary subjects related to food science and human health.Topics m...Food Science and Human Wellness(FSHW ISSN:2213-4530,CN 10-1750/TS)publishes original research papers demonstrating the latest advancement of multidisciplinary subjects related to food science and human health.Topics may include but not limited to:nutriology,biochemistry,microbiology,immunology and toxicology.展开更多
Food Science and Human Wellness(FSHW ISSN:2213-4530,,CN 10-1750/TS)publishes original research papers demonstrating the latest advancement of multidisciplinary subjects related to food science and human health.Topics ...Food Science and Human Wellness(FSHW ISSN:2213-4530,,CN 10-1750/TS)publishes original research papers demonstrating the latest advancement of multidisciplinary subjects related to food science and human health.Topics may include but not limited to:nutriology,biochemistry,microbiology,immunology and toxicology.展开更多
Food Science and Human Wellness(FSHW ISSN:2213-4530,CN 10-1750/TS)publishes original research papers demonstrating the latest advancement of multidisci-plinary subjects related to food science and human health..Topics...Food Science and Human Wellness(FSHW ISSN:2213-4530,CN 10-1750/TS)publishes original research papers demonstrating the latest advancement of multidisci-plinary subjects related to food science and human health..Topics may include but not limited to:nutriology,bio-chemistry,microbiology,immunology and toxicology.展开更多
Food Science and Human Wellness (FSHW ISSN:2213-4530, CN 10-1750/TS) publishes original research papers demonstrating the latest advancement of multidisciplinary subjects related to food science and human health.Topic...Food Science and Human Wellness (FSHW ISSN:2213-4530, CN 10-1750/TS) publishes original research papers demonstrating the latest advancement of multidisciplinary subjects related to food science and human health.Topics may include but not limited to: nutriology, biochemistry, microbiology, immunology and toxicology.展开更多
Food Science and Human Wellness(FSHW ISSN:2213-4530,CN 10-1750/TS)publishes original research papers demonstrating the latest advancement of multidisci-plinary subjects related to food science and human health.Topics ...Food Science and Human Wellness(FSHW ISSN:2213-4530,CN 10-1750/TS)publishes original research papers demonstrating the latest advancement of multidisci-plinary subjects related to food science and human health.Topics may include but not limited to:nutriology,bio-chemistry,microbiology,immunology and toxicology.展开更多
Food Science and Human Wellness(FSHW ISSN:2213-4530,CN 10-1750/TS)publishes original research papers demonstrating the latest advancement of multidisci-plinary subjects related to food science and human health.Topics ...Food Science and Human Wellness(FSHW ISSN:2213-4530,CN 10-1750/TS)publishes original research papers demonstrating the latest advancement of multidisci-plinary subjects related to food science and human health.Topics may include but not limited to:nutriology,bio-chemistry,microbiology,immunology and toxicology.展开更多
Food Science and Human Wellness(FSHW ISSN:2213-4530,CN 10-1750/TS)publishes original research papers demonstrating the latest advancement of multidisci-plinary subjects related to food science and human health.Topics ...Food Science and Human Wellness(FSHW ISSN:2213-4530,CN 10-1750/TS)publishes original research papers demonstrating the latest advancement of multidisci-plinary subjects related to food science and human health.Topics may include but not limited to:nutriology,bio-chemistry,microbiology,immunology and toxicology.展开更多
Food Science and Human Wellness(FSHW ISSN:2213-4530,CN 10-1750/TS)publishes original research papers demonstrating the latest advancement of multidisci-plinary subjects related to food science and human health.Topics ...Food Science and Human Wellness(FSHW ISSN:2213-4530,CN 10-1750/TS)publishes original research papers demonstrating the latest advancement of multidisci-plinary subjects related to food science and human health.Topics may include but not limited to:nutriology,bio-chemistry,microbiology,immunology and toxicology.展开更多
Food Science and Human Wellness(FSHW ISSN:2213-4530,CN 10-1750/TS)publishes original research papers demonstrating the latest advancement of multidisci-plinary subjects related to food science and human health.Topics ...Food Science and Human Wellness(FSHW ISSN:2213-4530,CN 10-1750/TS)publishes original research papers demonstrating the latest advancement of multidisci-plinary subjects related to food science and human health.Topics may include but not limited to:nutriology,bio-chemistry,microbiology,immunology and toxicology.展开更多
Food Science and Human Wellness(FSHW ISSN:2213-4530,CN10-1750/TS)publishes original research papers demonstrating the latest advancement of multidisci-plinary subjects related to food science and human health.Topics m...Food Science and Human Wellness(FSHW ISSN:2213-4530,CN10-1750/TS)publishes original research papers demonstrating the latest advancement of multidisci-plinary subjects related to food science and human health.Topics may include but not limited to:nutriology,bio-chemistry,microbiology,immunology and toxicology.Papers regarding components of food especially nutrients and non-nutrient bioactive compounds(with putative health benefits)are welcomed.FSHW aims to unveil the correlations between food science and human health through the dissemination of both fundamental and applied research outcomes worldwide.展开更多
Tumor microenvironment is composed of the tumor cells,stromal cells,microvascular tissue fluid,constitute small amount of infiltrating cells and cytokines.In recent years,more and more evidence that tumor microenviron...Tumor microenvironment is composed of the tumor cells,stromal cells,microvascular tissue fluid,constitute small amount of infiltrating cells and cytokines.In recent years,more and more evidence that tumor microenvironment play an important role in tumorigenesis.Tumor cells,immune cells and other mesenchymal cells interact and create an immunosuppressive microenvironment through a variety of immunosuppressive factors which vascular endothelial growth factor（VEGF）,transformed growth factor-β<sub>1</sub>（TGF-β<sub>1</sub>）and interleukin-10（IL-10）),which suppress immunology functions and promote tumor cells to escape immune surveillance,ultimately leading to tumor growth and metastasis.Dendritic cells（DCs）,the most potent antigen presenting cell as now known,play a key role in the anti-tumor immune process.The pre-展开更多
We are pleased to announce the launch of a new international peer-reviewed journal-Food Science and Human Wellness,ISSN 2213-4530,which is an open access journal,produced and hosted by Elsevier B.V.on behalf of Beijin...We are pleased to announce the launch of a new international peer-reviewed journal-Food Science and Human Wellness,ISSN 2213-4530,which is an open access journal,produced and hosted by Elsevier B.V.on behalf of Beijing Academy of Food Sciences.Food Science and Human Wellness is an international peer-reviewed English journal that provides a forum for the dissemination of the latest scientific results in food science,nutriology,immunology and crossfield research.The journal focuses on both fundamental and applied research outcomes worldwide。展开更多
National Jewish Center for Immunology and Respiratory Medicine（Denver,CO）的 Terri Finkel 提出问题:用病毒表面蛋白 gp120制成的 HIV 疫苗实际上在加速病程发展吗?她认为,答案恐怕是肯定的。Finkel 在其最近发表的一份研究报告...National Jewish Center for Immunology and Respiratory Medicine（Denver,CO）的 Terri Finkel 提出问题:用病毒表面蛋白 gp120制成的 HIV 疫苗实际上在加速病程发展吗?她认为,答案恐怕是肯定的。Finkel 在其最近发表的一份研究报告中指出,由 gp120或抗-gp120抗体交联的 CD<sub>4</sub> T 细胞可通过一种“apoptosis”机制自身破坏。一旦 T 细胞被触发,此过程即发生,因为 apoptosis 与细胞的靶抗原有关。展开更多
基金supported by the National Science Foundation for Distinguished Young Scholars,China(82025021).
文摘Critical care medicine focuses on understanding the pathophysiological mechanisms and treatment approaches for life-threatening conditions,including sepsis,severe trauma/burns,hemorrhagic shock,heatstroke,and acute pancreatitis,all of which have high incidence rates.These conditions are primarily characterized by acute multi-organ dysfunction,with sudden onset,severe illness,and high mortality rates.Additionally,critical care treatment demands substantial medical resources,imposing significant economic burdens on patients’families and society.In recent years,critical care medicine has achieved notable progress,especially in multidisciplinary integration with immunology-based fields.Collaboration across disciplines has not only accelerated advancements in critical care but also propelled the rapid development of modern immunology.This paper provides an overview and assessment of the cross-disciplinary fusion between critical care medicine and immunology,exploring how these fields related extensions mutually enhance each other.It further analyzes China’s potential to become a global leader in this area within the next 5 to 10 years.
文摘The immune checkpoint blockade has revolutionized cancer treatment.However,not all cancer types are susceptible to this therapy.Even in melanoma,one of the best scenario,about half of the patients do not respond to immune checkpoint blockade.Since CD8+T cell is the main driving force behind cancer elimination,then having a complete and competent T cell repertoire to cover all possible cancer antigens expressed by cancer cells should be a determining factor to the success of this therapy.Conversely,if there are'holes'in patients’T cell repertoire and/or'weak spots'manifested as functional dysregulation or exhaustion on T cells specific to a set of cancer antigens that dominantly expressed by cancer cells,cancer immune escape is inevitable.However,these two types of cancer immune escape might need different treatment strategies:the first group with'holes'in the T cell repertoire,whether the'holes'are taking on a form of missing T cells to cover these cancer antigens or missing high-affinity TCRs that are known to be more sensitive to antigen stimulation,would be benefited from TCR re-directed adoptive cell transfer(ACT)therapy;the other group with T cell repertoire'weak spots'would be benefited from immune checkpoint blockade alone or in combination with additional stimulatory factors such as cytokines and peptide vaccine.In the past decade,we have developed several tools to profile the T cell repertoire from T cell receptor diversity to T cell receptor affinity to high-throughput linking antigen specificity to single T cell receptor sequences in large scale.In this talk,I will first introduce these tools and then give examples on how we use them to answer some of the fundamental questions in systems immunology with a focus on cancer immunology,which in turn help us design new therapeutics immune engineering.
文摘北京大学系统生物医学研究所尹玉新教授课题组最新研究发现了自身免疫系统调控开关——双重特异性磷酸酶2（dual-specificity phosphatase 2,DUSP2/PAC1）,它可以调控自身免疫反应,影响自身免疫疾病的发生发展,其相关研究论文＂The phosphatase DUSP2 controls the activity of the transcription activator STAT3 and regulates TH17 differentiation＂于2015年10月19日在线发表于Nature Immunology，北京大学基础医学院吕丹博士和2009级基础医学八年制博士研究生刘亮为该论文的共同第一作者。该项研究得到国家重点基础研究发展计划（973计划）、国家自然科学基金和北京大学一清华大学生命科学联合中心的支持。
文摘Food Science and Human Wellness(FSHW ISSN:2213-4530,CN 10-1750/TS)publishes original research papers demonstrating the latest advancement of multidisciplinary subjects related to food science and human health.Topics may include but not limited to:nutriology,biochemistry,microbiology,immunology and toxicology.
文摘Food Science and Human Wellness(FSHW ISSN:2213-4530,CN 10-1750/TS)publishes original research papers demonstrating the latest advancement of multidisciplinary subjects related to food science and human health.Topics may include but not limited to:nutriology,biochemistry,microbiology,immunology and toxicology.
文摘Food Science and Human Wellness(FSHW ISSN:2213-4530,CN 10-1750/TS)publishes original research papers demonstrating the latest advancement of multidisciplinary subjects related to food science and human health.Topics may include but not limited to:nutriology,biochemistry,microbiology,immunology and toxicology.
文摘Food Science and Human Wellness(FSHW ISSN:2213-4530,,CN 10-1750/TS)publishes original research papers demonstrating the latest advancement of multidisciplinary subjects related to food science and human health.Topics may include but not limited to:nutriology,biochemistry,microbiology,immunology and toxicology.
文摘Food Science and Human Wellness(FSHW ISSN:2213-4530,CN 10-1750/TS)publishes original research papers demonstrating the latest advancement of multidisci-plinary subjects related to food science and human health..Topics may include but not limited to:nutriology,bio-chemistry,microbiology,immunology and toxicology.
文摘Food Science and Human Wellness (FSHW ISSN:2213-4530, CN 10-1750/TS) publishes original research papers demonstrating the latest advancement of multidisciplinary subjects related to food science and human health.Topics may include but not limited to: nutriology, biochemistry, microbiology, immunology and toxicology.
文摘Food Science and Human Wellness(FSHW ISSN:2213-4530,CN 10-1750/TS)publishes original research papers demonstrating the latest advancement of multidisci-plinary subjects related to food science and human health.Topics may include but not limited to:nutriology,bio-chemistry,microbiology,immunology and toxicology.
文摘Food Science and Human Wellness(FSHW ISSN:2213-4530,CN 10-1750/TS)publishes original research papers demonstrating the latest advancement of multidisci-plinary subjects related to food science and human health.Topics may include but not limited to:nutriology,bio-chemistry,microbiology,immunology and toxicology.
文摘Food Science and Human Wellness(FSHW ISSN:2213-4530,CN 10-1750/TS)publishes original research papers demonstrating the latest advancement of multidisci-plinary subjects related to food science and human health.Topics may include but not limited to:nutriology,bio-chemistry,microbiology,immunology and toxicology.
文摘Food Science and Human Wellness(FSHW ISSN:2213-4530,CN 10-1750/TS)publishes original research papers demonstrating the latest advancement of multidisci-plinary subjects related to food science and human health.Topics may include but not limited to:nutriology,bio-chemistry,microbiology,immunology and toxicology.
文摘Food Science and Human Wellness(FSHW ISSN:2213-4530,CN 10-1750/TS)publishes original research papers demonstrating the latest advancement of multidisci-plinary subjects related to food science and human health.Topics may include but not limited to:nutriology,bio-chemistry,microbiology,immunology and toxicology.
文摘Food Science and Human Wellness(FSHW ISSN:2213-4530,CN10-1750/TS)publishes original research papers demonstrating the latest advancement of multidisci-plinary subjects related to food science and human health.Topics may include but not limited to:nutriology,bio-chemistry,microbiology,immunology and toxicology.Papers regarding components of food especially nutrients and non-nutrient bioactive compounds(with putative health benefits)are welcomed.FSHW aims to unveil the correlations between food science and human health through the dissemination of both fundamental and applied research outcomes worldwide.
文摘Tumor microenvironment is composed of the tumor cells,stromal cells,microvascular tissue fluid,constitute small amount of infiltrating cells and cytokines.In recent years,more and more evidence that tumor microenvironment play an important role in tumorigenesis.Tumor cells,immune cells and other mesenchymal cells interact and create an immunosuppressive microenvironment through a variety of immunosuppressive factors which vascular endothelial growth factor（VEGF）,transformed growth factor-β<sub>1</sub>（TGF-β<sub>1</sub>）and interleukin-10（IL-10）),which suppress immunology functions and promote tumor cells to escape immune surveillance,ultimately leading to tumor growth and metastasis.Dendritic cells（DCs）,the most potent antigen presenting cell as now known,play a key role in the anti-tumor immune process.The pre-
文摘We are pleased to announce the launch of a new international peer-reviewed journal-Food Science and Human Wellness,ISSN 2213-4530,which is an open access journal,produced and hosted by Elsevier B.V.on behalf of Beijing Academy of Food Sciences.Food Science and Human Wellness is an international peer-reviewed English journal that provides a forum for the dissemination of the latest scientific results in food science,nutriology,immunology and crossfield research.The journal focuses on both fundamental and applied research outcomes worldwide。
文摘National Jewish Center for Immunology and Respiratory Medicine（Denver,CO）的 Terri Finkel 提出问题:用病毒表面蛋白 gp120制成的 HIV 疫苗实际上在加速病程发展吗?她认为,答案恐怕是肯定的。Finkel 在其最近发表的一份研究报告中指出,由 gp120或抗-gp120抗体交联的 CD<sub>4</sub> T 细胞可通过一种“apoptosis”机制自身破坏。一旦 T 细胞被触发,此过程即发生,因为 apoptosis 与细胞的靶抗原有关。
