A computer program MACA was developed for simulating high-dose ion implantation into amorphous solids. The topology of amorphous solids was modelled by adjusting the free flight path distribution between collisions, s...A computer program MACA was developed for simulating high-dose ion implantation into amorphous solids. The topology of amorphous solids was modelled by adjusting the free flight path distribution between collisions, so that the radial distribution function will characterize the short - range order and long - range disorder of amorphous targets. A simulation example is given.展开更多
1文献来源Kansara R,Shenkier TN,Connors JM,et al.Rituximab with high-dose Methotrexate in primary central nervous system lymphoma[J].Am J Hematol,2015,90（12）：1149-1154.2证据水平2a。
目的:根据急性淋巴细胞白血病(ALL)患儿在不同时间点的甲氨蝶呤(MTX)血药浓度,预测大剂量甲氨蝶呤(HDMTX)的清除和毒性。方法:采集接受HDMTX治疗的198例急性淋巴细胞白血病患儿(累积303例次输液)不同时间点血样,通过改良酶放大免疫法测...目的:根据急性淋巴细胞白血病(ALL)患儿在不同时间点的甲氨蝶呤(MTX)血药浓度,预测大剂量甲氨蝶呤(HDMTX)的清除和毒性。方法:采集接受HDMTX治疗的198例急性淋巴细胞白血病患儿(累积303例次输液)不同时间点血样,通过改良酶放大免疫法测定不同时间点MTX水平。通过受试者工作特征(ROC)曲线对MTX水平与毒性的相关性进行评价。另选取22例患儿进行模型验证,预测其准确度和特异性。结果:42 h MTX水平用于预测延迟清除的最佳浓度上限为1.50μmol/L,灵敏度为82.17%;用于预测安全阈值的最佳浓度上限为0.76μmol/L,灵敏度为90.78%。66 h MTX水平用于预测毒性的最佳浓度上限为0.50μmol/L,灵敏度为89.09%;用于预测无毒性的最佳浓度上限为0.10μmol/L,灵敏度为92.73%。22例进行模型验证的患儿中,42 h MTX水平用于预测延迟清除的准确度为80.60%;用于预测安全阈值的准确度为85.78%,特异度为91.50%。66 h MTX水平用于预测毒性的准确度为89.18%;用于预测无毒性的准确度为87.24%,特异度为92.20%。结论:输液后66 h内各时间点MTX水平可被准确测量,42 h MTX水平可用于延迟清除的预测,66 h MTX水平可用于毒性预测。展开更多
文摘A computer program MACA was developed for simulating high-dose ion implantation into amorphous solids. The topology of amorphous solids was modelled by adjusting the free flight path distribution between collisions, so that the radial distribution function will characterize the short - range order and long - range disorder of amorphous targets. A simulation example is given.
文摘1文献来源Kansara R,Shenkier TN,Connors JM,et al.Rituximab with high-dose Methotrexate in primary central nervous system lymphoma[J].Am J Hematol,2015,90（12）：1149-1154.2证据水平2a。
文摘目的:根据急性淋巴细胞白血病(ALL)患儿在不同时间点的甲氨蝶呤(MTX)血药浓度,预测大剂量甲氨蝶呤(HDMTX)的清除和毒性。方法:采集接受HDMTX治疗的198例急性淋巴细胞白血病患儿(累积303例次输液)不同时间点血样,通过改良酶放大免疫法测定不同时间点MTX水平。通过受试者工作特征(ROC)曲线对MTX水平与毒性的相关性进行评价。另选取22例患儿进行模型验证,预测其准确度和特异性。结果:42 h MTX水平用于预测延迟清除的最佳浓度上限为1.50μmol/L,灵敏度为82.17%;用于预测安全阈值的最佳浓度上限为0.76μmol/L,灵敏度为90.78%。66 h MTX水平用于预测毒性的最佳浓度上限为0.50μmol/L,灵敏度为89.09%;用于预测无毒性的最佳浓度上限为0.10μmol/L,灵敏度为92.73%。22例进行模型验证的患儿中,42 h MTX水平用于预测延迟清除的准确度为80.60%;用于预测安全阈值的准确度为85.78%,特异度为91.50%。66 h MTX水平用于预测毒性的准确度为89.18%;用于预测无毒性的准确度为87.24%,特异度为92.20%。结论:输液后66 h内各时间点MTX水平可被准确测量,42 h MTX水平可用于延迟清除的预测,66 h MTX水平可用于毒性预测。
