Objective Complications after transsphenoidal surgery for pituitary adenoma have been well documented in the literatures,but the occurrence of delved sudden sensorineural hearing loss(SNHL)after pituitary adenoma rese...Objective Complications after transsphenoidal surgery for pituitary adenoma have been well documented in the literatures,but the occurrence of delved sudden sensorineural hearing loss(SNHL)after pituitary adenoma resection is extremely rare.In this study three cases who developed sudden SNHL 3 to 7 days after pituitary adenoma surgery without experiencing cerebrospinal fluid leak or meningitis were presented,and the possible causes of SNHL were discussed.Methods Three cases with sudden hearing loss after transsphenoidal surgery for pituitary adenoma were reviewed.The past medical history,onset of sudden hearing loss,accompanying symptoms such as headache,tinnitus,dizziness and aural fullness,and the post-operative MRI images,therapy and hearing results were reported.Results Three cases developed profound sudden SNHL on the 3rd to 7th post-operative day,all accompanied by prior headache,tinnitus and dizziness.One patient developed episodic vertigo,ear fullness accompanying with fluctuating hearing loss in the first post-operative month.Two patients had past medical history of arteriosclerosis and coronary heart disease or cerebral infarction.Two of three demonstrated obstructive hydrocephalus on MRI on the first post-operative day.Under treatment with prednisone orally,dexamethasone intratympanic mjection,neurotrophic and vasodilatation drugs for 3 to 8 months,hearing of all three improved partially.Obstructive hydrocephalus and ischemia might be responsible for the hearing loss.Conclusion Post-operative obstructive hydrocephalus and ischemia of labyrinthine arteries might lead to the delayed SNHL after transsphenoidal surgery for pituitary adenoma.展开更多
Sudden deafness is one of the commonest acute symptoms in otolaryngology.In recent years,the incidence of sudden deafness is on the rise all over the world,but its etiology is still unclear,and the prognosis is greatl...Sudden deafness is one of the commonest acute symptoms in otolaryngology.In recent years,the incidence of sudden deafness is on the rise all over the world,but its etiology is still unclear,and the prognosis is greatly different.Traditional Chinese medicine(TCM)believes that the onset of sudden deafness is related to the liver,gallbladder,heart and triple energizer meridians.This article mainly explored the key points of common syndromes,TCM nursing methods and health guidance of sudden deafness.展开更多
The objectives of this review were to 1)summarize the available evidence on the impact of hearing loss on quality of life(QOL)among U.S.active-duty service members,2)describe the QOL instruments that have been used to...The objectives of this review were to 1)summarize the available evidence on the impact of hearing loss on quality of life(QOL)among U.S.active-duty service members,2)describe the QOL instruments that have been used to quantify the impact of hearing loss on quality of life,3)examine national population-level secondary databases and report on their utility for studying the impact of hearing loss on QOL among active-duty service members,and 4)provide recommendations for future studies that seek to quantify the impact of hearing loss in this population.There is a lack of literature that addresses the intersection of hearing impairment,the military population,and quality of life measures.For audiological research,U.S.military personnel offer a unique research population,as they are exposed to noise levels and blast environments that are highly unusual in civilian work settings and can serve as a model population for studying the impact on QOL associated with these conditions.This review recommends conducting a study on the active-duty service member population using a measurement instrument suitable for determining decreases in QOL specifically due to hearing loss.展开更多
Hearing plays a vital role in the performance of a soldier and is important for speech processing. Noise-induced hearing loss is a significant impairment in the military and can affect combat performance. Military per...Hearing plays a vital role in the performance of a soldier and is important for speech processing. Noise-induced hearing loss is a significant impairment in the military and can affect combat performance. Military personnel are constantly exposed to high levels of noise and it is not surprising that noise induced hearing loss and tinnitus remain the second most prevalent service-connected disabilities. Unfortunately, unlike civilian personnel, military personnel have little option but to remain in noisy environments in order to complete specific tasks and missions. Use of hearing protection devices and follow-up audiological tests have become the mainstay of prevention of noise-induced hearing loss. This review focuses on sources of noise within the military, pathophysiology and management of patients with noise induced hearing loss.展开更多
目的探讨非综合征型听神经病患者的基因定位突变特征及候选基因筛查情况。方法选择存在5代遗传史的X-连锁听神经病发病家系,纳入研究患者40例作为基因定位克隆分析病例,同时选择2016年1月~2019年3月非综合征型听神经病28例、健康志愿者4...目的探讨非综合征型听神经病患者的基因定位突变特征及候选基因筛查情况。方法选择存在5代遗传史的X-连锁听神经病发病家系,纳入研究患者40例作为基因定位克隆分析病例,同时选择2016年1月~2019年3月非综合征型听神经病28例、健康志愿者40名、低频听力减退家系患者30例作为耳畸蛋白(otoferlin,OTOF)基因、Wolfram综合征1(Wolfram syndrome 1,WFS1)基因突变筛查、分子流行病学分析。经DNAStar软件实施序列分析。结果经40个微卫星标记扫描X染色体基因组发现,最大对数优势比(logarithum of the odds,LOD)2.34,X连锁遗传分析获得的阳性结果相关判定值>2;家族系中8个体出现一次重组,出现于DXS1220与DXS8064、DXS8084与DXS8106间,故可明确定位区域于DXS1220-DXS8084间;AUNX1基因座定位在Xq23-27.3间,其遗传距离是28.07 Mb。筛查结果分析,28例非综合征型听神经病患者中存在1个新突变位点能诱发氨基酸变化,即3447G>T错义突变、1075D>Y天冬氨酸转变成酪氨酸。对28例非综合征型听神经病患者实施WFS1基因突变测定,发现存在2个新突变位点,即2766G>A杂合突变和2328A>G杂合,并A→G突变;2328A>G杂合,A→G 720异亮氨酸>缬氨酸(I>V),是非综合征型听神经病患者特有。结论非综合征型听神经病存在特异与相应致病基因座位,创建和非综合征型听神经病有关基因检测方法,能指导分析、诊断非综合征型听神经病相关分子遗传机制。展开更多
Objective:To study whether adenovirus-mediated human β-nerve growth factor (Ad-hNGFβ) gene has any protective effect on blast hearing impairment. Methods:Deafness was induced by blast exposure (172.0 dB) in 30 healt...Objective:To study whether adenovirus-mediated human β-nerve growth factor (Ad-hNGFβ) gene has any protective effect on blast hearing impairment. Methods:Deafness was induced by blast exposure (172.0 dB) in 30 healthy guinea pigs. On day 7 of blast exposure, Ad-hNGFβ was infused into the perilymphatic space of 20 animals as the study group (hNGFβ group), and artificial perilymph fluid (APF) was infused into the perilymphatic space of the other 10 animals as the control group. At weeks 1, 4 and 8 after blast exposure, the animals were sacrificed and the cochleae were removed for immunohistochemical and HE stainings. Results: Expression of Ad-hNGFβ protein was detected in each turn of the cochlea at the 1st week, with almost equal intensity in all turns. At the 4th week, the reactive intensity of the expression of Ad-hNGFβ protein decreased. At the 8th week, no expression was detectable. The results of HE staining showed that the amount of spiral ganglions in hNGFβ group was significantly greater than that of the control group at week 4 (P<0.01). Conclusion: Ad-hNGFβ can be expressed at a high level and for a relatively long period in the blast impaired cochlea, suggesting that Ad-hNGFβ has a protective effect on cochlear spiral ganglion cells after blast exposure and the efficient gene transfer into cochlea had been achieved without toxicity.展开更多
Auditory cortical cvokod rcsponse(ACER) and auditory brainstom cvoked response (ABR) were recorded in guinea pigs before and after irradiation of ^(60)Co γ-ray. A single dose of irradiation on head was 90Gy and 70Gy ...Auditory cortical cvokod rcsponse(ACER) and auditory brainstom cvoked response (ABR) were recorded in guinea pigs before and after irradiation of ^(60)Co γ-ray. A single dose of irradiation on head was 90Gy and 70Gy in two groups, respectively. Two h after irradiation. the threshold shift was 12. 5 dB and 9 dB, and the ACER post-irradiation amplitude ex- ceeded the maximum pre-irradiation value by 20% and 37%. Six h after irradiation, the threshold shift increased to 37 dB and the maximum amplitnde decreased to the level of pre-irradiation in 70Gy-group. In another group, right auditory bulla arca was irradiated with a total dose of 45Gy in a course of six fractions/two weeks. Fourteen d after irradiation, the threshold shift of ABR was 118 dB and the latency of wave I was longer. The amplitude-intensity curve was after irradiation. Histological observation using scanning showed that only outer hair- cells in the basal coil of the cochlea were 6 h after irrdiation 50Gy-group. Bul 16 h later, outer, hair cells in all coils of the cochlea were found to be destroyed extensively and inner cells were destroyed slightly. In 45Gy-group, 14 d after irradiation, outer hair cells in all coils of the cochlea were damaged and no inmer hair cell was injured severely.展开更多
文摘Objective Complications after transsphenoidal surgery for pituitary adenoma have been well documented in the literatures,but the occurrence of delved sudden sensorineural hearing loss(SNHL)after pituitary adenoma resection is extremely rare.In this study three cases who developed sudden SNHL 3 to 7 days after pituitary adenoma surgery without experiencing cerebrospinal fluid leak or meningitis were presented,and the possible causes of SNHL were discussed.Methods Three cases with sudden hearing loss after transsphenoidal surgery for pituitary adenoma were reviewed.The past medical history,onset of sudden hearing loss,accompanying symptoms such as headache,tinnitus,dizziness and aural fullness,and the post-operative MRI images,therapy and hearing results were reported.Results Three cases developed profound sudden SNHL on the 3rd to 7th post-operative day,all accompanied by prior headache,tinnitus and dizziness.One patient developed episodic vertigo,ear fullness accompanying with fluctuating hearing loss in the first post-operative month.Two patients had past medical history of arteriosclerosis and coronary heart disease or cerebral infarction.Two of three demonstrated obstructive hydrocephalus on MRI on the first post-operative day.Under treatment with prednisone orally,dexamethasone intratympanic mjection,neurotrophic and vasodilatation drugs for 3 to 8 months,hearing of all three improved partially.Obstructive hydrocephalus and ischemia might be responsible for the hearing loss.Conclusion Post-operative obstructive hydrocephalus and ischemia of labyrinthine arteries might lead to the delayed SNHL after transsphenoidal surgery for pituitary adenoma.
文摘Sudden deafness is one of the commonest acute symptoms in otolaryngology.In recent years,the incidence of sudden deafness is on the rise all over the world,but its etiology is still unclear,and the prognosis is greatly different.Traditional Chinese medicine(TCM)believes that the onset of sudden deafness is related to the liver,gallbladder,heart and triple energizer meridians.This article mainly explored the key points of common syndromes,TCM nursing methods and health guidance of sudden deafness.
基金supported by the Air Force Research Laboratory under Contract No.FA8650-12-C-6358
文摘The objectives of this review were to 1)summarize the available evidence on the impact of hearing loss on quality of life(QOL)among U.S.active-duty service members,2)describe the QOL instruments that have been used to quantify the impact of hearing loss on quality of life,3)examine national population-level secondary databases and report on their utility for studying the impact of hearing loss on QOL among active-duty service members,and 4)provide recommendations for future studies that seek to quantify the impact of hearing loss in this population.There is a lack of literature that addresses the intersection of hearing impairment,the military population,and quality of life measures.For audiological research,U.S.military personnel offer a unique research population,as they are exposed to noise levels and blast environments that are highly unusual in civilian work settings and can serve as a model population for studying the impact on QOL associated with these conditions.This review recommends conducting a study on the active-duty service member population using a measurement instrument suitable for determining decreases in QOL specifically due to hearing loss.
文摘Hearing plays a vital role in the performance of a soldier and is important for speech processing. Noise-induced hearing loss is a significant impairment in the military and can affect combat performance. Military personnel are constantly exposed to high levels of noise and it is not surprising that noise induced hearing loss and tinnitus remain the second most prevalent service-connected disabilities. Unfortunately, unlike civilian personnel, military personnel have little option but to remain in noisy environments in order to complete specific tasks and missions. Use of hearing protection devices and follow-up audiological tests have become the mainstay of prevention of noise-induced hearing loss. This review focuses on sources of noise within the military, pathophysiology and management of patients with noise induced hearing loss.
文摘目的探讨非综合征型听神经病患者的基因定位突变特征及候选基因筛查情况。方法选择存在5代遗传史的X-连锁听神经病发病家系,纳入研究患者40例作为基因定位克隆分析病例,同时选择2016年1月~2019年3月非综合征型听神经病28例、健康志愿者40名、低频听力减退家系患者30例作为耳畸蛋白(otoferlin,OTOF)基因、Wolfram综合征1(Wolfram syndrome 1,WFS1)基因突变筛查、分子流行病学分析。经DNAStar软件实施序列分析。结果经40个微卫星标记扫描X染色体基因组发现,最大对数优势比(logarithum of the odds,LOD)2.34,X连锁遗传分析获得的阳性结果相关判定值>2;家族系中8个体出现一次重组,出现于DXS1220与DXS8064、DXS8084与DXS8106间,故可明确定位区域于DXS1220-DXS8084间;AUNX1基因座定位在Xq23-27.3间,其遗传距离是28.07 Mb。筛查结果分析,28例非综合征型听神经病患者中存在1个新突变位点能诱发氨基酸变化,即3447G>T错义突变、1075D>Y天冬氨酸转变成酪氨酸。对28例非综合征型听神经病患者实施WFS1基因突变测定,发现存在2个新突变位点,即2766G>A杂合突变和2328A>G杂合,并A→G突变;2328A>G杂合,A→G 720异亮氨酸>缬氨酸(I>V),是非综合征型听神经病患者特有。结论非综合征型听神经病存在特异与相应致病基因座位,创建和非综合征型听神经病有关基因检测方法,能指导分析、诊断非综合征型听神经病相关分子遗传机制。
基金Supported by the"Eleventh Five-Year Plan"Medical Science Research Foundation of the PLA(No.06MA157)
文摘Objective:To study whether adenovirus-mediated human β-nerve growth factor (Ad-hNGFβ) gene has any protective effect on blast hearing impairment. Methods:Deafness was induced by blast exposure (172.0 dB) in 30 healthy guinea pigs. On day 7 of blast exposure, Ad-hNGFβ was infused into the perilymphatic space of 20 animals as the study group (hNGFβ group), and artificial perilymph fluid (APF) was infused into the perilymphatic space of the other 10 animals as the control group. At weeks 1, 4 and 8 after blast exposure, the animals were sacrificed and the cochleae were removed for immunohistochemical and HE stainings. Results: Expression of Ad-hNGFβ protein was detected in each turn of the cochlea at the 1st week, with almost equal intensity in all turns. At the 4th week, the reactive intensity of the expression of Ad-hNGFβ protein decreased. At the 8th week, no expression was detectable. The results of HE staining showed that the amount of spiral ganglions in hNGFβ group was significantly greater than that of the control group at week 4 (P<0.01). Conclusion: Ad-hNGFβ can be expressed at a high level and for a relatively long period in the blast impaired cochlea, suggesting that Ad-hNGFβ has a protective effect on cochlear spiral ganglion cells after blast exposure and the efficient gene transfer into cochlea had been achieved without toxicity.
文摘Auditory cortical cvokod rcsponse(ACER) and auditory brainstom cvoked response (ABR) were recorded in guinea pigs before and after irradiation of ^(60)Co γ-ray. A single dose of irradiation on head was 90Gy and 70Gy in two groups, respectively. Two h after irradiation. the threshold shift was 12. 5 dB and 9 dB, and the ACER post-irradiation amplitude ex- ceeded the maximum pre-irradiation value by 20% and 37%. Six h after irradiation, the threshold shift increased to 37 dB and the maximum amplitnde decreased to the level of pre-irradiation in 70Gy-group. In another group, right auditory bulla arca was irradiated with a total dose of 45Gy in a course of six fractions/two weeks. Fourteen d after irradiation, the threshold shift of ABR was 118 dB and the latency of wave I was longer. The amplitude-intensity curve was after irradiation. Histological observation using scanning showed that only outer hair- cells in the basal coil of the cochlea were 6 h after irrdiation 50Gy-group. Bul 16 h later, outer, hair cells in all coils of the cochlea were found to be destroyed extensively and inner cells were destroyed slightly. In 45Gy-group, 14 d after irradiation, outer hair cells in all coils of the cochlea were damaged and no inmer hair cell was injured severely.
