Aptamers are a type of single-chain oligonucleotide that can combine with a specific target.Due to their simple preparation,easy modification,stable structure and reusability,aptamers have been widely applied as bioch...Aptamers are a type of single-chain oligonucleotide that can combine with a specific target.Due to their simple preparation,easy modification,stable structure and reusability,aptamers have been widely applied as biochemical sensors for medicine,food safety and environmental monitoring.However,there is little research on aptamer-target binding mechanisms,which limits their application and development.Computational simulation has gained much attention for revealing aptamer-target binding mechanisms at the atomic level.This work summarizes the main simulation methods used in the mechanistic analysis of aptamer-target complexes,the characteristics of binding between aptamers and different targets(metal ions,small organic molecules,biomacromolecules,cells,bacteria and viruses),the types of aptamer-target interactions and the factors influencing their strength.It provides a reference for further use of simulations in understanding aptamer-target binding mechanisms.展开更多
This is a brief review on the recent book: Duality System in Applied Mechanics and Optimal Control, by Zhong Wan-Xie, published by Kluwer Academic Publishers, 2004. The book represents a significant effort to re-estab...This is a brief review on the recent book: Duality System in Applied Mechanics and Optimal Control, by Zhong Wan-Xie, published by Kluwer Academic Publishers, 2004. The book represents a significant effort to re-establish the historic and deep tie between control and mechanics by striving to connect and integrate concepts, methods, and algorithms in mechanics and control so that a unified framework can be established for both analytical and computational purposes. Clearly, it has demonstrated that the duality system method can be used as a mathematical and systematic foundation to deal with many important concepts and problems in both mechanics and control. This book is not only very useful for research and applications, but also extremely helpful for multidisciplinary curriculum development when students from one field are trying to learning and applying concepts and methods from the other field.展开更多
This paper deals with the mechanics problem of dynamic walking of anthropomorphic biped robots. Through analysing the mechanics system of this kind of robots in detail, the motion constraint equations are established,...This paper deals with the mechanics problem of dynamic walking of anthropomorphic biped robots. Through analysing the mechanics system of this kind of robots in detail, the motion constraint equations are established, three mechanics laws describing the r展开更多
This article demonstrates a novel approach for material nonlinear analysis.This analysis procedure eliminates tedious and lengthy step by step incremental and then iterative procedure adopted classically and gives dir...This article demonstrates a novel approach for material nonlinear analysis.This analysis procedure eliminates tedious and lengthy step by step incremental and then iterative procedure adopted classically and gives direct results in the linear as well as in nonlinear range of the material behavior.Use of elastic moduli is eliminated.Instead,stress and strain functions are used as the material input in the analysis procedure.These stress and strain functions are directly derived from the stress-strain behavior of the material by the method of curve fitting.This way,the whole stress-strain diagram is utilized in the analysis which naturally exposes the response of structure when loading is in nonlinear range of the material behavior.It is found that it is an excellent computational procedure adopted so far for material nonlinear analysis which gives very accurate results,easy to adopt and simple in calculations.The method eliminates all types of linearity assumptions in basic derivations of equations and hence,eliminates all types of possibility of errors in the analysis procedure as well.As it is required to know stress distribution in the structural body by proper modelling and structural idealization,the proposed analysis approach can be regarded as stress-based analysis procedure.Basic problems such as uniaxial problem,beam bending,and torsion problems are solved.It is found that approach is very suitable for solving the problems of fracture mechanics.Energy release rate for plate with center crack and double cantilever beam specimen is also evaluated.The approach solves the fracture problem with relative ease in strength of material style calculations.For all problems,results are compared with the classical displacement-based liner theory.展开更多
虽然异构计算系统的应用可以加快神经网络参数的处理,但系统功耗也随之剧增。良好的功耗预测方法是异构系统优化功耗和处理多类型工作负载的基础,基于此,通过改进多层感知机-注意力模型,提出一种面向CPU/GPU异构计算系统多类型工作负载...虽然异构计算系统的应用可以加快神经网络参数的处理,但系统功耗也随之剧增。良好的功耗预测方法是异构系统优化功耗和处理多类型工作负载的基础,基于此,通过改进多层感知机-注意力模型,提出一种面向CPU/GPU异构计算系统多类型工作负载的功耗预测算法。首先,考虑服务器功耗与系统特征,建立一种基于特征的工作负载功耗模型;其次,针对现有的功耗预测算法不能解决系统特征与系统功耗之间的长程依赖的问题,提出一种改进的基于多层感知机-注意力模型的功耗预测算法Prophet,该算法改进多层感知机实现各个时刻的系统特征的提取,并使用注意力机制综合这些特征,从而有效解决系统特征与系统功耗之间的长程依赖问题;最后,在实际系统中开展相关实验,将所提算法分别与MLSTM_PM(Power consumption Model based on Multi-layer Long Short-Term Memory)和ENN_PM(Power consumption Model based on Elman Neural Network)等功耗预测算法对比。实验结果表明,Prophet具有较高的预测精准性,与MLSTM_PM算法相比,在工作负载blk、memtest和busspd上将平均相对误差(MRE)分别降低了1.22、1.01和0.93个百分点,并且具有较低的复杂度,表明了所提算法的有效性及可行性。展开更多
文摘Aptamers are a type of single-chain oligonucleotide that can combine with a specific target.Due to their simple preparation,easy modification,stable structure and reusability,aptamers have been widely applied as biochemical sensors for medicine,food safety and environmental monitoring.However,there is little research on aptamer-target binding mechanisms,which limits their application and development.Computational simulation has gained much attention for revealing aptamer-target binding mechanisms at the atomic level.This work summarizes the main simulation methods used in the mechanistic analysis of aptamer-target complexes,the characteristics of binding between aptamers and different targets(metal ions,small organic molecules,biomacromolecules,cells,bacteria and viruses),the types of aptamer-target interactions and the factors influencing their strength.It provides a reference for further use of simulations in understanding aptamer-target binding mechanisms.
基金Supported by the Outstanding Young Scientist Research Fund from the National Natural Science Foundation of P. R. China (60125310)
文摘This is a brief review on the recent book: Duality System in Applied Mechanics and Optimal Control, by Zhong Wan-Xie, published by Kluwer Academic Publishers, 2004. The book represents a significant effort to re-establish the historic and deep tie between control and mechanics by striving to connect and integrate concepts, methods, and algorithms in mechanics and control so that a unified framework can be established for both analytical and computational purposes. Clearly, it has demonstrated that the duality system method can be used as a mathematical and systematic foundation to deal with many important concepts and problems in both mechanics and control. This book is not only very useful for research and applications, but also extremely helpful for multidisciplinary curriculum development when students from one field are trying to learning and applying concepts and methods from the other field.
文摘This paper deals with the mechanics problem of dynamic walking of anthropomorphic biped robots. Through analysing the mechanics system of this kind of robots in detail, the motion constraint equations are established, three mechanics laws describing the r
文摘This article demonstrates a novel approach for material nonlinear analysis.This analysis procedure eliminates tedious and lengthy step by step incremental and then iterative procedure adopted classically and gives direct results in the linear as well as in nonlinear range of the material behavior.Use of elastic moduli is eliminated.Instead,stress and strain functions are used as the material input in the analysis procedure.These stress and strain functions are directly derived from the stress-strain behavior of the material by the method of curve fitting.This way,the whole stress-strain diagram is utilized in the analysis which naturally exposes the response of structure when loading is in nonlinear range of the material behavior.It is found that it is an excellent computational procedure adopted so far for material nonlinear analysis which gives very accurate results,easy to adopt and simple in calculations.The method eliminates all types of linearity assumptions in basic derivations of equations and hence,eliminates all types of possibility of errors in the analysis procedure as well.As it is required to know stress distribution in the structural body by proper modelling and structural idealization,the proposed analysis approach can be regarded as stress-based analysis procedure.Basic problems such as uniaxial problem,beam bending,and torsion problems are solved.It is found that approach is very suitable for solving the problems of fracture mechanics.Energy release rate for plate with center crack and double cantilever beam specimen is also evaluated.The approach solves the fracture problem with relative ease in strength of material style calculations.For all problems,results are compared with the classical displacement-based liner theory.
文摘虽然异构计算系统的应用可以加快神经网络参数的处理,但系统功耗也随之剧增。良好的功耗预测方法是异构系统优化功耗和处理多类型工作负载的基础,基于此,通过改进多层感知机-注意力模型,提出一种面向CPU/GPU异构计算系统多类型工作负载的功耗预测算法。首先,考虑服务器功耗与系统特征,建立一种基于特征的工作负载功耗模型;其次,针对现有的功耗预测算法不能解决系统特征与系统功耗之间的长程依赖的问题,提出一种改进的基于多层感知机-注意力模型的功耗预测算法Prophet,该算法改进多层感知机实现各个时刻的系统特征的提取,并使用注意力机制综合这些特征,从而有效解决系统特征与系统功耗之间的长程依赖问题;最后,在实际系统中开展相关实验,将所提算法分别与MLSTM_PM(Power consumption Model based on Multi-layer Long Short-Term Memory)和ENN_PM(Power consumption Model based on Elman Neural Network)等功耗预测算法对比。实验结果表明,Prophet具有较高的预测精准性,与MLSTM_PM算法相比,在工作负载blk、memtest和busspd上将平均相对误差(MRE)分别降低了1.22、1.01和0.93个百分点,并且具有较低的复杂度,表明了所提算法的有效性及可行性。
