Using K-T optimality condition of nonsmooth optimization, we establish two equivalent systems of the nonsmooth equations for the constrained minimax problem directly. Then generalized Newton methods are applied to so...Using K-T optimality condition of nonsmooth optimization, we establish two equivalent systems of the nonsmooth equations for the constrained minimax problem directly. Then generalized Newton methods are applied to solve these systems of the nonsmooth equations. Thus a new approach to solving the constrained minimax problem is developed.展开更多
This paper carefully analyses the possibility of that a generalized KdV equa- tion possesses a family of solutions of the finite series form,and thus a kind of its explicit complex exact solutions is cxhibited.These c...This paper carefully analyses the possibility of that a generalized KdV equa- tion possesses a family of solutions of the finite series form,and thus a kind of its explicit complex exact solutions is cxhibited.These complex solutions constitute real exact so- lutions to th e system of complex form of the above generalized KdV equation.展开更多
目的:探究腹部浅表超声引导下介入治疗对中晚期胰腺癌患者的近期疗效及其对免疫水平的影响。方法:选择2018年5月至2020年3月于岳池县人民医院确诊的中晚期胰腺癌患者152例为研究对象,其中84例采用联合化疗方式治疗,68例采用单纯化疗方...目的:探究腹部浅表超声引导下介入治疗对中晚期胰腺癌患者的近期疗效及其对免疫水平的影响。方法:选择2018年5月至2020年3月于岳池县人民医院确诊的中晚期胰腺癌患者152例为研究对象,其中84例采用联合化疗方式治疗,68例采用单纯化疗方式治疗,通过倾向性评分匹配(PSM)法按1∶1匹配后两组各60例。比较匹配后两组临床资料,并采用广义估计方程评价不同治疗方法对中晚期胰腺癌近期疗效及免疫水平的影响。结果:匹配后两组年龄、BMI、肿瘤部位、性别、肿瘤大小、肿瘤分期差异均无统计学意义(P>0.05)。匹配后两组患者经治疗后局部控制率(LCR)呈下降趋势(P<0.05),联合化疗组局部无进展生存期(LPFS)、总生存期(OS)中位数均高于单纯化疗组(P<0.05)。联合化疗组和单纯化疗组治疗前CA19-9水平差异无统计学意义(P>0.05)。联合化疗组患者治疗后CA19-9水平呈连续下降趋势,6个月随访结果较治疗前显著降低;单纯化疗组治疗后CA19-9水平整体变化呈先降后升,1个月为最低点,CA19-9水平比治疗前明显降低,其余时期随访结果与治疗前差异无统计学意义(P>0.05)。单纯化疗组与联合化疗组治疗后7 d、14 d CA19-9水平差异无统计学意义(P>0.05),联合化疗组1个月、3个月、6个月CA19-9水平明显低于单纯化疗组(P<0.05)。联合化疗组所有免疫指标均呈先升后降趋势,1个月达到最高点,治疗后6个月总T细胞数较治疗前显著降低(P<0.05),CD3^(+)T、NK细胞、IL-2、IFN-γ仍高于治疗前(P<0.05),其余指标与治疗前差异无统计学意义(P>0.05)。单纯化疗组CD4^(+)T/CD8^(+)T变化趋势不显著,其余指标与联合化疗组趋势一致(P<0.05),治疗后6个月总T细胞、CD3^(+)T细胞、NK细胞数、IL-2水平较治疗前更低(P<0.05),其余指标与治疗前差异无统计学意义(P>0.05)。随访期内,联合化疗组总T细胞数、CD3^(+)T细胞数、NK细胞数、IL-2、IFN-γ、IL-6水平较单纯化疗组偏高(P>0.05)。随访14 d和3个月联合化疗组CD4^(+)T/CD8^(+)T显著高于单纯化疗组(P<0.05),其余随访时间差异无统计学意义(P>0.05)。广义估计方程评估结果显示,所有指标差异均有统计学意义。结论:腹部浅表超声引导下介入治疗能够有效提高中晚期胰腺癌近期疗效和免疫水平。展开更多
文摘Using K-T optimality condition of nonsmooth optimization, we establish two equivalent systems of the nonsmooth equations for the constrained minimax problem directly. Then generalized Newton methods are applied to solve these systems of the nonsmooth equations. Thus a new approach to solving the constrained minimax problem is developed.
文摘This paper carefully analyses the possibility of that a generalized KdV equa- tion possesses a family of solutions of the finite series form,and thus a kind of its explicit complex exact solutions is cxhibited.These complex solutions constitute real exact so- lutions to th e system of complex form of the above generalized KdV equation.
文摘目的:探究腹部浅表超声引导下介入治疗对中晚期胰腺癌患者的近期疗效及其对免疫水平的影响。方法:选择2018年5月至2020年3月于岳池县人民医院确诊的中晚期胰腺癌患者152例为研究对象,其中84例采用联合化疗方式治疗,68例采用单纯化疗方式治疗,通过倾向性评分匹配(PSM)法按1∶1匹配后两组各60例。比较匹配后两组临床资料,并采用广义估计方程评价不同治疗方法对中晚期胰腺癌近期疗效及免疫水平的影响。结果:匹配后两组年龄、BMI、肿瘤部位、性别、肿瘤大小、肿瘤分期差异均无统计学意义(P>0.05)。匹配后两组患者经治疗后局部控制率(LCR)呈下降趋势(P<0.05),联合化疗组局部无进展生存期(LPFS)、总生存期(OS)中位数均高于单纯化疗组(P<0.05)。联合化疗组和单纯化疗组治疗前CA19-9水平差异无统计学意义(P>0.05)。联合化疗组患者治疗后CA19-9水平呈连续下降趋势,6个月随访结果较治疗前显著降低;单纯化疗组治疗后CA19-9水平整体变化呈先降后升,1个月为最低点,CA19-9水平比治疗前明显降低,其余时期随访结果与治疗前差异无统计学意义(P>0.05)。单纯化疗组与联合化疗组治疗后7 d、14 d CA19-9水平差异无统计学意义(P>0.05),联合化疗组1个月、3个月、6个月CA19-9水平明显低于单纯化疗组(P<0.05)。联合化疗组所有免疫指标均呈先升后降趋势,1个月达到最高点,治疗后6个月总T细胞数较治疗前显著降低(P<0.05),CD3^(+)T、NK细胞、IL-2、IFN-γ仍高于治疗前(P<0.05),其余指标与治疗前差异无统计学意义(P>0.05)。单纯化疗组CD4^(+)T/CD8^(+)T变化趋势不显著,其余指标与联合化疗组趋势一致(P<0.05),治疗后6个月总T细胞、CD3^(+)T细胞、NK细胞数、IL-2水平较治疗前更低(P<0.05),其余指标与治疗前差异无统计学意义(P>0.05)。随访期内,联合化疗组总T细胞数、CD3^(+)T细胞数、NK细胞数、IL-2、IFN-γ、IL-6水平较单纯化疗组偏高(P>0.05)。随访14 d和3个月联合化疗组CD4^(+)T/CD8^(+)T显著高于单纯化疗组(P<0.05),其余随访时间差异无统计学意义(P>0.05)。广义估计方程评估结果显示,所有指标差异均有统计学意义。结论:腹部浅表超声引导下介入治疗能够有效提高中晚期胰腺癌近期疗效和免疫水平。
