Background Damage to the central nervous system(CNS)usually leads to the activation of astrocytes,followed by glial scar formation.For years,glial scar has been thought as a major obstacle for successful axon regenera...Background Damage to the central nervous system(CNS)usually leads to the activation of astrocytes,followed by glial scar formation.For years,glial scar has been thought as a major obstacle for successful axon regeneration.However,increasing evidence suggests a beneficial role for this scar tissue as part of the endogenous local immune regulation and repair process.Surprisingly,in contrast to scars in other tissues,glial scars(mainly consist of reactive astrocytes)in both rat cortex and spinal cord were recently found to be significantly softer than healthy CNS tissues.Naive astrocytes have been found to change their phenotype to reactive astrocytes and gradually into scar-forming astrocytes,upregulating the astrocyte marker glial fibrillary acidic protein(GFAP),vimentin,and inflammatory proteins in almost all known brain disorders.Such phenotype transformation process has been widely thought unidirectional or irreversible.However,recent research revealed the environment-dependent plasticity of astrocyte phenotypes,with reactive astrocytes could revert in retrograde to naive astrocytes in proper microenvironment.In consideration of the important roles of mechanical cues in CNS and the unique softening behavior of glial scars,it is of great interesting to study the effects of dynamic changes of matrix stiffness on astrocyte phenotypic switch.Materials&methods Primary astrocyes were isolated from the cortex of SpragueDawley(SD)rats at PI.After cultured for 2 weeks,astrocytes were encapsulated into a set of three-dimensional(3D)hybrid hydrogel system composed of type I collagen and alginate.Immunofluorescence and Western blot expression analysis were applied for characterizting cell responses to different and dynamically changed matrix stiffness.A molecular dynamics model was developed for simulation.Results&discussion In this work,we established an in-vitro model to study the effects of dynamic changes of matrix stiffness on astrocyte phenotypic switchings in 3D.To simulate native cellular environment,we fabricated a set of hybrid hydrogel system composed of type I collagen and alginate.The stiffness of the hybrid hydrogels was demonstrated to be dynamically changed by adding calcium chloride or sodium citrate to crosslink or decrosslink alginate,respectively.Using 3D culture models,we showed that the decrease of matrix stiffness could promote astrocyte activation,with upregulated GFAP and IL-1β.In addition,3D cultured astrocytes spread greater with decreasing matrix stiffness.Moreover,we surprisingly found that astrocyte phenotype could be switched by dynamically changing matrix stiffness.Specifically,matrix stiffening reverted the activation of astrocytes,whereas matrix softening induced astrocyte activation.We further demonstrated that matrix stiffness-induced astrocyte activation was mediated through cytoskeletal tension and YAP protein.To some extent,YAP inhibition enhanced the responses of astrocytes to matrix stiffness.These may guide researchersto re-examine the role of matrix stiffness in reactive astrogliosis in vivo,and inspire the development of novel therapeutic approach for reducing glial scar following injury,enabling axonal regrowth and improving functional recovery by exploiting the benefits of mechanobiology studies.Conclusions Taken together,our results clarify the effects of matrix stiffness and its dynamic changes on phenotypic swtich of astrocytes in three dimensions and reveal environmental factors that regulate astrocytic phenotype transformation process,which may provide potential therapeutic approach for CNS injury.展开更多
Since the 18th CPC National Congress,the Party Central Committee with General Secretary Xi Jinping as the core has been committed to the construction of ecological civilization,scientific and in-depth understanding of...Since the 18th CPC National Congress,the Party Central Committee with General Secretary Xi Jinping as the core has been committed to the construction of ecological civilization,scientific and in-depth understanding of the law of human and economic and social development,creatively proposed a series of new strategies,and has formed a comprehensive and systematic Xi Jinping’s ecological view.The basic connotation is:adhering to the ecological economic view of green development,focusing on the domestic and international ecological political view,constructing an ecological cultural view in harmony between man and nature,and an ecological social view unifying environmental protection and people’s happinesses.Xi Jinping’s ecological view is the inheritance and development of Marxist ecological theory,the enrichment and perfection of theoretical system of socialism with Chinese characteristics (SCC),the new understanding of the laws governing the development of human civilization,the important content for the Chinese dream,and an action to build a beautiful China,thus contributing Chinese wisdom to global ecological governance.展开更多
Vertical hot ring rolling(VHRR) process has the characteristics of nonlinearity,time-variation and being susceptible to disturbance.Furthermore,the ring's growth is quite fast within a short time,and the rolled ri...Vertical hot ring rolling(VHRR) process has the characteristics of nonlinearity,time-variation and being susceptible to disturbance.Furthermore,the ring's growth is quite fast within a short time,and the rolled ring's position is asymmetrical.All of these cause that the ring's dimensions cannot be measured directly.Through analyzing the relationships among the dimensions of ring blanks,the positions of rolls and the ring's inner and outer diameter,the soft measurement model of ring's dimensions is established based on the radial basis function neural network(RBFNN).A mass of data samples are obtained from VHRR finite element(FE) simulations to train and test the soft measurement NN model,and the model's structure parameters are deduced and optimized by genetic algorithm(GA).Finally,the soft measurement system of ring's dimensions is established and validated by the VHRR experiments.The ring's dimensions were measured artificially and calculated by the soft measurement NN model.The results show that the calculation values of GA-RBFNN model are close to the artificial measurement data.In addition,the calculation accuracy of GA-RBFNN model is higher than that of RBFNN model.The research results suggest that the soft measurement NN model has high precision and flexibility.The research can provide practical methods and theoretical guidance for the accurate measurement of VHRR process.展开更多
For the Sylvester continued fraction expansions of real numbers,FAN et al.(2007)proved that,for almost all real numbers,the nth partial quotient grows exponentially with respect to the product of the first n-1 partial...For the Sylvester continued fraction expansions of real numbers,FAN et al.(2007)proved that,for almost all real numbers,the nth partial quotient grows exponentially with respect to the product of the first n-1 partial quotients.In this paper,we establish the Hausdorff dimension of the exceptional set where the growth rate is a general function.展开更多
Deep geothermal extraction processes expose rock masses to frequent and significant temperature fluctuations. Developing a comprehensive understanding of the shear fracture mechanisms and crack propagation behaviors i...Deep geothermal extraction processes expose rock masses to frequent and significant temperature fluctuations. Developing a comprehensive understanding of the shear fracture mechanisms and crack propagation behaviors in rocks under the influence of cyclic heating is imperative for optimizing geothermal energy extraction. This study encompasses several critical aspects under cyclic heating conditions, including the assessment of stress distribution states, the characterization of two-dimensional fracture paths, the quantitative analysis of three-dimensional damage characteristics on fracture surfaces, and the determination of the fractal dimension of debris generated after the failure of granite. The test results demonstrate that cyclic heating has a pronounced adverse effect on the physical and mechanical properties of granite. Consequently, stress tends to develop and propagate in a direction perpendicular to the two-dimensional fracture path. This leads to an increase in the extent of tensile damage on the fracture surface and accelerates the overall rock failure process. This increases the number of small-sized debris, raises the fractal dimension, and enhances the rock’s rupture degree. In practical enhanced geothermal energy extraction, the real-time monitoring of fracture propagation within the reservoir rock mass is achieved through the analysis of rock debris generated during the staged fracturing process.展开更多
The geological structure of coal seams in China is remarkably varied and complex,with coalbed methane reservoirs marked by significant heterogeneity and low permeability,creating substantial technical challenges for e...The geological structure of coal seams in China is remarkably varied and complex,with coalbed methane reservoirs marked by significant heterogeneity and low permeability,creating substantial technical challenges for efficient extraction.This study systematically investigates the impact of liquid nitrogen immersion(LNI)on the coal’s pore structure and its mechanism of enhancing permeability with a combination of quantitative nuclear magnetic resonance(NMR)analysis,nitrogen adsorption experiments,and fractal dimension calculations.The results demonstrate that LNI can damage the coal’s pore structure and promote fracture expansion through thermal stress induction and moisture phase transformation,thereby enhancing the permeability of coal seams.The T_(2)peak area in the NMR experiments on coal samples subjected to LNI treatment shows a significant increase,the Brunauer-Emmett-Teller(BET)specific surface area decreases to 6.02 m^(2)/g,and the Barrett-Joyner-Halenda(BJH)total pore volume increases to 14.99 mm^(3)/g.Furthermore,changes in fractal dimensions(D_(1)rising from 2.804 to 2.837,and D_(2)falling from 2.757 to 2.594)indicate a notable enhancement in the complexity of the pore structure.With increasing LNI cycles,the adsorption capacity of the coal samples diminishes,suggesting a significant optimization of the pore structure.This optimization is particularly evident in the reconstruction of the micropore structure,which in turn greatly enhances the complexity and connectivity of the sample’s pore network.In summary,the study concludes that LNI technology can effectively improve the permeability of coal seams and the extraction efficiency of coalbed methane by optimizing the micropore structure and enhancing pore connectivity,which offers a potential method for enhancing the permeability of gas-bearing coal seams and facilitating the development and utilization of coalbed methane.展开更多
Two-dimensional energetic materials(2DEMs),characterized by their exceptional interlayer sliding properties,are recognized as exemplar of low-sensitivity energetic materials.However,the diversity of available 2DEMs is...Two-dimensional energetic materials(2DEMs),characterized by their exceptional interlayer sliding properties,are recognized as exemplar of low-sensitivity energetic materials.However,the diversity of available 2DEMs is severely constrained by the absence of efficient methods for rapidly predicting crystal packing modes from molecular structures,impeding the high-throughput rational design of such materials.In this study,we employed quantified indicators,such as hydrogen bond dimension and maximum planar separation,to quickly screen 172DEM and 16 non-2DEM crystal structures from a crystal database.They were subsequently compared and analyzed,focusing on hydrogen bond donor-acceptor combinations,skeleton features,and intermolecular interactions.Our findings suggest that theπ-πpacking interaction energy is a key determinant in the formation of layered packing modes by planar energetic molecules,with its magnitude primarily influenced by the strongest dimericπ-πinteraction(π-π2max).Consequently,we have delineated a critical threshold forπ-π2max to discern layered packing modes and formulated a theoretical model for predictingπ-π2max,grounded in molecular electrostatic potential and dipole moment analysis.The predictive efficacy of this model was substantiated through external validation on a test set comprising 31 planar energetic molecular crystals,achieving an accuracy of 84%and a recall of 75%.Furthermore,the proposed model shows superior classification predictive performance compared to typical machine learning methods,such as random forest,on the external validation samples.This contribution introduces a novel methodology for the identification of crystal packing modes in 2DEMs,potentially accelerating the design and synthesis of high-energy,low-sensitivity 2DEMs.展开更多
The crystal structure of the title complex, [Cu(C23H26N2)Cl2]2·2CH2Cl2, has been determined by single-crystal, X-ray diffraction techniques. The compound crystallizes as dark-green prisms in space group P21/c of ...The crystal structure of the title complex, [Cu(C23H26N2)Cl2]2·2CH2Cl2, has been determined by single-crystal, X-ray diffraction techniques. The compound crystallizes as dark-green prisms in space group P21/c of the monoclinic system, with Z=4 and unit cell dimensions a=1.710 9(7) nm, b=2.395 2(11) nm, c=1.348 9(6) nm and β=110.651(8)°. The complex consists of two similar but crystallographically independent dimers, of which Cu(Ⅱ) centers display five-coordinated trigonal-bipyramidal geometry with Cu-Cu separations in two centrosymmetric dimers are 0.345 1 and 0.347 8 nm, respectively, and in each dimer the two copper centers share a common edge formed by two bridging chloride ions, each being equatorial. Solvent molecules of CH2Cl2 are packed together in the crystal lattice. CCDC: 253299.展开更多
INTRODUCTION Fractals are a new class of geometric objects developed by Mandelbrot(1967,1977,1982) and used in the study of natural phenomena.They have been applied to many aspects of geological sciences, e.g., the sp...INTRODUCTION Fractals are a new class of geometric objects developed by Mandelbrot(1967,1977,1982) and used in the study of natural phenomena.They have been applied to many aspects of geological sciences, e.g., the spatial, temporal, magnitude and frequency relationships of earthquakes (Kagan and Knopoff, 1981; King 1983),展开更多
Determining Average Linear Dimension and Volume of Korean Lungs for Lung Phantom Construction.Sook Yang 1,Jeongin Kim 1,Seung Jin Choi 1,Kyung Won Lee 2(1.Radiation Health Institute,172,Dolma-ro,Bundang-gu,Seongnam-si...Determining Average Linear Dimension and Volume of Korean Lungs for Lung Phantom Construction.Sook Yang 1,Jeongin Kim 1,Seung Jin Choi 1,Kyung Won Lee 2(1.Radiation Health Institute,172,Dolma-ro,Bundang-gu,Seongnam-si,Gyeonggi-do,Republic of Korea;2.Seoul National University Bundang Hospital,173,Gumi-ro,Bundang-gu,Seongnam-si,Gyeonggi-do,Republic of Korea;3.Radiation Health Institute,172,Dolma-ro,Bundang-gu,Seongnam-si,Gyeonggi-do,Republic of Korea 13605;4.Seoul National University,Bundang Hospital,173,Gumi-ro,Bundang-gu,Seongnam-si,Gyeonggi-do,Republic of Korea,13620)Abstract: The purpose of this study was to determine the average size and volume of lungs and to simulate the morphology of internal organs for the development of a Korean adult lung phantom. The body-size data of 2,195 males and 2,293 females aged between 20 and 60 y were included to calculate the average physical dimensions. Two hundred datasets of computed tomography corresponding to the average physique range were collected to measure the average linear dimensions (the length of x, y, and z-axis) of lungs.展开更多
应水利部岩土力学与工程重点实验室（下称“岩土重点实验室”）的邀请,美国亚利桑那大学PinnadiwaH.S.W.Kulatilake教授于2017年1月4日在岩土重点实验室做了题为＂Recent Developments on Rock Mass Stability Investigations Associa...应水利部岩土力学与工程重点实验室（下称“岩土重点实验室”）的邀请,美国亚利桑那大学PinnadiwaH.S.W.Kulatilake教授于2017年1月4日在岩土重点实验室做了题为＂Recent Developments on Rock Mass Stability Investigations Associated with Surface and Underground Excavations in Three Dimensions”的学术报告.岩土重点实验室主任郞爱清教授级高级工程师主持会议,总工朱杰兵教授级高级工程师、副总工张家发教授级高级工程师、赵根教授级高级工程师与岩基所副所长尹健民教授级高级工程师、总工丁秀丽教授级高级工程师以及各学科的博士、硕士共30余人参加了此次学术交流会.展开更多
The split-Hopkinson pressure bar(SHPB)and digital image correlation(DIC)techniques are combined to analyze the dynamic compressive failure process of coal samples,and the box fractal dimension is used to quantitativel...The split-Hopkinson pressure bar(SHPB)and digital image correlation(DIC)techniques are combined to analyze the dynamic compressive failure process of coal samples,and the box fractal dimension is used to quantitatively analyze the dynamic changes in the coal sample cracks under impact load conditions with different loading rates.The experimental results show that the fractal dimension can quantitatively describe the evolution process of coal fractures under dynamic load.During the dynamic compression process,the evolution of the coal sample cracks presents distinct stages.In the crack propagation stage,the fractal dimension increases rapidly with the progress of loading,and in the crack widening stage,the fractal dimension increases slowly with the progress of loading.The initiation of the crack propagation phase of the coal samples gradually occurs more quickly with increasing loading rate;the initial cracks appear earlier.At the same loading time point,when the loading rate is greater,the fractal dimension of the cracks observed in the coal sample is greater.展开更多
The relationship among the surface fissure ratio, moisture content, seepage coefficient and deformation modulus of field unsaturated expansive soil in Nanning, Guangxi Province, China, was obtained by a direct or indi...The relationship among the surface fissure ratio, moisture content, seepage coefficient and deformation modulus of field unsaturated expansive soil in Nanning, Guangxi Province, China, was obtained by a direct or indirect method. Digital images of expansive soil of the surface fissure with different moisture contents were analyzed with the binarization statistic method. In addition, the fissure fractal dimension was computed with a self-compiled program. Combined with in situ seepage and loading plate tests, the relationship among the surface fissure ratio, moisture content, seepage coefficient and deformation modulus was initially established. The surface fissure ratio and moisture content show a linear relation, ＂y=-0.019 1x＋1.028 5＂ for rufous expansive soil and ＂y=-0.07 1x＋2.610 5＂ for grey expansive soil. Soil initial seepage coefficient and surface fissure ratio show a power function relation, ＂y=1× 10^-9exp（15.472x）＂ for rufous expansive soil and ＂y=5× 10^-7exp（4.209 6x）＂ for grey expansive soil. Grey expansive soil deformation modulus and surface fissure ratio show a power fimction relation of ＂y=3.935 7exp（0.993 6x）＂. Based on the binarization and fractal dimension methods, the results show that the surface fissure statistics can depict the fissure distribution in the view of two dimensions. And the evolvement behaviors of permeability and the deformation modulus can indirectly describe the developing state of the fissure. The analysis reflects that the engineering behaviors of unsaturated expansive soil are objectively influenced by fissure.展开更多
基金financially supported by the National Natural Science Foundation of China ( 11872298, 11602191,1161101223,11532009)the China Postdoctoral Science Foundation ( 2018M631141)the Shaanxi Postdoctoral Science Foundation,and the Fundamental Research Funds for the Central Universities ( Z201811336)
文摘Background Damage to the central nervous system(CNS)usually leads to the activation of astrocytes,followed by glial scar formation.For years,glial scar has been thought as a major obstacle for successful axon regeneration.However,increasing evidence suggests a beneficial role for this scar tissue as part of the endogenous local immune regulation and repair process.Surprisingly,in contrast to scars in other tissues,glial scars(mainly consist of reactive astrocytes)in both rat cortex and spinal cord were recently found to be significantly softer than healthy CNS tissues.Naive astrocytes have been found to change their phenotype to reactive astrocytes and gradually into scar-forming astrocytes,upregulating the astrocyte marker glial fibrillary acidic protein(GFAP),vimentin,and inflammatory proteins in almost all known brain disorders.Such phenotype transformation process has been widely thought unidirectional or irreversible.However,recent research revealed the environment-dependent plasticity of astrocyte phenotypes,with reactive astrocytes could revert in retrograde to naive astrocytes in proper microenvironment.In consideration of the important roles of mechanical cues in CNS and the unique softening behavior of glial scars,it is of great interesting to study the effects of dynamic changes of matrix stiffness on astrocyte phenotypic switch.Materials&methods Primary astrocyes were isolated from the cortex of SpragueDawley(SD)rats at PI.After cultured for 2 weeks,astrocytes were encapsulated into a set of three-dimensional(3D)hybrid hydrogel system composed of type I collagen and alginate.Immunofluorescence and Western blot expression analysis were applied for characterizting cell responses to different and dynamically changed matrix stiffness.A molecular dynamics model was developed for simulation.Results&discussion In this work,we established an in-vitro model to study the effects of dynamic changes of matrix stiffness on astrocyte phenotypic switchings in 3D.To simulate native cellular environment,we fabricated a set of hybrid hydrogel system composed of type I collagen and alginate.The stiffness of the hybrid hydrogels was demonstrated to be dynamically changed by adding calcium chloride or sodium citrate to crosslink or decrosslink alginate,respectively.Using 3D culture models,we showed that the decrease of matrix stiffness could promote astrocyte activation,with upregulated GFAP and IL-1β.In addition,3D cultured astrocytes spread greater with decreasing matrix stiffness.Moreover,we surprisingly found that astrocyte phenotype could be switched by dynamically changing matrix stiffness.Specifically,matrix stiffening reverted the activation of astrocytes,whereas matrix softening induced astrocyte activation.We further demonstrated that matrix stiffness-induced astrocyte activation was mediated through cytoskeletal tension and YAP protein.To some extent,YAP inhibition enhanced the responses of astrocytes to matrix stiffness.These may guide researchersto re-examine the role of matrix stiffness in reactive astrogliosis in vivo,and inspire the development of novel therapeutic approach for reducing glial scar following injury,enabling axonal regrowth and improving functional recovery by exploiting the benefits of mechanobiology studies.Conclusions Taken together,our results clarify the effects of matrix stiffness and its dynamic changes on phenotypic swtich of astrocytes in three dimensions and reveal environmental factors that regulate astrocytic phenotype transformation process,which may provide potential therapeutic approach for CNS injury.
基金Phased Achievements of the Collaborative Innovation Center for the Theoretical Research of Socialism with Chinese Characteristics(Beijing University of Technology)(Project Name:17 Technology Innovation Service Capability-Collaborative Innovation Center Construction of Socialist Theory with Chinese Characteristics in Beijing Colleges and Universities 036000546617516)Beijing Science and Technology Research on Social Organization Development(S0027005201501)+1 种基金research on China’s Industrial Common Technology Innovation System(JE027005201401)research on Academic Ecological Construction of Capital University(JE014014200801)
文摘Since the 18th CPC National Congress,the Party Central Committee with General Secretary Xi Jinping as the core has been committed to the construction of ecological civilization,scientific and in-depth understanding of the law of human and economic and social development,creatively proposed a series of new strategies,and has formed a comprehensive and systematic Xi Jinping’s ecological view.The basic connotation is:adhering to the ecological economic view of green development,focusing on the domestic and international ecological political view,constructing an ecological cultural view in harmony between man and nature,and an ecological social view unifying environmental protection and people’s happinesses.Xi Jinping’s ecological view is the inheritance and development of Marxist ecological theory,the enrichment and perfection of theoretical system of socialism with Chinese characteristics (SCC),the new understanding of the laws governing the development of human civilization,the important content for the Chinese dream,and an action to build a beautiful China,thus contributing Chinese wisdom to global ecological governance.
基金Project(51205299)supported by the National Natural Science Foundation of ChinaProject(2015M582643)supported by the China Postdoctoral Science Foundation+2 种基金Project(2014BAA008)supported by the Science and Technology Support Program of Hubei Province,ChinaProject(2014-IV-144)supported by the Fundamental Research Funds for the Central Universities of ChinaProject(2012AAA07-01)supported by the Major Science and Technology Achievements Transformation&Industrialization Program of Hubei Province,China
文摘Vertical hot ring rolling(VHRR) process has the characteristics of nonlinearity,time-variation and being susceptible to disturbance.Furthermore,the ring's growth is quite fast within a short time,and the rolled ring's position is asymmetrical.All of these cause that the ring's dimensions cannot be measured directly.Through analyzing the relationships among the dimensions of ring blanks,the positions of rolls and the ring's inner and outer diameter,the soft measurement model of ring's dimensions is established based on the radial basis function neural network(RBFNN).A mass of data samples are obtained from VHRR finite element(FE) simulations to train and test the soft measurement NN model,and the model's structure parameters are deduced and optimized by genetic algorithm(GA).Finally,the soft measurement system of ring's dimensions is established and validated by the VHRR experiments.The ring's dimensions were measured artificially and calculated by the soft measurement NN model.The results show that the calculation values of GA-RBFNN model are close to the artificial measurement data.In addition,the calculation accuracy of GA-RBFNN model is higher than that of RBFNN model.The research results suggest that the soft measurement NN model has high precision and flexibility.The research can provide practical methods and theoretical guidance for the accurate measurement of VHRR process.
基金Supported by Projects from Chongqing Municipal Science and Technology Commission(CSTB2022NSCQ-MSX0445)。
文摘For the Sylvester continued fraction expansions of real numbers,FAN et al.(2007)proved that,for almost all real numbers,the nth partial quotient grows exponentially with respect to the product of the first n-1 partial quotients.In this paper,we establish the Hausdorff dimension of the exceptional set where the growth rate is a general function.
基金Project(52409132) supported by the National Natural Science Foundation of ChinaProject(ZR2024QE018) supported by the Natural Science Foundation of Shandong Province,China+2 种基金Project(BK20240431) supported by Basic Research Program of Jiangsu,ChinaProject(SNKJ2023A07-R14) supported by the Major Key Technical Research Projects of Shandong Energy Group,ChinaProject(2024M751813) supported by China Postdoctoral Science Foundation。
文摘Deep geothermal extraction processes expose rock masses to frequent and significant temperature fluctuations. Developing a comprehensive understanding of the shear fracture mechanisms and crack propagation behaviors in rocks under the influence of cyclic heating is imperative for optimizing geothermal energy extraction. This study encompasses several critical aspects under cyclic heating conditions, including the assessment of stress distribution states, the characterization of two-dimensional fracture paths, the quantitative analysis of three-dimensional damage characteristics on fracture surfaces, and the determination of the fractal dimension of debris generated after the failure of granite. The test results demonstrate that cyclic heating has a pronounced adverse effect on the physical and mechanical properties of granite. Consequently, stress tends to develop and propagate in a direction perpendicular to the two-dimensional fracture path. This leads to an increase in the extent of tensile damage on the fracture surface and accelerates the overall rock failure process. This increases the number of small-sized debris, raises the fractal dimension, and enhances the rock’s rupture degree. In practical enhanced geothermal energy extraction, the real-time monitoring of fracture propagation within the reservoir rock mass is achieved through the analysis of rock debris generated during the staged fracturing process.
基金Projects(52204226,52104204,52474276)supported by the National Natural Science Foundation of ChinaProject(tsqnz20221140)supported by the Taishan Scholars Project of China+1 种基金Projects(ZR2022QE243,ZR2024ME097)supported by the Natural Science Foundation of Shandong Province of ChinaProject(252300421010)supported by the Excellent Youth Foundation of Henan Scientific Committee,China。
文摘The geological structure of coal seams in China is remarkably varied and complex,with coalbed methane reservoirs marked by significant heterogeneity and low permeability,creating substantial technical challenges for efficient extraction.This study systematically investigates the impact of liquid nitrogen immersion(LNI)on the coal’s pore structure and its mechanism of enhancing permeability with a combination of quantitative nuclear magnetic resonance(NMR)analysis,nitrogen adsorption experiments,and fractal dimension calculations.The results demonstrate that LNI can damage the coal’s pore structure and promote fracture expansion through thermal stress induction and moisture phase transformation,thereby enhancing the permeability of coal seams.The T_(2)peak area in the NMR experiments on coal samples subjected to LNI treatment shows a significant increase,the Brunauer-Emmett-Teller(BET)specific surface area decreases to 6.02 m^(2)/g,and the Barrett-Joyner-Halenda(BJH)total pore volume increases to 14.99 mm^(3)/g.Furthermore,changes in fractal dimensions(D_(1)rising from 2.804 to 2.837,and D_(2)falling from 2.757 to 2.594)indicate a notable enhancement in the complexity of the pore structure.With increasing LNI cycles,the adsorption capacity of the coal samples diminishes,suggesting a significant optimization of the pore structure.This optimization is particularly evident in the reconstruction of the micropore structure,which in turn greatly enhances the complexity and connectivity of the sample’s pore network.In summary,the study concludes that LNI technology can effectively improve the permeability of coal seams and the extraction efficiency of coalbed methane by optimizing the micropore structure and enhancing pore connectivity,which offers a potential method for enhancing the permeability of gas-bearing coal seams and facilitating the development and utilization of coalbed methane.
基金support from National Natural Science Foundation of China(Grant Nos.22275145,22305189and 21875184)Natural Science Foundation of Shaanxi Province(Grant Nos.2022JC-10 and 2024JC-YBQN-0112).
文摘Two-dimensional energetic materials(2DEMs),characterized by their exceptional interlayer sliding properties,are recognized as exemplar of low-sensitivity energetic materials.However,the diversity of available 2DEMs is severely constrained by the absence of efficient methods for rapidly predicting crystal packing modes from molecular structures,impeding the high-throughput rational design of such materials.In this study,we employed quantified indicators,such as hydrogen bond dimension and maximum planar separation,to quickly screen 172DEM and 16 non-2DEM crystal structures from a crystal database.They were subsequently compared and analyzed,focusing on hydrogen bond donor-acceptor combinations,skeleton features,and intermolecular interactions.Our findings suggest that theπ-πpacking interaction energy is a key determinant in the formation of layered packing modes by planar energetic molecules,with its magnitude primarily influenced by the strongest dimericπ-πinteraction(π-π2max).Consequently,we have delineated a critical threshold forπ-π2max to discern layered packing modes and formulated a theoretical model for predictingπ-π2max,grounded in molecular electrostatic potential and dipole moment analysis.The predictive efficacy of this model was substantiated through external validation on a test set comprising 31 planar energetic molecular crystals,achieving an accuracy of 84%and a recall of 75%.Furthermore,the proposed model shows superior classification predictive performance compared to typical machine learning methods,such as random forest,on the external validation samples.This contribution introduces a novel methodology for the identification of crystal packing modes in 2DEMs,potentially accelerating the design and synthesis of high-energy,low-sensitivity 2DEMs.
文摘The crystal structure of the title complex, [Cu(C23H26N2)Cl2]2·2CH2Cl2, has been determined by single-crystal, X-ray diffraction techniques. The compound crystallizes as dark-green prisms in space group P21/c of the monoclinic system, with Z=4 and unit cell dimensions a=1.710 9(7) nm, b=2.395 2(11) nm, c=1.348 9(6) nm and β=110.651(8)°. The complex consists of two similar but crystallographically independent dimers, of which Cu(Ⅱ) centers display five-coordinated trigonal-bipyramidal geometry with Cu-Cu separations in two centrosymmetric dimers are 0.345 1 and 0.347 8 nm, respectively, and in each dimer the two copper centers share a common edge formed by two bridging chloride ions, each being equatorial. Solvent molecules of CH2Cl2 are packed together in the crystal lattice. CCDC: 253299.
文摘INTRODUCTION Fractals are a new class of geometric objects developed by Mandelbrot(1967,1977,1982) and used in the study of natural phenomena.They have been applied to many aspects of geological sciences, e.g., the spatial, temporal, magnitude and frequency relationships of earthquakes (Kagan and Knopoff, 1981; King 1983),
文摘Determining Average Linear Dimension and Volume of Korean Lungs for Lung Phantom Construction.Sook Yang 1,Jeongin Kim 1,Seung Jin Choi 1,Kyung Won Lee 2(1.Radiation Health Institute,172,Dolma-ro,Bundang-gu,Seongnam-si,Gyeonggi-do,Republic of Korea;2.Seoul National University Bundang Hospital,173,Gumi-ro,Bundang-gu,Seongnam-si,Gyeonggi-do,Republic of Korea;3.Radiation Health Institute,172,Dolma-ro,Bundang-gu,Seongnam-si,Gyeonggi-do,Republic of Korea 13605;4.Seoul National University,Bundang Hospital,173,Gumi-ro,Bundang-gu,Seongnam-si,Gyeonggi-do,Republic of Korea,13620)Abstract: The purpose of this study was to determine the average size and volume of lungs and to simulate the morphology of internal organs for the development of a Korean adult lung phantom. The body-size data of 2,195 males and 2,293 females aged between 20 and 60 y were included to calculate the average physical dimensions. Two hundred datasets of computed tomography corresponding to the average physique range were collected to measure the average linear dimensions (the length of x, y, and z-axis) of lungs.
文摘应水利部岩土力学与工程重点实验室（下称“岩土重点实验室”）的邀请,美国亚利桑那大学PinnadiwaH.S.W.Kulatilake教授于2017年1月4日在岩土重点实验室做了题为＂Recent Developments on Rock Mass Stability Investigations Associated with Surface and Underground Excavations in Three Dimensions”的学术报告.岩土重点实验室主任郞爱清教授级高级工程师主持会议,总工朱杰兵教授级高级工程师、副总工张家发教授级高级工程师、赵根教授级高级工程师与岩基所副所长尹健民教授级高级工程师、总工丁秀丽教授级高级工程师以及各学科的博士、硕士共30余人参加了此次学术交流会.
基金Projects(51822403,51827901)supported by the National Natural Science Foundation of ChinaProject(2019ZT08G315)supported by the Department of Science and Technology of Guangdong Province,China。
文摘The split-Hopkinson pressure bar(SHPB)and digital image correlation(DIC)techniques are combined to analyze the dynamic compressive failure process of coal samples,and the box fractal dimension is used to quantitatively analyze the dynamic changes in the coal sample cracks under impact load conditions with different loading rates.The experimental results show that the fractal dimension can quantitatively describe the evolution process of coal fractures under dynamic load.During the dynamic compression process,the evolution of the coal sample cracks presents distinct stages.In the crack propagation stage,the fractal dimension increases rapidly with the progress of loading,and in the crack widening stage,the fractal dimension increases slowly with the progress of loading.The initiation of the crack propagation phase of the coal samples gradually occurs more quickly with increasing loading rate;the initial cracks appear earlier.At the same loading time point,when the loading rate is greater,the fractal dimension of the cracks observed in the coal sample is greater.
基金Projects(41102229,51109208)supported by the National Natural Science Foundation of ChinaProject(2011CDB407)supported by Natural Science Foundation of Hubei Province,ChinaProject supported by Qing Lan Project of Jiangsu Province,China
文摘The relationship among the surface fissure ratio, moisture content, seepage coefficient and deformation modulus of field unsaturated expansive soil in Nanning, Guangxi Province, China, was obtained by a direct or indirect method. Digital images of expansive soil of the surface fissure with different moisture contents were analyzed with the binarization statistic method. In addition, the fissure fractal dimension was computed with a self-compiled program. Combined with in situ seepage and loading plate tests, the relationship among the surface fissure ratio, moisture content, seepage coefficient and deformation modulus was initially established. The surface fissure ratio and moisture content show a linear relation, ＂y=-0.019 1x＋1.028 5＂ for rufous expansive soil and ＂y=-0.07 1x＋2.610 5＂ for grey expansive soil. Soil initial seepage coefficient and surface fissure ratio show a power function relation, ＂y=1× 10^-9exp（15.472x）＂ for rufous expansive soil and ＂y=5× 10^-7exp（4.209 6x）＂ for grey expansive soil. Grey expansive soil deformation modulus and surface fissure ratio show a power fimction relation of ＂y=3.935 7exp（0.993 6x）＂. Based on the binarization and fractal dimension methods, the results show that the surface fissure statistics can depict the fissure distribution in the view of two dimensions. And the evolvement behaviors of permeability and the deformation modulus can indirectly describe the developing state of the fissure. The analysis reflects that the engineering behaviors of unsaturated expansive soil are objectively influenced by fissure.
