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Connectivity map技术在中药研究中的应用 被引量:9
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作者 张晓芳 康永波 +1 位作者 苏君鸿 孔祥阳 《浙江大学学报(农业与生命科学版)》 CAS CSCD 北大核心 2016年第5期543-550,共8页
Connectivity map(CMap)是基于RNA芯片研究药物作用机制和药物重定位的技术与数据资源,主要的优势在于能够高效地对全基因组上的基因表达做整体分析。相对于低通量的药理学、毒理学方法以及色谱技术,该技术能以全面、高通量、准确等优... Connectivity map(CMap)是基于RNA芯片研究药物作用机制和药物重定位的技术与数据资源,主要的优势在于能够高效地对全基因组上的基因表达做整体分析。相对于低通量的药理学、毒理学方法以及色谱技术,该技术能以全面、高通量、准确等优点广泛应用于药物研究。尤其对由多种化合物共同作用发挥疗效的中药,CMap技术可以突破"药物-靶标"测定技术的单一性困难,对中药的作用机制做综合性分析,从分子水平上阐明中药的药物作用机制,有利于开发自主知识产权的中药,也为中药获取国际认可奠定理论基础。本文系统介绍CMap技术在中药研究方面的应用潜力,同时对该技术研究中药的作用机制、药物重定位及鉴别有效成分进行评价,还对推动中药走向国际市场做了具体分析与展望。 展开更多
关键词 connectivity MAP技术 中药 作用机制 药物重定位 有效成分
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Quantitative Correlation between Group Connectivity Index and Property of Flotation Reagent 被引量:2
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作者 Cao, YC Jiang, YR +1 位作者 Xue, YL Wang, DZ 《Journal of Central South University》 SCIE EI CAS 2000年第1期25-28,共4页
Topological method is applied firstly to calculate the group connectivity indexes of some flotation reagents for sulfide minerals and oxide minerals. The study reveals that some properties of flotation reagents, such ... Topological method is applied firstly to calculate the group connectivity indexes of some flotation reagents for sulfide minerals and oxide minerals. The study reveals that some properties of flotation reagents, such as group electronegativity, energy criterion, solubility product of chemicals and maximum wavelength of ultraviolet absorbency, have linear correlation with the first order group connectivity index (GCI) of polar group, and the related coefficients are all larger than 0.900. The GCI can be used to characterize the structure of groups, and is a sort of new effective structural parameter to study the quantitative structure activity relationship of flotation reagents. 展开更多
关键词 FLOTATION REAGENTS group connectivity INDEX PROPERTY QUANTITATIVE CORRELATION
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Relay movement control for maintaining connectivity in aeronautical ad hoc networks 被引量:2
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作者 李杰 孙志强 +2 位作者 师博浩 宫二玲 谢红卫 《Journal of Central South University》 SCIE EI CAS CSCD 2016年第4期850-858,共9页
As a new sort of mobile ad hoc network(MANET), aeronautical ad hoc network(AANET) has fleet-moving airborne nodes(ANs) and suffers from frequent network partitioning due to the rapid-changing topology. In this work, t... As a new sort of mobile ad hoc network(MANET), aeronautical ad hoc network(AANET) has fleet-moving airborne nodes(ANs) and suffers from frequent network partitioning due to the rapid-changing topology. In this work, the additional relay nodes(RNs) is employed to repair the network and maintain connectivity in AANET. As ANs move, RNs need to move as well in order to re-establish the topology as quickly as possible. The network model and problem definition are firstly given, and then an online approach for RNs' movement control is presented to make ANs achieve certain connectivity requirement during run time. By defining the minimum cost feasible moving matrix(MCFM), a fast algorithm is proposed for RNs' movement control problem. Simulations demonstrate that the proposed algorithm outperforms other control approaches in the highly-dynamic environment and is of great potential to be applied in AANET. 展开更多
关键词 aeronautical ad hoc network (AANET) mobile ad hoc networks topology control network connectivity movement control
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Flocking of multi-robot systems with connectivity maintenance on directed graphs
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作者 Yutian Mao Lihua Dou +1 位作者 Hao Fang Jie Chen 《Journal of Systems Engineering and Electronics》 SCIE EI CSCD 2014年第3期470-482,共13页
Analysis and design techniques for cooperative flocking of nonholonomic multi-robot systems with connectivity maintenance on directed graphs are presented. First, a set of bounded and smoothly distributed control prot... Analysis and design techniques for cooperative flocking of nonholonomic multi-robot systems with connectivity maintenance on directed graphs are presented. First, a set of bounded and smoothly distributed control protocols are devised via carefully designing a class of bounded artificial potential fields (APF) which could guarantee the connectivity maintenance, col ision avoidance and distance stabilization simultaneously during the system evolution. The connectivity of the underlying network can be preserved, and the desired stable flocking behavior can be achieved provided that the initial communication topology is strongly connected rather than undirected or balanced, which relaxes the constraints for group topology and extends the previous work to more generalized directed graphs. Furthermore, the proposed control algorithm is extended to solve the flocking problem with a virtual leader. In this case, it is shown that al robots can asymptotically move with the desired velocity and orientation even if there is only one informed robot in the team. Finally, nontrivial simulations and experiments are conducted to verify the effectiveness of the proposed algorithm. 展开更多
关键词 multi-robot system nonholonomic kinematics FLOCKING directed network connectivity maintenance bounded artificial potential field (APF).
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Current status and diversity of fish resources in the Pinglu Canal Century Project
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作者 LU Jia TANG Wei +3 位作者 WANG Li XU Shengxian ZHANG Peng YANG Shengfa 《水利水电技术(中英文)》 北大核心 2025年第4期131-144,共14页
[Objective]The channel straightening project of the Pinglu Canal has fragmented the river course,compromising the integrity of original river course and causing ecosystem patchiness.Understanding the current status of... [Objective]The channel straightening project of the Pinglu Canal has fragmented the river course,compromising the integrity of original river course and causing ecosystem patchiness.Understanding the current status of fish resources and the characteristics of their diversity is crucial for the ecological management of the Pinglu Canal.[Methods]During the spring and autumn in 2021 and 2022,a survey of fish resources and species diversity in the Pinglu Canal was conducted using multi-mesh gill nets.A total of 125 fish species were collected,belonging to 10 orders,34 families,and 89 genera.[Results]The result showed that the Pinglu Canal contained three nationally protected Class II species,two endemic species of the Qinjiang River,three anadromous/migratory species,and eight invasive species,accounting for 2.4%,1.6%,2.4%,and 6.4%of the total species,respectively.The fish community primarily consisted of mid-and bottom-dwelling,adhesive-egg-laying,and omnivorous species.The Shannon-Wiener,Simpson,Margalef,and Pielou indices of the fish community in the Pinglu Canal ranged from 2.347 to 2.757,0.081 to 0.151,3.493 to 4.382,and 0.812 to 0.892,respectively.These indices showed relatively uniform distribution across different river reaches.[Conclusion]The result indicate that the fish community structure in the Pinglu Canal is relatively uniform.The reach from the Yujiang River to the Shaping River shows higher stability,while other river reaches experience moderate or severe disturbances.This study provides supplementary baseline data on the fish community structure in the Pinglu Canal and explores the potential impact of inter-basin connectivity on fish resources,aiming to provide a scientific basis for habitat restoration assessments after the channel straightening project. 展开更多
关键词 Pinglu Canal Project inter-basin connectivity fish resources community structure BIODIVERSITY influencing factors
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基于基因表达谱的途径筛选肺腺癌治疗药物 被引量:5
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作者 王桂平 叶云 +4 位作者 杨晓勤 陈新美 梁爽 郑文岭 马文丽 《中国临床药理学与治疗学》 CAS CSCD 2010年第3期266-272,共7页
目的:探讨基于基因表达谱的途径在肺腺癌治疗药物筛选中的应用。方法:从GEO数据库中获得GSE10072和GSE7670两个数据集,然后利用dchip软件进行差异表达基因分析,采用基因集富集方法(gene set enrichment analysis,GSEA)对肺腺癌进行通路... 目的:探讨基于基因表达谱的途径在肺腺癌治疗药物筛选中的应用。方法:从GEO数据库中获得GSE10072和GSE7670两个数据集,然后利用dchip软件进行差异表达基因分析,采用基因集富集方法(gene set enrichment analysis,GSEA)对肺腺癌进行通路富集分析,最后通过Connectivity map(Cmap)筛选肺腺癌候选治疗化合物,并进行实验验证。结果:共获得差异表达基因379个,其中上调基因94个,下调基因285个;GSEA主要富集到细胞周期等18条信号通路与肺腺癌相关;通过Cmap分析,筛选到Vorinos-tat、15-delta prostaglandin J2、trichostatin A、tanespi mycin等8种候选药物或化合物,在进一步的实验中也证实15d-PGJ(2)可有效抑制A549细胞的增殖。结论:基于基因表达谱的途径为药物发现提供新思路,加速了药物发现过程。 展开更多
关键词 基因表达谱 肺腺癌 connectivity MAP
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《地理教学》主编段玉山教授团队应邀出访英国牛津,深化中英地理教育交流
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《地理教学》 北大核心 2025年第9期F0002-F0002,F0003,共2页
2025年4月14日至18日,应英国地理协会(Geographical Association,GA)邀请,《地理教学》主编、华东师范大学地理科学学院段玉山教授与团队博士后缪鑫赴英国牛津,参加GA 2025年年会。GA年会是全球规模最大、影响最广的地理教育专业会议之... 2025年4月14日至18日,应英国地理协会(Geographical Association,GA)邀请,《地理教学》主编、华东师范大学地理科学学院段玉山教授与团队博士后缪鑫赴英国牛津,参加GA 2025年年会。GA年会是全球规模最大、影响最广的地理教育专业会议之一,汇聚了世界各地的地理教师、地理教育研究者、公共教育空间(如博物馆和国家公园)中的地理教育实践者、出版社和政策制定者等数千人。2025年年会以“联结的地理(Connected Geographies)”为主题,为期三天。 展开更多
关键词 GA年会 Connected Geographies 段玉山 地理教学
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基于药物表达谱模式筛选结肠癌候选治疗药物 被引量:3
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作者 王纯忠 杨邵宇 +2 位作者 肖慧莲 刘丽娜 王桂平 《中国肿瘤生物治疗杂志》 CAS CSCD 北大核心 2016年第2期212-217,共6页
目的:药物表达谱是发现药物新用途的重要模式,本项目探讨药物表达谱模式在结肠癌候选药物筛选中的应用价值。方法:首先,从Pub Med的GEO数据库中获取结肠癌表达谱数据集(No.GSE41258),从美国Memorial Sloan-Kettering癌症中心筛选出53对... 目的:药物表达谱是发现药物新用途的重要模式,本项目探讨药物表达谱模式在结肠癌候选药物筛选中的应用价值。方法:首先,从Pub Med的GEO数据库中获取结肠癌表达谱数据集(No.GSE41258),从美国Memorial Sloan-Kettering癌症中心筛选出53对配对的结肠癌与癌旁正常组织样本数据,采用RMAexpress软件进行质量分析;然后,采用Dchip软件建立结肠癌特征性表达谱;最后通过Connectivity Map(CMAP)进行结肠癌候选化合物的筛选和实验验证。结果:经芯片质量分析,选择36对配对样本进行后续分析;构建了一个由371个基因组成的结肠癌特征性表达谱,其中上调基因94个,下调基因277个;通过CMAP分析,筛选到vorinostat、tanespimycin(17-AAG)等10种候选药物,选择其中一种富集分数较高的药物17-AAG进行验证;后续实验证实17-AAG可有效抑制结肠癌SW480和HT29株细胞的增殖,其作用24和48 h时,SW480细胞的IC50分别为0.73和0.41μmol/L;而HT29细胞的IC50分别为0.72和0.50μmol/L。流式术分析显示,17-AAG可使结肠癌细胞阻滞于G1期。结论:本项目基于药物表达谱模式筛选到多种结肠癌候选药物,揭示药物表达谱模式在药物发现中具有重要意义。 展开更多
关键词 基因表达谱 结肠癌 connectivity Map 候选治疗药物
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Look-ahead horizon-based energy optimization with traffic prediction for connected HEVs
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作者 XU Fu-guo SHEN Tie-long 《控制理论与应用》 北大核心 2025年第8期1534-1542,共9页
With the development of fast communication technology between ego vehicle and other traffic participants,and automated driving technology,there is a big potential in the improvement of energy efficiency of hybrid elec... With the development of fast communication technology between ego vehicle and other traffic participants,and automated driving technology,there is a big potential in the improvement of energy efficiency of hybrid electric vehicles(HEVs).Moreover,the terrain along the driving route is a non-ignorable factor for energy efficiency of HEV running on the hilly streets.This paper proposes a look-ahead horizon-based optimal energy management strategy to jointly improve the efficiencies of powertrain and vehicle for connected and automated HEVs on the road with slope.Firstly,a rule-based framework is developed to guarantee the success of automated driving in the traffic scenario.Then a constrained optimal control problem is formulated to minimize the fuel consumption and the electricity consumption under the satisfaction of inter-vehicular distance constraint between ego vehicle and preceding vehicle.Both speed planning and torque split of hybrid powertrain are provided by the proposed approach.Moreover,the preceding vehicle speed in the look-ahead horizon is predicted by extreme learning machine with real-time data obtained from communication of vehicle-to-everything.The optimal solution is derived through the Pontryagin’s maximum principle.Finally,to verify the effectiveness of the proposed algorithm,a traffic-in-the-loop powertrain platform with data from real world traffic environment is built.It is found that the fuel economy for the proposed energy management strategy improves in average 17.0%in scenarios of different traffic densities,compared to the energy management strategy without prediction of preceding vehicle speed. 展开更多
关键词 look-ahead horizon connected and automated vehicle(CAV) hybrid electric vehicle(HEV) energy efficiency optimization traffic prediction
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Reliability of multi-dimensional network systems with nodes having stochastic connection ranges
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作者 FU Yuqiang MA Xiaoyang ZHAO Fei 《Journal of Systems Engineering and Electronics》 2025年第4期1017-1023,共7页
This paper proposes a reliability evaluation model for a multi-dimensional network system,which has potential to be applied to the internet of things or other practical networks.A multi-dimensional network system with... This paper proposes a reliability evaluation model for a multi-dimensional network system,which has potential to be applied to the internet of things or other practical networks.A multi-dimensional network system with one source element and multiple sink elements is considered first.Each element can con-nect with other elements within a stochastic connection ranges.The system is regarded as successful as long as the source ele-ment remains connected with all sink elements.An importance measure is proposed to evaluate the performance of non-source elements.Furthermore,to calculate the system reliability and the element importance measure,a multi-valued decision diagram based approach is structured and its complexity is analyzed.Finally,a numerical example about the signal transfer station system is illustrated to analyze the system reliability and the ele-ment importance measure. 展开更多
关键词 multi-dimensional network multi-valued decision diagram stochastic connection range reliability analysis impor-tance measure.
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Impact performance of a floating slab with a longitudinal connection track under fatigue loading
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作者 LI Pei-cheng ZENG Zhi-ping +3 位作者 WANG Wei-dong LI Ping YE Meng-xuan LI Qiu-yi 《Journal of Central South University》 2025年第2期678-690,共13页
In order to accommodate higher speeds,heavier axle weights,and vibration damping criteria,a new floating slab structure was proposed.The new type of floating slab track structure was composed of three prefabricated fl... In order to accommodate higher speeds,heavier axle weights,and vibration damping criteria,a new floating slab structure was proposed.The new type of floating slab track structure was composed of three prefabricated floating slabs longitudinally interconnected with magnesium ammonium phosphate concrete(MPC).This study investigated the dynamic performance of the structure.We constructd a full-scale indoor experimental model to scrutinize the disparities in the impact performance between a longitudinally connected floating slab track and its longitudinally disconnected counterpart.Additionally,a long-term fatigue experiment was conducted to assess the impact performance of longitudinally connected floating slab tracks under fatigue loading.The findings are described in the following.1)The new structure effectively suppresses ground vibrations,exhibiting a well-balanced energy distribution profile.However,the imposition of fatigue loading leads to a reduction in the damping performance of the steel spring damping system,thereby reducing its capacity to attenuate structural vibrations and leading to an increase in ground vibration energy;2)After 107 loading cycles,the attenuation rate of the vibration acceleration for the MPC increases by 171.9%.Conversely,at the corresponding disconnected location,the attenuation rate of ground vibration acceleration decreases by 65.6%.In conclusion,longitudinally connected floating slab tracks exhibit superior vibration reduction performance.While the vibration reduction performance of longitudinally connected floating slab tracks may diminish to some extent during long-term service,these tracks continue to meet specific vibration reduction requirements. 展开更多
关键词 longitudinally connected floating slab track full-scale experimental model fatigue experiment drop hammer in impact dynamic response
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基于网络环境的选课系统 被引量:1
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作者 邓万友 《大庆石油学院学报》 CAS 北大核心 2005年第6期85-88,共4页
以学分制下选课制的基础理论为前提,分析了JDBC(Java DataBase Connectivity)等Web数据库开发技术及网络安全性技术;阐述了基于网络环境选课系统的设计思想、工作原理和运行机制;设计并实现了网络化的选修课程管理系统.试验表明,该系统... 以学分制下选课制的基础理论为前提,分析了JDBC(Java DataBase Connectivity)等Web数据库开发技术及网络安全性技术;阐述了基于网络环境选课系统的设计思想、工作原理和运行机制;设计并实现了网络化的选修课程管理系统.试验表明,该系统运行稳定、速度快且效率较高、自适应性较强,符合学分制管理体制对选课系统的要求. 展开更多
关键词 选课系统 网络环境 数据库 JDBC(Java Data Base connectivity) JSP(Java SERVE Pages)
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基于JSP的模具制造执行管理系统关键技术研究
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作者 余建国 冯梅琳 李淑娟 《机床与液压》 北大核心 2006年第2期209-210,共2页
针对当前模具制造企业存在的一些典型问题,研究基于JSP(Java Server Pages)的模具制造执行管理系统。分析了系统的功能模型,对开发中的关键技术进行了讨论并阐述了其实现过程。
关键词 JSP JDBC(Java DATABASE connectivity) 执行管理系统
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基于应用层负载均衡策略的分析与研究 被引量:22
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作者 张前进 齐美彬 李莉 《计算机工程与应用》 CSCD 北大核心 2007年第32期138-142,共5页
介绍了Round Robin(RR),Weighted Round Robin(WRR),Least Connection(LC)和Weighted Least Connection(WLC)四种负载均衡算法,对这四种算法进行性能仿真。根据模拟得到的相关数据绘制各个算法的负载均衡度性能曲线,并对每个算法进行了... 介绍了Round Robin(RR),Weighted Round Robin(WRR),Least Connection(LC)和Weighted Least Connection(WLC)四种负载均衡算法,对这四种算法进行性能仿真。根据模拟得到的相关数据绘制各个算法的负载均衡度性能曲线,并对每个算法进行了性能分析。在此基础上设置三种不同的模拟模型,对四种算法进行更深入的测试和性能比较。 展开更多
关键词 负载均衡算法 ROUND Robin(RR)算法 WEIGHTED ROUND Robin(WRR)算法 Least Connection(LC)算法 WEIGHTED Least Connection(WLC)算法
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STK/Connect模块在GPS仿真演示系统中的应用 被引量:10
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作者 潘成胜 张馨 李定主 《火力与指挥控制》 CSCD 北大核心 2008年第10期117-120,共4页
卫星工具软件STK(Satellite Tool Kit)是航天领域中进行卫星系统分析和仿真的有效工具,其重要模块之一STK/Connect可提供用户在客户机/服务器环境下与STK连接的功能。在深入研究STK/Connect模块的核心技术的基础上,详细说明了第三方应... 卫星工具软件STK(Satellite Tool Kit)是航天领域中进行卫星系统分析和仿真的有效工具,其重要模块之一STK/Connect可提供用户在客户机/服务器环境下与STK连接的功能。在深入研究STK/Connect模块的核心技术的基础上,详细说明了第三方应用程序与STK进行通信的方法,并将其应用于GPS应用仿真演示系统,同时进行了编程实现,取得了较好的效果。 展开更多
关键词 卫星工具软件 STK/Connect GPS
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基于Level Set方法的Visible Human Being虚拟人图像处理 被引量:3
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作者 张坤 罗立民 +1 位作者 舒华忠 杨芳 《安徽大学学报(自然科学版)》 CAS 北大核心 2005年第4期66-69,共4页
提出了将基于区域的VectorConfidenceConnected的低级分割方法和基于边界的LevelSet高级分割方法相组合的分割方法,使得边界的平滑性得到了保持;既有效地结合了医学专家的医学背景知识,又提高了分割处理的速度,很好的处理了医学图像中... 提出了将基于区域的VectorConfidenceConnected的低级分割方法和基于边界的LevelSet高级分割方法相组合的分割方法,使得边界的平滑性得到了保持;既有效地结合了医学专家的医学背景知识,又提高了分割处理的速度,很好的处理了医学图像中常见的拓扑结构,实验结果表明该方法切实可行。 展开更多
关键词 VECTOR CONFIDENCE Connected方法 Level SET方法 医学图像 图像分割
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博弈机器人的行为规划 被引量:7
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作者 张小川 候鑫磊 涂飞 《重庆理工大学学报(自然科学)》 CAS 2014年第4期99-103,共5页
博弈行为是博弈机器人智能的外在表现,行为选择是提高机器人智能的重要手段之一,而博弈行为体系是行为选择的重要基础。通过模拟人类下棋过程,提出了博弈机器人的行为过程结构,依据系统分类思想,构建了博弈机器人的博弈行为体系,提出了... 博弈行为是博弈机器人智能的外在表现,行为选择是提高机器人智能的重要手段之一,而博弈行为体系是行为选择的重要基础。通过模拟人类下棋过程,提出了博弈机器人的行为过程结构,依据系统分类思想,构建了博弈机器人的博弈行为体系,提出了博弈行为规划方法,借助六子棋博弈平台,验证了研究成果的有效性。 展开更多
关键词 机器博弈 博弈机器人 行为规划 六子棋 CONNECT6
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基于STK的Connect模块设计与应用 被引量:12
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作者 李弢 陈立云 +1 位作者 连云峰 高秀峰 《科学技术与工程》 2008年第22期6110-6112,6121,共4页
卫星工具软件(STK)是广泛用于航天工程全过程的先进卫星系统分析软件,具有准确的仿真能力,但在实际应用中经常遇到STK与应用程序的集成问题。介绍了利用STK/Connect模块实现STK与VC集成的方法,并通过一个通信卫星链路的应用实例详细说... 卫星工具软件(STK)是广泛用于航天工程全过程的先进卫星系统分析软件,具有准确的仿真能力,但在实际应用中经常遇到STK与应用程序的集成问题。介绍了利用STK/Connect模块实现STK与VC集成的方法,并通过一个通信卫星链路的应用实例详细说明了两者联合编程的步骤。两者的集成有效地利用了STK准确的仿真能力与VC高效的数据分析能力,提高了仿真分析系统开发的灵活性。 展开更多
关键词 卫星工具软件 Connect模块 仿真
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基于ISI Current Contents Connect的学科网站研究——以气象学为例 被引量:1
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作者 朱紫阳 张艳 顾建新 《图书情报知识》 CSSCI 北大核心 2008年第5期62-66,共5页
本文从专家推荐网站入手对学科网站进行研究,以气象学为例,通过检索ISI Current Contents Connect数据库,对学科网站的地理分布、语种分布、信息来源、出版者及关键词进行统计分析,总结出学科网站的一些特点。最后对目前学科网络信息资... 本文从专家推荐网站入手对学科网站进行研究,以气象学为例,通过检索ISI Current Contents Connect数据库,对学科网站的地理分布、语种分布、信息来源、出版者及关键词进行统计分析,总结出学科网站的一些特点。最后对目前学科网络信息资源研究提出了自己的看法。 展开更多
关键词 ISI CURRENT CONTENTS Connect气象学 学科网站
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基于STK的GPS威胁仿真评估 被引量:1
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作者 李智 陈浩光 +1 位作者 丁哲峰 马峰 《四川兵工学报》 CAS 2009年第10期80-83,共4页
分析了GPS的军事应用价值,定义了GPS的3个军事价值指标,利用STK(卫星仿真工具包)的STK/Coverage模块对GPS系统的几何精度因子(GDOP)值进行了仿真计算,得到了GPS对特定区域在一个仿真周期内的有效时间报告,并通过STK/Connect模块实现了VC... 分析了GPS的军事应用价值,定义了GPS的3个军事价值指标,利用STK(卫星仿真工具包)的STK/Coverage模块对GPS系统的几何精度因子(GDOP)值进行了仿真计算,得到了GPS对特定区域在一个仿真周期内的有效时间报告,并通过STK/Connect模块实现了VC和STK的集成,有效地对GPS威胁性进行了仿真分析,得到一些具有应用价值的威胁评估结果. 展开更多
关键词 GPS威胁 STK/Connect模块 威胁评估
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