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From Children's Creativity to Second Language Learning
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作者 赵刚 《陕西师范大学学报(哲学社会科学版)》 CSSCI 北大核心 2002年第S3期124-127,共4页
关键词 children’s CREATIVITY MOTHER TONGUE SECOND language feedback
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Family-relatedFactorsThatInfluenceChildren’sAcademicAchievementsinSchool
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作者 何献忠 《陕西师范大学学报(哲学社会科学版)》 CSSCI 北大核心 2002年第S1期323-328,共6页
This essay studies various family-related factors that influence a child’s academic achievement in school in P.R. China. The factors are illustrated under three categories: the family’s social class and education, e... This essay studies various family-related factors that influence a child’s academic achievement in school in P.R. China. The factors are illustrated under three categories: the family’s social class and education, early home environment and family material condition. The author discusses the relevant factors by way of relating the knowledge of social environment to his own experiences as a student and then teacher in China. The essay closes with a discussion directing the public’s attention to the concern about home-related factors influencing a child’s academic achievements in school. 展开更多
关键词 family related factors childrens academic achievements home environment material condition
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Respiratory complications of propofol,sevoflurane,and dexmedetomidine anesthesia for fiberoptic bronchoscopy in children aged 1 month to 3 years:a randomized trial 被引量:1
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作者 Amir Shafa Mohammad Montasery +4 位作者 Sedighe Shahhosseini Majid Keivanfar Asieh Maghami Mehr Mahtab Ebrahim Babaei Mohammad Jafari 《南方医科大学学报》 CAS CSCD 北大核心 2024年第9期1631-1636,共6页
Objective To evaluate the effect of propofol,sevoflurane,and dexmedetomidine on respiratory complications inchildren undergoing fiberoptic bronchoscopy(FOB).Methods This double-blind randomized clinical trial was cond... Objective To evaluate the effect of propofol,sevoflurane,and dexmedetomidine on respiratory complications inchildren undergoing fiberoptic bronchoscopy(FOB).Methods This double-blind randomized clinical trial was conductedamong 120 children aged 1 month to 3 years undergoing FOB.The patients were randomized into 3 groups(n=40)foranesthesia induction with sevoflurane inhalation,1 mg/kg propofol,or 1μg/kg dexmedetomidine before bronchoscopy,andthe changes in hemodynamic parameters,sedation level,and respiratory complications during and after the procedure wereassessed.Results The patients'heart rate during bronchoscopy was significantly lower and the mean arterial blood pressuresignificantly higher in dexmedetomidine group than in sevoflurane and propofol groups(P<0.05).Cough duringbronchoscopy did not occur in any of the cases in propofol group,while the highest frequency of cough was recorded indexmedetomidine group.The incidence of laryngospasm in the propofol group(12.5%)was significantly lower than those insevoflurane and dexmedetomidine groups(30%and 32.5%,respectively)(P<0.05).Conclusion Sevoflurane and propofol aresafe and suitable for anesthesia induction in children below 3 years of age undergoing diagnostic FOB and can achieve bettersedative effect and lower the incidences of cough and respiratory complications as compared with dexmedetomidine. 展开更多
关键词 fiberoptic bronchoscopy PROPOFOL SEVOFLURANE DEXMEDETOMIDINE children
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A Childhood lost? A case of Gulu Support Children Organization in Northern Uganda
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作者 Eria Serwajja 《地学前缘》 EI CAS CSCD 北大核心 2009年第S1期60-60,共1页
The number of children affected in conflicts is on the rise in Africa.All childhood experiences of such children are nightmares by war.The conflict in Northern Uganda continues to attract local,national and internatio... The number of children affected in conflicts is on the rise in Africa.All childhood experiences of such children are nightmares by war.The conflict in Northern Uganda continues to attract local,national and international attention.Once a vibrant area,Gulu has been shuttered by the Lord Resistance Army (LRA)atrocities,a region where several vehicles were burnt and people were butchered.The purpose of 展开更多
关键词 GUSCO-Gulu SUPPORT children ORGANIZATION Night COMMUTING LRA-Lords resistance army
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The Extra-and Intra-Hepatic Ducts of Congenital Choledochal Cyst in Infants and Children
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作者 陈丽英 潘恩源 +4 位作者 杭俊德 靳家文 李心元 王慧贞 李正 《中国医科大学学报》 CAS CSCD 1990年第S1期33-39,共7页
Congenital choledochal cyst is frequently seen ininfants and children in China. The extra-hepatic ductalchanges have been well described, but the changes in theintra-hepatic ducts in choledochal cyst are less well kno... Congenital choledochal cyst is frequently seen ininfants and children in China. The extra-hepatic ductalchanges have been well described, but the changes in theintra-hepatic ducts in choledochal cyst are less well known.This report is composed of 2 groups of patients: thirty-four cases who were operated upon between 1971 and1982 were followed post-operatively by plain abdominalfilm and barium meal examination and a group of 26cases receiving PTC between 1982 and 1984. In this lattergroup, both extra-and intra-hepatic ducts were shownsatisfactorily by PTC. In 23 cases (88.5%) besides thedilatation of the extra-hepatic duct, there were differentdegree and different forms of dilatation of the intra-hepatic ducts. In 10 cases(38.5%)the branches peripheralto the dilated main intra-hepatic ducts were found to benormal, in the other 10 cases (38.5%) the more peripheralbranches abruptly narrowed or were obliterated. In one case(3.8%) the entire intra-hepatic ductal system were dilatedwith a bead-like appearance. In only 3 cases were theintra-hepatic ducts normal (11.5%). Moreover the dilata-tion of the intra-hepatic ducts were found to persist longafter the obstruction was relieved in 28 cases (82.3%) ofthe 34 post-operative cases. Due to the frequent associationof intra-hepatic ductal dilatation with choledochal cyst,the various forms of dilatation and persistance of dilata-tion after relief of the obstruction, the term congenital biliary dilatation is suggested for this disease. 展开更多
关键词 HEPATIC ducts choledochal CYST INFANTS children
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Pharmacokinetics and pharmacodynamics of cisatracurium in children undergoing cleft lip or cleft palate repair surgery
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作者 Wei-jia HAO LI Jing-yi +5 位作者 Yi MA Jie XIONG Ping-xiang XU Yu-hang LI Xiao-tong ZHANG Xiao-rong LI 《中国药理学与毒理学杂志》 CAS CSCD 北大核心 2017年第10期1021-1022,共2页
OBJECTIVE The aim of the study was to characterize the pharmacokinetics(PK) and pharmacodynamics(PD) profile of cisatracurium in 0-2 years and 2-5 years old children patients with cheilopalatognathus,to find if there ... OBJECTIVE The aim of the study was to characterize the pharmacokinetics(PK) and pharmacodynamics(PD) profile of cisatracurium in 0-2 years and 2-5 years old children patients with cheilopalatognathus,to find if there are some connections between the different muscle relaxation action and different PK procedure.METHODS 14 children patients were divided into two groups,≤2 years and 2-5 years group,venous samples were taken before injection of a 0.15 mg·kg-1 dose of cisatracurium and then at 2,5,10,30,60,90,and 120 min.Cisatracurium plasma concentrations were determined by ultra-performance liquid chromatography/electrospray ionization/triple quadrupole tandem mass spectrometer system(UPLC/MS/MS).The degree of neuromuscular block was measured by train of four(TOF) testing.An indirect PK-PD link model with a sigmoid E max model was established using Win Nonlin software.The model were applied to PK and PD data analysis,respectively.RESULTS The TOF monitor parameters showed that cisatracurium works very quickly,the onset time were(2.64±0.93) min and(2.59 ± 0.90) min for ≤2 years and 2-5 years group respectively.Young children ≤2 years have longer muscle blocking duration time(62.5 ± 6.01 min vs 53.86 ± 12.18 min) and slower recovery index(32.14±7.10 min and 27.43±10.63 min) than those children in group of 2-5 years.More children ≤2 years have postoperative complication than that in 2-5 children.PK parameters showed that there were no statistical differences in blood concentration and pharmacokinetic parameters.While the concentration of cisatracurium in muscle site calculated by using PK/PD model were higher and longer for ≤2 year children than that of 2-5 year children.This means that cisatracurium could stay at high concentration for a longer time in younger children' muscle tissue.CONCLUSION As a result young children tend to have postoperative complications related to slower muscle recovery action and increased concentration in skeletal muscle.So more careful observation and monitor are needed for younger children,our study could be of use in clinical practice for the administration of cisatracurium to children patients. 展开更多
关键词 CISATRACURIUM children PK/PD
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Early serious adverse event in immediate postoperative period in children underwent cardiac surgery
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作者 Shengli Li A-RWICK Butt 《中国循环杂志》 CSCD 北大核心 2018年第S01期152-153,共2页
Objective Despite dramatic advances in surgical technique and perioperative care,some children still suffered serious adverse event in early postoperative period which were associated with increased morbidity and mort... Objective Despite dramatic advances in surgical technique and perioperative care,some children still suffered serious adverse event in early postoperative period which were associated with increased morbidity and mortality.There was little information regarding the impact of adverse events on the postoperative recovery,especially the serious adverse events occurring immediately after surgery.We sought to evaluate the early postoperative serious adverse events and examine the impact of them on postoperative recovery. 展开更多
关键词 EARLY SERIOUS ADVERSE event children underwent CARDIAC surgery
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Ultrasonic manifestations and age distribution of internal abdominal hernia in children
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作者 KUANG Bin YANG Chunjiang TANG Yi 《中国医学影像技术》 CSCD 北大核心 2024年第8期1204-1207,共4页
Objective To observe the ultrasonic manifestations and age distribution of internal abdominal hernia in children.Methods Data of 53 children with internal abdominal hernia confirmed by operation were retrospectively a... Objective To observe the ultrasonic manifestations and age distribution of internal abdominal hernia in children.Methods Data of 53 children with internal abdominal hernia confirmed by operation were retrospectively analyzed.The ultrasonic findings were observed,and the age distribution of children was analyzed.Results Among 53 cases,"cross sign"was observed in 22 cases(22/53,41.51%),and"hernia ring beak sign"was detected in 26 cases(26/53,49.06%)by preoperative ultrasound,according to which 21 cases were diagnosed as internal abdominal hernia,with the accuracy of 39.62%(21/53).Meanwhile,manifestations of intestinal obstruction were noticed in 48 cases(48/53,90.57%),and intestinal necrosis was considered in 22 cases(22/53,41.51%).Four cases were misdiagnosed as intestinal perforation,appendicitis,intestinal atresia and volvulus,each in 1 case.The onset age of postoperative adhesive band internal hernia was larger than that of mesenteric hiatal hernia(P<0.05),while no significant difference of onset age was found among other types of internal abdominal hernias(all P>0.05).Intestinal ischemic necrosis was found in 25 cases,while the incidence of intestinal necrosis in children aged≤1 year,>1 and≤3 years,>3 and≤7 years and those>7 years was 66.67%(12/18),33.33%(4/12),36.36%(4/11)and 41.67%(5/12),respectively.Conclusion The characteristic ultrasonic findings of internal abdominal hernia in children included"cross sign"and"hernia ring beak sign".Internal abdominal hernia in children under 1 year had high risk of intestinal necrosis. 展开更多
关键词 hernia abdominal children ULTRASONOGRAPHY
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孩手心中的天堂——《小鞋子》Children of Heaven分析
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作者 个个 《电影文学》 北大核心 2002年第4期20-21,共2页
小男孩阿里无意中把妹妹莎拉的鞋弄丢了,为了不加重父母负担,两人每天穿阿里的一双破球鞋上学,上午男校哥哥阿里穿,下午女校妹妹莎拉穿。为了不耽误莎拉上学,阿里每天放学都是跑回家的,并由此锻炼出了长跑的好本领。小城里举行学生的长... 小男孩阿里无意中把妹妹莎拉的鞋弄丢了,为了不加重父母负担,两人每天穿阿里的一双破球鞋上学,上午男校哥哥阿里穿,下午女校妹妹莎拉穿。为了不耽误莎拉上学,阿里每天放学都是跑回家的,并由此锻炼出了长跑的好本领。小城里举行学生的长跑比赛,阿里为了第三名的球鞋奖品,积极地参加了比赛。最后,阿里夺得了第一名的成绩,爸爸也为妹妹买了一双新鞋,生活正越变越好……影片分析: 每个人在儿时似乎都会有各种各样的梦想,有的远大,有的天真。而《小鞋子》中的小男孩阿里在片中的全部梦想就是为妹妹莎拉得到一双新鞋,妹妹的旧鞋因为自己的疏忽丢失了,他觉得自己有责任为妹妹再得到一双。 展开更多
关键词 《小鞋子》 阿里 莎拉 children of Heaven 天堂
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The Legal Support for the Protection of the Disabled Children's Rights and Interests
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作者 Chang Xiaoming Xu Qiaoxian 《学术界》 CSSCI 北大核心 2014年第9期293-300,共8页
How to protect the disabled children’s rights and interests legally has been a very serious,urgent realistic subject.Today,the problems in the protection of the disabled children’s rights and interests become obviou... How to protect the disabled children’s rights and interests legally has been a very serious,urgent realistic subject.Today,the problems in the protection of the disabled children’s rights and interests become obvious,mainly including that the right to exist is not protected,the right to education is changed,the right to development is not implemented,the right to participate is not respected,and the right to be protected is not safeguarded,etc.As the legal position of the protection of the disabled children’s rights and interests is absent,it is imperative to choose the legal support ways for the protection of the disabled children’s rights and interests. 展开更多
关键词 权益保护 法律支持 残疾儿童 儿童保护 法律地位 权利 利益
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Studies on the Models of Children' s Foreign Language Education
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作者 Li Qingzhao 《学术界》 CSSCI 北大核心 2015年第7期302-309,共8页
There are hot arguments on foreign language learning "the sooner the better" and it is critical to children' s foreign language education policies.This study combs series of empirical studies and models ... There are hot arguments on foreign language learning "the sooner the better" and it is critical to children' s foreign language education policies.This study combs series of empirical studies and models to analyze disadvantages of the belief of foreign language education "the sooner the better" in China.The findings are:1.Age is not the key factor to foreign language achievement,learning strategies,language distance and mother language proficiency are important factors that can not be ignored;2.The results in external foreign language studies can not be used directly to guide domestic foreign language education policies,for practical demands must be taken in consideration. 展开更多
关键词 外语学习 教育模式 儿童 教育政策 序列分析 学习策略 距离和
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Narration and Healing of Psychological Trauma in Chinese Left-behind Children
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作者 Yan Jiezhi 《学术界》 CSSCI 北大核心 2017年第8期299-306,共8页
The problem of left-behind children appears under the background of China’s industrialization,urbanization and modernization with the deepening of its reform and opening up. From 1980s,literature began to give attent... The problem of left-behind children appears under the background of China’s industrialization,urbanization and modernization with the deepening of its reform and opening up. From 1980s,literature began to give attention to this special phenomenon.Many writers wrote about children’s psychological trauma in alienated families and social environment,and also gave suggestions on the healing of left-behind children’ psychological trauma in their works. This paper argues that the weakening of family education,the deficiency of schooling and the low social coordination are essential factors that lead to the psychological trauma of left-behind children in rural China. Joint effort from family,school and society contribute to the healing of the trauma,among which,love,writings and speeches are effective ways. 展开更多
关键词 儿童心理 中国农村 创伤 康复 社会环境 家庭教育 学校教育 工业化
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Methods in Analyzing Abdominal Fat of Obese Children and Adolescents
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作者 Xiao-fei Zheng Qing-ya Tan +2 位作者 Ye-xuan Tao Wei Lu Wei Cai 《临床儿科杂志》 CAS CSCD 北大核心 2009年第1期1-6,共6页
关键词 肥胖 儿童 核磁共振成像 超声检查 临床分析
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女性妊娠期坚持地中海饮食对儿童健康影响的研究进展
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作者 张芳 喻蓉艳 +3 位作者 占倩倩 康飞飞 吴瑶君 吴波 《护理研究》 北大核心 2026年第6期1038-1042,共5页
对女性妊娠期坚持地中海饮食对儿童健康的影响进行综述,以期为今后制定妊娠期女性风险优化管理与防控策略提供参考。
关键词 妊娠期 地中海饮食 孕妇 婴幼儿 健康效应 儿童 综述
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儿童及青少年组织细胞坏死性淋巴结炎临床特点及影响热程的危险因素分析
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作者 陆彬彬 王文婷 +5 位作者 陆超 李俊霞 李赟颉 濮亚宁 韩婷婷 邹黎 《南京医科大学学报(自然科学版)》 北大核心 2026年第4期561-567,共7页
目的:分析儿童及青少年组织细胞坏死性淋巴结炎的临床特征、治疗、转归及影响发热时间的危险因素。方法:回顾性分析南京医科大学第一附属医院收治的35例组织细胞坏死性淋巴结炎患儿的临床资料,比较短程发热(发热时长≤2周,17例)与长程发... 目的:分析儿童及青少年组织细胞坏死性淋巴结炎的临床特征、治疗、转归及影响发热时间的危险因素。方法:回顾性分析南京医科大学第一附属医院收治的35例组织细胞坏死性淋巴结炎患儿的临床资料,比较短程发热(发热时长≤2周,17例)与长程发热(发热时长>2周,18例)两组间的临床特征及危险因素。结果:35例患者年龄为(14.69±2.42)岁,男女比例1.06∶1。所有病例均有淋巴结肿大,颈部淋巴结肿大占85.7%,伴触痛者74.3%,发热者97.14%。常见实验室异常包括乳酸脱氢酶升高(65.7%)、血沉增快(65.7%)、白细胞减少(62.86%)、中性粒细胞减少(51.43%)、超敏C反应蛋白升高(54.29%)及铁蛋白升高(45.71%);17.1%的患者抗核抗体检测呈阳性。长程发热组在颈外淋巴结肿大、白细胞减少、中性粒细胞减少、抗核抗体阳性及多项炎症指标升高方面比例更高(P<0.05)。Logistic回归分析提示铁蛋白升高是热程延长的独立危险因素。27例患者使用抗感染药物均无效,22例患者活检后使用糖皮质激素中位退热时间为2 d,且短程发热组退热更快(P<0.05)。随访6个月~2年,2例患者复发,无1例发展为自身免疫性疾病。结论:儿童及青少年组织细胞坏死性淋巴结炎以发热、颈部淋巴结肿痛、白细胞减少和血沉增快为主要表现,铁蛋白升高是热程延长的独立危险因素。该病诊断依靠淋巴结活检,抗感染药物治疗通常无效,糖皮质激素治疗疗效较好。 展开更多
关键词 组织细胞坏死性淋巴结炎 儿童 青少年 临床特点 治疗
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不同视觉输入及任务条件下痉挛型偏瘫儿童平衡与下肢生物力学变化
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作者 梁冠军 徐欢岚 +3 位作者 张何威 张大力 顾琴 李明娣 《中国康复理论与实践》 北大核心 2026年第3期345-355,共11页
目的探讨不同视觉输入及任务条件对痉挛型偏瘫儿童平衡功能与下肢生物力学特征的影响。方法2025年3月至7月,选取苏州大学附属儿童医院6~9岁痉挛型偏瘫儿童30例(偏瘫组)和健康儿童30例(对照组),采用2(组别:偏瘫组/对照组)×2(任务:... 目的探讨不同视觉输入及任务条件对痉挛型偏瘫儿童平衡功能与下肢生物力学特征的影响。方法2025年3月至7月,选取苏州大学附属儿童医院6~9岁痉挛型偏瘫儿童30例(偏瘫组)和健康儿童30例(对照组),采用2(组别:偏瘫组/对照组)×2(任务:单任务/双任务)×2(视觉:睁眼/闭眼)混合试验设计。试验前1周,完成Fugl-Meyer评定量表下肢部分(FMA-LE)、儿童功能独立性评定量表(WeeFIM)和韦氏儿童智力量表(WISC-Ⅳ)评价。使用三维步态分析系统和足底压力测试系统采集时空参数步速、步长、步频、步宽,运动学参数髋/膝/踝关节角度,动力学参数前足负荷比、压力中心(CoP)偏移量,计算双任务成本(DTC)。结果时空参数显示,双任务及闭眼条件下偏瘫组步速、步长降低,步宽增大,组别、任务、视觉对步速、步长、步宽交互效应显著(F>4.886,P<0.05)。运动学参数显示,双任务时偏瘫组髋关节屈曲角度增大、踝关节背屈角度减小,闭眼时膝关节屈曲角度增大,三者对各关节角度交互效应显著(F>4.876,P<0.05)。动力学参数显示,双任务及闭眼条件下,偏瘫组前足负荷比、CoP前后偏移量降低,CoP侧向偏移量增大,三者对CoP偏移量交互效应显著(F>4.355,P<0.05)。除睁眼步频DTC外,偏瘫组DTC均显著高于对照组(|t|>14.393,P<0.001)。相关性分析显示,FMA-LE评分与DTC呈强负相关(|r|>0.731,P<0.01),WeeFIM评分、工作记忆指数与步速、步频DTC呈中等负相关(|r|>0.462,P<0.05)。结论痉挛型偏瘫儿童的步态和平衡受双任务和视觉的双重影响。视觉剥夺与双任务叠加显著加剧其步态异常。DTC与运动功能、工作记忆有较强的相关性。 展开更多
关键词 痉挛型偏瘫 儿童 生物力学 双任务 视觉输入 平衡功能
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儿童组织细胞坏死性淋巴结炎47例病例系列报告
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作者 李莎 欧榕琼 +2 位作者 王海燕 张碧红 檀卫平 《中国循证儿科杂志》 北大核心 2026年第1期72-75,共4页
背景近年来儿童组织细胞坏死性淋巴结炎(histiocytic necrotizing lymphadenitis,HNL)患病率逐渐升高,HNL临床表现个体差异大,实验室检查缺乏特异性,早期易误诊、漏诊。目的分析HNL的临床特点,以提高对该病的认识。设计病例系列报告。... 背景近年来儿童组织细胞坏死性淋巴结炎(histiocytic necrotizing lymphadenitis,HNL)患病率逐渐升高,HNL临床表现个体差异大,实验室检查缺乏特异性,早期易误诊、漏诊。目的分析HNL的临床特点,以提高对该病的认识。设计病例系列报告。方法通过医院电子病历系统回顾性收集并分析中山大学孙逸仙纪念医院儿科2008年1月至2024年12月收治的HNL患儿的临床资料。主要结局指标临床表现、实验室检查结果、治疗和预后情况。结果47例患儿中男34例(72.3%)、女13例,中位发病年龄10(2∼14)岁。所有患儿均有淋巴结肿大,42例(89.4%)伴发热,33例(70.2%)存在血液系统受累,28例(59.6%)存在肝和(或)脾肿大,13例(27.6%)合并过敏性疾病。实验室检查主要表现为红细胞沉降率升高34例(72.3%),白细胞降低33例(70.2%),C反应蛋白升高20例(42.5%)。部分患儿伴血清总IgE水平升高(55.0%,22/40)、血清EB病毒-DNA阳性(43.6%,17/39)、肺炎支原体抗体阳性(40.5%,15/37)、抗核抗体阳性(28.6%,10/35)。32例(68.1%)患儿予糖皮质激素治疗,12例(25.5%)加用免疫抑制剂治疗,其中9例予来氟米特,3例予羟氯喹。1例在确诊HNL 2年半后复发,3例发展为系统性红斑狼疮。结论HNL好发于学龄期儿童,男性高发,常合并EB病毒及肺炎支原体感染,部分伴有过敏性疾病,糖皮质激素治疗有效;对于复发、合并自身免疫现象且伴有抗核抗体阳性的患儿加用免疫抑制剂预后良好。对于合并抗核抗体阳性患儿,应予长期密切随访,警惕进展为其他自身免疫性疾病。 展开更多
关键词 组织细胞坏死性淋巴结炎 儿童 临床特点
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贝林妥欧单抗治疗儿童复发/难治急性B淋巴细胞白血病21例的临床分析
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作者 薛玉娟 王毓 +3 位作者 陆爱东 贾月萍 张乐萍 曾慧敏 《中国实验血液学杂志》 北大核心 2026年第1期7-13,共7页
目的:评估贝林妥欧单抗治疗儿童复发/难治急性B淋巴细胞白血病(R/RB-ALL)的疗效及安全性,并对影响贝林妥欧单抗疗效的临床因素进行初步探索。方法:回顾性分析2021年4月至2023年12月北京大学人民医院儿科应用贝林妥欧单抗治疗的21例R/RB-... 目的:评估贝林妥欧单抗治疗儿童复发/难治急性B淋巴细胞白血病(R/RB-ALL)的疗效及安全性,并对影响贝林妥欧单抗疗效的临床因素进行初步探索。方法:回顾性分析2021年4月至2023年12月北京大学人民医院儿科应用贝林妥欧单抗治疗的21例R/RB-ALL患儿的临床资料。结果:21例患儿中,男10例,女11例,中位年龄4(2-17)岁;单纯骨髓复发5例,骨髓联合中枢神经系统复发1例,单纯微小残留病(MRD)复发3例,单纯分子学复发5例,MRD联合分子学复发2例,难治5例。贝林妥欧单抗治疗前基线原始细胞≥5%的患儿8例,贝林妥欧单抗治疗后,其中7例(87.5%)获得完全缓解(CR),3例(37.5%)MRD转阴。贝林妥欧单抗治疗前MRD和/或分子学阳性(骨髓CR)的患儿13例,贝林妥欧单抗治疗后,其中12例(92.3%)获得MRD和/或分子学转阴。21例患儿的中位随访时间为13.1(6.5-34.9)个月,1年OS率为(92.3±7.4)%。影响贝林妥欧单抗短期疗效的因素包括治疗前原始细胞比例(P=0.026)及MRD水平(P=0.026)。未发生3级及以上细胞因子释放综合征,无神经系统事件发生。结论:贝林妥欧单抗在儿童R/RB-ALL中的短期疗效良好,尤其是在低肿瘤负荷患儿中的疗效更优。临床不良反应可控,安全性高。 展开更多
关键词 贝林妥欧单抗 急性B淋巴细胞白血病 儿童 复发 难治
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三甲儿童医院肠外营养智能处方审核系统构建及应用
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作者 刘蕾 王瑞丽 +3 位作者 马瑞娟 邢慧资 裴保方 张胜男 《肠外与肠内营养》 北大核心 2026年第1期30-35,共6页
目的:构建儿童肠外营养智能处方审核系统,规范不合理用药行为。方法:分别在适应证和禁忌证、给药途径与方式、营养成分完整性、营养成分用量、稳定性、并发症监测等方面制定处方审核规则,并根据处方问题予以“提醒、警告、拦截”三级干... 目的:构建儿童肠外营养智能处方审核系统,规范不合理用药行为。方法:分别在适应证和禁忌证、给药途径与方式、营养成分完整性、营养成分用量、稳定性、并发症监测等方面制定处方审核规则,并根据处方问题予以“提醒、警告、拦截”三级干预处置措施。比较系统运行前(2024年6~8月)和运行后(2024年10~12月)本院肠外营养医嘱点评情况,以及医嘱干预情况,检验应用效果。结果:系统启用后,审核模式由触发单一药品的独立审核规则到对医嘱中所有药品的每一种成分、含量根据相应的公式进行审核,由以提示为主转向以审核干预为主,并可结合病儿信息进行个性化审核,PN审核模块运行前后处方点评合格率由80.46%提升至95.00%(P<0.001),实时问题处方干预率由9.81%提升至18.98%(P<0.001)。结论:儿童肠外营养智能处方审核系统的应用,提高了处方合格率,保障了儿童肠外营养使用合理性。 展开更多
关键词 儿童 肠外营养 智能 处方审核
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先天性肾上腺皮质增生症儿童家庭生活质量及影响因素研究
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作者 刘倩 蔡桂仪 +5 位作者 欧辉 方佳 谢姗姗 曾颖 钟婷 张利峰 《中国护理管理》 北大核心 2026年第1期45-50,共6页
目的:描述先天性肾上腺皮质增生症(Congenital Adrenal Hyperplasia,CAH)儿童的家庭生活质量并探讨其主要影响因素,为临床针对性护理提供参考。方法:采用方便抽样法,以2022年5月至2023年12月于广州市某三级甲等医院儿童内分泌专科就诊的... 目的:描述先天性肾上腺皮质增生症(Congenital Adrenal Hyperplasia,CAH)儿童的家庭生活质量并探讨其主要影响因素,为临床针对性护理提供参考。方法:采用方便抽样法,以2022年5月至2023年12月于广州市某三级甲等医院儿童内分泌专科就诊的196名CAH儿童及其父母为研究对象,采用比奇中心家庭生活质量量表、父母育儿胜任感量表、领悟社会支持量表进行调查。采用多重线性回归分析生活质量的影响因素。结果:CAH儿童家庭生活质量的满意度总分为(95.07±14.12)分,其中家庭互动(23.76±3.58)分、情感健康(14.66±2.78)分、父母养育(23.31±3.73)分、身体健康与物质福利(19.09±3.65)分、残障相关支持(14.26±3.20)分,其中得分最低为残障相关支持维度,最高为家庭互动维度。父母学历越高、育儿胜任感水平越高、获得社会支持越多者,家庭生活质量越高(P<0.05)。结论:CAH儿童的家庭生活质量总体有待提高,尤其是残障相关支持亟须改善。需要重点关注父母文化程度较低的家庭,通过增强父母的育儿自我效能,并提供有针对性的支持,可改善其家庭生活质量。 展开更多
关键词 先天性肾上腺皮质增生症 儿童 家庭生活质量 满意度 育儿胜任感 社会支持
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