·AIM:To identify various risk factors that may play a significant role in the development of congenital nasolacrimal duct obstruction(CNLDO).·METHODS:This observational case-control study included a case gro...·AIM:To identify various risk factors that may play a significant role in the development of congenital nasolacrimal duct obstruction(CNLDO).·METHODS:This observational case-control study included a case group of 122 children less than two years of age with CNLDO who underwent probing and irrigation treatment at the ophthalmology department of Imam Khomeini Hospital in Ahvaz,Iran,from June 2022 to June2024.A control group of 122 age-matched children without CNLDO was also included for comparison.Data was collected from the children's medical records.·RESULTS:The study found a significant correlation between the occurrence of CNLDO and several maternal factors,such as preeclampsia,the use of levothyroxine,hypothyroidism,having more than three pregnancies(gravidity>3),natural pregnancy,and gestational diabetes mellitus.Additionally,in children,factors,such as oxygen therapy,anemia,reflux,jaundice,and a family history of CNLDO in first-degree relatives were associated with CNLDO,and maternal preeclampsia and hypothyroidism were found to significantly increase the risk of developing CNLDO in children.·CONCLUSION:Given that CNLDO affects both premature and full-term children,the present findings may potentially facilitate the early identification of children and infants at risk of nasolacrimal duct obstruction,thereby preventing the onset of chronic dacryocystitis.展开更多
Background The knowledge about the prevalence of schizophrenia among people with intellectual disabilities(ID)is sparse,particularly concerning the distribution in different age groups.Aims To investigate the prevalen...Background The knowledge about the prevalence of schizophrenia among people with intellectual disabilities(ID)is sparse,particularly concerning the distribution in different age groups.Aims To investigate the prevalence of diagnoses in the schizophrenia spectrum among people with ID compared with the general population(gPop).Methods This was an 8-year longitudinal register study.The participants were all residents of Skane on 1 January 2014.People with a diagnosis of ID(F7 in International Statistical Classificationof Diseases and RelatedHealth Problems 10th Revision)or Down syndrome(DS;Q90),or service and support for people with ID/autism spectrum disorder(ASD)comprised the ID cohort(n=14716).After excluding family members of people in the ID cohort,the remaining population of Skane comprised the gPop cohort(n=1226955).The primary outcome measure was having at least one diagnosis in the schizophrenia spectrum(F20-F29).Secondary outcomes were single diagnoses within the schizophrenia spectrum.Results The prevalence of schizophrenia spectrum diagnoses was 7.2%in the ID cohort.This was more than an eightfold increase compared with the gPop(relative risk(RR)8.45;95%CI 7.94 to 9.00).The risk was also high among children(aged 0-18 years at the start of the study period;RR 9.42;95%CI 7.36 to 12.05).In the subcohort comprising those with a diagnosis of DS,the risk of schizophrenia diagnosis was more than twice as high as in gPop.Concomitant ASD or genetic syndrome did not carry an excess risk among people with ID when compared with the gPop.Conclusions The findings of the present study support earlier assumptions that people with vulnerable brains develop psychotic disorders more frequently and that the onset age is lower than among people in the gPop.Habilitation services for children and adolescents,as well as general mental health services,should keep in mind that schizophrenia may be present when children and adolescents show severely decreased functioning,anxiety oraggressive behaviour.展开更多
China is home to the second largest population of children and adolescents in the world.Yet demographic shifts mean that the government must manage the challenge of fewer children with the needs of an ageing populatio...China is home to the second largest population of children and adolescents in the world.Yet demographic shifts mean that the government must manage the challenge of fewer children with the needs of an ageing population,while considering the delicate tension between economic growth and environmental sustainability.We mapped the health problems and risks of contemporary school-aged children and adolescents in China against current national health policies.We involved multidisciplinary experts,including young people,with the aim of identifying actionable strategies and specific recommendations to promote child and adolescent health and wellbeing.Notwithstanding major improvements in their health over the past few decades,contemporary Chinese children and adolescents face distinct social challenges,including high academic pressures and youth unemployment,and new health concerns including obesity,mental health issues,and sexually transmitted infections.Inequality by gender,geography,and ethnicity remains a feature of health risks and outcomes.We identified a mismatch between current health determinants,risks and outcomes,and government policies.展开更多
In recent years,a great majority of excellent foreign children' s literary works have sprung up in the domestic market,so the translation of children' literature are drawn much attention.However,the relevant s...In recent years,a great majority of excellent foreign children' s literary works have sprung up in the domestic market,so the translation of children' literature are drawn much attention.However,the relevant studies which guide the translation of children literature are quite few.Reception Aesthetics which take readers reception as a goal provides a new prospective for the translation of children s literature and promote its development.展开更多
Translation of children's literature has developed so quickly in recent years that many scholars have turned to research it. However, as special readers, children's reading ability are limited. This thesis ana...Translation of children's literature has developed so quickly in recent years that many scholars have turned to research it. However, as special readers, children's reading ability are limited. This thesis analyzes and discusses the features of children's book and the possible strategies on translation of children's book.展开更多
Polysystem Theory was developed in 1970s by Israeli scholar Itamar Even-Zohar,and was well known for its three circumstances.Children' literature,as a special branch of literature,attracts more and more research n...Polysystem Theory was developed in 1970s by Israeli scholar Itamar Even-Zohar,and was well known for its three circumstances.Children' literature,as a special branch of literature,attracts more and more research nowadays.This paper explores the process of translation of Children' s Literature in China under polysystem.展开更多
With the development of society and the prosperity of Chinese literature,as a part of China’s soft power,Chinese chil dren literature is faced with the problem of international dissemination.The English version of Ca...With the development of society and the prosperity of Chinese literature,as a part of China’s soft power,Chinese chil dren literature is faced with the problem of international dissemination.The English version of Cao Wenxuan’s Bronze and Sunflow er won Hans Christian Andersen Award,the top award of children’s literature,which is a successful example of such dissemina tion.Therefore,the Chinese-English translation skills employed are worth studying.This paper aims to analyze the skills used to in the translation of short clauses,reiterative locution,simile,parallelism and dingzhen from the perspective of reception theory.It is found that by using such translation skills as omission,alliteration,repetition of prepositions and pronouns,and literal translation,the translator preserves and recreates the effect of the original text in ways that are more acceptable and idiomatic for the target reader.展开更多
Children are the future of the society. Of all the factors of children's innovation is the most important. The concept of innovation has been closely tied to the push for school choice, serving as a key rationale ...Children are the future of the society. Of all the factors of children's innovation is the most important. The concept of innovation has been closely tied to the push for school choice, serving as a key rationale for such choice plans of school assignment. While innovation continually put forward throughout Chinese education, some versions of school choice are specifically designed to accelerate the pace of innovation. This presentation will provide an analysis of acceleration of innovation.展开更多
Children's literature being a unique type of literary at a peripheral position,it is difficult for translators to reappear itsessence in the target text,due to the diverse cultures and language conventions.Since F...Children's literature being a unique type of literary at a peripheral position,it is difficult for translators to reappear itsessence in the target text,due to the diverse cultures and language conventions.Since Functional Equivalence Theory emphasizesthe functional equivalence between ST and TL which provides a new idea and method for literary translation,the thesis makes ananalysis of the Chinese version of Charlotte's Web.This comes from the perspective of Functional Equivalence Theory so as to dis-cusses whether Functional Equivalence Theory is effective in the translation of children's literature,and how has it been em-ployed.The thesis hopes that children's literature will be paid more attention,and the prosperity of children's literature transla-tion will be promoted.展开更多
Charles Dickens—the greatest representative of English critical realism writer in the 19th century.The age when he lived and his own experience contributed to his more attention to the low-class people of the society...Charles Dickens—the greatest representative of English critical realism writer in the 19th century.The age when he lived and his own experience contributed to his more attention to the low-class people of the society and children's education.His first work of critical realism Oliver Twist is also not exceptional which shows attention of the children's education,compassion and concerning about children's growth in the novel.The author argues from the view of pedagogy to analyze the causes of the tragic fate of five secondary typical characters(Monks,Dick,Noah,Dodger and Charley)to reveal children's educational view of Charles Dickens—the harmony of family relationships,the humanization of school system and the fraternity of social system in Oliver Twist.At the same time,the author would study that children educational view of Charles Dickens's influence on the children's education in our country,especially for the education of delinquent children in modern society.展开更多
Alice's Adventures in Wonderland literature development has been blocked by the monotonous theme orientation and plots off the real life. In this paper, Alice has served as an illustrative case study to present so...Alice's Adventures in Wonderland literature development has been blocked by the monotonous theme orientation and plots off the real life. In this paper, Alice has served as an illustrative case study to present some enlightenment to show creation should base on child-orientation and give detail opinions to help Chinese children's literary writers rethink the children's literature before and during the creation.展开更多
Dickens' works not only exposes the hypo crisy, greedy, turpitude upper-class society and bourgeoisies atrocity to public in Britian of the 19th century, but also shows the lower classes' miserable situation w...Dickens' works not only exposes the hypo crisy, greedy, turpitude upper-class society and bourgeoisies atrocity to public in Britian of the 19th century, but also shows the lower classes' miserable situation with deep simpathy and indignation, especially children. This essay briefly introduces the Dickens life experience and his works. And based on it, analyses the children charaters and formation of his humanitarianism.展开更多
Objective To estimate the clinical and pathological features of pancreatic solid cystic papillary tumor (SCPT) in children. Methods From 2000 to 2005, 8 cases with SCPT of the pancreas were analyzed retrospectively. A...Objective To estimate the clinical and pathological features of pancreatic solid cystic papillary tumor (SCPT) in children. Methods From 2000 to 2005, 8 cases with SCPT of the pancreas were analyzed retrospectively. All cases but one were females. Average age was 12.8 years. By case review, we discussed the clinical and pathological features of SCPT in children. Results The chief complains were abdominal pain and palpable mass. There were 3 cases in the head, 1 case in the body, and 4 cases in the tail of pancreas. The procedures employed included local resection (1 case), distal pancreatectomy (5 cases), pancreaticoduodenectomy (1 case), and biopsy (1 case). Histological examination showed solid with cystic areas and papillary protrusions in the 8 cases; as for immunohistochemical examinations, the positive rate was 100% for α-antitrypsin (AACT), 87.5% for vinmentin, and 62.5% for neuron-specific enolase (NSE). The patients were followed up for 2 months to 4 years but one was lost by follow-up and all were alive postoperatively. SCPT in 2 cases relapsed. Conclusion Occurring predominantly in young females, SCPT is usually curable by surgical resection with a favorable prognosis.展开更多
BACKGROUND：Pancreatic damage in critically ill patients is associated with the progressive failure of multiple organs, but little is known about its clinical characteristics. At present, no guidelines are available f...BACKGROUND：Pancreatic damage in critically ill patients is associated with the progressive failure of multiple organs, but little is known about its clinical characteristics. At present, no guidelines are available for the diagnosis and management of pancreatic damage. This study was undertaken to analyze the clinical and pathologic characteristics of pancreatic necrosis in critically ill children, and to find some biological markers of pancreatic damage or pancreatic necrosis.METHODS： We retrospectively reviewed the clinical data, laboratory results, and autopsy findings of 25 children, who were admitted to Hunan Children＇s Hospital, China from 2003 to 2009, and died of multiple organ failure. The autopsy revealed pancreatic necrosis in 5 children, in whom sectional or gross autopsy was performed. RESULTS： The 5 children had acute onset and a fever. Two children had abdominal pain and 2 had abdominal bulging, flatulence and gastrointestinal bleeding. Four children had abnormal liver function, characterized by decreased albumin and 3 children had elevated level of C-reactive protein （CRP）. B-ultrasonography revealed abnormal acoustic image of the pancreas in all children, and autopsy confirmed pancreatic necrosis, which may be associated with the damage of the adrenal gland, liver, lung, heart, spleen, kidney, intestine, thymus, mediastinal and mesenteric lymph nodes and other organs. Children 1 and 2 died of acute hemorrhagic necrotizing pancreatitis （AHNP）; children 3-5 died of multiple organ dysfunction syndrome （MODS） due to pancreatic necrosis. CONCLUSION： Pancreatic damage or pancreatic necrosis in critically ill children is characterized by acute onset, severity, short course, multiple organ damage or failure. It may be asymptomatic in early stage, and easy to be ignored.展开更多
BACKGROUND:The latest sepsis definition includes both infection and organ failure,as evidenced by the sequential organ failure assessment(SOFA)score.However,the applicability of the pediatric SOFA score(pSOFA)is not y...BACKGROUND:The latest sepsis definition includes both infection and organ failure,as evidenced by the sequential organ failure assessment(SOFA)score.However,the applicability of the pediatric SOFA score(pSOFA)is not yet determined.This study evaluated the effectiveness of both pSOFA and system inflammatory reaction syndrome(SIRS)scores in predicting sepsis-related pediatric deaths.METHODS:This is a retrospective multi-center cohort study including hospitalized patients<18 years old with diagnosed or not-yet-diagnosed infections.Multivariate analyses were carried out to evaluate risk factors for in-hospital mortality.According to Youden index(YI),three sub-categories of pSOFA were screened out and a new simplified pSOFA score(spSOFA)was formed.The effectiveness and accuracy of prediction of pSOFA,SIRS and spSOFA was retrieved from the area under the receiver operating characteristic curve(AUROC)and Delong’s test.RESULTS:A total of 1,092 participants were eligible for this study,and carried a 23.4%in-hospital mortality rate.The 24-h elevated pSOFA score(24 h-pSOFA),bloodstream infection,and mechanical ventilation(MV)requirement were major risk factors associated with sepsis-related deaths.The AUROC analysis confirmed that the spSOFA provided good predictive capability in sepsis-related pediatric deaths,relative to the 24 h-pSOFA and SIRS.CONCLUSIONS:The pSOFA score performed better than SIRS in diagnosing infected children with high mortality risk.However,it is both costly and cumbersome.We,therefore,proposed spSOFA to accurately predict patient outcome,without the disadvantages.Nevertheless,additional investigations,involving a large sample population,are warranted to confirm the conclusion of this study.展开更多
Background:Until January 18,2021,coronavirus disease-2019(COVID-19)has infected more than 93 million individuals and has caused a certain degree of panic.Viral pneumonia caused by common viruses such as respiratory sy...Background:Until January 18,2021,coronavirus disease-2019(COVID-19)has infected more than 93 million individuals and has caused a certain degree of panic.Viral pneumonia caused by common viruses such as respiratory syncytial virus,rhinovirus,human metapneumovirus,human bocavirus,and parainfluenza viruses have been more common in children.However,the incidence of COVID-19 in children was significantly lower than that in adults.The purpose of this study was to describe the clinical manifestations,treatment and outcomes of COVID-19 in children compared with those of other sources of viral pneumonia diagnosed during the COVID-19 outbreak.Methods:Children with COVID-19 and viral pneumonia admitted to 20 hospitals were enrolled in this retrospective multi-center cohort study.A total of 64 children with COVID-19 were defined as the COVID-19 cohort,of which 40 children who developed pneumonia were defined as the COVID-19 pneumonia cohort.Another 284 children with pneumonia caused by other viruses were defined as the viral pneumonia cohort.The epidemiologic,clinical,and laboratory findings were compared by Kolmogorov-Smirnov test,t-test,Mann-Whitney U test and Contingency table method.Drug usage,immunotherapy,blood transfusion,and need for oxygen support were collected as the treatment indexes.Mortality,intensive care needs and symptomatic duration were collected as the outcome indicators.Results:Compared with the viral pneumonia cohort,children in the COVID-19 cohort were mostly exposed to family members confirmed to have COVID-19(53/64 vs.23/284),were of older median age(6.3 years vs.3.2 years),and had a higher proportion of ground-glass opacity(GGO)on computed tomography(18/40 vs.0/38,P<0.001).Children in the COVID-19 pneumonia cohort had a lower proportion of severe cases(1/40 vs.38/284,P=0.048),and lower cases with high fever(3/40 vs.167/284,P<0.001),requiring intensive care(1/40 vs.32/284,P<0.047)and with shorter symptomatic duration(median 5d vs.8d,P<0.001).The proportion of cases with evaluated inflammatory indicators,biochemical indicators related to organ or tissue damage,D-dimer and secondary bacterial infection were lower in the COVID-19 pneumonia cohort than those in the viral pneumonia cohort(P<0.05).No statistical differences were found in the duration of positive PCR results from pharyngeal swabs in 25 children with COVID-19 who received antiviral drugs(lopinavir-ritonavir,ribavirin,and arbidol)as compared with duration in 39 children without antiviral therapy(median 10d vs.9d,P=0.885).Conclusions:The symptoms and severity of COVID-19 pneumonia in children were no more severe than those in children with other viral pneumonia.Lopinavir-ritonavir,ribavirin and arbidol do not shorten the duration of positive PCR results from pharyngeal swabs in children with COVID-19.During the COVID-19 outbreak,attention also must be given to children with infection by other pathogens infection.展开更多
BACKGROUND:Ultrasound has the first line investigation role in the diagnosis of acute appendicitis in children.The purpose of this study was to perform a quality assessment review on the visualization rate of appendix...BACKGROUND:Ultrasound has the first line investigation role in the diagnosis of acute appendicitis in children.The purpose of this study was to perform a quality assessment review on the visualization rate of appendix on ultrasound in children in the community hospital setting.METHODS:A retrospective chart review of the abdominal ultrasound findings for the visualization of the appendix was performed on paediatric patients ranging from 5 to 18 years.Data were collected from the two community hospitals of Toronto by using hospital electronic medical record for the ultrasound findings in patients presented with abdominal pain.RESULTS:Data from two community hospitals indicated visualization rate of the appendix as 11.0%and 23.2%for site 1 and site 2 respectively.In cases where the ultrasound was repeated the visualization rate remains the same.A two-proportion z-test was performed to find whether the visualization of appendix increases the likelihood of diagnosing appendicitis.The results revealed that the visualization of an appendix(P=0.52),significantly improved the diagnosis of appendicitis(z=34,P<0.001).CONCLUSION:Visualization of an appendix on ultrasound increases the likelihood of correctly diagnosing appendicitis.In our study,we found low visualization rate of appendix on ultrasound that could be the result of many factors that contribute towards the low visualization rate of an appendix on ultrasound.Hence,the challenges in identifying appendix should be minimized to improve the visualization and diagnosis of appendicitis on ultrasound.展开更多
Background The Developmental, Individual-differences, Relationship-based model(DIR/Floortime) is one of the well-known therapies for autism spectrum disorder(ASD), in which its main principle is to promote holistic de...Background The Developmental, Individual-differences, Relationship-based model(DIR/Floortime) is one of the well-known therapies for autism spectrum disorder(ASD), in which its main principle is to promote holistic development of an individual and relationships between the caregivers and children. Parental engagement is an essential element to DIR/Floortime treatment and involved with various factors. Finding those supporting factors and eliminating factors that might be an obstacle for parental engagement are essential for children with ASD to receive the full benefits of treatment.Aim To examine the association between parents, children and provider and service factors with parental engagement in DIR/Floortime treatment.Methods This is a cross-sectional study of parents with children aged 2–12 years who were diagnosed with ASD. Data were collected using a parent, child, provider and service factors questionnaire. Patient Health Questionaire-9, Clinical Global Impressions-Severity and Childhood Autism Rating Scale were also used to collect data. For parent engagement in DIR/Floortime, we evaluated quality of parental engagement in DIR/Floortime and parent application of DIR/Floortime techniques at home. Finally, Clinical Global Impressions-Improvement and Functional Emotional Developmental Level were used to assess child development.Results Parents who were married, had lower income and higher knowledge of DIR/Floortime theory were more likely to have higher parent engagement(χ2=4.43, p=0.035; χ2=13.1, p<0.001 and χ2=4.06, p=0.044 respectively). Furthermore, severity of the diagnosis and the continuation of the treatment significantly correlated with parent engagement(χ2=5.83, p=0.016 and χ2=4.72, p=0.030 respectively). It was found that parents who applied the techniques for more than 1 hour/day, or had a high-quality parent engagement, significantly correlated with better improvement in child development(t=-2.03, p=0.049; t=-2.00, p=0.053, respectively).Conclusion Factors associated with parents, children, and provider and service factors had a significant correlation with parent engagement in DIR/Floortime in which children whose parents had more engagement in DIR/Floortime techniques had better improvement in child development.展开更多
The clinical data of 3 patients with rhabdomyolysis(RM)caused by different viral infections were retrospectively reviewed.The diagnoses were established according to the clinical symptoms,physical signs,myocardial enz...The clinical data of 3 patients with rhabdomyolysis(RM)caused by different viral infections were retrospectively reviewed.The diagnoses were established according to the clinical symptoms,physical signs,myocardial enzymes,and muscle biopsy.Case 1 was a 11-year-old boy with influenza A virus infection,whose major symptoms were fever,cough and myalgia.After the treatment of active anti-virus,hydration,and alkalinization,the patient completely recovered.Case 2 was a 10-year-old girl with Epstein-Barr(EB)virus infection who had significant musculoskeletal pain and muscle weakness symptoms with significantly elevated serum creatine kinase.After active hydration and anti-infective treatment,the patient s condition returned to normal.Case 3 was a 15-year・old boy with human cytomegalovirus infection,whose symptoms were mainly repeated fever,accompanied by myalgia and facial edema.Antibacterial therapy was ineffective,and the disease progressed with respiratory muscle weakness and multiple organ injuries.After antiviral treatment,respiratory support and hemofiltration,the symptoms relieved and patient recovered without sequela.With literature review,we believe that although influenza virus,Epstein-Barr virus and cytomegalovirus rarely cause RM in children,it should be attached attention to.With early diagnosis and treatment,the prognosis is favorable.展开更多
BACKGROUND： There is a lack of evidence on description of burden and cases of childhood poisoning in developing countries. This study aimed to assess the characteristics of children with acute poisoning, and factors ...BACKGROUND： There is a lack of evidence on description of burden and cases of childhood poisoning in developing countries. This study aimed to assess the characteristics of children with acute poisoning, and factors for time of presentation to health facility and nature of poisoning.METHODS： A cross-sectional study was conducted at three major pediatric referral hospitals in Addis Ababa, Ethiopia. Description of demographics of children with acute poisoning and factors associated with time to presentation and nature of poisoning were analyzed. Data were entered to Epi info 3.5.3 and analyzed with SPSS version 20.RESULTS： Over three years, we retrieved records of a total of 128 children admitted for acute poisoning. The mean age of victims was 5.46 （SD, standard deviation=4.48） years. The majority （29.7%） were poisoned by prescribed drugs. Most poisoning incidents （73.5%） were unintentional in nature. The median time to health facility visit was 15.5 hours. Age less than 2 years was related to earlier presentation to health facility （P=0.010, OR=0.28, 95%CI=0.10–0.74）. Children with age more than 5 years was more likely to have intentional poisoning （χ2=25.06, P〈0.0001）. None of the victims was provided psychosocial evaluation and counseling.CONCLUSION： Most poisoning incidents are unintentional. Prescribed drugs are the commonest causes. Psychosocial counseling and care for the affected children is lacking. Family and community education should be given on prevention of poisoning. We recommend that caregivers take the required action in keeping prescribed drugs at home. Psychosocial support should be part of care and treatment of children with poisoning.展开更多
文摘·AIM:To identify various risk factors that may play a significant role in the development of congenital nasolacrimal duct obstruction(CNLDO).·METHODS:This observational case-control study included a case group of 122 children less than two years of age with CNLDO who underwent probing and irrigation treatment at the ophthalmology department of Imam Khomeini Hospital in Ahvaz,Iran,from June 2022 to June2024.A control group of 122 age-matched children without CNLDO was also included for comparison.Data was collected from the children's medical records.·RESULTS:The study found a significant correlation between the occurrence of CNLDO and several maternal factors,such as preeclampsia,the use of levothyroxine,hypothyroidism,having more than three pregnancies(gravidity>3),natural pregnancy,and gestational diabetes mellitus.Additionally,in children,factors,such as oxygen therapy,anemia,reflux,jaundice,and a family history of CNLDO in first-degree relatives were associated with CNLDO,and maternal preeclampsia and hypothyroidism were found to significantly increase the risk of developing CNLDO in children.·CONCLUSION:Given that CNLDO affects both premature and full-term children,the present findings may potentially facilitate the early identification of children and infants at risk of nasolacrimal duct obstruction,thereby preventing the onset of chronic dacryocystitis.
基金study was funded by F0RTE(2019-00105 and 2021-01862).
文摘Background The knowledge about the prevalence of schizophrenia among people with intellectual disabilities(ID)is sparse,particularly concerning the distribution in different age groups.Aims To investigate the prevalence of diagnoses in the schizophrenia spectrum among people with ID compared with the general population(gPop).Methods This was an 8-year longitudinal register study.The participants were all residents of Skane on 1 January 2014.People with a diagnosis of ID(F7 in International Statistical Classificationof Diseases and RelatedHealth Problems 10th Revision)or Down syndrome(DS;Q90),or service and support for people with ID/autism spectrum disorder(ASD)comprised the ID cohort(n=14716).After excluding family members of people in the ID cohort,the remaining population of Skane comprised the gPop cohort(n=1226955).The primary outcome measure was having at least one diagnosis in the schizophrenia spectrum(F20-F29).Secondary outcomes were single diagnoses within the schizophrenia spectrum.Results The prevalence of schizophrenia spectrum diagnoses was 7.2%in the ID cohort.This was more than an eightfold increase compared with the gPop(relative risk(RR)8.45;95%CI 7.94 to 9.00).The risk was also high among children(aged 0-18 years at the start of the study period;RR 9.42;95%CI 7.36 to 12.05).In the subcohort comprising those with a diagnosis of DS,the risk of schizophrenia diagnosis was more than twice as high as in gPop.Concomitant ASD or genetic syndrome did not carry an excess risk among people with ID when compared with the gPop.Conclusions The findings of the present study support earlier assumptions that people with vulnerable brains develop psychotic disorders more frequently and that the onset age is lower than among people in the gPop.Habilitation services for children and adolescents,as well as general mental health services,should keep in mind that schizophrenia may be present when children and adolescents show severely decreased functioning,anxiety oraggressive behaviour.
文摘China is home to the second largest population of children and adolescents in the world.Yet demographic shifts mean that the government must manage the challenge of fewer children with the needs of an ageing population,while considering the delicate tension between economic growth and environmental sustainability.We mapped the health problems and risks of contemporary school-aged children and adolescents in China against current national health policies.We involved multidisciplinary experts,including young people,with the aim of identifying actionable strategies and specific recommendations to promote child and adolescent health and wellbeing.Notwithstanding major improvements in their health over the past few decades,contemporary Chinese children and adolescents face distinct social challenges,including high academic pressures and youth unemployment,and new health concerns including obesity,mental health issues,and sexually transmitted infections.Inequality by gender,geography,and ethnicity remains a feature of health risks and outcomes.We identified a mismatch between current health determinants,risks and outcomes,and government policies.
文摘In recent years,a great majority of excellent foreign children' s literary works have sprung up in the domestic market,so the translation of children' literature are drawn much attention.However,the relevant studies which guide the translation of children literature are quite few.Reception Aesthetics which take readers reception as a goal provides a new prospective for the translation of children s literature and promote its development.
文摘Translation of children's literature has developed so quickly in recent years that many scholars have turned to research it. However, as special readers, children's reading ability are limited. This thesis analyzes and discusses the features of children's book and the possible strategies on translation of children's book.
文摘Polysystem Theory was developed in 1970s by Israeli scholar Itamar Even-Zohar,and was well known for its three circumstances.Children' literature,as a special branch of literature,attracts more and more research nowadays.This paper explores the process of translation of Children' s Literature in China under polysystem.
文摘With the development of society and the prosperity of Chinese literature,as a part of China’s soft power,Chinese chil dren literature is faced with the problem of international dissemination.The English version of Cao Wenxuan’s Bronze and Sunflow er won Hans Christian Andersen Award,the top award of children’s literature,which is a successful example of such dissemina tion.Therefore,the Chinese-English translation skills employed are worth studying.This paper aims to analyze the skills used to in the translation of short clauses,reiterative locution,simile,parallelism and dingzhen from the perspective of reception theory.It is found that by using such translation skills as omission,alliteration,repetition of prepositions and pronouns,and literal translation,the translator preserves and recreates the effect of the original text in ways that are more acceptable and idiomatic for the target reader.
文摘Children are the future of the society. Of all the factors of children's innovation is the most important. The concept of innovation has been closely tied to the push for school choice, serving as a key rationale for such choice plans of school assignment. While innovation continually put forward throughout Chinese education, some versions of school choice are specifically designed to accelerate the pace of innovation. This presentation will provide an analysis of acceleration of innovation.
文摘Children's literature being a unique type of literary at a peripheral position,it is difficult for translators to reappear itsessence in the target text,due to the diverse cultures and language conventions.Since Functional Equivalence Theory emphasizesthe functional equivalence between ST and TL which provides a new idea and method for literary translation,the thesis makes ananalysis of the Chinese version of Charlotte's Web.This comes from the perspective of Functional Equivalence Theory so as to dis-cusses whether Functional Equivalence Theory is effective in the translation of children's literature,and how has it been em-ployed.The thesis hopes that children's literature will be paid more attention,and the prosperity of children's literature transla-tion will be promoted.
文摘Charles Dickens—the greatest representative of English critical realism writer in the 19th century.The age when he lived and his own experience contributed to his more attention to the low-class people of the society and children's education.His first work of critical realism Oliver Twist is also not exceptional which shows attention of the children's education,compassion and concerning about children's growth in the novel.The author argues from the view of pedagogy to analyze the causes of the tragic fate of five secondary typical characters(Monks,Dick,Noah,Dodger and Charley)to reveal children's educational view of Charles Dickens—the harmony of family relationships,the humanization of school system and the fraternity of social system in Oliver Twist.At the same time,the author would study that children educational view of Charles Dickens's influence on the children's education in our country,especially for the education of delinquent children in modern society.
文摘Alice's Adventures in Wonderland literature development has been blocked by the monotonous theme orientation and plots off the real life. In this paper, Alice has served as an illustrative case study to present some enlightenment to show creation should base on child-orientation and give detail opinions to help Chinese children's literary writers rethink the children's literature before and during the creation.
文摘Dickens' works not only exposes the hypo crisy, greedy, turpitude upper-class society and bourgeoisies atrocity to public in Britian of the 19th century, but also shows the lower classes' miserable situation with deep simpathy and indignation, especially children. This essay briefly introduces the Dickens life experience and his works. And based on it, analyses the children charaters and formation of his humanitarianism.
文摘Objective To estimate the clinical and pathological features of pancreatic solid cystic papillary tumor (SCPT) in children. Methods From 2000 to 2005, 8 cases with SCPT of the pancreas were analyzed retrospectively. All cases but one were females. Average age was 12.8 years. By case review, we discussed the clinical and pathological features of SCPT in children. Results The chief complains were abdominal pain and palpable mass. There were 3 cases in the head, 1 case in the body, and 4 cases in the tail of pancreas. The procedures employed included local resection (1 case), distal pancreatectomy (5 cases), pancreaticoduodenectomy (1 case), and biopsy (1 case). Histological examination showed solid with cystic areas and papillary protrusions in the 8 cases; as for immunohistochemical examinations, the positive rate was 100% for α-antitrypsin (AACT), 87.5% for vinmentin, and 62.5% for neuron-specific enolase (NSE). The patients were followed up for 2 months to 4 years but one was lost by follow-up and all were alive postoperatively. SCPT in 2 cases relapsed. Conclusion Occurring predominantly in young females, SCPT is usually curable by surgical resection with a favorable prognosis.
文摘BACKGROUND：Pancreatic damage in critically ill patients is associated with the progressive failure of multiple organs, but little is known about its clinical characteristics. At present, no guidelines are available for the diagnosis and management of pancreatic damage. This study was undertaken to analyze the clinical and pathologic characteristics of pancreatic necrosis in critically ill children, and to find some biological markers of pancreatic damage or pancreatic necrosis.METHODS： We retrospectively reviewed the clinical data, laboratory results, and autopsy findings of 25 children, who were admitted to Hunan Children＇s Hospital, China from 2003 to 2009, and died of multiple organ failure. The autopsy revealed pancreatic necrosis in 5 children, in whom sectional or gross autopsy was performed. RESULTS： The 5 children had acute onset and a fever. Two children had abdominal pain and 2 had abdominal bulging, flatulence and gastrointestinal bleeding. Four children had abnormal liver function, characterized by decreased albumin and 3 children had elevated level of C-reactive protein （CRP）. B-ultrasonography revealed abnormal acoustic image of the pancreas in all children, and autopsy confirmed pancreatic necrosis, which may be associated with the damage of the adrenal gland, liver, lung, heart, spleen, kidney, intestine, thymus, mediastinal and mesenteric lymph nodes and other organs. Children 1 and 2 died of acute hemorrhagic necrotizing pancreatitis （AHNP）; children 3-5 died of multiple organ dysfunction syndrome （MODS） due to pancreatic necrosis. CONCLUSION： Pancreatic damage or pancreatic necrosis in critically ill children is characterized by acute onset, severity, short course, multiple organ damage or failure. It may be asymptomatic in early stage, and easy to be ignored.
文摘BACKGROUND:The latest sepsis definition includes both infection and organ failure,as evidenced by the sequential organ failure assessment(SOFA)score.However,the applicability of the pediatric SOFA score(pSOFA)is not yet determined.This study evaluated the effectiveness of both pSOFA and system inflammatory reaction syndrome(SIRS)scores in predicting sepsis-related pediatric deaths.METHODS:This is a retrospective multi-center cohort study including hospitalized patients<18 years old with diagnosed or not-yet-diagnosed infections.Multivariate analyses were carried out to evaluate risk factors for in-hospital mortality.According to Youden index(YI),three sub-categories of pSOFA were screened out and a new simplified pSOFA score(spSOFA)was formed.The effectiveness and accuracy of prediction of pSOFA,SIRS and spSOFA was retrieved from the area under the receiver operating characteristic curve(AUROC)and Delong’s test.RESULTS:A total of 1,092 participants were eligible for this study,and carried a 23.4%in-hospital mortality rate.The 24-h elevated pSOFA score(24 h-pSOFA),bloodstream infection,and mechanical ventilation(MV)requirement were major risk factors associated with sepsis-related deaths.The AUROC analysis confirmed that the spSOFA provided good predictive capability in sepsis-related pediatric deaths,relative to the 24 h-pSOFA and SIRS.CONCLUSIONS:The pSOFA score performed better than SIRS in diagnosing infected children with high mortality risk.However,it is both costly and cumbersome.We,therefore,proposed spSOFA to accurately predict patient outcome,without the disadvantages.Nevertheless,additional investigations,involving a large sample population,are warranted to confirm the conclusion of this study.
基金Scientific Research Project of Military Logistics Department,Grant Award Number:CLB20J032。
文摘Background:Until January 18,2021,coronavirus disease-2019(COVID-19)has infected more than 93 million individuals and has caused a certain degree of panic.Viral pneumonia caused by common viruses such as respiratory syncytial virus,rhinovirus,human metapneumovirus,human bocavirus,and parainfluenza viruses have been more common in children.However,the incidence of COVID-19 in children was significantly lower than that in adults.The purpose of this study was to describe the clinical manifestations,treatment and outcomes of COVID-19 in children compared with those of other sources of viral pneumonia diagnosed during the COVID-19 outbreak.Methods:Children with COVID-19 and viral pneumonia admitted to 20 hospitals were enrolled in this retrospective multi-center cohort study.A total of 64 children with COVID-19 were defined as the COVID-19 cohort,of which 40 children who developed pneumonia were defined as the COVID-19 pneumonia cohort.Another 284 children with pneumonia caused by other viruses were defined as the viral pneumonia cohort.The epidemiologic,clinical,and laboratory findings were compared by Kolmogorov-Smirnov test,t-test,Mann-Whitney U test and Contingency table method.Drug usage,immunotherapy,blood transfusion,and need for oxygen support were collected as the treatment indexes.Mortality,intensive care needs and symptomatic duration were collected as the outcome indicators.Results:Compared with the viral pneumonia cohort,children in the COVID-19 cohort were mostly exposed to family members confirmed to have COVID-19(53/64 vs.23/284),were of older median age(6.3 years vs.3.2 years),and had a higher proportion of ground-glass opacity(GGO)on computed tomography(18/40 vs.0/38,P<0.001).Children in the COVID-19 pneumonia cohort had a lower proportion of severe cases(1/40 vs.38/284,P=0.048),and lower cases with high fever(3/40 vs.167/284,P<0.001),requiring intensive care(1/40 vs.32/284,P<0.047)and with shorter symptomatic duration(median 5d vs.8d,P<0.001).The proportion of cases with evaluated inflammatory indicators,biochemical indicators related to organ or tissue damage,D-dimer and secondary bacterial infection were lower in the COVID-19 pneumonia cohort than those in the viral pneumonia cohort(P<0.05).No statistical differences were found in the duration of positive PCR results from pharyngeal swabs in 25 children with COVID-19 who received antiviral drugs(lopinavir-ritonavir,ribavirin,and arbidol)as compared with duration in 39 children without antiviral therapy(median 10d vs.9d,P=0.885).Conclusions:The symptoms and severity of COVID-19 pneumonia in children were no more severe than those in children with other viral pneumonia.Lopinavir-ritonavir,ribavirin and arbidol do not shorten the duration of positive PCR results from pharyngeal swabs in children with COVID-19.During the COVID-19 outbreak,attention also must be given to children with infection by other pathogens infection.
文摘BACKGROUND:Ultrasound has the first line investigation role in the diagnosis of acute appendicitis in children.The purpose of this study was to perform a quality assessment review on the visualization rate of appendix on ultrasound in children in the community hospital setting.METHODS:A retrospective chart review of the abdominal ultrasound findings for the visualization of the appendix was performed on paediatric patients ranging from 5 to 18 years.Data were collected from the two community hospitals of Toronto by using hospital electronic medical record for the ultrasound findings in patients presented with abdominal pain.RESULTS:Data from two community hospitals indicated visualization rate of the appendix as 11.0%and 23.2%for site 1 and site 2 respectively.In cases where the ultrasound was repeated the visualization rate remains the same.A two-proportion z-test was performed to find whether the visualization of appendix increases the likelihood of diagnosing appendicitis.The results revealed that the visualization of an appendix(P=0.52),significantly improved the diagnosis of appendicitis(z=34,P<0.001).CONCLUSION:Visualization of an appendix on ultrasound increases the likelihood of correctly diagnosing appendicitis.In our study,we found low visualization rate of appendix on ultrasound that could be the result of many factors that contribute towards the low visualization rate of an appendix on ultrasound.Hence,the challenges in identifying appendix should be minimized to improve the visualization and diagnosis of appendicitis on ultrasound.
文摘Background The Developmental, Individual-differences, Relationship-based model(DIR/Floortime) is one of the well-known therapies for autism spectrum disorder(ASD), in which its main principle is to promote holistic development of an individual and relationships between the caregivers and children. Parental engagement is an essential element to DIR/Floortime treatment and involved with various factors. Finding those supporting factors and eliminating factors that might be an obstacle for parental engagement are essential for children with ASD to receive the full benefits of treatment.Aim To examine the association between parents, children and provider and service factors with parental engagement in DIR/Floortime treatment.Methods This is a cross-sectional study of parents with children aged 2–12 years who were diagnosed with ASD. Data were collected using a parent, child, provider and service factors questionnaire. Patient Health Questionaire-9, Clinical Global Impressions-Severity and Childhood Autism Rating Scale were also used to collect data. For parent engagement in DIR/Floortime, we evaluated quality of parental engagement in DIR/Floortime and parent application of DIR/Floortime techniques at home. Finally, Clinical Global Impressions-Improvement and Functional Emotional Developmental Level were used to assess child development.Results Parents who were married, had lower income and higher knowledge of DIR/Floortime theory were more likely to have higher parent engagement(χ2=4.43, p=0.035; χ2=13.1, p<0.001 and χ2=4.06, p=0.044 respectively). Furthermore, severity of the diagnosis and the continuation of the treatment significantly correlated with parent engagement(χ2=5.83, p=0.016 and χ2=4.72, p=0.030 respectively). It was found that parents who applied the techniques for more than 1 hour/day, or had a high-quality parent engagement, significantly correlated with better improvement in child development(t=-2.03, p=0.049; t=-2.00, p=0.053, respectively).Conclusion Factors associated with parents, children, and provider and service factors had a significant correlation with parent engagement in DIR/Floortime in which children whose parents had more engagement in DIR/Floortime techniques had better improvement in child development.
基金Fund supported by the National Natural Science Foundation of China(81770026)Natural Science Foundation of Jilin Province(20180101157JC).
文摘The clinical data of 3 patients with rhabdomyolysis(RM)caused by different viral infections were retrospectively reviewed.The diagnoses were established according to the clinical symptoms,physical signs,myocardial enzymes,and muscle biopsy.Case 1 was a 11-year-old boy with influenza A virus infection,whose major symptoms were fever,cough and myalgia.After the treatment of active anti-virus,hydration,and alkalinization,the patient completely recovered.Case 2 was a 10-year-old girl with Epstein-Barr(EB)virus infection who had significant musculoskeletal pain and muscle weakness symptoms with significantly elevated serum creatine kinase.After active hydration and anti-infective treatment,the patient s condition returned to normal.Case 3 was a 15-year・old boy with human cytomegalovirus infection,whose symptoms were mainly repeated fever,accompanied by myalgia and facial edema.Antibacterial therapy was ineffective,and the disease progressed with respiratory muscle weakness and multiple organ injuries.After antiviral treatment,respiratory support and hemofiltration,the symptoms relieved and patient recovered without sequela.With literature review,we believe that although influenza virus,Epstein-Barr virus and cytomegalovirus rarely cause RM in children,it should be attached attention to.With early diagnosis and treatment,the prognosis is favorable.
文摘BACKGROUND： There is a lack of evidence on description of burden and cases of childhood poisoning in developing countries. This study aimed to assess the characteristics of children with acute poisoning, and factors for time of presentation to health facility and nature of poisoning.METHODS： A cross-sectional study was conducted at three major pediatric referral hospitals in Addis Ababa, Ethiopia. Description of demographics of children with acute poisoning and factors associated with time to presentation and nature of poisoning were analyzed. Data were entered to Epi info 3.5.3 and analyzed with SPSS version 20.RESULTS： Over three years, we retrieved records of a total of 128 children admitted for acute poisoning. The mean age of victims was 5.46 （SD, standard deviation=4.48） years. The majority （29.7%） were poisoned by prescribed drugs. Most poisoning incidents （73.5%） were unintentional in nature. The median time to health facility visit was 15.5 hours. Age less than 2 years was related to earlier presentation to health facility （P=0.010, OR=0.28, 95%CI=0.10–0.74）. Children with age more than 5 years was more likely to have intentional poisoning （χ2=25.06, P〈0.0001）. None of the victims was provided psychosocial evaluation and counseling.CONCLUSION： Most poisoning incidents are unintentional. Prescribed drugs are the commonest causes. Psychosocial counseling and care for the affected children is lacking. Family and community education should be given on prevention of poisoning. We recommend that caregivers take the required action in keeping prescribed drugs at home. Psychosocial support should be part of care and treatment of children with poisoning.
