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CHARGE综合征1例病例报告
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作者 周斯斯 阮雯聪 +2 位作者 陈曦 何瑾 李海峰 《中国循证儿科杂志》 北大核心 2025年第2期157-160,共4页
回顾性分析2022年11月浙江大学医学院附属儿童医院康复科收治的1例CHARGE综合征患儿的临床资料及遗传学特点,并检索相关文献进行复习。患儿,女,3日龄,因“足月低出生体重儿,纳差3 d”首次就诊,后期就诊过程中,突出症状为喂养困难、生长... 回顾性分析2022年11月浙江大学医学院附属儿童医院康复科收治的1例CHARGE综合征患儿的临床资料及遗传学特点,并检索相关文献进行复习。患儿,女,3日龄,因“足月低出生体重儿,纳差3 d”首次就诊,后期就诊过程中,突出症状为喂养困难、生长发育迟缓、心脏畸形、感音神经性听觉丧失、外耳廓畸形;并检出CHD7基因致病性杂合变异c.23812384del(p.S794Lfs*8),父母均未检出该变异。行动脉导管结扎术及长期康复治疗后,患儿心脏畸形改善,吞咽及运动能力好转。因此,对于存在以上类似症状的患儿,需警惕CHARGE综合征,及时完善基因检测,以达到早诊断、早干预,改善预后。 展开更多
关键词 charge综合征 CHD7基因 诊断 儿童
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Study on the formation characteristics of underwater hemispherical shaped charge jet and its penetration performance into concrete 被引量:1
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作者 Chao Cao Jinxiang Wang +5 位作者 Lingquan Kong Kui Tang Yujie Xiao Yangchen Gu Ming Yang Jian Wang 《Defence Technology(防务技术)》 2025年第5期180-196,共17页
Shaped charge has been widely used for penetrating concrete.However,due to the obvious difference between the propagation of shock waves and explosion products in water and air,the theory governing the formation of sh... Shaped charge has been widely used for penetrating concrete.However,due to the obvious difference between the propagation of shock waves and explosion products in water and air,the theory governing the formation of shaped charge jets in water as well as the underwater penetration effect of concrete need to be studied.In this paper,we introduced a modified forming theory of an underwater hemispherical shaped charge,and investigated the behavior of jet formation and concrete penetration in both air and water experimentally and numerically.The results show that the modified jet forming theory predicts the jet velocity of the hemispherical liner with an error of less than 10%.The underwater jets exhibit at least 3%faster and 11%longer than those in air.Concrete shows different failure modes after penetration in air and water.The depth of penetration deepens at least 18.75%after underwater penetration,accompanied by deeper crater with 65%smaller radius.Moreover,cracks throughout the entire target are formed,whereas cracks exist only near the penetration hole in air.This comprehensive study provides guidance for optimizing the structure of shaped charge and improves the understanding of the permeability effect of concrete in water. 展开更多
关键词 Shaped charge jet Underwater penetration Formation characteristic Concrete failure
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Experimental and numerical investigation of cavity characteristics in behind-armor liquid-filled containers under shaped charge jet impact 被引量:1
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作者 Shixin Ma Xiangdong Li Lanwei Zhou 《Defence Technology(防务技术)》 2025年第5期242-259,共18页
The cavity characteristics in liquid-filled containers caused by high-velocity impacts represent an important area of research in hydrodynamic ram phenomena.The dynamic expansion of the cavity induces liquid pressure ... The cavity characteristics in liquid-filled containers caused by high-velocity impacts represent an important area of research in hydrodynamic ram phenomena.The dynamic expansion of the cavity induces liquid pressure variations,potentially causing catastrophic damage to the container.Current studies mainly focus on non-deforming projectiles,such as fragments,with limited exploration of shaped charge jets.In this paper,a uniquely experimental system was designed to record cavity profiles in behind-armor liquid-filled containers subjected to shaped charge jet impacts.The impact process was then numerically reproduced using the explicit simulation program ANSYS LS-DYNA with the Structured Arbitrary Lagrangian-Eulerian(S-ALE)solver.The formation mechanism,along with the dimensional and shape evolution of the cavity was investigated.Additionally,the influence of the impact kinetic energy of the jet on the cavity characteristics was analyzed.The findings reveal that the cavity profile exhibits a conical shape,primarily driven by direct jet impact and inertial effects.The expansion rates of both cavity length and maximum radius increase with jet impact kinetic energy.When the impact kinetic energy is reduced to 28.2 kJ or below,the length-to-diameter ratio of the cavity ultimately stabilizes at approximately 7. 展开更多
关键词 Cavity characteristics Shaped charge jet Behind-armor liquid-filled container Impact kinetic energy Hydrodynamic ram
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Time-resolved Electroluminescence of Charge Carrier Dynamics in Multiple-emitting-layer White QLEDs with Polyethyleneimine Interlayers
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作者 YAN Shanshan WANG Shen +2 位作者 LIANG Wencheng LIU Weiwei KONG Youchao 《发光学报》 北大核心 2025年第10期1851-1861,共11页
The charge carrier transport and recombination dynamics in the quantum dots-based light-emitting diodes(QLEDs)featuring multiple emitting layers(M-EMLs)has a great impact on the device performance.In this work,QLEDs b... The charge carrier transport and recombination dynamics in the quantum dots-based light-emitting diodes(QLEDs)featuring multiple emitting layers(M-EMLs)has a great impact on the device performance.In this work,QLEDs based on M-EMLs separated by polyethyleneimine ethoxylated(PEIE)layer with different stacking sequences of blue(B),green(G),and red(R)QDs layer were used to intuitively explore the injection,transportation and recombination processes of the charge carriers in QLEDs by using the time-resolved electroluminescence(TrEL)spectra.From the TrEL spectra mea-surements,green and red emissions were obtained first in the QLEDs with the EMLs sequences of G/PEIE/B/PEIE/R and B/PEIE/R/PEIE/G along the direction of light emission,respectively.While the QLEDs adopt EMLs sequences of B/PEIE/G/PEIE/R,the blue,green and red emissions were obtained nearly at the same time.The above phenomenon can be attributed to different charge carrier transmission and radiation recombination process in the EMLs due to different valence band offsets and conduction band offsets between R-,G-and B-QDs by using different sequences of EMLs.White emission with coordi-nates of(0.31,0.31)and correlated color temperature(CCT)of 5916 K was obtained in the QLEDs with the EMLs se-quences of B/PEIE/G/PEIE/R,which can be attributed to the relative uniform emission of B-,G-and R-QDs due to the effec-tive injection and radiation recombination of charge carriers in each of the EMLs.The above results have great significance for further understanding and improving the performance of QLEDs with M-EMLs. 展开更多
关键词 white QLEDs multiple emitting layers TrEL spectra charge carrier dynamics
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Simulation and experimental study on the use of shaped charge jet as transient antennas for radiating electromagnetic pulses
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作者 Jiahui Guo Bin Ma +2 位作者 Zhengxiang Huang Yong Peng Xin Jia 《Defence Technology(防务技术)》 2025年第5期260-274,共15页
In this study,the potential application of shaped charge jets as transient antennas for electromagnetic signal transmission was explored and an electromagnetic pulse radiation system with a shaped charge jet as a tran... In this study,the potential application of shaped charge jets as transient antennas for electromagnetic signal transmission was explored and an electromagnetic pulse radiation system with a shaped charge jet as a transient antenna was proposed.During the research,crucial characteristics of the transient antenna formed by a shaped charge with a 30 mm diameter,such as resonant frequency,radiation pattern,and radiation efficiency,were evaluated.The typical shaped charge jet morphology was obtained based on the simulations,in which it could insight the dynamic behavior of the shaped charge jet selected.An equivalent model experiment was employed to test the radiation efficiency,and it showed that a shorting pin loading method could increase the relative bandwidth of the jet antenna to 32.8%,and the experimental results correlate with the theoretical predictions for half-wave dipole antennas reasonably well.Additionally,variations in the diameter of the shaped charge jet were found to affect the input impedance and impedance bandwidth,while the length of the jet influenced the resonant frequency of the antenna.This suggests that altering these parameters can achieve reconfigurability of the jet antenna. 展开更多
关键词 Shaped charge Transient antenna Electromagnetic pulse Radiated power Reconfigurable antenna
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The detonation wave propagation and the calculation methods for shock wave overpressure distribution of composite charges
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作者 Jiaxin Yu Weibing Li +2 位作者 Junbao Li Xiaoming Wang Wenbin Li 《Defence Technology(防务技术)》 2025年第6期204-220,共17页
To explore the design criteria for composite charges and reveal the intrinsic relationship between the detonation wave propagation in composite charges and the overall energy distribution of shock waves,this study ana... To explore the design criteria for composite charges and reveal the intrinsic relationship between the detonation wave propagation in composite charges and the overall energy distribution of shock waves,this study analyzes the propagation and interaction processes of detonation waves in composite charges with different structural dimensions and explosive combinations. It also investigates the spatial distribution characteristics of the resulting shock wave loads. Based on dimensional analysis theory, a theoretical analysis of the shock wave overpressure distribution in free air fields is conducted. Utilizing the derived dimensionless function relationships, the hydrocode AUTODYN is employed to investigate the effects of charge structure parameters and explosive combinations on the internal overdriven detonation phenomena and the distribution of shock wave loads. It is found that the overdriven detonation phenomenon in the inner layer of composite charges increases the strength of the axial detonation wave,thereby enhancing the intensity of the primary end wave formed upon refraction into the air, which affects the distribution characteristics of the shock wave overpressure. Research has shown that increasing the thickness ratio and detonation velocity ratio of composite charges is beneficial for exacerbating the phenomenon of overdriven detonation, improving the primary end wave intensity and axial overpressure. This gain effect gradually weakens with the propagation of shock waves. When overdriven detonation occurs inside the composite charge, the detonation pressure first increases and then decreases. The Mach reflection pressure of the composite charge with a larger aspect ratio is attenuated to a greater extent. In addition, as the aspect ratio of the composite charge increases, the shock wave energy gradually flows from the axial direction to the radial direction. Therefore, as the aspect ratio of the composite charge increases, the primary end wave intensity and axial overpressure gradually decrease. 展开更多
关键词 Composite charge Overdriven detonation Shock wave overpressure Dimensional analysis Numerical simulation
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An efficient and accurate numerical method for simulating close-range blast loads of cylindrical charges based on neural network
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作者 Ting Liu Changhai Chen +2 位作者 Han Li Yaowen Yu Yuansheng Cheng 《Defence Technology(防务技术)》 2025年第2期257-271,共15页
To address the problems of low accuracy by the CONWEP model and poor efficiency by the Coupled Eulerian-Lagrangian(CEL)method in predicting close-range air blast loads of cylindrical charges,a neural network-based sim... To address the problems of low accuracy by the CONWEP model and poor efficiency by the Coupled Eulerian-Lagrangian(CEL)method in predicting close-range air blast loads of cylindrical charges,a neural network-based simulation(NNS)method with higher accuracy and better efficiency was proposed.The NNS method consisted of three main steps.First,the parameters of blast loads,including the peak pressures and impulses of cylindrical charges with different aspect ratios(L/D)at different stand-off distances and incident angles were obtained by two-dimensional numerical simulations.Subsequently,incident shape factors of cylindrical charges with arbitrary aspect ratios were predicted by a neural network.Finally,reflected shape factors were derived and implemented into the subroutine of the ABAQUS code to modify the CONWEP model,including modifications of impulse and overpressure.The reliability of the proposed NNS method was verified by related experimental results.Remarkable accuracy improvement was acquired by the proposed NNS method compared with the unmodified CONWEP model.Moreover,huge efficiency superiority was obtained by the proposed NNS method compared with the CEL method.The proposed NNS method showed good accuracy when the scaled distance was greater than 0.2 m/kg^(1/3).It should be noted that there is no need to generate a new dataset again since the blast loads satisfy the similarity law,and the proposed NNS method can be directly used to simulate the blast loads generated by different cylindrical charges.The proposed NNS method with high efficiency and accuracy can be used as an effective method to analyze the dynamic response of structures under blast loads,and it has significant application prospects in designing protective structures. 展开更多
关键词 Close-range air blast load Cylindrical charge Numerical method Neural network CEL method CONWEP model
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Investigation of penetration characteristics of shaped charge jet impacting behind-armor liquid-filled containers
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作者 Shixin Ma Yuchi Tang +1 位作者 Lanwei Zhou Xiangdong Li 《Defence Technology(防务技术)》 2025年第11期223-241,共19页
The impact of high-velocity penetrators into liquid-filled containers can generate hydrodynamic ram effects,potentially causing catastrophic structural damage to the container.Previous studies have primarily focused o... The impact of high-velocity penetrators into liquid-filled containers can generate hydrodynamic ram effects,potentially causing catastrophic structural damage to the container.Previous studies have primarily focused on undeformed penetrators,such as fragments or bullets,with limited attention directed toward shaped charge jets.This study investigates the penetration characteristics of shaped charge jets impacting behind-armor liquid-filled containers,with particular emphasis on jet-liquid interactions.A theoretical penetration model incorporating material compressibility and jet stretching was developed based on the virtual origin theory.A high-speed imaging experimental system was designed to capture the jet motion within the container.The impact process was numerically reproduced using ANSYS/LSDYNA,and the effects of standoff and overmatch on jet penetration were analyzed.The results reveal that jet stretching induced by increased standoff enhances the penetration velocity of the jet.A proportional relationship between the stretching factor(λ)and the overmatch parameter(I)was identified,withλranging from approximately 1.22 to 1.38 times I across the studied standoff range(80-220 mm).The findings offer a basis for future studies on the pressure distribution in the liquid and the structural response of containers. 展开更多
关键词 Shaped charge jet Behind-armor liquid-filled container Penetration characteristics Overmatch
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Experimental and numerical analysis of near-field detonation products and shock wave characteristics for cylindrical charge
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作者 Ruilong Ma Xinjie Wang +2 位作者 Sa You Zhimin Sun Fenglei Huang 《Defence Technology(防务技术)》 2025年第11期242-258,共17页
Predictions of extreme near-field blast wave for cylindrical charge is crucial for designing sympathetic detonation protection structures,yet the quantitative analysis of detonation products and shock wave field are s... Predictions of extreme near-field blast wave for cylindrical charge is crucial for designing sympathetic detonation protection structures,yet the quantitative analysis of detonation products and shock wave field are still insufficient.The present work conducted experiments and numerical simulations of nearfield explosion for kilogram scale cylindrical charge,and investigated the propagation and spatial distribution characteristics of incident and reflected blast waves.The results show that near-field reflected overpressure exhibits multi-peak structures,which are primarily governed by reflections of detonation products and shock wave.The reflected peak overpressure dominated by detonation products shows higher sensitivity to scaled distance.Meanwhile,the Rayleigh-Taylor instability(RTI)effect induces the evolutions of detonation products and shock wave interface from smooth to random microjets,increasing dispersion of secondary re flected peak overpressure.In free-field explosion,the incident peak overpressure exhibits a dual-peak structure,governed by the shock wave front and detonation products flowing past the gauge points.The incident peak overpressure dominated by detonation products is sensitive to orientations due to the charge structures.As the aspect ratio of charge increases from 0.6 to 8,the dominant radial azimuth angle region expands from 60°-90°to 30°-90°.An empirical model was developed to predict the spatial distributions of incident peak loads at arbitrary orientations for cylindrical charge with 0.6≤L/D≤8.0 and 0.06 m·kg^(-1/3) 展开更多
关键词 Near-field explosion Cylindrical charge Detonation products effect Peak loads spatial distribution Empirical predictive model
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Experimental and numerical study of the interaction between a shaped charge jet and a single ERA moving plate
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作者 Nicolas Reboul Ashwin Chinnayya +5 位作者 Frédéric Paintendre Simon Dalle Piagge Vincent Jaulin Jérôme Limido Anthony Collé Fabien Rondot 《Defence Technology(防务技术)》 2025年第8期126-140,共15页
An analysis of the interaction mechanisms between a Shaped Charge Jet(SCJ) and a single Moving Plate(MP) is proposed in this article using both experimental and numerical approaches. First, an experimental set-up is p... An analysis of the interaction mechanisms between a Shaped Charge Jet(SCJ) and a single Moving Plate(MP) is proposed in this article using both experimental and numerical approaches. First, an experimental set-up is presented. Four collision tests have been performed: two tests in Backward Moving Plate(BMP) configuration, where the plate moves in opposition to jet, and two tests in Forward Moving Plate(FMP) configuration, where the plate moves alongside the jet. Based on the virtual origin approximation,a methodology(the Virtual Origin Method, VOM) is developed to extract quantities from the X-ray images, which serve as comparative data. γSPH simulations are carried out to complete the analysis, as they well capture the disturbance dynamics observed in the experiments. Based on these complementary experimental and numerical results, a new physical description is proposed through a detailed analysis of the interaction. It is shown that the SCJ/MP interaction is driven at first order by the contact geometry. Thus, BMP and FMP configurations do not generate the same disturbances because their local flow geometries are different. In the collision point frame of reference, the BMP flows in the same direction as the jet, causing its overall deflection. On the contrary, the FMP flow opposes that of the jet leading to an alternative creation of fragments and ligaments. An in-depth study, using the VOM shows that deflection angles, fragment-ligament creation frequencies, and deflection velocities evolve as the interaction progresses through slower jet elements. 展开更多
关键词 Shaped charge jet disturbance Single moving plate Virtual origin method gSPH simulations
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Impact safety of CL-20-based explosive charge using detonation driving high velocity fragments
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作者 Gangling Jiao Tianchu Wang +3 位作者 Longjie Huang Chuanguo Ma Rui Liu Pengwan Chen 《Defence Technology(防务技术)》 2025年第6期298-305,共8页
The impact safety of explosive charges has been focused in these decades. The fragment impact is widely used to evaluate the response of explosive charges. In our work, the explosive detonation driving technique was u... The impact safety of explosive charges has been focused in these decades. The fragment impact is widely used to evaluate the response of explosive charges. In our work, the explosive detonation driving technique was used to generate a high velocity fragment with large mass. When the fragment masses are10 g, 16 g, 25 g, and 50 g, the highest velocity of fragments can reach 2400 m/s, 2100 m/s, 1900 m/s, and1400 m/s, respectively. The high velocity fragment with large mass was used to evaluate the safety of two kinds of CL-20 based explosive charges. The effects of the fragment mass and velocity were analyzed.Especially, the reaction extent was obtained based on visible phenomenon. The CL-20-based explosive charge containing Al had a higher safety level than that without Al. It was because Al had good ductility,and further improved the mechanical property of the material. Also, the numerical simulation was conducted to understand the reaction characteristics of the CL-20-based explosive charge. The results showed that as the fragment mass and velocity increased, the reaction became more violent. 展开更多
关键词 Impact safety Detonation driving fragments CL-20-Based explosive charge Reaction characteristics
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Influence of shaped charge jet state on its interaction with ERA flying plate
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作者 Nicolas Reboul Ashwin Chinnayya +5 位作者 Frederic Paintendre Simon Dalle Piagge Vincent Jaulin Jerome Limido Anthony Colle Fabien Rondot 《Defence Technology(防务技术)》 2025年第7期355-370,共16页
The Explosive Reactive Armors(ERA)are really efficient at reducing Shaped Charge Jet(SCJ)performance.The main destabilizing mechanism is the transverse movement of the front and rear moving plates(MP)on the SCJ.Theref... The Explosive Reactive Armors(ERA)are really efficient at reducing Shaped Charge Jet(SCJ)performance.The main destabilizing mechanism is the transverse movement of the front and rear moving plates(MP)on the SCJ.Therefore,a good understanding of the interaction SCJ/MP is essential for improving both weapon and armor systems.In a previous article,we have shown that interaction regimes are mainly influenced by the local collision geometry.Thus,in the collision point frame,the angle of collision be-tween the continuous SCJ and the MP is a key parameter.This flow angle is acute for the Backward Moving plate(BMP)moving against the SCJ and obtuse for the Forward Moving Plate(FMP)moving alongside it.In the former,the jet is simply deflected,which is the regime 1 of deflection.In the latter,the interaction turns on an alternative creation of fragment and ligament,which is the regime 2.Fragments are parts of the jet that are only slightly deflected while ligaments are the curved material bridges that connect two consecutive fragments.When stretching,the jet is systematically subject to instabilities that disturb its surface,creating necks along it.Their growth finally leads to the jet fragmentation.In this article,we focus on this jet distur-bance and its consequences on the SCJ/MP interaction.An experimental set-up was built to implement the interaction between a SCJ and a moving plate for different collision points,at different stand-off distances.The plate can interact with a smooth SCJ or a disturbed SCJ at a close and a far stand-off distance,respectively.One of the main results is the visualization of a regime change in SCJ/BMP interaction.A regime 1(deflection)interaction changes into a ligament regime interaction(similar to a FMP regime 2)when the collision point stand-off is increased.It is proposed that this change can be attributed as the increase of the amplitude of the jet surface disturbances.This phenomenon is well captured by the gSPH simula-tions.Finally,using both experimental and numerical approaches,we propose a new detailed analysis of the different phenomena occurring during the interaction between a disturbed-surface jet and a moving plate.Interaction regime changes are linked to jet local geometry changes.The interactions of a BMP with a smooth SCJ or with a disturbed surface SCJ are geometrically not the same and,thus,generate different local flows and interaction mechanisms.However,some other simulations have been carried out with constant velocity jet whose surface has been previously disturbed.These simulations underline the influence of both disturbance wavelength l and amplitude A on the interaction regimes.Surface disturbances of the SCJ,linked to its stretching,have a major influence on its interaction with a moving plate. 展开更多
关键词 Shaped charge jet disturbances Single moving plate Necks and bumps and fragmentation gSPH simulations
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Study on the effects of combustion characteristics of pyrotechnic charges on pyrotechnic shocks
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作者 Jingcheng Wang Shihui Xiong +2 位作者 Huina Mu Xiaogang Li Yuquan Wen 《Defence Technology(防务技术)》 2025年第4期79-98,共20页
This study calculates the combustion characteristics of various gas-generating and micro gas pyrotechnic charges,including aluminium/potassium perchlorate,boron/potassium nitrate,carbon black/potassium nitrate,and sil... This study calculates the combustion characteristics of various gas-generating and micro gas pyrotechnic charges,including aluminium/potassium perchlorate,boron/potassium nitrate,carbon black/potassium nitrate,and silicon-based delay compositions,using thermodynamic software.A multiphase flowthermal-solid coupling model was established,and the combustion process of the pyrotechnic charges within a closed bomb was simulated.The pyrotechnic shock generated by combustion was predicted.The combustion pressures and pyrotechnic shocks were measured.The simulation results demonstrated good agreement with experimental results.Additionally,the mechanism of shock generation by the combustion of pyrotechnic charges in the closed bomb was analyzed.The effects of the combustion characteristics of the pyrotechnic charges on the resulting pyrotechnic shocks were systematically investigated.Notably,the shock response spectrum of the gas-generating pyrotechnic charges is greater than that of the micro gas compositions at most frequencies,particularly in the mid-field pyrotechnic shocks(3-10 kHz).Furthermore,the pyrotechnic shocks increase approximately linearly with the impulse of the gas-generating pyrotechnic charges. 展开更多
关键词 Pyrotechnic charges Pyroshock Closed bomb tests Combustion characteristics Multiphase flow-thermal-solid coupling
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Experimental and numerical study on external explosions of cylindrical versus spherical charges at tunnel entrance
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作者 Dan Luo Jinsheng Hu +4 位作者 Anbao Wang Xiao Yu Mengmeng Zhang Meili Yao Chun Li 《Defence Technology(防务技术)》 2025年第4期227-243,共17页
Most of the existing studies on tunnel blast wave are based on spherical or grouped charges, however,conventional weapons are mostly cylindrical rather than spherical. In order to analyze the impact of cylindrical cha... Most of the existing studies on tunnel blast wave are based on spherical or grouped charges, however,conventional weapons are mostly cylindrical rather than spherical. In order to analyze the impact of cylindrical charges on the tunnel blast wave loads and to develop a quantitative calculation method, this study carried out experimental and numerical research. Initially, external explosion experiments were conducted using both 35 kg spherical charges and cylindrical charges with aspect ratio of 4.8 at two different distances from the tunnel entrance. Comparative analysis of the blast wave parameters in the tunnel revealed that the explosive equivalent of the cylindrical charges was significantly higher than that of the spherical charges. To address this, an equivalent coefficient κ based on the spherical charges was proposed for the cylindrical charges. Subsequently, numerical simulations were conducted for the experimental conditions, and the numerical simulation results match the experiments well. Through numerical calculations, the reliability of the equivalent coefficient κ under the experimental conditions was verified, and comparison analysis indicated that the explosion energy of cylindrical charges spreads more radially, resulting in more explosion energy entering the tunnel, which is the fundamental reason for the increase in tunnel blast wave loads. Additionally, analyzing the explosion energy ratio entering the tunnel is an effective method for calculating the equivalent coefficient κ. Finally, through more than one hundred sets of numerical calculation results, the impact of the proportional distance λ and the ratio of charge mass to the tunnel cross-section dimension φ on the equivalence coefficients κ was investigated. An empirical formula for the equivalence coefficient κ was derived through fitting, and the accuracy of the formula was validated through literature experimental results. The research findings of this paper will provide valuable guidance for the calculation of blast wave loads in tunnel. 展开更多
关键词 Cylindrical charges Tunnel blast wave Equivalent coefficient Empirical formula Experiment and numerical simulation
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Investigation of mixing performance and safety characteristics of polymer-based energetic materials simulant via screw-pressing blending extrusion charges 被引量:1
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作者 Gaoming Lin Huzeng Zong +6 位作者 Suwei Wang Huang Chen Siyu Yu Xiaojie Hao Kang Wang Yuanyuan Li Guohui Zhang 《Defence Technology(防务技术)》 2025年第2期287-305,共19页
The present study introduces a screw-pressing charging method to tackle deficiencies in automation and charge uniformity during the melt-casting of polymer-based energetic materials.To ensure the safety of the experim... The present study introduces a screw-pressing charging method to tackle deficiencies in automation and charge uniformity during the melt-casting of polymer-based energetic materials.To ensure the safety of the experiments,this study used inert materials with similar physical properties to partially substitute for the actual energetic components in the preparation of simulant materials.By thoroughly analyzing slurry physical properties,a simulation framework and an extensive performance evaluation method were developed.Such tools guide the design of the structure and configuration of process parameters.Results demonstrate that employing the Pin element significantly enhances radial mixing within the screw,minimizes temperature variations in the slurry,and improves both efficiency and safety in the mixing process.Further,adjustments such as widening the cone angle of the barrel,modifying the solid content of the slurry,and varying the speed of the screw can optimize the mechanical and thermal coupling in the flow field.These adjustments promote higher-quality slurry and create a safer production environment for the extrusion process. 展开更多
关键词 Polymer-based energetic materials Screw-pressing charging process Structural design Process safety Mixing performance
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CHARGE综合征人工耳蜗植入 被引量:11
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作者 李万鑫 王宁 +2 位作者 黄莎莎 李北成 戴朴 《中华耳科学杂志》 CSCD 北大核心 2017年第2期180-184,共5页
目的 CHARGE综合征表现为一系列临床症状,包括:眼组织病变(C)、心脏疾病(H)、后鼻孔闭锁(A)、生长与发育延迟和/或中枢神经系统异常(R)、生殖系统发育不良(G),以及耳部异常和/或耳聋(E)。该病是一种罕见的、通常散发的、常染色体显性遗... 目的 CHARGE综合征表现为一系列临床症状,包括:眼组织病变(C)、心脏疾病(H)、后鼻孔闭锁(A)、生长与发育延迟和/或中枢神经系统异常(R)、生殖系统发育不良(G),以及耳部异常和/或耳聋(E)。该病是一种罕见的、通常散发的、常染色体显性遗传的疾病,三分之二的病例由于CHD7基因突变引起。对于出现极重度感音神经性耳聋(SNHL)的该病患者,人工耳蜗植入(CI)对于听力和语言的疗效在文献报道中存在较大差异。本文总结了三例CHARGE综合征患者CI的疗效,并对相关文献进行回顾。方法三例诊断为CHARGE综合征的极重度SNHL患者,在我科接受CI,在常规术前检查外,对其CHD7基因进行测序。术后随访三年,对其听觉反应和言语发育进行监测。结果三例患者均成功完成CI,两例患者查出CHD7基因突变。耳部严重畸形的患者,手术难度较大。术后随访3年,一例患者有听力改善,但无言语发育;一例患者既无听觉反应,亦无言语发育;另一例患者听力明显改善,言语发育良好。结论患有极重度SNHL的CHARGE综合征患者,CI可能改善听觉反应和言语发育,但其转归并不总是理想的。对于耳部畸形的患者,手术难度较大。 展开更多
关键词 charge综合征 诊断标准 CHD7基因突变 人工耳蜗植入
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CHARGE综合征语前聋儿童人工耳蜗植入病例报道2例 被引量:4
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作者 王倩 陈伟 +3 位作者 陈艾婷 李佳楠 冀飞 杨仕明 《中华耳科学杂志》 CSCD 北大核心 2020年第4期675-677,共3页
CHARGE综合征的临床表现由多种疾病组成,其每个字母代表一种疾病的英文名称首字母,即:眼组织病变(C)、心脏疾病(H)、后鼻孔闭锁(A)、生长与发育延迟和/或中枢神经系统异常(R)、生殖系统发育不良(G),以及耳部异常和/或耳聋(E)[1]。目前,... CHARGE综合征的临床表现由多种疾病组成,其每个字母代表一种疾病的英文名称首字母,即:眼组织病变(C)、心脏疾病(H)、后鼻孔闭锁(A)、生长与发育延迟和/或中枢神经系统异常(R)、生殖系统发育不良(G),以及耳部异常和/或耳聋(E)[1]。目前,随着其致病基因CHD7检测的发现,大大提高了CHARGE诊断的精准度[2]。Sanlaville等研究结果显示CHARGE综合征为常染色体显性遗传的疾病,三分之二的病例由于CHD7基因突变引起[3]。人工耳蜗植入是治疗此种病征的方法之一,但其术后效果在文献中存在较大差异[4,5]。本文对两例语前聋儿童的疗效进行了报道。 展开更多
关键词 charge综合征 人工耳蜗 听力 言语康复
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新生儿CHARGE综合征5例临床及基因变异分析 被引量:1
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作者 王颍源 方盼盼 +3 位作者 陈蒙蒙 郭静 刘大鹏 康文清 《临床儿科杂志》 CAS CSCD 北大核心 2023年第11期846-851,共6页
目的分析5例诊断为新生儿CHARGE综合征患儿的临床特征及基因变异特点,明确死亡患儿的遗传学病因。方法收集5例患儿的临床资料,应用高通量测序技术对5例疑诊CHARGE综合征患儿进行检测,利用Sanger测序技术对可疑位点和核心家系成员进行验... 目的分析5例诊断为新生儿CHARGE综合征患儿的临床特征及基因变异特点,明确死亡患儿的遗传学病因。方法收集5例患儿的临床资料,应用高通量测序技术对5例疑诊CHARGE综合征患儿进行检测,利用Sanger测序技术对可疑位点和核心家系成员进行验证。结果5例患儿均存在结构畸形合并喂养困难(均排除鼻后孔闭锁),其中2例出现歪嘴哭。3例患儿合并鼻腔狭窄或者上气道塌陷综合征,因治疗效果差,不能撤离呼吸机最终死亡;1例患儿因家属放弃治疗死于家中;1例目前随访中。家系1为CHD7基因c.478 del(Y160Tfs*51)移码变异,家系2为CHD7基因c.5428C>T(P.R 1810*)无义变异,家系3为CHD7基因c.6292C>T(P.R 2098*)无义变异,家系4为CHD7基因c.4317 delA(p.Q 1440 S fs*3)移码变异,家系5为CHD7基因c.469C>T(P.R157*)无义变异。5个家系的父母均未携带相应的变异,均为新发变异。其中家系4的CHD7基因c.4317 delA为未报道的新变异。结论CHD7基因变异可能为5例患儿的致病原因,其中4例患儿死亡的遗传学病因可能为CHD7基因变异导致的系统畸形。对于类似多发畸形患儿临床诊断的同时应积极完善基因检测明确遗传学诊断,以提高对该病的认识。 展开更多
关键词 charge综合征 CHD7基因 新生儿
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Characteristics and mechanisms of strain waves generated in rock by cylindrical explosive charges 被引量:13
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作者 刘科伟 李萧翰 +3 位作者 李夕兵 姚志华 舒宗宪 袁明华 《Journal of Central South University》 SCIE EI CAS CSCD 2016年第11期2951-2957,共7页
A superposing principle, by suitably adding the strain waves from a number of concentrated explosive charges to approximate the waves generated by a cylindrical charge based on the strain wave of a point or small sphe... A superposing principle, by suitably adding the strain waves from a number of concentrated explosive charges to approximate the waves generated by a cylindrical charge based on the strain wave of a point or small spherical explosive charge generated in rock, is used to further study the triggering time of strain gauges installed in radial direction at same distances but different positions surrounding a cylindrical explosive charge in rock. The duration of the first compression phase and peak value of strain wave, and furthermore, their differences are analyzed and some explanations are given. Besides that, the gauge orientation in which the maximum peak value occurs is also discussed. At last, the effect of velocity of detonation(V.O.D.) of a cylindrical explosive charge on the strain waves generated in the surrounding rock is taken as key research and the pattern of peak amplitude of a strain wave varies with the V.O.D. is likely to have been found. 展开更多
关键词 cylindrical explosive charge strain wave concentrated explosive charge elemental strain wave superposing principle velocity of detonation(V O D velocity of propagation(V O P
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Jet formation and penetration performance of a double-layer charge liner with chemically-deposited tungsten as the inner liner 被引量:3
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作者 Bihui Hong Wenbin Li +2 位作者 Yiming Li Zhiwei Guo Binyou Yan 《Defence Technology(防务技术)》 SCIE EI CAS CSCD 2024年第3期374-385,共12页
This paper proposes a type of double-layer charge liner fabricated using chemical vapor deposition(CVD)that has tungsten as its inner liner.The feasibility of this design was evaluated through penetration tests.Double... This paper proposes a type of double-layer charge liner fabricated using chemical vapor deposition(CVD)that has tungsten as its inner liner.The feasibility of this design was evaluated through penetration tests.Double-layer charge liners were fabricated by using CVD to deposit tungsten layers on the inner surfaces of pure T2 copper liners.The microstructures of the tungsten layers were analyzed using a scanning electron microscope(SEM).The feasibility analysis was carried out by pulsed X-rays,slug-retrieval test and static penetration tests.The shaped charge jet forming and penetration law of inner tungsten-coated double-layer liner were studied by numerical simulation method.The results showed that the double-layer liners could form well-shaped jets.The errors between the X-ray test results and the numerical results were within 11.07%.A slug-retrieval test was found that the retrieved slug was similar to a numerically simulated slug.Compared with the traditional pure copper shaped charge jet,the penetration depth of the double-layer shaped charge liner increased by 11.4% and>10.8% respectively.In summary,the test results are good,and the numerical simulation is in good agreement with the test,which verified the feasibility of using the CVD method to fabricate double-layer charge liners with a high-density and high-strength refractory metal as the inner liner. 展开更多
关键词 Shaped charge Chemical vapor deposition TUNGSTEN Double-layer charge liner X-ray PENETRATION
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