In the past two decades,target-based therapies achieve the great success in adult leukemia.Two typical examples are the applications of all-trans retinoic acid(ATRA)/arsenic trioxide(ATO)and specific tyrosine kinase i...In the past two decades,target-based therapies achieve the great success in adult leukemia.Two typical examples are the applications of all-trans retinoic acid(ATRA)/arsenic trioxide(ATO)and specific tyrosine kinase inhibitor imatinib respectively in acute promyelocytic leukemia(APL)and chronic myeloid leukemia(CML).展开更多
Both geoparks and geosites are unique geological features of spectacular importance to earth science (global scientific importance) and the surrounding community.The Oldonyo Lengai(The God for the Maasai people and un...Both geoparks and geosites are unique geological features of spectacular importance to earth science (global scientific importance) and the surrounding community.The Oldonyo Lengai(The God for the Maasai people and unique active felsic magmatism)展开更多
Although small scale mining management is a complex task,many countries in the world have managed to develop mining management regimes that can improve the economic and environmental efficiency of the small scale mini...Although small scale mining management is a complex task,many countries in the world have managed to develop mining management regimes that can improve the economic and environmental efficiency of the small scale mining sector.This paper attempts to explore the mental picture of opportunities and challenges of the environmental management in small scale mining in Tanzania focusing on展开更多
The experiment was conducted to inoculate one-day old chicks with March's disease (MD) trivalent and herpesvirus of turkey (HVT) vaccines separately, and then to challenge them with virulent MD virus (vMDV) at the...The experiment was conducted to inoculate one-day old chicks with March's disease (MD) trivalent and herpesvirus of turkey (HVT) vaccines separately, and then to challenge them with virulent MD virus (vMDV) at the age of 15 days. and 5, 25, 45 and 75 days after the challenge with vMDV, comparing with the control-challenged chicks without immunization, to detect the immunoprotetive efficacy and dynamic changes of the inductive activity of interleukin-2(IL-2), expression of IL-2 receptor and proliferative function of T cells in thymus and spleen; the number of ANAE+T, AP+T cells and IgG, IgM, IgA antibody-producing cells in Bursa Fabricius, spleen,thymus, cecal tonsil and Harder gland; as the amount of T cells and IgG, IgM, IgA in peripheral blood as well as the content of IgG, IgM and IgA in the tear, trachea washings, bile and intestinal fluids of the experimental chicks. The experimental results firstly demonstrate that the immunorcgulation of IL-2, and IL-2 receptor, the cellualr and humoral immune responses were significantly enhanced in the central and peripheral immune organs; the local mucosal immune function were markedly amplified in the respiratory and digestive tracts of the immunized-challenged,chicks, which were closely correlated with the immunoprotection against MD; the immune response and immunoprotective effect of the trivalent vaccine-immunized chicks were much better than those of HVT vaccine-immunized chicks:展开更多
CIRAD(Montpellier,France) develops research activities centered on tropical and sub-tropical agricultural systems.Among others crops,cotton is the focus of a series of research programs in different disciplines from e...CIRAD(Montpellier,France) develops research activities centered on tropical and sub-tropical agricultural systems.Among others crops,cotton is the focus of a series of research programs in different disciplines from economics to breeding.Major areas in genetics and breeding relate to(1) genetic diversity,(2) cultivar development through classical and molecular breeding,and(3)展开更多
Although the EU President Van Rompuy expresses the belief that the EU-China strategic partnership and the people-to-people friendship will continue to flourish,more and more European intellectuals express their doubts...Although the EU President Van Rompuy expresses the belief that the EU-China strategic partnership and the people-to-people friendship will continue to flourish,more and more European intellectuals express their doubts about the strategic partnerships of EU-China relations.The reasons for the doubts are firstly European scholars place more emphasis on the differences between China and EU in ideology and political system;secondly,they believe that the establishment of the strategic partnership between China and EU was the result of EU and its Member States having implemented an "unconditional engagement" with China;thirdly,a series of differences between China and the EU on issues like trade,Africa,climate change in recent years.However the different ideas towards China EU strategic partnership have caused the partnership to face challenges as well as significant opportunities for development.展开更多
HPCC(high performance computing challenge)基准是由DARPA的HPCS(high productivity computing system)项目所发布的评价高性能计算系统的测试基准程序,自推出至今,受到工业界和学术界的广泛关注.但是,HPCC仍有不尽如人意之处,主要表...HPCC(high performance computing challenge)基准是由DARPA的HPCS(high productivity computing system)项目所发布的评价高性能计算系统的测试基准程序,自推出至今,受到工业界和学术界的广泛关注.但是,HPCC仍有不尽如人意之处,主要表现在其测试结果是若干个指标项,需要测试者和决策者根据这些测试指标项进行分析和评估,缺少一个整体的、直观而统一的评价结果.提出一种基于HPCC和层次分析法的高性能计算系统评价模型——AHPCC(a high performance computer system evaluation model based on HPCC),当系统通过运行HPCC得到测试结果后,使用AHPCC模型对这些测试参数按系统应用目标建立层次结构图,并最终计算得到各系统关于特定应用目标的单一分数.以12个已测出HPCC性能参数的系统为例,使用AHPCC模型计算并分析了系统评价结果.实验结果表明,AHPCC模型提供了实际系统的统一而直观的评价指标,其评价结果符合高性能系统的设计和应用特点.展开更多
面对企业员工实践技能要求的不断提高,培训学生的实践技能成为当前教学工作急需解决的问题。本文通过引进芬兰Cesim Oy公司推出的在线模拟课程平台(Cesim Global Challenge)和对其在"市场营销学"课程中的应用进行研究,以引起...面对企业员工实践技能要求的不断提高,培训学生的实践技能成为当前教学工作急需解决的问题。本文通过引进芬兰Cesim Oy公司推出的在线模拟课程平台(Cesim Global Challenge)和对其在"市场营销学"课程中的应用进行研究,以引起教师对实践教学活动的重视和对在线模拟课程的关注。展开更多
Bone marrow derived mesenchymal stem cells(MSCs)have been widely used to promote the repair or regeneration of damaged tissues.In previous studies,we have developed several stem cells based strategies to promote the b...Bone marrow derived mesenchymal stem cells(MSCs)have been widely used to promote the repair or regeneration of damaged tissues.In previous studies,we have developed several stem cells based strategies to promote the bone repair,which includes the BMP-2 gene medicine,construction of tissue engineering bone in bioreactor and clinical trial of enriched stem cell therapy.Among these studies,one challenge is to construct the tissue engineered bone at the large scale which face the problem of poor survivor of seeding cells in the scaffold interior.In our studies,the porousβ-TCP cylindrical scaffolds loading with MSCs were continuously perfused by a customized bioreactor(dynamic culture)at different flow rate or were immersed展开更多
文摘In the past two decades,target-based therapies achieve the great success in adult leukemia.Two typical examples are the applications of all-trans retinoic acid(ATRA)/arsenic trioxide(ATO)and specific tyrosine kinase inhibitor imatinib respectively in acute promyelocytic leukemia(APL)and chronic myeloid leukemia(CML).
文摘Both geoparks and geosites are unique geological features of spectacular importance to earth science (global scientific importance) and the surrounding community.The Oldonyo Lengai(The God for the Maasai people and unique active felsic magmatism)
文摘Although small scale mining management is a complex task,many countries in the world have managed to develop mining management regimes that can improve the economic and environmental efficiency of the small scale mining sector.This paper attempts to explore the mental picture of opportunities and challenges of the environmental management in small scale mining in Tanzania focusing on
文摘The experiment was conducted to inoculate one-day old chicks with March's disease (MD) trivalent and herpesvirus of turkey (HVT) vaccines separately, and then to challenge them with virulent MD virus (vMDV) at the age of 15 days. and 5, 25, 45 and 75 days after the challenge with vMDV, comparing with the control-challenged chicks without immunization, to detect the immunoprotetive efficacy and dynamic changes of the inductive activity of interleukin-2(IL-2), expression of IL-2 receptor and proliferative function of T cells in thymus and spleen; the number of ANAE+T, AP+T cells and IgG, IgM, IgA antibody-producing cells in Bursa Fabricius, spleen,thymus, cecal tonsil and Harder gland; as the amount of T cells and IgG, IgM, IgA in peripheral blood as well as the content of IgG, IgM and IgA in the tear, trachea washings, bile and intestinal fluids of the experimental chicks. The experimental results firstly demonstrate that the immunorcgulation of IL-2, and IL-2 receptor, the cellualr and humoral immune responses were significantly enhanced in the central and peripheral immune organs; the local mucosal immune function were markedly amplified in the respiratory and digestive tracts of the immunized-challenged,chicks, which were closely correlated with the immunoprotection against MD; the immune response and immunoprotective effect of the trivalent vaccine-immunized chicks were much better than those of HVT vaccine-immunized chicks:
文摘CIRAD(Montpellier,France) develops research activities centered on tropical and sub-tropical agricultural systems.Among others crops,cotton is the focus of a series of research programs in different disciplines from economics to breeding.Major areas in genetics and breeding relate to(1) genetic diversity,(2) cultivar development through classical and molecular breeding,and(3)
文摘Although the EU President Van Rompuy expresses the belief that the EU-China strategic partnership and the people-to-people friendship will continue to flourish,more and more European intellectuals express their doubts about the strategic partnerships of EU-China relations.The reasons for the doubts are firstly European scholars place more emphasis on the differences between China and EU in ideology and political system;secondly,they believe that the establishment of the strategic partnership between China and EU was the result of EU and its Member States having implemented an "unconditional engagement" with China;thirdly,a series of differences between China and the EU on issues like trade,Africa,climate change in recent years.However the different ideas towards China EU strategic partnership have caused the partnership to face challenges as well as significant opportunities for development.
文摘HPCC(high performance computing challenge)基准是由DARPA的HPCS(high productivity computing system)项目所发布的评价高性能计算系统的测试基准程序,自推出至今,受到工业界和学术界的广泛关注.但是,HPCC仍有不尽如人意之处,主要表现在其测试结果是若干个指标项,需要测试者和决策者根据这些测试指标项进行分析和评估,缺少一个整体的、直观而统一的评价结果.提出一种基于HPCC和层次分析法的高性能计算系统评价模型——AHPCC(a high performance computer system evaluation model based on HPCC),当系统通过运行HPCC得到测试结果后,使用AHPCC模型对这些测试参数按系统应用目标建立层次结构图,并最终计算得到各系统关于特定应用目标的单一分数.以12个已测出HPCC性能参数的系统为例,使用AHPCC模型计算并分析了系统评价结果.实验结果表明,AHPCC模型提供了实际系统的统一而直观的评价指标,其评价结果符合高性能系统的设计和应用特点.
基金supported by grants from the National Natural Science Foundation of China (10872131,81172549,31271015)a grant from the Shanghai Science and Technology Development Fund (11XD1403300)the key disciplines program of the Shanghai Municipal Education Commission(J50206)
文摘Bone marrow derived mesenchymal stem cells(MSCs)have been widely used to promote the repair or regeneration of damaged tissues.In previous studies,we have developed several stem cells based strategies to promote the bone repair,which includes the BMP-2 gene medicine,construction of tissue engineering bone in bioreactor and clinical trial of enriched stem cell therapy.Among these studies,one challenge is to construct the tissue engineered bone at the large scale which face the problem of poor survivor of seeding cells in the scaffold interior.In our studies,the porousβ-TCP cylindrical scaffolds loading with MSCs were continuously perfused by a customized bioreactor(dynamic culture)at different flow rate or were immersed
