目的探讨表达CD23的弥漫性大B细胞淋巴瘤(diffuse large B-cell lymphoma,DLBCL)的临床病理特点及可能的肿瘤相关免疫微环境。方法回顾性分析12例表达CD23的DLBCL临床病理资料,分析其临床、病理特点并研究其临床相关性及肿瘤相关免疫浸...目的探讨表达CD23的弥漫性大B细胞淋巴瘤(diffuse large B-cell lymphoma,DLBCL)的临床病理特点及可能的肿瘤相关免疫微环境。方法回顾性分析12例表达CD23的DLBCL临床病理资料,分析其临床、病理特点并研究其临床相关性及肿瘤相关免疫浸润。结果表达CD23的DLBCL约占所有DLBCL的9.45%;男女性各6例;平均发病年龄64.83岁;发生于淋巴结内者4例,结外者8例;9例为进展期(Ⅲ~Ⅳ期),3例为早期(Ⅰ~Ⅱ期);3例患者诊断后未经治疗且失访;1例患者手术后病情恶化死亡;8例患者经化疗后,2例死亡、1例进展、5例部分缓解。镜下肿瘤细胞均为弥漫浸润并破坏正常组织结构,可观察到肿瘤细胞呈现中心母细胞、免疫母细胞及间变性大细胞形态,其形态学均未见母细胞变及浆细胞样分化。Hans分型:除1例为GCB表型,其余11例均为非GCB表型。生物信息学研究发现CD23表达与调节性T细胞、NK细胞、浆细胞样树突细胞呈正相关,与中性粒细胞呈负相关。结论表达CD23的DLBCL患者主要为中老年人,以发生于淋巴结外为主,多为进展期(Ⅲ~Ⅳ期),随访结果显示其预后较差。形态学上相对于一般的DLBCL并无特殊,Hans分型提示肿瘤组织大多数为非GCB亚型,CD23表达对DLBCL的免疫微环境可能有一定的影响。展开更多
The complex containing ferroceneyl, Cd(dppf)I2(dppf=1,1 bis(diphenylphosphino) ferrocene), was synthesized and characterized by IR, Uv vis DRIS spectrum and X ray diffraction. The crystal belongs to monoclinic, space ...The complex containing ferroceneyl, Cd(dppf)I2(dppf=1,1 bis(diphenylphosphino) ferrocene), was synthesized and characterized by IR, Uv vis DRIS spectrum and X ray diffraction. The crystal belongs to monoclinic, space group C2/c, a=37.439(3)?, b=10.2472(6)?, c=18.719(1)?, β=110.4715(16)°, V=6727.8(8)?3, Z=8, Dc=1.818g·cm-3, F(000)=3536, μ=3.015mm-1, R=0.0308, wR=0.0692. dppf coordinates to Cd? as bidentate ligand, and the coordination environment of Cd? is a distorted tetrahedron. The electronic structures of Cd(dppf)I2 and Cd(dppf)Br2 are discussed by quantum chemistry calculation.展开更多
文摘目的探讨表达CD23的弥漫性大B细胞淋巴瘤(diffuse large B-cell lymphoma,DLBCL)的临床病理特点及可能的肿瘤相关免疫微环境。方法回顾性分析12例表达CD23的DLBCL临床病理资料,分析其临床、病理特点并研究其临床相关性及肿瘤相关免疫浸润。结果表达CD23的DLBCL约占所有DLBCL的9.45%;男女性各6例;平均发病年龄64.83岁;发生于淋巴结内者4例,结外者8例;9例为进展期(Ⅲ~Ⅳ期),3例为早期(Ⅰ~Ⅱ期);3例患者诊断后未经治疗且失访;1例患者手术后病情恶化死亡;8例患者经化疗后,2例死亡、1例进展、5例部分缓解。镜下肿瘤细胞均为弥漫浸润并破坏正常组织结构,可观察到肿瘤细胞呈现中心母细胞、免疫母细胞及间变性大细胞形态,其形态学均未见母细胞变及浆细胞样分化。Hans分型:除1例为GCB表型,其余11例均为非GCB表型。生物信息学研究发现CD23表达与调节性T细胞、NK细胞、浆细胞样树突细胞呈正相关,与中性粒细胞呈负相关。结论表达CD23的DLBCL患者主要为中老年人,以发生于淋巴结外为主,多为进展期(Ⅲ~Ⅳ期),随访结果显示其预后较差。形态学上相对于一般的DLBCL并无特殊,Hans分型提示肿瘤组织大多数为非GCB亚型,CD23表达对DLBCL的免疫微环境可能有一定的影响。
文摘The complex containing ferroceneyl, Cd(dppf)I2(dppf=1,1 bis(diphenylphosphino) ferrocene), was synthesized and characterized by IR, Uv vis DRIS spectrum and X ray diffraction. The crystal belongs to monoclinic, space group C2/c, a=37.439(3)?, b=10.2472(6)?, c=18.719(1)?, β=110.4715(16)°, V=6727.8(8)?3, Z=8, Dc=1.818g·cm-3, F(000)=3536, μ=3.015mm-1, R=0.0308, wR=0.0692. dppf coordinates to Cd? as bidentate ligand, and the coordination environment of Cd? is a distorted tetrahedron. The electronic structures of Cd(dppf)I2 and Cd(dppf)Br2 are discussed by quantum chemistry calculation.
