When an expanded-base pile is installed into ground, the cavity expansion associated with penetration of the enlarged pile base is followed by cavity contraction along the smaller-diameter pile shaft. In order to acco...When an expanded-base pile is installed into ground, the cavity expansion associated with penetration of the enlarged pile base is followed by cavity contraction along the smaller-diameter pile shaft. In order to account for the influence of cavity contraction on the change of bearing capacity of expanded-base pile, a theoretical calculation methodology, predicting the setup of expanded-base pile, was established by employing the cavity contraction theory to estimate the shaft resistance of expanded-base pile, and horizontal consolidation theory to predict the dissipation of excess pore pressure. Finally, the numerical solutions for the setup of expanded-base pile were obtained. The parametric study about the influence of cavity contraction on setup of expanded-base pile was carried out, while a field test was introduced. The parametric study shows that the decrements in radial pressure and the maximum pore water pressure after considering cavity contraction are increased as the expanded ratio(base diameter/shaft diameter) and rigidity index of soil are raised. The comparison between calculated and measured values shows that the calculated results of ultimate bearing capacity for expanded-base pile considering cavity contraction agree well with the measured values; however, the computations ignoring cavity contraction are 2.5-3.0 times the measured values.展开更多
The study was to investigate the effect of reducing central sympathetic nervous tone with clonidine on cardiomyocyte contraction,and further to analyze the influence of reducing the central sympathetic nervous tone on...The study was to investigate the effect of reducing central sympathetic nervous tone with clonidine on cardiomyocyte contraction,and further to analyze the influence of reducing the central sympathetic nervous tone on response of β1 and β2-AR in aged ventricular myocytes.Sprague-Dawley rats were randomly divided into three groups:adult group,aged group and aged group with clonidine.展开更多
With the urgent need to resolve complex behaviors in nonlinear evolution equations,this study makes a contribution by establishing the local existence of solutions for Cauchy problems associated with equations of mixe...With the urgent need to resolve complex behaviors in nonlinear evolution equations,this study makes a contribution by establishing the local existence of solutions for Cauchy problems associated with equations of mixed types.Our primary contribution is the establishment of solution existence,illuminating the dynamics of these complex equations.To tackle this challenging problem,we construct an approximate solution sequence and apply the contraction mapping principle to rigorously prove local solution existence.Our results significantly advance the understanding of nonlinear evolution equations of mixed types.Furthermore,they provide a versatile,powerful approach for tackling analogous challenges across physics,engineering,and applied mathematics,making this work a valuable reference for researchers in these fields.展开更多
Combat effectiveness of unmanned aerial vehicle(UAV)formations can be severely affected by the mission execution reliability.During the practical execution phase,there are inevitable risks where UAVs being destroyed o...Combat effectiveness of unmanned aerial vehicle(UAV)formations can be severely affected by the mission execution reliability.During the practical execution phase,there are inevitable risks where UAVs being destroyed or targets failed to be executed.To improve the mission reliability,a resilient mission planning framework integrates task pre-and re-assignment modules is developed in this paper.In the task pre-assignment phase,to guarantee the mission reliability,probability constraints regarding the minimum mission success rate are imposed to establish a multi-objective optimization model.And an improved genetic algorithm with the multi-population mechanism and specifically designed evolutionary operators is used for efficient solution.As in the task-reassignment phase,possible trigger events are first analyzed.A real-time contract net protocol-based algorithm is then proposed to address the corresponding emergency scenario.And the dual objective used in the former phase is adapted into a single objective to keep a consistent combat intention.Three cases of different scales demonstrate that the two modules cooperate well with each other.On the one hand,the pre-assignment module can generate high-reliability mission schedules as an elaborate mathematical model is introduced.On the other hand,the re-assignment module can efficiently respond to various emergencies and adjust the original schedule within a millisecond.The corresponding animation is accessible at bilibili.com/video/BV12t421w7EE for better illustration.展开更多
A task allocation problem for the heterogeneous unmanned aerial vehicle (UAV) swarm in unknown environments is studied in this paper.Considering that the actual mission environment information may be unknown,the UAV s...A task allocation problem for the heterogeneous unmanned aerial vehicle (UAV) swarm in unknown environments is studied in this paper.Considering that the actual mission environment information may be unknown,the UAV swarm needs to detect the environment first and then attack the detected targets.The heterogeneity of UAVs,multiple types of tasks,and the dynamic nature of task environment lead to uneven load and time sequence problems.This paper proposes an improved contract net protocol (CNP) based task allocation scheme,which effectively balances the load of UAVs and improves the task efficiency.Firstly,two types of task models are established,including regional reconnaissance tasks and target attack tasks.Secondly,for regional reconnaissance tasks,an improved CNP algorithm using the uncertain contract is developed.Through uncertain contracts,the area size of the regional reconnaissance task is determined adaptively after this task assignment,which can improve reconnaissance efficiency and resource utilization.Thirdly,for target attack tasks,an improved CNP algorithm using the fuzzy integrated evaluation and the double-layer negotiation is presented to enhance collaborative attack efficiency through adjusting the assignment sequence adaptively and multi-layer allocation.Finally,the effectiveness and advantages of the improved method are verified through comparison simulations.展开更多
Paleogene sedimentary basins exposed across much of the central and eastern Tibetan Plateau may record the early history of plateau uplift related to the Indo\|Asian collision. We conducted sedimentological and strati...Paleogene sedimentary basins exposed across much of the central and eastern Tibetan Plateau may record the early history of plateau uplift related to the Indo\|Asian collision. We conducted sedimentological and stratigraphic investigations in the northeastern Qiangtang terrane, eastern Tibetan Plateau. Our results indicate development of several nonmarine basins during Paleogene(?) time, probably synchronous with northeast\|southwest contractional deformation. The Nangqian and Xialaxiu basins (96°～97°E, 32°～33°N) are composed of 500～ 20000m thick successions of primarily clastic sediment indicative of lacustrine and alluvial\|fan depositional processes. Paleocurrent measurements and sediment compositional data indicate local sediment source areas composed of Carboniferous\|Triassic carbonate and sandstone and minor Tertiary volcanic rocks. The large variability of provenance and facies types suggest that each basin evolved independently, as opposed to regional development of a single integrated basin which was partitioned by later deformation.展开更多
The dynamic responses of the arch dam including dam-foundation-storage capacity of water system,using two different earthquake input models,i.e.viscous-spring artificial boundary(AB)condition and massless foundation(M...The dynamic responses of the arch dam including dam-foundation-storage capacity of water system,using two different earthquake input models,i.e.viscous-spring artificial boundary(AB)condition and massless foundation(MF),were studied and analyzed for the 269 m high Baihetan arch dam under construction in China.By using different input models,the stress and opening of contraction joints(OCJs)of arch dam under strong shock were taken into consideration.The results show that the earthquake input models have slight influence on the responses including earthquake stresses and openings of contraction joints in different extents.展开更多
Reservoir impoundment is related to several hydraulic engineering concerns,including irreversible valley contractions,landslides and reservoir-induced earthquakes.However,these phenomena,such as valley contractions,ar...Reservoir impoundment is related to several hydraulic engineering concerns,including irreversible valley contractions,landslides and reservoir-induced earthquakes.However,these phenomena,such as valley contractions,are hardly to be explained by the conventional method.The scientific understanding of water effects during impoundment and their hazards to hydraulic structure are needed.The effective stress law for fissured rock masses is introduced in the elasto-plastic model employing the Drucker-Prager criterion and implemented in the three dimension(3D)nonlinear finite element method(FEM)program Three-dimensional FINite Element(TFINE).The slope deforms towards river-way during impoundment since the increasing pore pressure in fissures changes stress state and leads to additional plastic deformation in the rock materials.The value of Biot coefficient and the influence of water on rock materials are discussed in detail.Thus,the mechanism of slope deformation during the impoundment of Jinping-I arch dam is revealed,and the deformation is accurately measured.The application of the effective stress law provides a method to consider stress assessment,deformation evaluation and stability estimate of hydraulic structures during the impoundment process.This is a beneficial exploration and an improvement of hydraulic engineering design.展开更多
Objective Patients with repaired tetralogy of Fallot(rTOF)account for the majority of cases with late onset right ventricle(RV)failure.The current surgical approach,including pulmonary valve replacement/insertion(PVR)...Objective Patients with repaired tetralogy of Fallot(rTOF)account for the majority of cases with late onset right ventricle(RV)failure.The current surgical approach,including pulmonary valve replacement/insertion(PVR),has yielded mixed results with some patients recover RV function and some do not.An innovative surgical approach was proposed to help ventricle to contract and improve RV function qualified by ejection fraction with one or more active contracting bands.Computational biomechanical modelling is a widely used method in cardiovascular study for investigation of mechanisms governing disease development,quantitative diagnostic and treatment strategies and improving surgical designs for better outcome.Muscle active contraction caused by zero-load sarcomere shortening leads to change of zero-load configurations.In lieu of experimenting using real surgery on animal or human,computational simulations(virtual surgery)were performed to test different band combination and insertion options to identify optimal surgery design and band insertion plan.Methods Cardiac magnetic resonance(CMR)data were obtained from one rTOF patient(sex:male,age:22.5 y)before pulmonary valve replacement surgery.The patient was suffering from RV dilation and dysfunction with RV end-systole volume 254.49ml and end-diastole volume 406.91 mL.A total of 15 computational RV/LV/Patch/Band combination models based on(CMR)imaging were constructed to investigate the influence of different band insertion surgery plans.These models included 5 different band insertion models combined and 3 different band contraction ratio(10%,15%and 20%band zero-stress length reduction).These models included 5 different band insertion models:Model 1 with one band at anterior to the middle of papillary muscle;Model 2 with one band at posterior to the middle of papillary muscle;Model 3 with 2 bands which are the ones from Models 1&2 combined;Model 4 with a band at the base of the papillary muscle;Model 5 with 3 bands which is a combination of Models 3&4.A pre-shrink process was performed on in-vivo begin-filling and end-systole MRI data to obtain diastole and systole zero4oad ventricle geometries.An extra 5%-8%shrinkage was applied to obtain corresponding systole zero-load geometry reflecting myocardium sarcomere shortening.The zero-load band length in systole was 10%,15%and 20%shorter than that in diastole according to their corresponding contraction ratio.The nonlinear Mooney-Rivlin model was used to describe the ventricle material properties with their material parameter values adjusted to match measured data with CMR.The band material properties were in the same scale with healthy right ventricle.The RV/LV/Band model construction and solution procedures were the same as described.Results Model 5 with band contraction ratio of 20%has the ability to improve RV ejection fraction to 41.07%,which represented a 3.61%absolute improvement,or 9.6%relative improvement using pre-PVR ejection fraction as the baseline number.The ejection fractions for Models 1-4 with band contraction ratio of 20%were 39.28%,39.47%,38.87%and 40.34%respectively.Compared to models with band contraction ratio15%and 20%,models with band contraction ratio 10%has the least ability on RV ejection fraction improvement with ejection fraction 38.28%,38.00%,38.81%,38.50%and 39.36%corresponding to Models 1-5.Conclusions This pilot work demonstrated that the band insertion surgery may have great potential to improve post-PVR RV cardiac function for patients with repaired TOF.More band contraction ratio and inserted band number may lead to better post-surgery outcome.Further investigations using in-vitro animal experiments and final patient studies are warranted.展开更多
Introduction Excessive narrowing of airways is the most important pathological feature of asthma,but its mechanism remains puzzling.One certain thing is that the contraction of airway smooth muscle(ASM)ultimately caus...Introduction Excessive narrowing of airways is the most important pathological feature of asthma,but its mechanism remains puzzling.One certain thing is that the contraction of airway smooth muscle(ASM)ultimately causes airway narrowing,thus both structural and functional alterations of airway smooth muscle(ASM)are thought as common final pathway responsible for the bronchial hyperresponsiveness(BHR),the hall mark of asthma.Many chemical and physical factors such as air pollutants,inflammatory agents,mechanical and geometrical properties of the microenvironment could influence structure and/or function of ASM cells.In addition,some re-展开更多
The development of nitroglycerine tolerance limits its clinical efficacy of nitric oxide(NO)donors. Several cellular mechanisms have been proposed to explain this phenomenon,one of which is an exaggerated production o...The development of nitroglycerine tolerance limits its clinical efficacy of nitric oxide(NO)donors. Several cellular mechanisms have been proposed to explain this phenomenon,one of which is an exaggerated production of reactive oxygen specious(ROS).The present study examined whether ROS contribute to the occurrence of nitroglycerine tolerance which is induced展开更多
The turbulent flows through the channels with abrupt cross-sectional changes are common and importantphysical process in nature.For a better prediction of the mean flow and turbulent characteristics for this problem,a...The turbulent flows through the channels with abrupt cross-sectional changes are common and importantphysical process in nature.For a better prediction of the mean flow and turbulent characteristics for this problem,atwo-dimensional depth-averaged numerical model is developed.The model is robust and accurate in reproducing therecirculation flow behind a groyne and turbulent flows in channels with abrupt cross-sectional changes,when com-pared to the available experimental data of mean velocities and turbulence kinetic energy.Our results reveal that theabrupt cross-sectional change of a channel can affect the flow pattern significantly and introduces the complex turbu-lence characteristics.In particular,when the channel has an abrupt expansion,the mean flow pattern is mainly in lon-gitudinal direction with rather small transverse component.Meanwhile,a recirculating region forms behind the expan-sion position and the turbulence has very strong intensity within this region.For the flow in the channel with an ab-rupt contraction,the longitudinal component of the flow is decreased by the obstruction on one side and accelerated onthe other side,whereas the transverse velocity is small.The turbulence is extraordinarily strong in the regions adja-cent to the contraction wall in the narrow channel.In both cases of abrupt cross-sectional changes,the TKE is genera-ted dominantly by the shear of the longitudinal velocities.展开更多
The first complete formulation of special relativity (SR) is that of Einstein who postulated the light speed invariance. The second level assumes the longitudinal length contractions and the slowing down of clock rate...The first complete formulation of special relativity (SR) is that of Einstein who postulated the light speed invariance. The second level assumes the longitudinal length contractions and the slowing down of clock rates by the same factor y-1. This level discusses the role of different synchronizations.In the third level SR is seen as a consequence of the spin motion of the elementary particles. It seems possible to detect the privileged system S for which the electromagnetic radiation due to the spin motion of all the electrons in the universe is isotropic.展开更多
A multi-sequential number-theoretic optimization method based on clustering was developed and applied to the optimization of functions with many local extrema. Details of the procedure to generate the clusters and the...A multi-sequential number-theoretic optimization method based on clustering was developed and applied to the optimization of functions with many local extrema. Details of the procedure to generate the clusters and the sequential schedules were given. The algorithm was assessed by comparing its performance with generalized simulated annealing algorithm in a difficult instructive example and a D-optimum experimental design problem. It is shown the presented algorithm to be more effective and reliable based on the two examples.展开更多
In supply chain management,an important research direction is to coordinate the supply chain through introducing flexible contracts.A supply chain contract is flexible if it can satisfy two conditions at the same time...In supply chain management,an important research direction is to coordinate the supply chain through introducing flexible contracts.A supply chain contract is flexible if it can satisfy two conditions at the same time：the supply chain is coordinated,and the total profit of the supply chain can be arbitrarily divided between the supply chain members.This paper puts out two contracts,a flexible return contract and a flexible wholesale price discount contract.In contrast to many of literature,the supply chain contracts with an endogenous wholesale price is specifically considered,and a detailed sensitivity analysis of the contract parameters is given.The paper also discusses the application of the contract in vendor-managed inventory（VMI） mode.The results show that the supply chain＇s performance is improved after introducing above contracts.All the findings are illustrated by numerical examples.展开更多
To improve the performance of the supply chain with one supplier and multiple retailers under deterministic price-sensitive customer demand, an optimal strategy is proposed based on knowledge discovery. First the dece...To improve the performance of the supply chain with one supplier and multiple retailers under deterministic price-sensitive customer demand, an optimal strategy is proposed based on knowledge discovery. First the decentralized system in which the supplier and the retailers are independent, profit-maximizing participants with the supplier acting as a Stackelberg game leader is studied. Numerical examples illustrate the importance of the coordination. The conventional quantity discount mechanism needs to be modified to coordinate the supply chain, so a revenue-sharing contract is proposed to coordinate such supply chain. Lastly, a special decision under certain demand rates is studied. The pricing and replenishment policies can be decided sequentially, which yields much less loss comparing with optimal decision when the demand rates are sufficiently large.展开更多
Based on a variety of geometric observations for location of solutions, a general and unified region analysis framework for developing constructive solvability of nonlinear operator equations are proposed. Within this...Based on a variety of geometric observations for location of solutions, a general and unified region analysis framework for developing constructive solvability of nonlinear operator equations are proposed. Within this framework, the methods including interval, ball and ellipsoid methods can be studied in a unified way. The ball algorithm, as a typical example, is in particular analysed.展开更多
With an elastic negative pole being driven by ultra so nic vibration and being moved along the surface of work-piece compliantly by ro bot, a new kind of effective EDM, the compliant EDM, cuts the electrically condu c...With an elastic negative pole being driven by ultra so nic vibration and being moved along the surface of work-piece compliantly by ro bot, a new kind of effective EDM, the compliant EDM, cuts the electrically condu ctive materials away and polishes work-piece of free-form surface. The study o f the contact force between the end of polishing tool and the surface of work-p iece is the key for the compliant EDM to study its cutting mechanism and to make better use of it. This paper makes a model for the contact force and verifies i t by experiments and simulation based on the theory of elastic body kinetics and dynamic stress concentration. The research work shows that this contact force i s caused by both the electrical impulsion of EDM and the mechanical force of ult rasonic vibration, the discharge frequency of compliant EDM has a much more clos er connection with the vibration frequency of polishing tool rather than the fre quency of ultrasonic vibration.展开更多
During the course of knowledge economic, setting up e nterprise dynamic alliances is gradually becoming the most effective way for the enterprises, which seek fast development. There are many researches about enter pr...During the course of knowledge economic, setting up e nterprise dynamic alliances is gradually becoming the most effective way for the enterprises, which seek fast development. There are many researches about enter prise dynamic alliances in other fields, but there is few research about leg al relationship among members of enterprise dynamic alliances and ownership of i ntellectual property achievements which are brought by dynamic alliances. Th is paper discusses legal relationship among members of dynamic alliances and own ership of intellectual property achievements under various legal relationshi ps from the point of view of law.展开更多
基金Project(LQ15E080002)supported by Zhejiang Provincial Natural Science Foundation of ChinaProjects(5150828251478228)supported by the National Natural Science Foundation of China
文摘When an expanded-base pile is installed into ground, the cavity expansion associated with penetration of the enlarged pile base is followed by cavity contraction along the smaller-diameter pile shaft. In order to account for the influence of cavity contraction on the change of bearing capacity of expanded-base pile, a theoretical calculation methodology, predicting the setup of expanded-base pile, was established by employing the cavity contraction theory to estimate the shaft resistance of expanded-base pile, and horizontal consolidation theory to predict the dissipation of excess pore pressure. Finally, the numerical solutions for the setup of expanded-base pile were obtained. The parametric study about the influence of cavity contraction on setup of expanded-base pile was carried out, while a field test was introduced. The parametric study shows that the decrements in radial pressure and the maximum pore water pressure after considering cavity contraction are increased as the expanded ratio(base diameter/shaft diameter) and rigidity index of soil are raised. The comparison between calculated and measured values shows that the calculated results of ultimate bearing capacity for expanded-base pile considering cavity contraction agree well with the measured values; however, the computations ignoring cavity contraction are 2.5-3.0 times the measured values.
文摘The study was to investigate the effect of reducing central sympathetic nervous tone with clonidine on cardiomyocyte contraction,and further to analyze the influence of reducing the central sympathetic nervous tone on response of β1 and β2-AR in aged ventricular myocytes.Sprague-Dawley rats were randomly divided into three groups:adult group,aged group and aged group with clonidine.
基金Supported by the National Natural Science Foundation of China(12201368,62376252)Key Project of Natural Science Foundation of Zhejiang Province(LZ22F030003)Zhejiang Province Leading Geese Plan(2024C02G1123882,2024C01SA100795).
文摘With the urgent need to resolve complex behaviors in nonlinear evolution equations,this study makes a contribution by establishing the local existence of solutions for Cauchy problems associated with equations of mixed types.Our primary contribution is the establishment of solution existence,illuminating the dynamics of these complex equations.To tackle this challenging problem,we construct an approximate solution sequence and apply the contraction mapping principle to rigorously prove local solution existence.Our results significantly advance the understanding of nonlinear evolution equations of mixed types.Furthermore,they provide a versatile,powerful approach for tackling analogous challenges across physics,engineering,and applied mathematics,making this work a valuable reference for researchers in these fields.
基金supported by the National Key Research and Development Plan(Grant No.2021YFB3302501)the National Natural Science Foundation of China(Grant Nos.12102077,12161076,U2241263).
文摘Combat effectiveness of unmanned aerial vehicle(UAV)formations can be severely affected by the mission execution reliability.During the practical execution phase,there are inevitable risks where UAVs being destroyed or targets failed to be executed.To improve the mission reliability,a resilient mission planning framework integrates task pre-and re-assignment modules is developed in this paper.In the task pre-assignment phase,to guarantee the mission reliability,probability constraints regarding the minimum mission success rate are imposed to establish a multi-objective optimization model.And an improved genetic algorithm with the multi-population mechanism and specifically designed evolutionary operators is used for efficient solution.As in the task-reassignment phase,possible trigger events are first analyzed.A real-time contract net protocol-based algorithm is then proposed to address the corresponding emergency scenario.And the dual objective used in the former phase is adapted into a single objective to keep a consistent combat intention.Three cases of different scales demonstrate that the two modules cooperate well with each other.On the one hand,the pre-assignment module can generate high-reliability mission schedules as an elaborate mathematical model is introduced.On the other hand,the re-assignment module can efficiently respond to various emergencies and adjust the original schedule within a millisecond.The corresponding animation is accessible at bilibili.com/video/BV12t421w7EE for better illustration.
基金National Natural Science Foundation of China (12202293)Sichuan Science and Technology Program (2023NSFSC0393,2022NSFSC1952)。
文摘A task allocation problem for the heterogeneous unmanned aerial vehicle (UAV) swarm in unknown environments is studied in this paper.Considering that the actual mission environment information may be unknown,the UAV swarm needs to detect the environment first and then attack the detected targets.The heterogeneity of UAVs,multiple types of tasks,and the dynamic nature of task environment lead to uneven load and time sequence problems.This paper proposes an improved contract net protocol (CNP) based task allocation scheme,which effectively balances the load of UAVs and improves the task efficiency.Firstly,two types of task models are established,including regional reconnaissance tasks and target attack tasks.Secondly,for regional reconnaissance tasks,an improved CNP algorithm using the uncertain contract is developed.Through uncertain contracts,the area size of the regional reconnaissance task is determined adaptively after this task assignment,which can improve reconnaissance efficiency and resource utilization.Thirdly,for target attack tasks,an improved CNP algorithm using the fuzzy integrated evaluation and the double-layer negotiation is presented to enhance collaborative attack efficiency through adjusting the assignment sequence adaptively and multi-layer allocation.Finally,the effectiveness and advantages of the improved method are verified through comparison simulations.
文摘Paleogene sedimentary basins exposed across much of the central and eastern Tibetan Plateau may record the early history of plateau uplift related to the Indo\|Asian collision. We conducted sedimentological and stratigraphic investigations in the northeastern Qiangtang terrane, eastern Tibetan Plateau. Our results indicate development of several nonmarine basins during Paleogene(?) time, probably synchronous with northeast\|southwest contractional deformation. The Nangqian and Xialaxiu basins (96°～97°E, 32°～33°N) are composed of 500～ 20000m thick successions of primarily clastic sediment indicative of lacustrine and alluvial\|fan depositional processes. Paleocurrent measurements and sediment compositional data indicate local sediment source areas composed of Carboniferous\|Triassic carbonate and sandstone and minor Tertiary volcanic rocks. The large variability of provenance and facies types suggest that each basin evolved independently, as opposed to regional development of a single integrated basin which was partitioned by later deformation.
基金Projects(51109029,51178081,51138001)supported by the National Natural Science Foundation of ChinaProject(2013CB035905)supported by the National Basic Research Program of China
文摘The dynamic responses of the arch dam including dam-foundation-storage capacity of water system,using two different earthquake input models,i.e.viscous-spring artificial boundary(AB)condition and massless foundation(MF),were studied and analyzed for the 269 m high Baihetan arch dam under construction in China.By using different input models,the stress and opening of contraction joints(OCJs)of arch dam under strong shock were taken into consideration.The results show that the earthquake input models have slight influence on the responses including earthquake stresses and openings of contraction joints in different extents.
基金Projects(51323014,51479097,51279086)supported by the National Natural Science Foundation of ChinaProject(2016-KY-2)supported by the State Key Laboratory of Hydroscience and Hydraulic Engineering,China
文摘Reservoir impoundment is related to several hydraulic engineering concerns,including irreversible valley contractions,landslides and reservoir-induced earthquakes.However,these phenomena,such as valley contractions,are hardly to be explained by the conventional method.The scientific understanding of water effects during impoundment and their hazards to hydraulic structure are needed.The effective stress law for fissured rock masses is introduced in the elasto-plastic model employing the Drucker-Prager criterion and implemented in the three dimension(3D)nonlinear finite element method(FEM)program Three-dimensional FINite Element(TFINE).The slope deforms towards river-way during impoundment since the increasing pore pressure in fissures changes stress state and leads to additional plastic deformation in the rock materials.The value of Biot coefficient and the influence of water on rock materials are discussed in detail.Thus,the mechanism of slope deformation during the impoundment of Jinping-I arch dam is revealed,and the deformation is accurately measured.The application of the effective stress law provides a method to consider stress assessment,deformation evaluation and stability estimate of hydraulic structures during the impoundment process.This is a beneficial exploration and an improvement of hydraulic engineering design.
基金supported in part by National Sciences Foundation of China grants ( 11672001, 81571691,81771844)
文摘Objective Patients with repaired tetralogy of Fallot(rTOF)account for the majority of cases with late onset right ventricle(RV)failure.The current surgical approach,including pulmonary valve replacement/insertion(PVR),has yielded mixed results with some patients recover RV function and some do not.An innovative surgical approach was proposed to help ventricle to contract and improve RV function qualified by ejection fraction with one or more active contracting bands.Computational biomechanical modelling is a widely used method in cardiovascular study for investigation of mechanisms governing disease development,quantitative diagnostic and treatment strategies and improving surgical designs for better outcome.Muscle active contraction caused by zero-load sarcomere shortening leads to change of zero-load configurations.In lieu of experimenting using real surgery on animal or human,computational simulations(virtual surgery)were performed to test different band combination and insertion options to identify optimal surgery design and band insertion plan.Methods Cardiac magnetic resonance(CMR)data were obtained from one rTOF patient(sex:male,age:22.5 y)before pulmonary valve replacement surgery.The patient was suffering from RV dilation and dysfunction with RV end-systole volume 254.49ml and end-diastole volume 406.91 mL.A total of 15 computational RV/LV/Patch/Band combination models based on(CMR)imaging were constructed to investigate the influence of different band insertion surgery plans.These models included 5 different band insertion models combined and 3 different band contraction ratio(10%,15%and 20%band zero-stress length reduction).These models included 5 different band insertion models:Model 1 with one band at anterior to the middle of papillary muscle;Model 2 with one band at posterior to the middle of papillary muscle;Model 3 with 2 bands which are the ones from Models 1&2 combined;Model 4 with a band at the base of the papillary muscle;Model 5 with 3 bands which is a combination of Models 3&4.A pre-shrink process was performed on in-vivo begin-filling and end-systole MRI data to obtain diastole and systole zero4oad ventricle geometries.An extra 5%-8%shrinkage was applied to obtain corresponding systole zero-load geometry reflecting myocardium sarcomere shortening.The zero-load band length in systole was 10%,15%and 20%shorter than that in diastole according to their corresponding contraction ratio.The nonlinear Mooney-Rivlin model was used to describe the ventricle material properties with their material parameter values adjusted to match measured data with CMR.The band material properties were in the same scale with healthy right ventricle.The RV/LV/Band model construction and solution procedures were the same as described.Results Model 5 with band contraction ratio of 20%has the ability to improve RV ejection fraction to 41.07%,which represented a 3.61%absolute improvement,or 9.6%relative improvement using pre-PVR ejection fraction as the baseline number.The ejection fractions for Models 1-4 with band contraction ratio of 20%were 39.28%,39.47%,38.87%and 40.34%respectively.Compared to models with band contraction ratio15%and 20%,models with band contraction ratio 10%has the least ability on RV ejection fraction improvement with ejection fraction 38.28%,38.00%,38.81%,38.50%and 39.36%corresponding to Models 1-5.Conclusions This pilot work demonstrated that the band insertion surgery may have great potential to improve post-PVR RV cardiac function for patients with repaired TOF.More band contraction ratio and inserted band number may lead to better post-surgery outcome.Further investigations using in-vitro animal experiments and final patient studies are warranted.
基金supported by National Natural Science Foundation of China(Grant No. 11172340)Training Program for Hundreds of Distinguished Leading Scientists of Chongqing+3 种基金Chongqing Natural Science Foundation(Grant No.CSTC2010BA5001,CSTC2012jjA0588)Fundamental Research Funds for the Central Universities(Grant No.CQDXWL-2012-123)Specialized Research Fund for the Doctoral Program of Higher Education of China(Grant No.20120191120032)Sharing Fund of Chongqing University's LargeScale Equipment(Grant No.2010063057,2011063048,2011063049)
文摘Introduction Excessive narrowing of airways is the most important pathological feature of asthma,but its mechanism remains puzzling.One certain thing is that the contraction of airway smooth muscle(ASM)ultimately causes airway narrowing,thus both structural and functional alterations of airway smooth muscle(ASM)are thought as common final pathway responsible for the bronchial hyperresponsiveness(BHR),the hall mark of asthma.Many chemical and physical factors such as air pollutants,inflammatory agents,mechanical and geometrical properties of the microenvironment could influence structure and/or function of ASM cells.In addition,some re-
文摘The development of nitroglycerine tolerance limits its clinical efficacy of nitric oxide(NO)donors. Several cellular mechanisms have been proposed to explain this phenomenon,one of which is an exaggerated production of reactive oxygen specious(ROS).The present study examined whether ROS contribute to the occurrence of nitroglycerine tolerance which is induced
基金supported,in part,by the National Natural Science Foundation of China(51061130547 and51279120)
文摘The turbulent flows through the channels with abrupt cross-sectional changes are common and importantphysical process in nature.For a better prediction of the mean flow and turbulent characteristics for this problem,atwo-dimensional depth-averaged numerical model is developed.The model is robust and accurate in reproducing therecirculation flow behind a groyne and turbulent flows in channels with abrupt cross-sectional changes,when com-pared to the available experimental data of mean velocities and turbulence kinetic energy.Our results reveal that theabrupt cross-sectional change of a channel can affect the flow pattern significantly and introduces the complex turbu-lence characteristics.In particular,when the channel has an abrupt expansion,the mean flow pattern is mainly in lon-gitudinal direction with rather small transverse component.Meanwhile,a recirculating region forms behind the expan-sion position and the turbulence has very strong intensity within this region.For the flow in the channel with an ab-rupt contraction,the longitudinal component of the flow is decreased by the obstruction on one side and accelerated onthe other side,whereas the transverse velocity is small.The turbulence is extraordinarily strong in the regions adja-cent to the contraction wall in the narrow channel.In both cases of abrupt cross-sectional changes,the TKE is genera-ted dominantly by the shear of the longitudinal velocities.
文摘The first complete formulation of special relativity (SR) is that of Einstein who postulated the light speed invariance. The second level assumes the longitudinal length contractions and the slowing down of clock rates by the same factor y-1. This level discusses the role of different synchronizations.In the third level SR is seen as a consequence of the spin motion of the elementary particles. It seems possible to detect the privileged system S for which the electromagnetic radiation due to the spin motion of all the electrons in the universe is isotropic.
基金Project supported by the Postdoctoral Science Foundation of Central South University
文摘A multi-sequential number-theoretic optimization method based on clustering was developed and applied to the optimization of functions with many local extrema. Details of the procedure to generate the clusters and the sequential schedules were given. The algorithm was assessed by comparing its performance with generalized simulated annealing algorithm in a difficult instructive example and a D-optimum experimental design problem. It is shown the presented algorithm to be more effective and reliable based on the two examples.
基金supported by the Science and Technology Project of Zhejiang Province (2009C110262009C35007)
文摘In supply chain management,an important research direction is to coordinate the supply chain through introducing flexible contracts.A supply chain contract is flexible if it can satisfy two conditions at the same time：the supply chain is coordinated,and the total profit of the supply chain can be arbitrarily divided between the supply chain members.This paper puts out two contracts,a flexible return contract and a flexible wholesale price discount contract.In contrast to many of literature,the supply chain contracts with an endogenous wholesale price is specifically considered,and a detailed sensitivity analysis of the contract parameters is given.The paper also discusses the application of the contract in vendor-managed inventory（VMI） mode.The results show that the supply chain＇s performance is improved after introducing above contracts.All the findings are illustrated by numerical examples.
基金the National Natural Science Foundation of China (70471034)the Talent Foundation of Nanjing University of Aeronautics and Astronautics (s0670-082).
文摘To improve the performance of the supply chain with one supplier and multiple retailers under deterministic price-sensitive customer demand, an optimal strategy is proposed based on knowledge discovery. First the decentralized system in which the supplier and the retailers are independent, profit-maximizing participants with the supplier acting as a Stackelberg game leader is studied. Numerical examples illustrate the importance of the coordination. The conventional quantity discount mechanism needs to be modified to coordinate the supply chain, so a revenue-sharing contract is proposed to coordinate such supply chain. Lastly, a special decision under certain demand rates is studied. The pricing and replenishment policies can be decided sequentially, which yields much less loss comparing with optimal decision when the demand rates are sufficiently large.
文摘Based on a variety of geometric observations for location of solutions, a general and unified region analysis framework for developing constructive solvability of nonlinear operator equations are proposed. Within this framework, the methods including interval, ball and ellipsoid methods can be studied in a unified way. The ball algorithm, as a typical example, is in particular analysed.
文摘With an elastic negative pole being driven by ultra so nic vibration and being moved along the surface of work-piece compliantly by ro bot, a new kind of effective EDM, the compliant EDM, cuts the electrically condu ctive materials away and polishes work-piece of free-form surface. The study o f the contact force between the end of polishing tool and the surface of work-p iece is the key for the compliant EDM to study its cutting mechanism and to make better use of it. This paper makes a model for the contact force and verifies i t by experiments and simulation based on the theory of elastic body kinetics and dynamic stress concentration. The research work shows that this contact force i s caused by both the electrical impulsion of EDM and the mechanical force of ult rasonic vibration, the discharge frequency of compliant EDM has a much more clos er connection with the vibration frequency of polishing tool rather than the fre quency of ultrasonic vibration.
基金Project (No .70 1 71 0 0 7)supportedbyNationalScienceFoundationofChina
文摘During the course of knowledge economic, setting up e nterprise dynamic alliances is gradually becoming the most effective way for the enterprises, which seek fast development. There are many researches about enter prise dynamic alliances in other fields, but there is few research about leg al relationship among members of enterprise dynamic alliances and ownership of i ntellectual property achievements which are brought by dynamic alliances. Th is paper discusses legal relationship among members of dynamic alliances and own ership of intellectual property achievements under various legal relationshi ps from the point of view of law.
