Background The role of human lineage mutations(HLMs)in human evolution through post-transcriptional modification is unclear.Aims To investigate the contribution of HLMs to human evolution through post-transcriptional ...Background The role of human lineage mutations(HLMs)in human evolution through post-transcriptional modification is unclear.Aims To investigate the contribution of HLMs to human evolution through post-transcriptional modification.Methods We applied a deep learning model Seqweaver to predict how HLMs impact RNA-binding protein affinity.Results We found that only 0.27%of HLMs had significant impacts on RNA-binding proteins at the threshold of the top 1%of human common variations.These HLMs enriched in a set of conserved genes highly expressed in adult excitatory neurons and prenatal Purkinje neurons,and were involved in synapse organisation and the GTPase pathway.These genes also carried excess damaging coding mutations that caused neurodevelopmental disorders,ataxia and schizophrenia.Among these genes,NTRK2 and ITPR1 had the most aggregated evidence of functional importance,suggesting their essential roles in cognition and bipedalism.Conclusions Our findings suggest that a small subset of human-specific mutations have contributed to human speciation through impacts on post-transcriptional modification of critical brain-related genes.展开更多
The invariance of the ordinary differential equations under the infinitesimal transformations was used to study the Lie symmetries and conserved quantities for the singular Lagrange system. The determining equations, ...The invariance of the ordinary differential equations under the infinitesimal transformations was used to study the Lie symmetries and conserved quantities for the singular Lagrange system. The determining equations, the restriction equations of the Lie symmetries and the form of conserved quantities of the system are obtained.展开更多
Aim To study the Lie symmetries and conserved quantities of holonomic mechanical systems in terms of qnasi-coordinates. Methods The definition of an infinitesimal generator for the holonomic mechanical systems in te...Aim To study the Lie symmetries and conserved quantities of holonomic mechanical systems in terms of qnasi-coordinates. Methods The definition of an infinitesimal generator for the holonomic mechanical systems in terms of quasi-coordinates was given. Lie's method of the invariance of ordinary differential equations under infinitesimal transformations was used. Results and Conclusion The determining equations of the Lie symmetries of holonomic mechanical systems in terms of quassi-coordinates are established. The structure equation and the form of conserved quantities are obtained. An example to illustrate the applicaiton of the result is given.展开更多
Aim To study the Lie symmetries and the consered quantities of the holonomic systems with remainder coordinates. Methods Using the invariance of the ordinary differential equations under the infinitesimal transformati...Aim To study the Lie symmetries and the consered quantities of the holonomic systems with remainder coordinates. Methods Using the invariance of the ordinary differential equations under the infinitesimal transformations to establish the determining equations and the restriction equations of the Lie symmetries of the systems. Results and Conclusion the structure equation and the form of conserved quantities were obtained. An example was given to illustrate the application of the result.展开更多
This paper studies conformal invariance and conserved quantity of third-order Lagrange equations for non- conserved mechanical systems. Third-order Lagrange equations, the definition and a determining equation of conf...This paper studies conformal invariance and conserved quantity of third-order Lagrange equations for non- conserved mechanical systems. Third-order Lagrange equations, the definition and a determining equation of conformal invariance of the system are presented. The conformal factor expression is deduced from conformal invariance and Lie symmetry. The necessary and sufficient condition that conformal invaxiance of the system would have Lie symmetry under single-parameter infinitesimal transformations is obtained. The corresponding conserved quantity of conformal invariance is derived with the aid of a structure equation. Lastly, an example is given to illustrate the application of the results.展开更多
To study Lie symmetry and the conserved quantity of a generalized Birkhoff system with additional terms, the determining equations of the Lie symmetry of the system is derived. A con- served quantity of Hojman＇ s typ...To study Lie symmetry and the conserved quantity of a generalized Birkhoff system with additional terms, the determining equations of the Lie symmetry of the system is derived. A con- served quantity of Hojman＇ s type and a Noether＇ s conserved quantity are deduced by the Lie symme- try under some conditions. One example is given to illustrate the application of the result.展开更多
Aim To study the Lie symmetries and conserved quantities of the dynamical equationsof relative motion for holonomic mechanical systems. Methods Lie's method of the invariance of ordinary differential equations u...Aim To study the Lie symmetries and conserved quantities of the dynamical equationsof relative motion for holonomic mechanical systems. Methods Lie's method of the invariance of ordinary differential equations under infinitesimal transformations was used. Results and Conclusion The determining equaiton of the Lie symmetries for the dynamical equationS of relative motion is established.The structure quation and the form conserved quantities are obtained. An example iD illustrate the application of the result is given.展开更多
This paper focuses on studying the Noether symmetry and the conserved quantity with non-standard Lagrangians, namely exponential Lagrangians and power-law Lagrangians on time scales. Firstly, for each case, the Hamilt...This paper focuses on studying the Noether symmetry and the conserved quantity with non-standard Lagrangians, namely exponential Lagrangians and power-law Lagrangians on time scales. Firstly, for each case, the Hamilton prin- ciple based on the action with non-standard Lagrangians on time scales is established, with which the corresponding Euler-Lagrange equation is given. Secondly, according to the invariance of the Hamilton action under the infinitesimal transformation, the Noether theorem for the dynamical system with non-standard Lagrangians on time scales is established. The proof of the theorem consists of two steps. First, it is proved under the infinitesimal transformations of a special one-parameter group without transforming time. Second, utilizing the technique of time-re-parameterization, the Noether theorem in a general form is obtained. The Noether-type conserved quantities with non-standard Lagrangians in both clas- sical and discrete cases are given. Finally, an example in Friedmann-Robertson-Walker spacetime and an example about second order Duffing equation are given to illustrate the application of the results.展开更多
A symmetry and a conserved quantity of the Birkhoff system are studied. The symmetry is called the Birkhoff symmetry. Its definition and criterion are given in this paper. A conserved quantity can be deduced by using ...A symmetry and a conserved quantity of the Birkhoff system are studied. The symmetry is called the Birkhoff symmetry. Its definition and criterion are given in this paper. A conserved quantity can be deduced by using the symmetry. An example is given to illustrate the application of the result.展开更多
This paper studies the Mei symmetry and Mei conserved quantity for nonholonomic systems of unilateral Chetaev type in Nielsen style. The differential equations of motion of the system above are established. The defini...This paper studies the Mei symmetry and Mei conserved quantity for nonholonomic systems of unilateral Chetaev type in Nielsen style. The differential equations of motion of the system above are established. The definition and the criteria of Mei symmetry, loosely Mei symmetry, strictly Mei symmetry for the system are given in this paper. The existence condition and the expression of Mei conserved quantity are deduced directly by using Mei symmetry. An example is given to illustrate the application of the results.展开更多
We obtain a new type of conserved quantity of Mei symmetry for the motion of mechanico--electrical coupling dynamical systems under the infinitesimal transformations. A criterion of Mei symmetry for the mechanico-elec...We obtain a new type of conserved quantity of Mei symmetry for the motion of mechanico--electrical coupling dynamical systems under the infinitesimal transformations. A criterion of Mei symmetry for the mechanico-electrical coupling dynamical systems is given. Simultaneously, the condition of existence of the new conserved quantity of Mei symmetry for mechanico-electrical coupling dynamical systems is obtained. Finally, an example is given to illustrate the application of the results.展开更多
The invariance of the differential equations under the infinitesimal transformations was used to study the Lie symmetries and conserved quantities of arbitrary order nonholonomic systems. The determining equations, th...The invariance of the differential equations under the infinitesimal transformations was used to study the Lie symmetries and conserved quantities of arbitrary order nonholonomic systems. The determining equations, the restriction equations, the structure equation and the form of the conserved quantities were obtained.展开更多
In this paper the conformal invariance by infinitesimal transformations of first order Lagrange systems is discussed in detail. The necessary and sufficient conditions of conformal invariance and Lie symmetry simultan...In this paper the conformal invariance by infinitesimal transformations of first order Lagrange systems is discussed in detail. The necessary and sufficient conditions of conformal invariance and Lie symmetry simultaneously by the action of infinitesimal transformations are given. Then it gets the Hojman conserved quantities of conformal invariance by the infinitesimal transformations. Finally an example is given to illustrate the application of the results.展开更多
This paper studies a new type of conserved quantity which is directly induced by Lie symmetry of the Lagrange system. Firstly, the criterion of Lie symmetry for the Lagrange system is given. Secondly, the conditions o...This paper studies a new type of conserved quantity which is directly induced by Lie symmetry of the Lagrange system. Firstly, the criterion of Lie symmetry for the Lagrange system is given. Secondly, the conditions of existence of the new conserved quantity as well as its forms are proposed. Lastly, an example is given to illustrate the application of the result.展开更多
This paper discusses in detail the conformal invariance by infinitesimal transformations of a dynamical system of relative motion. The necessary and sufficient conditions of conformal invariance and Lie symmetry are g...This paper discusses in detail the conformal invariance by infinitesimal transformations of a dynamical system of relative motion. The necessary and sufficient conditions of conformal invariance and Lie symmetry are given simultaneously by the action of infinitesimal transformations. Then it obtains the conserved quantities of conformal invariance by the infinitesimal transformations. Finally an example is given to illustrate the application of the results.展开更多
In this paper, the Noether symmetries and the conserved quantities for a Hamilton system with time delay are dis-cussed. Firstly, the variational principles with time delay for the Hamilton system are given, and the H...In this paper, the Noether symmetries and the conserved quantities for a Hamilton system with time delay are dis-cussed. Firstly, the variational principles with time delay for the Hamilton system are given, and the Hamilton canonical equations with time delay are established. Secondly, according to the invariance of the function under the infinitesimal transformations of the group, the basic formulas for the variational of the Hamilton action with time delay are discussed, the definitions and the criteria of the Noether symmetric transformations and quasi-symmetric transformations with time delay are obtained, and the relationship between the Noether symmetry and the conserved quantity with time delay is studied. In addition, examples are given to illustrate the application of the results.展开更多
This paper studies conformal invariance and conserved quantities of Hamilton system. The definition and the determining equation of conformal invariance for Hamilton system are provided. The relationship between the c...This paper studies conformal invariance and conserved quantities of Hamilton system. The definition and the determining equation of conformal invariance for Hamilton system are provided. The relationship between the conformal invariance and the Lie symmetry are discussed, and the necessary and sufficient condition that the conformal invariance would be the Lie symmetry of the system under the infinitesimal one-parameter transformation group is deduced. It gives the conserved quantities of the system and an example for illustration.展开更多
This paper studies a new type of conserved quantity which is directly induced by Mei symmetry of the Lagrange system. Firstly, the definition and criterion of Mei symmetry for the Lagrange system are given. Secondly, ...This paper studies a new type of conserved quantity which is directly induced by Mei symmetry of the Lagrange system. Firstly, the definition and criterion of Mei symmetry for the Lagrange system are given. Secondly, a coordination function is introduced, and the conditions of existence of the new conserved quantity as well as its forms are proposed. Lastly, an illustrated example is given. The result indicates that the coordination function can be selected properly according to the demand for finding the gauge function, and thereby the gauge function can be found more easily. Furthermore, since the choice of the coordination function has multiformity, many more conserved quantities of Mei symmetry for the Lagrange system can be obtained.展开更多
This paper investigates structure equation and Mei conserved quantity of Mei symmetry of Appell equations for non-Chetaev nonholonomic systems. Appell equations and differential equations of motion for non-Chetaev non...This paper investigates structure equation and Mei conserved quantity of Mei symmetry of Appell equations for non-Chetaev nonholonomic systems. Appell equations and differential equations of motion for non-Chetaev nonholonomic mechanical systems are established. A new expression of the total derivative of the function with respect to time t along the trajectory of a curve of the system is obtained, the definition and the criterion of Mei symmetry of Appell equations under the infinitesimal transformations of groups are also given. The expressions of the structure equation and the Mei conserved quantity of Mei symmetry in the Appell function are obtained. An example is given to illustrate the application of the results.展开更多
This paper focuses on studying the Lie symmetry and a conserved quantity of a system of first-order differential equations. The determining equations of the Lie symmetry for a system of first-order differential equati...This paper focuses on studying the Lie symmetry and a conserved quantity of a system of first-order differential equations. The determining equations of the Lie symmetry for a system of first-order differential equations, from which a kind of conserved quantity is deduced, are presented. And their general conclusion is applied to a Hamilton system, a Birkhoff system and a generalized Hamilton system. Two examples are given to illustrate the application of the results.展开更多
基金supported by grants from the 2030 Science and Technology Innovation Key Program of Ministry of Science and Technology of China(No.2022ZD020910001)the Natural Science Foundation of Shanghai(No.21ZR1428600)the Medical-Engineering Cross Foundation of Shanghai Jiao Tong University(No.YG2022ZD026,21Z510902252,23X010302269).
文摘Background The role of human lineage mutations(HLMs)in human evolution through post-transcriptional modification is unclear.Aims To investigate the contribution of HLMs to human evolution through post-transcriptional modification.Methods We applied a deep learning model Seqweaver to predict how HLMs impact RNA-binding protein affinity.Results We found that only 0.27%of HLMs had significant impacts on RNA-binding proteins at the threshold of the top 1%of human common variations.These HLMs enriched in a set of conserved genes highly expressed in adult excitatory neurons and prenatal Purkinje neurons,and were involved in synapse organisation and the GTPase pathway.These genes also carried excess damaging coding mutations that caused neurodevelopmental disorders,ataxia and schizophrenia.Among these genes,NTRK2 and ITPR1 had the most aggregated evidence of functional importance,suggesting their essential roles in cognition and bipedalism.Conclusions Our findings suggest that a small subset of human-specific mutations have contributed to human speciation through impacts on post-transcriptional modification of critical brain-related genes.
文摘The invariance of the ordinary differential equations under the infinitesimal transformations was used to study the Lie symmetries and conserved quantities for the singular Lagrange system. The determining equations, the restriction equations of the Lie symmetries and the form of conserved quantities of the system are obtained.
文摘Aim To study the Lie symmetries and conserved quantities of holonomic mechanical systems in terms of qnasi-coordinates. Methods The definition of an infinitesimal generator for the holonomic mechanical systems in terms of quasi-coordinates was given. Lie's method of the invariance of ordinary differential equations under infinitesimal transformations was used. Results and Conclusion The determining equations of the Lie symmetries of holonomic mechanical systems in terms of quassi-coordinates are established. The structure equation and the form of conserved quantities are obtained. An example to illustrate the applicaiton of the result is given.
文摘Aim To study the Lie symmetries and the consered quantities of the holonomic systems with remainder coordinates. Methods Using the invariance of the ordinary differential equations under the infinitesimal transformations to establish the determining equations and the restriction equations of the Lie symmetries of the systems. Results and Conclusion the structure equation and the form of conserved quantities were obtained. An example was given to illustrate the application of the result.
基金Project supported by the Graduate Students Innovative Foundation of China University of Petroleum (East China) (Grant NoS2009-19)
文摘This paper studies conformal invariance and conserved quantity of third-order Lagrange equations for non- conserved mechanical systems. Third-order Lagrange equations, the definition and a determining equation of conformal invariance of the system are presented. The conformal factor expression is deduced from conformal invariance and Lie symmetry. The necessary and sufficient condition that conformal invaxiance of the system would have Lie symmetry under single-parameter infinitesimal transformations is obtained. The corresponding conserved quantity of conformal invariance is derived with the aid of a structure equation. Lastly, an example is given to illustrate the application of the results.
基金Supported by the National Natural Science Foundation of China(10772025)the Key Program of the National Natural Science Foundation of China(10932002)
文摘To study Lie symmetry and the conserved quantity of a generalized Birkhoff system with additional terms, the determining equations of the Lie symmetry of the system is derived. A con- served quantity of Hojman＇ s type and a Noether＇ s conserved quantity are deduced by the Lie symme- try under some conditions. One example is given to illustrate the application of the result.
文摘Aim To study the Lie symmetries and conserved quantities of the dynamical equationsof relative motion for holonomic mechanical systems. Methods Lie's method of the invariance of ordinary differential equations under infinitesimal transformations was used. Results and Conclusion The determining equaiton of the Lie symmetries for the dynamical equationS of relative motion is established.The structure quation and the form conserved quantities are obtained. An example iD illustrate the application of the result is given.
基金supported by the National Natural Science Foundation of China(Grant Nos.11572212 and 11272227)the Innovation Program of Suzhou University of Science and Technology,China(Grant No.SKYCX16 012)
文摘This paper focuses on studying the Noether symmetry and the conserved quantity with non-standard Lagrangians, namely exponential Lagrangians and power-law Lagrangians on time scales. Firstly, for each case, the Hamilton prin- ciple based on the action with non-standard Lagrangians on time scales is established, with which the corresponding Euler-Lagrange equation is given. Secondly, according to the invariance of the Hamilton action under the infinitesimal transformation, the Noether theorem for the dynamical system with non-standard Lagrangians on time scales is established. The proof of the theorem consists of two steps. First, it is proved under the infinitesimal transformations of a special one-parameter group without transforming time. Second, utilizing the technique of time-re-parameterization, the Noether theorem in a general form is obtained. The Noether-type conserved quantities with non-standard Lagrangians in both clas- sical and discrete cases are given. Finally, an example in Friedmann-Robertson-Walker spacetime and an example about second order Duffing equation are given to illustrate the application of the results.
基金Project supported by the National Natural Science Foundation of China （Grant No 10572021） and the Special Research Fund for the Doctoral Program of Higher Education of China （Grant No 20040007022）.
文摘A symmetry and a conserved quantity of the Birkhoff system are studied. The symmetry is called the Birkhoff symmetry. Its definition and criterion are given in this paper. A conserved quantity can be deduced by using the symmetry. An example is given to illustrate the application of the result.
基金supported by the National Natural Science Foundation of China (Grant No 10572021)
文摘This paper studies the Mei symmetry and Mei conserved quantity for nonholonomic systems of unilateral Chetaev type in Nielsen style. The differential equations of motion of the system above are established. The definition and the criteria of Mei symmetry, loosely Mei symmetry, strictly Mei symmetry for the system are given in this paper. The existence condition and the expression of Mei conserved quantity are deduced directly by using Mei symmetry. An example is given to illustrate the application of the results.
基金supported by the National Natural Science Foundation of China (Grant No.11072218)
文摘We obtain a new type of conserved quantity of Mei symmetry for the motion of mechanico--electrical coupling dynamical systems under the infinitesimal transformations. A criterion of Mei symmetry for the mechanico-electrical coupling dynamical systems is given. Simultaneously, the condition of existence of the new conserved quantity of Mei symmetry for mechanico-electrical coupling dynamical systems is obtained. Finally, an example is given to illustrate the application of the results.
文摘The invariance of the differential equations under the infinitesimal transformations was used to study the Lie symmetries and conserved quantities of arbitrary order nonholonomic systems. The determining equations, the restriction equations, the structure equation and the form of the conserved quantities were obtained.
基金supported by the National Natural Science Foundation of China (Grant Nos 10372053,10572021 and 10772025)the National Natural Science Foundation of Henan province of China(Grant No 0311010900)
文摘In this paper the conformal invariance by infinitesimal transformations of first order Lagrange systems is discussed in detail. The necessary and sufficient conditions of conformal invariance and Lie symmetry simultaneously by the action of infinitesimal transformations are given. Then it gets the Hojman conserved quantities of conformal invariance by the infinitesimal transformations. Finally an example is given to illustrate the application of the results.
文摘This paper studies a new type of conserved quantity which is directly induced by Lie symmetry of the Lagrange system. Firstly, the criterion of Lie symmetry for the Lagrange system is given. Secondly, the conditions of existence of the new conserved quantity as well as its forms are proposed. Lastly, an example is given to illustrate the application of the result.
基金supported by the National Natural Science Foundation of China (Grant No 10372053)the Natural Science Foundation of Henan Province,China (Grant Nos 082300410330 and 082300410370)
文摘This paper discusses in detail the conformal invariance by infinitesimal transformations of a dynamical system of relative motion. The necessary and sufficient conditions of conformal invariance and Lie symmetry are given simultaneously by the action of infinitesimal transformations. Then it obtains the conserved quantities of conformal invariance by the infinitesimal transformations. Finally an example is given to illustrate the application of the results.
基金Project supported by the National Natural Science Foundation of China(Grant Nos.10972151 and 11272227)the Innovation Program for Scientific Research in Higher Education Institution of Jiangsu Province,China(Grant No.CXLX11 0961)the Innovation Program for Scientific Research of Suzhou University of Science and Technology,China(Grant No.SKCX12S 039)
文摘In this paper, the Noether symmetries and the conserved quantities for a Hamilton system with time delay are dis-cussed. Firstly, the variational principles with time delay for the Hamilton system are given, and the Hamilton canonical equations with time delay are established. Secondly, according to the invariance of the function under the infinitesimal transformations of the group, the basic formulas for the variational of the Hamilton action with time delay are discussed, the definitions and the criteria of the Noether symmetric transformations and quasi-symmetric transformations with time delay are obtained, and the relationship between the Noether symmetry and the conserved quantity with time delay is studied. In addition, examples are given to illustrate the application of the results.
基金supported by the National Natural Science Foundation of China (Grant Nos 10572021 and 10772025)the Doctoral Program Foundation of Institution of Higher Education of China (Grant No 20040007022)
文摘This paper studies conformal invariance and conserved quantities of Hamilton system. The definition and the determining equation of conformal invariance for Hamilton system are provided. The relationship between the conformal invariance and the Lie symmetry are discussed, and the necessary and sufficient condition that the conformal invariance would be the Lie symmetry of the system under the infinitesimal one-parameter transformation group is deduced. It gives the conserved quantities of the system and an example for illustration.
文摘This paper studies a new type of conserved quantity which is directly induced by Mei symmetry of the Lagrange system. Firstly, the definition and criterion of Mei symmetry for the Lagrange system are given. Secondly, a coordination function is introduced, and the conditions of existence of the new conserved quantity as well as its forms are proposed. Lastly, an illustrated example is given. The result indicates that the coordination function can be selected properly according to the demand for finding the gauge function, and thereby the gauge function can be found more easily. Furthermore, since the choice of the coordination function has multiformity, many more conserved quantities of Mei symmetry for the Lagrange system can be obtained.
基金Project supported by the National Natural Science Foundation of China (Grant No 10572021)
文摘This paper investigates structure equation and Mei conserved quantity of Mei symmetry of Appell equations for non-Chetaev nonholonomic systems. Appell equations and differential equations of motion for non-Chetaev nonholonomic mechanical systems are established. A new expression of the total derivative of the function with respect to time t along the trajectory of a curve of the system is obtained, the definition and the criterion of Mei symmetry of Appell equations under the infinitesimal transformations of groups are also given. The expressions of the structure equation and the Mei conserved quantity of Mei symmetry in the Appell function are obtained. An example is given to illustrate the application of the results.
基金Project supported by the National Natural Science Foundation of China （Grant No 10272021） and the Doctoral Program Foundation of Institution of Higher Education of China （Grant No 20040007022）.
文摘This paper focuses on studying the Lie symmetry and a conserved quantity of a system of first-order differential equations. The determining equations of the Lie symmetry for a system of first-order differential equations, from which a kind of conserved quantity is deduced, are presented. And their general conclusion is applied to a Hamilton system, a Birkhoff system and a generalized Hamilton system. Two examples are given to illustrate the application of the results.
