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Challenges and Suggestions of Ethical Review on Clinical Research Involving Brain-Computer Interfaces
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作者 Xue-Qin Wang Hong-Qiang Sun +3 位作者 Jia-Yue Si Zi-Yan Lin Xiao-Mei Zhai Lin Lu 《Chinese Medical Sciences Journal》 CAS CSCD 2024年第2期131-139,共9页
Brain-computer interface(BCI)technology is rapidly advancing in medical research and application.As an emerging biomedical engineering technology,it has garnered significant attention in the clinical research of brain... Brain-computer interface(BCI)technology is rapidly advancing in medical research and application.As an emerging biomedical engineering technology,it has garnered significant attention in the clinical research of brain disease diagnosis and treatment,neurological rehabilitation,and mental health.However,BCI also raises several challenges and ethical concerns in clinical research.In this article,the authors investigate and discuss three aspects of BCI in medicine and healthcare:the state of international ethical governance,multidimensional ethical challenges pertaining to BCI in clinical research,and suggestive concerns for ethical review.Despite the great potential of frontier BCI research and development in the field of medical care,the ethical challenges induced by itself and the complexities of clinical research and brain function have put forward new special fields for ethics in BCI.To ensure"responsible innovation"in BCI research in healthcare and medicine,the creation of an ethical global governance framework and system,along with special guidelines for cutting-edge BCI research in medicine,is suggested. 展开更多
关键词 brain-computer interface clinical research BIOETHICS ethical governance ethical review
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Application of Brain-Computer-Interface in Awareness Detection Using Machine Learning Methods 被引量:1
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作者 Kaiqiang Feng Weilong Lin +6 位作者 Feng Wu Chengxin Pang Liang Song Yijia Wu Rong Cao Huiliang Shang Xinhua Zeng 《China Communications》 SCIE CSCD 2022年第6期279-291,共13页
The awareness detection in patients with disorders of consciousness currently relies on behavioral observations and CRS-R tests,however,the misdiagnosis rates have been relatively high.In this study,we applied brain-c... The awareness detection in patients with disorders of consciousness currently relies on behavioral observations and CRS-R tests,however,the misdiagnosis rates have been relatively high.In this study,we applied brain-computer interface(BCI)to awareness detection with a passive auditory stimulation paradigm.12 subjects with normal hearing were invited to collect electroencephalogram(EEG)based on a BCI communication system,in which EEG signals are transmitted wirelessly.After necessary preprocessing,RBF-SVM and EEGNet were used for algorithm realization and analysis.For a single subject,RBF-SVM can distinguish his(her)name stimuli awareness with classification accuracies ranging from 60-95%.EEGNet was used to learn all subjects'data and improved accuracy to 78.04%for characteristics finding and model generalization.Moreover,we completed the supplementary analysis work from the time domain and time-frequency domain.This study applied BCI communication to human awareness detection,proposed a passive auditory paradigm,and proved the effectiveness,which could be an inspiration for brain,mental or physical diseases diagnosis and detection. 展开更多
关键词 brain-computer interface EEG awareness detection machine learning deep learning
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Non-invasive EEG-based brain-computer interfaces in patients with disorders of consciousness 被引量:1
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作者 Emilia Mikoajewska Dariusz Mikoajewski 《Journal of Medical Colleges of PLA(China)》 CAS 2014年第2期109-114,共6页
Disorders of consciousness(DoCs) are chronic conditions resulting usually from severe neurological deficits. The limitations of the existing diagnosis systems and methodologies cause a need for additional tools for re... Disorders of consciousness(DoCs) are chronic conditions resulting usually from severe neurological deficits. The limitations of the existing diagnosis systems and methodologies cause a need for additional tools for relevant patients with DoCs assessment, including brain-computer interfaces(BCIs). Recent progress in BCIs' clinical applications may offer important breakthroughs in the diagnosis and therapy of patients with DoCs. Thus the clinical significance of BCI applications in the diagnosis of patients with DoCs is hard to overestimate. One of them may be brain-computer interfaces. The aim of this study is to evaluate possibility of non-invasive EEG-based brain-computer interfaces in diagnosis of patients with DOCs in post-acute and long-term care institutions. 展开更多
关键词 neurological disorders disorders of consciousness brain-computer interfaces EEG-based BCIs
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Double Deep Q-Network Decoder Based on EEG Brain-Computer Interface 被引量:1
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作者 REN Min XU Renyu ZHU Ting 《ZTE Communications》 2023年第3期3-10,共8页
Brain-computer interfaces(BCI)use neural activity as a control signal to enable direct communication between the human brain and external devices.The electrical signals generated by the brain are captured through elec... Brain-computer interfaces(BCI)use neural activity as a control signal to enable direct communication between the human brain and external devices.The electrical signals generated by the brain are captured through electroencephalogram(EEG)and translated into neural intentions reflecting the user’s behavior.Correct decoding of the neural intentions then facilitates the control of external devices.Reinforcement learning-based BCIs enhance decoders to complete tasks based only on feedback signals(rewards)from the environment,building a general framework for dynamic mapping from neural intentions to actions that adapt to changing environments.However,using traditional reinforcement learning methods can have challenges such as the curse of dimensionality and poor generalization.Therefore,in this paper,we use deep reinforcement learning to construct decoders for the correct decoding of EEG signals,demonstrate its feasibility through experiments,and demonstrate its stronger generalization on motion imaging(MI)EEG data signals with high dynamic characteristics. 展开更多
关键词 brain-computer interface(BCI) electroencephalogram(EEG) deep reinforcement learning(Deep RL) motion imaging(MI)generalizability
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Common Spatial Pattern Ensemble Classifier and Its Application in Brain-Computer Interface 被引量:5
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作者 Xu Lei Ping Yang Peng Xu Tie-Jun Liu De-Zhong Yao 《Journal of Electronic Science and Technology of China》 2009年第1期17-21,共5页
Abstract-Common spatial pattern (CSP) algorithm is a successful tool in feature estimate of brain-computer interface (BCI). However, CSP is sensitive to outlier and may result in poor outcomes since it is based on... Abstract-Common spatial pattern (CSP) algorithm is a successful tool in feature estimate of brain-computer interface (BCI). However, CSP is sensitive to outlier and may result in poor outcomes since it is based on pooling the covariance matrices of trials. In this paper, we propose a simple yet effective approach, named common spatial pattern ensemble (CSPE) classifier, to improve CSP performance. Through division of recording channels, multiple CSP filters are constructed. By projection, log-operation, and subtraction on the original signal, an ensemble classifier, majority voting, is achieved and outlier contaminations are alleviated. Experiment results demonstrate that the proposed CSPE classifier is robust to various artifacts and can achieve an average accuracy of 83.02%. 展开更多
关键词 brain-computer interface channel selection classifier ensemble common spatial pattern.
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Probabilistic Methods in Multi-Class Brain-Computer Interface 被引量:1
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作者 Ping Yang Xu Lei Tie-Jun Liu Peng Xu De-Zhong Yao 《Journal of Electronic Science and Technology of China》 2009年第1期12-16,共5页
Abstract-Two probabilistic methods are extended to research multi-class motor imagery of brain-computer interface (BCI): support vector machine (SVM) with posteriori probability (PSVM) and Bayesian linear discr... Abstract-Two probabilistic methods are extended to research multi-class motor imagery of brain-computer interface (BCI): support vector machine (SVM) with posteriori probability (PSVM) and Bayesian linear discriminant analysis with probabilistic output (PBLDA). A comparative evaluation of these two methods is conducted. The results shows that: 1) probabilistie information can improve the performance of BCI for subjects with high kappa coefficient, and 2) PSVM usually results in a stable kappa coefficient whereas PBLDA is more efficient in estimating the model parameters. 展开更多
关键词 Bayesian linear discriminant analysis brain-computer interface kappa coefficient support vector machine.
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Transfer Learning Algorithm Design for Feature Transfer Problem in Motor Imagery Brain-computer Interface
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作者 Yu Zhang Huaqing Li +3 位作者 Heng Dong Zheng Dai Xing Chen Zhuoming Li 《China Communications》 SCIE CSCD 2022年第2期39-46,共8页
The non-stationary of the motor imagery electroencephalography(MI-EEG)signal is one of the main limitations for the development of motor imagery brain-computer interfaces(MI-BCI).The nonstationary of the MI-EEG signal... The non-stationary of the motor imagery electroencephalography(MI-EEG)signal is one of the main limitations for the development of motor imagery brain-computer interfaces(MI-BCI).The nonstationary of the MI-EEG signal and the changes of the experimental environment make the feature distribution of the testing set and training set deviates,which reduces the classification accuracy of MI-BCI.In this paper,we propose a Kullback–Leibler divergence(KL)-based transfer learning algorithm to solve the problem of feature transfer,the proposed algorithm uses KL to measure the similarity between the training set and the testing set,adds support vector machine(SVM)classification probability to classify and weight the covariance,and discards the poorly performing samples.The results show that the proposed algorithm can significantly improve the classification accuracy of the testing set compared with the traditional algorithms,especially for subjects with medium classification accuracy.Moreover,the algorithm based on transfer learning has the potential to improve the consistency of feature distribution that the traditional algorithms do not have,which is significant for the application of MI-BCI. 展开更多
关键词 brain-computer interface motor imagery feature transfer transfer learning domain adaptation
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Design of an EEG Preamplifier for Brain-Computer Interface
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作者 Xian-Jie Pu Tie-Jun Liu De-Zhong Yao 《Journal of Electronic Science and Technology of China》 2009年第1期56-60,共5页
As a non-invasive neurophysiologieal index for brain-computer interface (BCI), electroencephalogram (EEG) attracts much attention at present. In order to have a portable BCI, a simple and efficient pre-amplifier i... As a non-invasive neurophysiologieal index for brain-computer interface (BCI), electroencephalogram (EEG) attracts much attention at present. In order to have a portable BCI, a simple and efficient pre-amplifier is crucial in practice. In this work, a preamplifier based on the characteristics of EEG signals is designed, which consists of a highly symmetrical input stage, low-pass filter, 50 Hz notch filter and a post amplifier. A prototype of this EEG module is fabricated and EEG data are obtained through an actual experiment. The results demonstrate that the EEG preamplifier will be a promising unit for BCI in the future. 展开更多
关键词 brain-computer interface(BCI) electroencephalogram(EEG) FILTERING interference pre amplifier.
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基于HHT和CSSD的多域融合自适应脑电特征提取方法 被引量:36
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作者 李明爱 崔燕 +1 位作者 杨金福 郝冬梅 《电子学报》 EI CAS CSCD 北大核心 2013年第12期2479-2486,共8页
为改善运动想象脑电信号特征提取的自适应性和实时性,提出一种基于希尔伯特-黄变换(HHT)与共空域子空间分解算法(CSSD)的特征提取方法(HCSSD).在对脑电信号进行预处理的基础上,定义一种相对距离准则优选脑电极组合;计算脑电的Hilbert瞬... 为改善运动想象脑电信号特征提取的自适应性和实时性,提出一种基于希尔伯特-黄变换(HHT)与共空域子空间分解算法(CSSD)的特征提取方法(HCSSD).在对脑电信号进行预处理的基础上,定义一种相对距离准则优选脑电极组合;计算脑电的Hilbert瞬时能量谱和边际能量谱,以获取脑电的时-频特征,并基于CSSD提取其空域特征,采用串行特征融合策略得到脑电的时-频-空特征;设计学习矢量量化神经网络分类器,实现脑电数据分类.在训练集与测试集间隔一周且减少导联数量的情况下,基于HCSSD对左手小指和舌头的运动想象ECoG脑电数据的平均识别率为92%.实验结果表明:HCSSD在增强特征提取方法的自适应性、改善实时性的同时,提高了脑电信号识别率,为便携式BCI系统在康复领域的应用创造了条件. 展开更多
关键词 脑机接口 运动想象 希尔伯特-黄变换 共空域子空间分解 特征融合 自适应 brain-computer interface (BCI) motor imagery (MI) hilbert-huang transform (HHT) common spatial sub-space decomposition (CSSD )
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Artificial Intelligence in Healthcare and Medicine:Promises,Ethical Challenges and Governance 被引量:10
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作者 关健 《Chinese Medical Sciences Journal》 CAS CSCD 2019年第2期76-83,共8页
Artificial intelligence (AI) is rapidly being applied to a wide range of fields,including medicine,and has been considered as an approach that may augment or substitute human professionals in primary healthcare.Howeve... Artificial intelligence (AI) is rapidly being applied to a wide range of fields,including medicine,and has been considered as an approach that may augment or substitute human professionals in primary healthcare.However,AI also raises several challenges and ethical concerns.In this article,the author investigates and discusses three aspects of AI in medicine and healthcare:the application and promises of AI,special ethical concerns pertaining to AI in some frontier fields,and suggestive ethical governance systems.Despite great potentials of frontier AI research and development in the field of medical care,the ethical challenges induced by its applications has put forward new requirements for governance.To ensure “trustworthy” AI applications in healthcare and medicine,the creation of an ethical global governance framework and system as well as special guidelines for frontier AI applications in medicine are suggested.The most important aspects include the roles of governments in ethical auditing and the responsibilities of stakeholders in the ethical governance system. 展开更多
关键词 artificial INTELLIGENCE medical ETHICS ETHICAL GOVERNANCE machine learning brain-computer interaction brain-inspired computer ROBOTS biohybrids
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A User-Friendly SSVEP-Based BCI Using Imperceptible Phase-Coded Flickers at 60Hz 被引量:1
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作者 Lu Jiang Weihua Pei Yijun Wang 《China Communications》 SCIE CSCD 2022年第2期1-14,共14页
A brain-computer interface(BCI)system based on steady-state visual evoked potentials(SSVEP)was developed by four-class phase-coded stimuli.SSVEPs elicited by flickers at 60Hz,which is higher than the critical fusion f... A brain-computer interface(BCI)system based on steady-state visual evoked potentials(SSVEP)was developed by four-class phase-coded stimuli.SSVEPs elicited by flickers at 60Hz,which is higher than the critical fusion frequency(CFF),were compared with those at 15Hz and 30Hz.SSVEP components in electroencephalogram(EEG)were detected using task related component analysis(TRCA)method.Offline analysis with 17 subjects indicated that the highest information transfer rate(ITR)was 29.80±4.65bpm with 0.5s data length for 60Hz and the classification accuracy was 70.07±4.15%.The online BCI system reached an averaged classification accuracy of 87.75±3.50%at 60Hz with 4s,resulting in an ITR of 16.73±1.63bpm.In particular,the maximum ITR for a subject was 80bpm with 0.5s at 60Hz.Although the BCI performance of 60Hz was lower than that of 15Hz and 30Hz,the results of the behavioral test indicated that,with no perception of flicker,the BCI system with 60Hz was more comfortable to use than 15Hz and 30Hz.Correlation analysis revealed that SSVEP with higher signal-to-noise ratio(SNR)corresponded to better classification performance and the improvement in comfortableness was accompanied by a decrease in performance.This study demonstrates the feasibility and potential of a user-friendly SSVEP-based BCI using imperceptible flickers. 展开更多
关键词 brain-computer interface ELECTROENCEPHALOGRAM steady-state visual evoked potentials imperceptible flickers phase coding task related component analysis
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An Algorithm for Idle-State Detection and Continuous Classifier Design in Motor-Imagery-Based BCI 被引量:3
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作者 Yu Huang Qiang Wu Xu Lei Ping Yang Peng Xu De-Zhong Yao 《Journal of Electronic Science and Technology of China》 2009年第1期27-33,共7页
Abstract-The development of asynchronous brain-computer interface (BCI) based on motor imagery (M1) poses the research in algorithms for detecting the nontask states (i.e., idle state) and the design of continuo... Abstract-The development of asynchronous brain-computer interface (BCI) based on motor imagery (M1) poses the research in algorithms for detecting the nontask states (i.e., idle state) and the design of continuous classifiers that classify continuously incoming electroencephalogram (EEG) samples. An algorithm is proposed in this paper which integrates two two-class classifiers to detect idle state and utilizes a sliding window to achieve continuous outputs. The common spatial pattern (CSP) algorithm is used to extract features of EEG signals and the linear support vector machine (SVM) is utilized to serve as classifier. The algorithm is applied on dataset IVb of BCI competition Ⅲ, with a resulting mean square error of 0.66. The result indicates that the proposed algorithm is feasible in the first step of the development of asynchronous systems. 展开更多
关键词 brain-computer interface competition common spatial pattern continuous classifier idle state motor imagery support vector machine.
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Semi-Supervised Learning Based on Manifold in BCI 被引量:1
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作者 Ji-Ying Zhong Xu Lei De-Zhong Yao 《Journal of Electronic Science and Technology of China》 2009年第1期22-26,共5页
A Laplacian support vector machine (LapSVM) algorithm, a semi-supervised learning based on manifold, is introduced to brain-computer interface (BCI) to raise the classification precision and reduce the subjects' ... A Laplacian support vector machine (LapSVM) algorithm, a semi-supervised learning based on manifold, is introduced to brain-computer interface (BCI) to raise the classification precision and reduce the subjects' training complexity. The data are collected from three subjects in a three-task mental imagery experiment. LapSVM and transductive SVM (TSVM) are trained with a few labeled samples and a large number of unlabeled samples. The results confirm that LapSVM has a much better classification than TSVM. 展开更多
关键词 brain-computer interface manifold learning semi-supervised learning support vector machine.
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Listening to the Brain in Real Time-The Chengdu Brainwave Music 被引量:1
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作者 Dan Wu Yang Liu De-Zhong Yao 《Journal of Electronic Science and Technology of China》 2009年第1期34-39,共6页
Electroencephalogram (EEG) provides a window for the activity of the human brain. As a novel form of the brain-computer interface (BCI), the online/offline EEG data may be interpreted through its auditory represen... Electroencephalogram (EEG) provides a window for the activity of the human brain. As a novel form of the brain-computer interface (BCI), the online/offline EEG data may be interpreted through its auditory representation which can be considered as a specific tool in EEG monitoring and analysis. In this work, after a comprehensive comparison of the various designs of brainwave music generations, a waveform event mapping system for music display in real time-- the Chengdu Brainwave Music (CBM) is proposed, which is a special on-line BCI system. In CBM, the user datagram protocol (UDP) is adopted to transport EEG data from the recorder to a music generator. The CBM could possibly be used as an audio feedback tool in BCI, or a monitoring tool in clinic EEG, and a subject specified music therapy method. 展开更多
关键词 brain-computer interface electro-encephalogram sonification.
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BCI+VR Rehabilitation Design of Closed-Loop Motor Imagery Based on the Degree of Drug Addiction
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作者 Xuelin Gu Banghua Yang +4 位作者 Shouwei Gao Honghao Gao Linfeng Yan Ding Xu Wen Wang 《China Communications》 SCIE CSCD 2022年第2期62-72,共11页
After abusing drugs for long,drug users will experience deteriorated self-control cognitive ability,and poor emotional regulation.This paper designs a closed-loop virtual-reality(VR),motorimagery(MI)rehabilitation tra... After abusing drugs for long,drug users will experience deteriorated self-control cognitive ability,and poor emotional regulation.This paper designs a closed-loop virtual-reality(VR),motorimagery(MI)rehabilitation training system based on brain-computer interface(BCI)(MI-BCI+VR),aiming to enhance the self-control,cognition,and emotional regulation of drug addicts via personalized rehabilitation schemes.This paper is composed of two parts.In the first part,data of 45 drug addicts(mild:15;moderate:15;and severe:15)is tested with electroencephalogram(EEG)and near-infrared spectroscopy(NIRS)equipment(EEG-NIRS)under the dual-mode,synchronous signal collection paradigm.Using these data sets,a dual-modal signal convolutional neural network(CNN)algorithm is then designed based on decision fusion to detect and classify the addiction degree.In the second part,the MIBCI+VR rehabilitation system is designed,optimizing the Filter Bank Common Spatial Pattern(FBCSP)algorithm used in MI,and realizing MI-EEG intention recognition.Eight VR rehabilitation scenes are devised,achieving the communication between MI-BCI and VR scene models.Ten subjects are selected to test the rehabilitation system offline and online,and the test accuracy verifies the feasibility of the system.In future,it is suggested to develop personalized rehabilitation programs and treatment cycles based on the addiction degree. 展开更多
关键词 drug addiction degree brain-computer interface motor imagery virtual reality drug addiction rehabilitation
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fMRI-BCI:a Review
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作者 Da-Huan Li Qin Gao Wei-Shuai Lv Hua-Fu Chen 《Journal of Electronic Science and Technology of China》 2009年第1期78-81,共4页
Functional magnetic resonance imaging (fMRI) is a new tool for brain-computer interface (BCI). This paper presents an overview to fMRI-BCI. Our attention is mainly put on the methods of signal acquisition, signal ... Functional magnetic resonance imaging (fMRI) is a new tool for brain-computer interface (BCI). This paper presents an overview to fMRI-BCI. Our attention is mainly put on the methods of signal acquisition, signal preprocessing, and signal analysis of basic fMRI-BCI structure. The available softwares and the applications of fMRI-BCI are briefly introduced. At last, we suggest focusing on some technologies to make fMRI-BCI more perfect. 展开更多
关键词 brain-computer interface functional magnetic resonance imaging real-time signal processing.
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A Study on SSVEP-Based BCI
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作者 Zheng-Hua Wu De-Zhong Yao 《Journal of Electronic Science and Technology of China》 2009年第1期7-11,共5页
-Brain-computer interface (BCI) can help the deformity person finish some basic activities. In this paper, we concern some critical aspects of SSVEP based BCI, including stimulator selection, method of SSVEP extract... -Brain-computer interface (BCI) can help the deformity person finish some basic activities. In this paper, we concern some critical aspects of SSVEP based BCI, including stimulator selection, method of SSVEP extracting in a short time, stimulating frequency selection, and signal electrode selection. The conclusion is that the stimulator type should be based on the complexity of the BCI system, the method based on wavelet analysis is more valid than the power spectrum method in extracting the SSVEP in a short period, and the selections of stimulating frequency and electrode are important in designing a BCI system. These contents are meaningful for implementing a real SSVEP-based BCI. 展开更多
关键词 brain-computer interface electro-encephalogram steady-state visual evoked potential.
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眼外肌定量分析技术可评估甲状腺相关眼病的炎症活动性 被引量:1
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作者 李霜 杨超 +2 位作者 宋丽娜 杨艳 刘月君 《分子影像学杂志》 2023年第5期858-862,共5页
目的评估^(99m)Tc-DTPA眼眶SPECT/CT显像眼外肌定量分析技术在甲状腺相关眼病(TAO)炎性活动性的临床应用价值。方法回顾性分析我院行^(99m)Tc-DTPA眼眶SPECT/CT显像检查的44例TAO患者,按照临床活动性评分(CAS)将TAO患者分为活动期组(CAS... 目的评估^(99m)Tc-DTPA眼眶SPECT/CT显像眼外肌定量分析技术在甲状腺相关眼病(TAO)炎性活动性的临床应用价值。方法回顾性分析我院行^(99m)Tc-DTPA眼眶SPECT/CT显像检查的44例TAO患者,按照临床活动性评分(CAS)将TAO患者分为活动期组(CAS≥3,n=23)和非活动期组(CAS<3,n=21)。在^(99m)Tc-DTPA眼眶SPECT/CT衰减校正图像中,选择眼外肌区域中摄取放射性核素最多的图像层面,分别勾画双侧眼外肌的感兴趣区,测量其放射性计数最大值,选取视神经水平枕叶脑组织的感兴趣区作为本底,计算眼外肌与视神经水平枕叶脑组织显像剂摄取比值(UR),同时将每侧UR值最高的眼外肌作为炎症程度受累最为严重的眼外肌,选取UR_(max)值比较其组间差异,以评价对TAO活动性的诊断效能。结果活动期TAO患者的眼外肌UR_(max)高于非活动期TAO患者,差异有统计学意义(P<0.05)。TAO患者的眼外肌UR_(max)与其CAS呈正相关关系(r=0.799,P<0.05);在评估TAO临床活动性方面,眼外肌UR_(max)和CAS具有一致性(Kappa值=0.915,P<0.05);ROC曲线下面积为0.975,区分活动期与非活动期的UR_(max)阈值为5.2,其敏感度为87.5%,特异性为100%。结论本研究所使用眼外肌定量分析技术的测量方法能够直接显示每条眼外肌的炎性反应,可准确定位受累的眼外肌,使双侧眼外肌靶区勾画更加精准,还可以测量各眼外肌的放射性核素摄取比值即UR值,能够更加准确地评估TAO的炎症活动性程度。 展开更多
关键词 甲状腺相关性眼病 ^(99m)锝-二乙烯三胺五乙酸 SPECT/CT 眼外肌与视神经水平枕叶脑组织显像剂摄取比值 临床活动性评分
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