Objective To evaluate the effect of the cardiopulmonary bypass (CPB) on the pulmonary function in infants with or withoutpulmonary hypertension in congential ventricular septal defect (VSD). MethodsTwenty infants with...Objective To evaluate the effect of the cardiopulmonary bypass (CPB) on the pulmonary function in infants with or withoutpulmonary hypertension in congential ventricular septal defect (VSD). MethodsTwenty infants with VSD were enrolled in the study fromJan. to Dec.2004. They were divided into two groups: pulmonary hypertension group and non-pulmonary hypertension group, ten infantsrespectively. Pulmonary function parameters were measured before CPB and 3, 6, 9, 12, 15, 18, 21, 24h after CPB, the following datawere recorded: duration for mechanical ventilation (Tmv) and staying in the cardiac intensive care unit (Tcicu) after cardiac surgery.Results Before CPB, the pulmonary function parameters in non-pulmonary hypertension group were more superior than in pulmonary hy-pertension group (P<0.01). By contraries, the pulmonary function parameters in every time stage after CPB statistically significant de-creased in non-pulmonary hypertension group (P<0.05), especially at 6, 9, and 15h after CPB (P<0.01). In pulmonary hyperten-sion group, the pulmonary function parameters in 3h after CPB were more improved than before CPB, though there was no statistical sig-nificance. But they had statistically significant decreased at9, 12, 15h after CPB (P<0.05). There was a similar change in pulmonaryfunction between two groups at 21, 24h after CPB. Conclusion Exposure to CPB adversely affects pulmonary function after surgicalrepair of VSD in infants. We consider that the benefits of the surgical correction in infants with pulmonary hypertension outweight the neg-ative effects of CPB on pulmonary function. We should improve cardiac function to avoid the presence of the nadir trough in pulmonaryfunction. The infants with pulomonary hypertension also have ability to wean from mechanical ventilation as soon as possible, if the hemo-dynamics is stable, and without the responsive pulmonary hypertension or pulmonary hypertension crisis after surgical repair.展开更多
Background Recent studies have shown that the mortality of patients with coronary artery bypass grafting(CABG)can be reduced by ticagrelor,but the effect on the vascular patency of the bridge and other cardiovascular ...Background Recent studies have shown that the mortality of patients with coronary artery bypass grafting(CABG)can be reduced by ticagrelor,but the effect on the vascular patency of the bridge and other cardiovascular events is not clear.Methods A database of patients with coronary artery bypass grafting in our hospital from October 2013 to December 2016,40 patients with ticagrelor and aspirin after the surgery.展开更多
Objective The study aimed to compare quality of saphenous vein(SV)grafts,wound complications,and clinical outcomes between endoscopic vein harvesting(EVH)technique and open vein harvesting(OVH)technique of coronary ar...Objective The study aimed to compare quality of saphenous vein(SV)grafts,wound complications,and clinical outcomes between endoscopic vein harvesting(EVH)technique and open vein harvesting(OVH)technique of coronary artery bypass graft(CABG)surgery.Methods One hundred patients with multi-vessel coronary disease underwent elective CABG using SV grafts were prospectively recruited and randomized into two groups.展开更多
Digital infrared thermography is suitable for monitoring the planar two-dimensional temperature distribution of curved surfaces of objects by sensing their infrared radiation. Cardiac infrared thermography also has a ...Digital infrared thermography is suitable for monitoring the planar two-dimensional temperature distribution of curved surfaces of objects by sensing their infrared radiation. Cardiac infrared thermography also has a thermal coronary angiography alias. This study proposes a digital image processing methodology for locating blood clot blockage. This methodology contains four consequent processes. The two-dimensional gray scale infrared thermograph pixels are first binarized and classified as background or coronary arteries using multi-thresh adaptive segmentation.The coronary artery contours are extracted from segmented raw pixels using continuous pepper-like pixel removal,erosion,subtraction,recursive neighborhood visiting,contour point-list construction and short edge deletion.In the third process one coronary artery branch is selected by physicians for calculating the longest curved central axis using morphological thinning and neighborhood analysis. In the last process the nearest left and right distances from each pixel along the directional central axis to its corresponding boundary contour are added as the coronary artery variable diameter at the current pixel's position. A variable diameter versus straighten length diagram along this axial curved path is plotted to provide useful physiological information to the physician. An obstruction rate equation is then defined to calculate the possible vascular blockage positions with the local minimal rates. Finally,preoperative cases are tested to prove the predictive positions are correct in comparison to individual patient myocardial perfusion imaging.展开更多
目的评价HA380血液灌流治疗对心肺转流(CPB)心脏手术患者术后谵妄(POD)的影响。方法本研究采用前瞻性队列研究设计,选择2024年1—12月于CPB下行心脏手术的患者206例,男120例,女86例,年龄37~75岁,BMI 18.5~32.0 kg/m^(2),ASAⅢ或Ⅳ级,手...目的评价HA380血液灌流治疗对心肺转流(CPB)心脏手术患者术后谵妄(POD)的影响。方法本研究采用前瞻性队列研究设计,选择2024年1—12月于CPB下行心脏手术的患者206例,男120例,女86例,年龄37~75岁,BMI 18.5~32.0 kg/m^(2),ASAⅢ或Ⅳ级,手术类型包括冠状动脉搭桥术、心脏瓣膜置换术或冠状动脉搭桥心脏瓣膜置换联合手术。根据术中是否使用HA380血液灌流治疗将患者分为两组:HA组(n=82)与对照组(n=124)。记录术后7 d内术后认知功能障碍的发生情况及持续时间及术后1个月的认知功能。记录术后机械通气时间、术后ICU治疗时间、术后住院时间、术后并发症的发生情况。于切皮前、术后6、24、48 h采用ELISA法检测血浆炎性因子白细胞介素-6(IL-6)、白细胞介素-8(IL-8)、肿瘤坏死因子-α(TNF-α)及脑损伤标记物tau、胶质纤维酸性蛋白(GFAP)浓度。结果与对照组比较,HA组术后7 d内POD发生率明显降低(P<0.05),术后6 h IL-6、IL-8、TNF-α和GFAP蛋白浓度明显降低(P<0.05),术后24 h IL-6、IL-8、TNF-α、tau和GFAP蛋白浓度明显降低(P<0.05),术后48 h IL-6、TNF-α和tau蛋白浓度明显降低(P<0.05)。两组术后机械通气时间、术后ICU治疗时间、术后住院时间、术后并发症发生率差异无统计学意义。结论CPB心脏手术患者使用HA380血液灌流治疗能够降低术后炎性因子及脑损伤标记物浓度,降低POD发生率。展开更多
To investigate the overall performance of reverse energy bypass scramjet,firstly a variable spe⁃cific heat method combined with a chemical balance calculation module for combustion products were used to es⁃tablish a b...To investigate the overall performance of reverse energy bypass scramjet,firstly a variable spe⁃cific heat method combined with a chemical balance calculation module for combustion products were used to es⁃tablish a benchmark scramjet performance evaluation model.Based on the test data of typical flying point of Mach 7 with the altitude of 29 km,the reliability of the model was verified.The deviations of parameters such as the to⁃tal pressure loss of combustor between the model and the test data were analyzed.Furtherly,an analytical method for post-combustion magnetohydrodynamic power generation was established;by embedding the above method into the overall performance evaluation model,performance prediction considering the power generation effect was realized.Finally,based on the above model,variety regulations of the inlet and the outlet parameters of the power generation channel and performance parameters including the engine specific impulse and the unit thrust under different enthalpy extraction ratios and load factors were analyzed.It could be concluded that the model can reliably predict the variations of key parameters.As the value of the load factor increases,the value of the conduc⁃tivity required to reach the specified enthalpy extraction ratio first decreases and then increases,which is approxi⁃mately parabolic.In order to reduce the demand for the gas conductivity for MHD power generation,the load fac⁃tor should be around 0.5.When the load factor is 0.4 and the magnetic induction intensity is 2.5 T,if the enthalpy extraction ratio reaches 0.5%,the engine specific impulse performance reduces about 3.58%.展开更多
文摘Objective To evaluate the effect of the cardiopulmonary bypass (CPB) on the pulmonary function in infants with or withoutpulmonary hypertension in congential ventricular septal defect (VSD). MethodsTwenty infants with VSD were enrolled in the study fromJan. to Dec.2004. They were divided into two groups: pulmonary hypertension group and non-pulmonary hypertension group, ten infantsrespectively. Pulmonary function parameters were measured before CPB and 3, 6, 9, 12, 15, 18, 21, 24h after CPB, the following datawere recorded: duration for mechanical ventilation (Tmv) and staying in the cardiac intensive care unit (Tcicu) after cardiac surgery.Results Before CPB, the pulmonary function parameters in non-pulmonary hypertension group were more superior than in pulmonary hy-pertension group (P<0.01). By contraries, the pulmonary function parameters in every time stage after CPB statistically significant de-creased in non-pulmonary hypertension group (P<0.05), especially at 6, 9, and 15h after CPB (P<0.01). In pulmonary hyperten-sion group, the pulmonary function parameters in 3h after CPB were more improved than before CPB, though there was no statistical sig-nificance. But they had statistically significant decreased at9, 12, 15h after CPB (P<0.05). There was a similar change in pulmonaryfunction between two groups at 21, 24h after CPB. Conclusion Exposure to CPB adversely affects pulmonary function after surgicalrepair of VSD in infants. We consider that the benefits of the surgical correction in infants with pulmonary hypertension outweight the neg-ative effects of CPB on pulmonary function. We should improve cardiac function to avoid the presence of the nadir trough in pulmonaryfunction. The infants with pulomonary hypertension also have ability to wean from mechanical ventilation as soon as possible, if the hemo-dynamics is stable, and without the responsive pulmonary hypertension or pulmonary hypertension crisis after surgical repair.
文摘Background Recent studies have shown that the mortality of patients with coronary artery bypass grafting(CABG)can be reduced by ticagrelor,but the effect on the vascular patency of the bridge and other cardiovascular events is not clear.Methods A database of patients with coronary artery bypass grafting in our hospital from October 2013 to December 2016,40 patients with ticagrelor and aspirin after the surgery.
文摘Objective The study aimed to compare quality of saphenous vein(SV)grafts,wound complications,and clinical outcomes between endoscopic vein harvesting(EVH)technique and open vein harvesting(OVH)technique of coronary artery bypass graft(CABG)surgery.Methods One hundred patients with multi-vessel coronary disease underwent elective CABG using SV grafts were prospectively recruited and randomized into two groups.
基金the financial support of this research under grant No.103-2218-E-234-001
文摘Digital infrared thermography is suitable for monitoring the planar two-dimensional temperature distribution of curved surfaces of objects by sensing their infrared radiation. Cardiac infrared thermography also has a thermal coronary angiography alias. This study proposes a digital image processing methodology for locating blood clot blockage. This methodology contains four consequent processes. The two-dimensional gray scale infrared thermograph pixels are first binarized and classified as background or coronary arteries using multi-thresh adaptive segmentation.The coronary artery contours are extracted from segmented raw pixels using continuous pepper-like pixel removal,erosion,subtraction,recursive neighborhood visiting,contour point-list construction and short edge deletion.In the third process one coronary artery branch is selected by physicians for calculating the longest curved central axis using morphological thinning and neighborhood analysis. In the last process the nearest left and right distances from each pixel along the directional central axis to its corresponding boundary contour are added as the coronary artery variable diameter at the current pixel's position. A variable diameter versus straighten length diagram along this axial curved path is plotted to provide useful physiological information to the physician. An obstruction rate equation is then defined to calculate the possible vascular blockage positions with the local minimal rates. Finally,preoperative cases are tested to prove the predictive positions are correct in comparison to individual patient myocardial perfusion imaging.
文摘目的评价HA380血液灌流治疗对心肺转流(CPB)心脏手术患者术后谵妄(POD)的影响。方法本研究采用前瞻性队列研究设计,选择2024年1—12月于CPB下行心脏手术的患者206例,男120例,女86例,年龄37~75岁,BMI 18.5~32.0 kg/m^(2),ASAⅢ或Ⅳ级,手术类型包括冠状动脉搭桥术、心脏瓣膜置换术或冠状动脉搭桥心脏瓣膜置换联合手术。根据术中是否使用HA380血液灌流治疗将患者分为两组:HA组(n=82)与对照组(n=124)。记录术后7 d内术后认知功能障碍的发生情况及持续时间及术后1个月的认知功能。记录术后机械通气时间、术后ICU治疗时间、术后住院时间、术后并发症的发生情况。于切皮前、术后6、24、48 h采用ELISA法检测血浆炎性因子白细胞介素-6(IL-6)、白细胞介素-8(IL-8)、肿瘤坏死因子-α(TNF-α)及脑损伤标记物tau、胶质纤维酸性蛋白(GFAP)浓度。结果与对照组比较,HA组术后7 d内POD发生率明显降低(P<0.05),术后6 h IL-6、IL-8、TNF-α和GFAP蛋白浓度明显降低(P<0.05),术后24 h IL-6、IL-8、TNF-α、tau和GFAP蛋白浓度明显降低(P<0.05),术后48 h IL-6、TNF-α和tau蛋白浓度明显降低(P<0.05)。两组术后机械通气时间、术后ICU治疗时间、术后住院时间、术后并发症发生率差异无统计学意义。结论CPB心脏手术患者使用HA380血液灌流治疗能够降低术后炎性因子及脑损伤标记物浓度,降低POD发生率。
文摘To investigate the overall performance of reverse energy bypass scramjet,firstly a variable spe⁃cific heat method combined with a chemical balance calculation module for combustion products were used to es⁃tablish a benchmark scramjet performance evaluation model.Based on the test data of typical flying point of Mach 7 with the altitude of 29 km,the reliability of the model was verified.The deviations of parameters such as the to⁃tal pressure loss of combustor between the model and the test data were analyzed.Furtherly,an analytical method for post-combustion magnetohydrodynamic power generation was established;by embedding the above method into the overall performance evaluation model,performance prediction considering the power generation effect was realized.Finally,based on the above model,variety regulations of the inlet and the outlet parameters of the power generation channel and performance parameters including the engine specific impulse and the unit thrust under different enthalpy extraction ratios and load factors were analyzed.It could be concluded that the model can reliably predict the variations of key parameters.As the value of the load factor increases,the value of the conduc⁃tivity required to reach the specified enthalpy extraction ratio first decreases and then increases,which is approxi⁃mately parabolic.In order to reduce the demand for the gas conductivity for MHD power generation,the load fac⁃tor should be around 0.5.When the load factor is 0.4 and the magnetic induction intensity is 2.5 T,if the enthalpy extraction ratio reaches 0.5%,the engine specific impulse performance reduces about 3.58%.
