Objective The aim of this study was to determine the effect of successful coronary revascularisation on left ventricular diastolic function.Methods We consecutively studied the diastolic function by Doppler echocardio...Objective The aim of this study was to determine the effect of successful coronary revascularisation on left ventricular diastolic function.Methods We consecutively studied the diastolic function by Doppler echocardiography in 125 patients with one vessel disease before and 48 hours after selective coronary angioplasty. The following parameters of left ventricular diastolic function were evaluated: peak early (VE, m/s) and peak late diastolic (VA, m/s) flow velocity, E/A ratio, acceleration time (AT, ms), deceleration time (DT, ms) and isovolumetric relaxation time (IVRT, ms). Ejection fraction (EF; %) was determined and used to characterise systolic left ventricular function. Results All of the patients were initially successful treated with coronary angioplasty (residual stenosis <40% ). In 98 patients( 78.4% ) stents were used to improve an inadequate result after coronary angioplasty. Both patient groups (27 patients with coronary angioplasty and 98 patients with combined coronary angioplasty and stent implantation) showed no relevant differences concerning sex, age, atherosclerotic risk factors, exercise capacity and results of exercise electrocardiography. All patients who underwent stent implantation showed an early improvement of left ventricular diastolic function 48 hours after revascularisation. Surprisingly there was no significant short term improvement (48 hours) of diastolic function in patients with initially successful angioplasty.Conclusions We suppose that stent implantation might normalize coronary blood flow faster than that of coronary balloon angioplasty.展开更多
Background In an effort to avoid x-ray and contrast agents for patients of atrial fibrillation(AF)with chronic kidney disease,we developed a method for transcatheter closure of left atrial appendage(LAA)under the guid...Background In an effort to avoid x-ray and contrast agents for patients of atrial fibrillation(AF)with chronic kidney disease,we developed a method for transcatheter closure of left atrial appendage(LAA)under the guidance of transesophageal echocardiography(TEE)without fluoroscopy.展开更多
Background Cryoballoon ablation has been demonstrated to be an effective way for the treatment of atrial fibrilation(AF).However,in the population with high risk of thromboembolism,long-term oral anticoagulants are st...Background Cryoballoon ablation has been demonstrated to be an effective way for the treatment of atrial fibrilation(AF).However,in the population with high risk of thromboembolism,long-term oral anticoagulants are still in need,which lead to the odds of hemorrhage.As previous studies confirmed,left atrial appendage closure(LAAC)could decrease the risk of thromboembolism in AF patients,and may substitute for the long term anticoagulation.Therefore,we attempted to combine both these operations for AF.展开更多
Background It’s essential to prevent from thrombosis on device without increasing the risk of bleeding complications after successfully implanted left atrial appendage device.At present,no guidelines recommend about ...Background It’s essential to prevent from thrombosis on device without increasing the risk of bleeding complications after successfully implanted left atrial appendage device.At present,no guidelines recommend about postoperative antithrombotic therapy of left atrial appendage closure(LAAC).The purpose of this study is to investigate the safety and efficacy of different antithrombotic therapies after LAAC.展开更多
Objective To observe the value of deep learning echocardiographic intelligent model for evaluation on left ventricular(LV)regional wall motion abnormalities(RWMA).Methods Apical two-chamber,three-chamber and four-cham...Objective To observe the value of deep learning echocardiographic intelligent model for evaluation on left ventricular(LV)regional wall motion abnormalities(RWMA).Methods Apical two-chamber,three-chamber and four-chamber views two-dimensional echocardiograms were obtained prospectively in 205 patients with coronary heart disease.The model for evaluating LV regional contractile function was constructed using a five-fold cross-validation method to automatically identify the presence of RWMA or not,and the performance of this model was assessed taken manual interpretation of RWMA as standards.Results Among 205 patients,RWMA was detected in totally 650 segments in 83 cases.LV myocardial segmentation model demonstrated good efficacy for delineation of LV myocardium.The average Dice similarity coefficient for LV myocardial segmentation results in the apical two-chamber,three-chamber and four-chamber views was 0.85,0.82 and 0.88,respectively.LV myocardial segmentation model accurately segmented LV myocardium in apical two-chamber,three-chamber and four-chamber views.The mean area under the curve(AUC)of RWMA identification model was 0.843±0.071,with sensitivity of(64.19±14.85)%,specificity of(89.44±7.31)%and accuracy of(85.22±4.37)%.Conclusion Deep learning echocardiographic intelligent model could be used to automatically evaluate LV regional contractile function,hence rapidly and accurately identifying RWMA.展开更多
【目的】为了探讨应用4D左心房自动定量分析(4D Auto LAQ)软件测定的左房容积和应变值对鉴别毛细血管前肺动脉高压和毛细血管后肺动脉高压的价值,并与肺-左心房应变偶联指数(ePLAGS)的鉴别能力进行比较。【方法】本研究为回顾性研究,共...【目的】为了探讨应用4D左心房自动定量分析(4D Auto LAQ)软件测定的左房容积和应变值对鉴别毛细血管前肺动脉高压和毛细血管后肺动脉高压的价值,并与肺-左心房应变偶联指数(ePLAGS)的鉴别能力进行比较。【方法】本研究为回顾性研究,共纳入了自2021年7月至2022年4月就诊于中山大学附属第一医院门诊或住院部的98例高概率肺动脉高压(PH)患者,收集所有患者的临床病史及实验室资料。根据肺动脉楔压(PAWP)将所有患者分为2组:毛细血管前PH组(PAWP≤15 mmHg)及毛细血管后PH组(PAWP>15 mmHg)。所纳入的患者均接受了经胸超声心动图检查,并应用4D Auto LAQ软件自动测量左房容积和应变参数。【结果】根据PAWP的数值,入选患者分为两组:毛细血管前PH组[n=39,年龄(53±24)岁]和毛细血管后PH组[n=59,年龄(57±18)岁]。与毛细血管前PH组相比,毛细血管后PH组的最大左心房容量指数(LAVImax)、最小左心房容量指数(LAVImin)和左心房射血前的容量指数(LAVIpreA)显著增加,而左心房储备期纵向应变值(LASr)和左心房导管期纵向应变值(LAScd)明显降低。多元逻辑回归分析显示,LAVImax[OR:1.40;95%CI:(1.052,1.872);P=0.021]和LAScd[OR:1.76;95%CI:(1.183,2.489);P=0.004]是检测毛细血管后PH的强大独立预测因子。ROC曲线分析表明,LAVImax(AUC=0.82,P<0.001)和LAScd(AUC=0.78,P<0.001)在预测毛细血管后PH组方面具有很高的辨别力,其临界值分别为35.69 mL/m^(2)(敏感性86%,特异性74%)和-9%(敏感性80%,特异性70%)。【结论】:应用4D auto LAQ测量的LAVImax和LAScd是区分毛细血管前和毛细血管后PH患者有价值的参数,且其鉴别能力优于肺-左心房应变偶联指数(ePLAGS)。展开更多
目的观察老年心房颤动患者单核细胞与高密度脂蛋白胆固醇比值(monocyte to high density lipoprotein cholesterol ratio,MHR)、血栓素B_(2)(thromboxane B_(2),TXB_(2))水平变化与左心耳血栓发生风险的关联性。方法回顾性纳入2022年5月...目的观察老年心房颤动患者单核细胞与高密度脂蛋白胆固醇比值(monocyte to high density lipoprotein cholesterol ratio,MHR)、血栓素B_(2)(thromboxane B_(2),TXB_(2))水平变化与左心耳血栓发生风险的关联性。方法回顾性纳入2022年5月至2024年5月四川省人民医院收治的老年心房颤动患者152例,根据经食管超声心动图检出左心耳血栓情况将患者分为血栓组46例和非血栓组106例。测定患者MHR、TXB_(2)水平,分析MHR、TXB_(2)水平对左心耳血栓风险的预测效能。结果老年心房颤动伴左心耳血栓组年龄、左心房内径(left atrial diameter,LAD)、单核细胞计数及持续性心房颤动比例明显高于非血栓组(P<0.01),而高密度脂蛋白胆固醇、左心室射血分数(left ventricular ejection fraction,LVEF)明显低于非血栓组(P<0.05,P<0.01),血栓组MHR、TXB_(2)水平明显高于非血栓组(P<0.01);多因素logistic回归分析显示,年龄(OR=1.244,95%CI:1.022~1.466,P=0.028)、持续性心房颤动(OR=29.290,95%CI:4.573~187.610,P=0.000)、LAD(OR=1.502,95%CI:1.203~1.876,P=0.000)、MHR(OR=1.115,95%CI:1.055~1.178,P=0.000)、TXB_(2)(OR=1.064,95%CI:1.031~1.097,P=0.000)是影响老年心房颤动患者发生左心耳血栓的危险因素,LVEF(OR=0.813,95%CI:0.707~0.935,P=0.004)是老年心房颤动患者发生左心耳血栓的保护因素;ROC曲线显示,MHR、TXB_(2)水平变化评估老年心房颤动患者左心耳血栓发生风险的曲线下面积分别为0.767和0.829。结论MHR、TXB_(2)在老年心房颤动伴左心耳血栓患者中异常升高,是影响患者左心耳血栓发生的危险因素,并对左心耳血栓风险具有一定的预测评估价值。展开更多
目的:应用四维自动左心房定量分析(4D Auto LAQ)技术评估经导管主动脉瓣置换术(TAVR)治疗患者术后早期左心房容积和功能改善情况。方法:选取2020年6月—2022年6月在四川省人民医院行TAVR的43例患者,分别于术前3 d及术后3月行心脏超声检...目的:应用四维自动左心房定量分析(4D Auto LAQ)技术评估经导管主动脉瓣置换术(TAVR)治疗患者术后早期左心房容积和功能改善情况。方法:选取2020年6月—2022年6月在四川省人民医院行TAVR的43例患者,分别于术前3 d及术后3月行心脏超声检查。常规测量二维超声心动图参数,应用4D Auto LAQ技术测量四维左心房容积及应变参数,分析TAVR患者手术前后各参数差异。结果:术后3月,TAVR患者主动脉瓣峰值血流速度(AV)较术前显著降低(P<0.001),左心房排空容积指数(LAEVI)、左心房被动排血容积(LAVp)、左心房被动排血容积指数(LAVIp)、左心房射血分数(LAEF)、左心房被动排血分数(LApEF)较术前增大(P<0.05),左心房最小容积(LAVmin)、左心房最小容积指数(LAVImin)、左心房最大容积(LAVmax)、左心房最大容积指数(LAVImax)、左心房主动收缩前容积(LAVpreA)、左心房主动收缩前容积指数(LAVIpreA)、左心房主动排空容积(LAVa)、左心房主动排空容积指数(LAVIa)较术前减小(P<0.05),左心房应变参数均较术前改善(P<0.05),而左心室舒张早期二尖瓣前向血流频谱(E峰)、左心房排空容积(LAEV)、左心房主动射血分数(LAaEF)变化不明显(P>0.05)。结论:4D Auto LAQ技术可有效评估TAVR治疗患者术后早期左心房容积和功能改善情况,有望为评价TAVR疗效提供可靠的参考指标。展开更多
文摘Objective The aim of this study was to determine the effect of successful coronary revascularisation on left ventricular diastolic function.Methods We consecutively studied the diastolic function by Doppler echocardiography in 125 patients with one vessel disease before and 48 hours after selective coronary angioplasty. The following parameters of left ventricular diastolic function were evaluated: peak early (VE, m/s) and peak late diastolic (VA, m/s) flow velocity, E/A ratio, acceleration time (AT, ms), deceleration time (DT, ms) and isovolumetric relaxation time (IVRT, ms). Ejection fraction (EF; %) was determined and used to characterise systolic left ventricular function. Results All of the patients were initially successful treated with coronary angioplasty (residual stenosis <40% ). In 98 patients( 78.4% ) stents were used to improve an inadequate result after coronary angioplasty. Both patient groups (27 patients with coronary angioplasty and 98 patients with combined coronary angioplasty and stent implantation) showed no relevant differences concerning sex, age, atherosclerotic risk factors, exercise capacity and results of exercise electrocardiography. All patients who underwent stent implantation showed an early improvement of left ventricular diastolic function 48 hours after revascularisation. Surprisingly there was no significant short term improvement (48 hours) of diastolic function in patients with initially successful angioplasty.Conclusions We suppose that stent implantation might normalize coronary blood flow faster than that of coronary balloon angioplasty.
文摘Background In an effort to avoid x-ray and contrast agents for patients of atrial fibrillation(AF)with chronic kidney disease,we developed a method for transcatheter closure of left atrial appendage(LAA)under the guidance of transesophageal echocardiography(TEE)without fluoroscopy.
文摘Background Cryoballoon ablation has been demonstrated to be an effective way for the treatment of atrial fibrilation(AF).However,in the population with high risk of thromboembolism,long-term oral anticoagulants are still in need,which lead to the odds of hemorrhage.As previous studies confirmed,left atrial appendage closure(LAAC)could decrease the risk of thromboembolism in AF patients,and may substitute for the long term anticoagulation.Therefore,we attempted to combine both these operations for AF.
文摘Background It’s essential to prevent from thrombosis on device without increasing the risk of bleeding complications after successfully implanted left atrial appendage device.At present,no guidelines recommend about postoperative antithrombotic therapy of left atrial appendage closure(LAAC).The purpose of this study is to investigate the safety and efficacy of different antithrombotic therapies after LAAC.
文摘Objective To observe the value of deep learning echocardiographic intelligent model for evaluation on left ventricular(LV)regional wall motion abnormalities(RWMA).Methods Apical two-chamber,three-chamber and four-chamber views two-dimensional echocardiograms were obtained prospectively in 205 patients with coronary heart disease.The model for evaluating LV regional contractile function was constructed using a five-fold cross-validation method to automatically identify the presence of RWMA or not,and the performance of this model was assessed taken manual interpretation of RWMA as standards.Results Among 205 patients,RWMA was detected in totally 650 segments in 83 cases.LV myocardial segmentation model demonstrated good efficacy for delineation of LV myocardium.The average Dice similarity coefficient for LV myocardial segmentation results in the apical two-chamber,three-chamber and four-chamber views was 0.85,0.82 and 0.88,respectively.LV myocardial segmentation model accurately segmented LV myocardium in apical two-chamber,three-chamber and four-chamber views.The mean area under the curve(AUC)of RWMA identification model was 0.843±0.071,with sensitivity of(64.19±14.85)%,specificity of(89.44±7.31)%and accuracy of(85.22±4.37)%.Conclusion Deep learning echocardiographic intelligent model could be used to automatically evaluate LV regional contractile function,hence rapidly and accurately identifying RWMA.
文摘【目的】为了探讨应用4D左心房自动定量分析(4D Auto LAQ)软件测定的左房容积和应变值对鉴别毛细血管前肺动脉高压和毛细血管后肺动脉高压的价值,并与肺-左心房应变偶联指数(ePLAGS)的鉴别能力进行比较。【方法】本研究为回顾性研究,共纳入了自2021年7月至2022年4月就诊于中山大学附属第一医院门诊或住院部的98例高概率肺动脉高压(PH)患者,收集所有患者的临床病史及实验室资料。根据肺动脉楔压(PAWP)将所有患者分为2组:毛细血管前PH组(PAWP≤15 mmHg)及毛细血管后PH组(PAWP>15 mmHg)。所纳入的患者均接受了经胸超声心动图检查,并应用4D Auto LAQ软件自动测量左房容积和应变参数。【结果】根据PAWP的数值,入选患者分为两组:毛细血管前PH组[n=39,年龄(53±24)岁]和毛细血管后PH组[n=59,年龄(57±18)岁]。与毛细血管前PH组相比,毛细血管后PH组的最大左心房容量指数(LAVImax)、最小左心房容量指数(LAVImin)和左心房射血前的容量指数(LAVIpreA)显著增加,而左心房储备期纵向应变值(LASr)和左心房导管期纵向应变值(LAScd)明显降低。多元逻辑回归分析显示,LAVImax[OR:1.40;95%CI:(1.052,1.872);P=0.021]和LAScd[OR:1.76;95%CI:(1.183,2.489);P=0.004]是检测毛细血管后PH的强大独立预测因子。ROC曲线分析表明,LAVImax(AUC=0.82,P<0.001)和LAScd(AUC=0.78,P<0.001)在预测毛细血管后PH组方面具有很高的辨别力,其临界值分别为35.69 mL/m^(2)(敏感性86%,特异性74%)和-9%(敏感性80%,特异性70%)。【结论】:应用4D auto LAQ测量的LAVImax和LAScd是区分毛细血管前和毛细血管后PH患者有价值的参数,且其鉴别能力优于肺-左心房应变偶联指数(ePLAGS)。
文摘目的观察老年心房颤动患者单核细胞与高密度脂蛋白胆固醇比值(monocyte to high density lipoprotein cholesterol ratio,MHR)、血栓素B_(2)(thromboxane B_(2),TXB_(2))水平变化与左心耳血栓发生风险的关联性。方法回顾性纳入2022年5月至2024年5月四川省人民医院收治的老年心房颤动患者152例,根据经食管超声心动图检出左心耳血栓情况将患者分为血栓组46例和非血栓组106例。测定患者MHR、TXB_(2)水平,分析MHR、TXB_(2)水平对左心耳血栓风险的预测效能。结果老年心房颤动伴左心耳血栓组年龄、左心房内径(left atrial diameter,LAD)、单核细胞计数及持续性心房颤动比例明显高于非血栓组(P<0.01),而高密度脂蛋白胆固醇、左心室射血分数(left ventricular ejection fraction,LVEF)明显低于非血栓组(P<0.05,P<0.01),血栓组MHR、TXB_(2)水平明显高于非血栓组(P<0.01);多因素logistic回归分析显示,年龄(OR=1.244,95%CI:1.022~1.466,P=0.028)、持续性心房颤动(OR=29.290,95%CI:4.573~187.610,P=0.000)、LAD(OR=1.502,95%CI:1.203~1.876,P=0.000)、MHR(OR=1.115,95%CI:1.055~1.178,P=0.000)、TXB_(2)(OR=1.064,95%CI:1.031~1.097,P=0.000)是影响老年心房颤动患者发生左心耳血栓的危险因素,LVEF(OR=0.813,95%CI:0.707~0.935,P=0.004)是老年心房颤动患者发生左心耳血栓的保护因素;ROC曲线显示,MHR、TXB_(2)水平变化评估老年心房颤动患者左心耳血栓发生风险的曲线下面积分别为0.767和0.829。结论MHR、TXB_(2)在老年心房颤动伴左心耳血栓患者中异常升高,是影响患者左心耳血栓发生的危险因素,并对左心耳血栓风险具有一定的预测评估价值。
文摘目的:应用四维自动左心房定量分析(4D Auto LAQ)技术评估经导管主动脉瓣置换术(TAVR)治疗患者术后早期左心房容积和功能改善情况。方法:选取2020年6月—2022年6月在四川省人民医院行TAVR的43例患者,分别于术前3 d及术后3月行心脏超声检查。常规测量二维超声心动图参数,应用4D Auto LAQ技术测量四维左心房容积及应变参数,分析TAVR患者手术前后各参数差异。结果:术后3月,TAVR患者主动脉瓣峰值血流速度(AV)较术前显著降低(P<0.001),左心房排空容积指数(LAEVI)、左心房被动排血容积(LAVp)、左心房被动排血容积指数(LAVIp)、左心房射血分数(LAEF)、左心房被动排血分数(LApEF)较术前增大(P<0.05),左心房最小容积(LAVmin)、左心房最小容积指数(LAVImin)、左心房最大容积(LAVmax)、左心房最大容积指数(LAVImax)、左心房主动收缩前容积(LAVpreA)、左心房主动收缩前容积指数(LAVIpreA)、左心房主动排空容积(LAVa)、左心房主动排空容积指数(LAVIa)较术前减小(P<0.05),左心房应变参数均较术前改善(P<0.05),而左心室舒张早期二尖瓣前向血流频谱(E峰)、左心房排空容积(LAEV)、左心房主动射血分数(LAaEF)变化不明显(P>0.05)。结论:4D Auto LAQ技术可有效评估TAVR治疗患者术后早期左心房容积和功能改善情况,有望为评价TAVR疗效提供可靠的参考指标。
