A sacrificial reductant-free copper-catalyzed benzylic C-H alkoxylation with N-Fluorobenzenesulfonimide(NFSI)was reported.Mechanistic studies suggested a novel pathway for the generation of active CuI species from Cu(...A sacrificial reductant-free copper-catalyzed benzylic C-H alkoxylation with N-Fluorobenzenesulfonimide(NFSI)was reported.Mechanistic studies suggested a novel pathway for the generation of active CuI species from Cu(OAc)2,NFSI and MeOH.A proper loading amount of copper catalyst was found to balance the reaction rates of benzylic C-H alkoxylation and overoxidation of benzyl ether to exhibit the best performance.展开更多
基金supported by USTC Research Funds of the Double First-Class Initiative(YD2060002024)Youth Innovation Promotion Association CAS(2020448)+2 种基金National Natur-al Science Foundation of China(22171254)Anhui Provincial Natural Science Foundation(2108085MB58)Start-up Research Fund from University of Science and Technology of China(KY2060000216).
文摘A sacrificial reductant-free copper-catalyzed benzylic C-H alkoxylation with N-Fluorobenzenesulfonimide(NFSI)was reported.Mechanistic studies suggested a novel pathway for the generation of active CuI species from Cu(OAc)2,NFSI and MeOH.A proper loading amount of copper catalyst was found to balance the reaction rates of benzylic C-H alkoxylation and overoxidation of benzyl ether to exhibit the best performance.
