用Fischer Helferich方法,对2,3 环氧丙基2,3,4,6 四 O 乙酰基 β D 吡喃型葡萄糖苷的合成方法进行了研究。以D 葡萄糖为原料,在碱性条件下乙酰化得到1,2,3,4,6 五 O 乙酰基 β D 葡萄糖。然后在SnCl4催化下与烯丙醇反应得到2,3,4,6 四...用Fischer Helferich方法,对2,3 环氧丙基2,3,4,6 四 O 乙酰基 β D 吡喃型葡萄糖苷的合成方法进行了研究。以D 葡萄糖为原料,在碱性条件下乙酰化得到1,2,3,4,6 五 O 乙酰基 β D 葡萄糖。然后在SnCl4催化下与烯丙醇反应得到2,3,4,6 四 O 乙酰基 β D 吡喃型葡萄糖烯丙苷。再经间氯过氧苯甲酸氧化得到目标化合物2,3 环氧丙基2,3,4,6 四 O 乙酰基 β D 吡喃型葡萄糖苷。其路线要比文献报道的少一步,总收率可达40%。目标化合物的结构经IR、13CNMR、EIMS和元素分析得到了确证。展开更多
A series of protected and deprotected 2 - deoxy -2 - aromatic acyl -β- D - glucopyranoses are prepared. Six of them are confirmed by IR,1H NMR,13C NMR and elementary analyses. The preliminary antibacterial activities...A series of protected and deprotected 2 - deoxy -2 - aromatic acyl -β- D - glucopyranoses are prepared. Six of them are confirmed by IR,1H NMR,13C NMR and elementary analyses. The preliminary antibacterial activities against staphylococcus albus and escherichia coli are studied. The result show that all the deprotected products has a good antibacterial ability to the two bacterias,while the products protected by acetyl show no activity.展开更多
文摘用Fischer Helferich方法,对2,3 环氧丙基2,3,4,6 四 O 乙酰基 β D 吡喃型葡萄糖苷的合成方法进行了研究。以D 葡萄糖为原料,在碱性条件下乙酰化得到1,2,3,4,6 五 O 乙酰基 β D 葡萄糖。然后在SnCl4催化下与烯丙醇反应得到2,3,4,6 四 O 乙酰基 β D 吡喃型葡萄糖烯丙苷。再经间氯过氧苯甲酸氧化得到目标化合物2,3 环氧丙基2,3,4,6 四 O 乙酰基 β D 吡喃型葡萄糖苷。其路线要比文献报道的少一步,总收率可达40%。目标化合物的结构经IR、13CNMR、EIMS和元素分析得到了确证。
文摘A series of protected and deprotected 2 - deoxy -2 - aromatic acyl -β- D - glucopyranoses are prepared. Six of them are confirmed by IR,1H NMR,13C NMR and elementary analyses. The preliminary antibacterial activities against staphylococcus albus and escherichia coli are studied. The result show that all the deprotected products has a good antibacterial ability to the two bacterias,while the products protected by acetyl show no activity.
