In this paper, it was found that isopropylidene (1-hydroxy-3-oxo-butylidene) malonate 4 was a heat unstable compound and the one step convenient methods for preparation of 4-hydroxy-6-methyl-2-pyrone 1 and 3-carboxy-4...In this paper, it was found that isopropylidene (1-hydroxy-3-oxo-butylidene) malonate 4 was a heat unstable compound and the one step convenient methods for preparation of 4-hydroxy-6-methyl-2-pyrone 1 and 3-carboxy-4-hydroxy-6-methyl-2-pyrone 2 in good yields were reported. Isopropylidene malonate 3、diketen and triethylamine reacted in chloroform to give 2, and in the mixture of dichloromethane and chlorobenzene to offer 1.展开更多
In this paper, CoMFA method was applied to study the 3D QSAR on a series of 3 anilinomethylene 6 alkyl (aryl) 5,6 2H dihydropyran 2, 4 dione compounds, which were designed and synthesized referring to the natural toxi...In this paper, CoMFA method was applied to study the 3D QSAR on a series of 3 anilinomethylene 6 alkyl (aryl) 5,6 2H dihydropyran 2, 4 dione compounds, which were designed and synthesized referring to the natural toxic Alternaric acid structure. The results displayed the information on modification of primary molecules and further synthesis of new bioactive compounds.展开更多
The title compound 3 was synthesized from diethylguanidine nitrate（2） obtained from diethylamine, CaCN2 and HNO3. The mixture consisted of 0.5 mol 2, 0.55 mol acetonyl propionate, 3 g benzyltriethylammonium chloride...The title compound 3 was synthesized from diethylguanidine nitrate（2） obtained from diethylamine, CaCN2 and HNO3. The mixture consisted of 0.5 mol 2, 0.55 mol acetonyl propionate, 3 g benzyltriethylammonium chloride, and 44 g NaOH was refluxed for 4 hours to give 85 g 3, in yield 94.6%.展开更多
A series of 2 amimo 3 cyano 7,7 dimethyl 4 aryl 5 oxo 5,6,7,8 tetra 4H chromenes were synthesized in the absence of catalyst. Their structures were determined by IR, 1H NMR, and single crystal X ray diffraction.
以5,6-二甲氧基-2-(4-吡啶基)-亚甲基-1-茚酮(Ⅱ)和溴化苄(Ⅲ)为原料,合成盐酸多奈哌齐的关键中间体1-苄基-4-(5,6-二甲氧基-1-茚酮-2-亚甲基)-吡啶(Ⅰ).研究了主要因素对反应的影响,n(Ⅱ)∶n(Ⅲ)=1∶1.3,反应时间60 m in,收率为92.8%....以5,6-二甲氧基-2-(4-吡啶基)-亚甲基-1-茚酮(Ⅱ)和溴化苄(Ⅲ)为原料,合成盐酸多奈哌齐的关键中间体1-苄基-4-(5,6-二甲氧基-1-茚酮-2-亚甲基)-吡啶(Ⅰ).研究了主要因素对反应的影响,n(Ⅱ)∶n(Ⅲ)=1∶1.3,反应时间60 m in,收率为92.8%.经核磁共振谱图分析确认为目标产物.进一步讨论了反应的动力学过程,并建立了动力学方程.展开更多
文摘In this paper, it was found that isopropylidene (1-hydroxy-3-oxo-butylidene) malonate 4 was a heat unstable compound and the one step convenient methods for preparation of 4-hydroxy-6-methyl-2-pyrone 1 and 3-carboxy-4-hydroxy-6-methyl-2-pyrone 2 in good yields were reported. Isopropylidene malonate 3、diketen and triethylamine reacted in chloroform to give 2, and in the mixture of dichloromethane and chlorobenzene to offer 1.
文摘In this paper, CoMFA method was applied to study the 3D QSAR on a series of 3 anilinomethylene 6 alkyl (aryl) 5,6 2H dihydropyran 2, 4 dione compounds, which were designed and synthesized referring to the natural toxic Alternaric acid structure. The results displayed the information on modification of primary molecules and further synthesis of new bioactive compounds.
文摘The title compound 3 was synthesized from diethylguanidine nitrate（2） obtained from diethylamine, CaCN2 and HNO3. The mixture consisted of 0.5 mol 2, 0.55 mol acetonyl propionate, 3 g benzyltriethylammonium chloride, and 44 g NaOH was refluxed for 4 hours to give 85 g 3, in yield 94.6%.
文摘A series of 2 amimo 3 cyano 7,7 dimethyl 4 aryl 5 oxo 5,6,7,8 tetra 4H chromenes were synthesized in the absence of catalyst. Their structures were determined by IR, 1H NMR, and single crystal X ray diffraction.
文摘以5,6-二甲氧基-2-(4-吡啶基)-亚甲基-1-茚酮(Ⅱ)和溴化苄(Ⅲ)为原料,合成盐酸多奈哌齐的关键中间体1-苄基-4-(5,6-二甲氧基-1-茚酮-2-亚甲基)-吡啶(Ⅰ).研究了主要因素对反应的影响,n(Ⅱ)∶n(Ⅲ)=1∶1.3,反应时间60 m in,收率为92.8%.经核磁共振谱图分析确认为目标产物.进一步讨论了反应的动力学过程,并建立了动力学方程.
