Dihydroquinazolin-4(3H)-ones were synthesized by the reaction of o-nitrobenzamides with aromatic aldehydes or cyclones promoted by the low-valent titanium reagent(TiCl 4-Zn system). The products were characterized by ...Dihydroquinazolin-4(3H)-ones were synthesized by the reaction of o-nitrobenzamides with aromatic aldehydes or cyclones promoted by the low-valent titanium reagent(TiCl 4-Zn system). The products were characterized by elementary analysis, IR, 1H NMR and X-ray single crystal diffraction. This method possesses the advantages of easily accessible starting materials, convenient manipulation and moderate to high yields.展开更多
6-(bromomethyl)-2-methylquinazolin-4(3H)-one is the important intermediate which is first-line drugs for treating colon and rectal cancers.In order to investigate the Raltitrexed better,to optimizeby production method...6-(bromomethyl)-2-methylquinazolin-4(3H)-one is the important intermediate which is first-line drugs for treating colon and rectal cancers.In order to investigate the Raltitrexed better,to optimizeby production method,we designed a synthetic route based related literature by cycling,ammoniation and bromination.The process provided high yield,synthetic methodology.The yield of 6-(bromomethyl)-2-methylquinazolin-4(3H)-one was up to 64.8%展开更多
文摘Dihydroquinazolin-4(3H)-ones were synthesized by the reaction of o-nitrobenzamides with aromatic aldehydes or cyclones promoted by the low-valent titanium reagent(TiCl 4-Zn system). The products were characterized by elementary analysis, IR, 1H NMR and X-ray single crystal diffraction. This method possesses the advantages of easily accessible starting materials, convenient manipulation and moderate to high yields.
文摘6-(bromomethyl)-2-methylquinazolin-4(3H)-one is the important intermediate which is first-line drugs for treating colon and rectal cancers.In order to investigate the Raltitrexed better,to optimizeby production method,we designed a synthetic route based related literature by cycling,ammoniation and bromination.The process provided high yield,synthetic methodology.The yield of 6-(bromomethyl)-2-methylquinazolin-4(3H)-one was up to 64.8%
