The title compound 3 was synthesized from diethylguanidine nitrate（2） obtained from diethylamine, CaCN2 and HNO3. The mixture consisted of 0.5 mol 2, 0.55 mol acetonyl propionate, 3 g benzyltriethylammonium chloride...The title compound 3 was synthesized from diethylguanidine nitrate（2） obtained from diethylamine, CaCN2 and HNO3. The mixture consisted of 0.5 mol 2, 0.55 mol acetonyl propionate, 3 g benzyltriethylammonium chloride, and 44 g NaOH was refluxed for 4 hours to give 85 g 3, in yield 94.6%.展开更多
文摘The title compound 3 was synthesized from diethylguanidine nitrate（2） obtained from diethylamine, CaCN2 and HNO3. The mixture consisted of 0.5 mol 2, 0.55 mol acetonyl propionate, 3 g benzyltriethylammonium chloride, and 44 g NaOH was refluxed for 4 hours to give 85 g 3, in yield 94.6%.
基金supported by the "111 Project" from the Ministry of Education of China and the State Administration of Foreign Expert Affairs of China(No.111-2-07)National Science and Technology Major Projects of China(No.2012ZX09103-101-030)and the Project Program of State Key Laboratory of Natural Medicines,China Pharmaceutical University(No.ZJ12009)
