以硫脲和氯乙酸为原料,在无溶剂和350 W微波辐射4 m in条件下,缩合生成中间体2,4-噻唑烷二酮(Ⅰ)产率91.5%;随后在无溶剂和400 W微波辐射5 m in条件下,通过V ilsm e ier甲酰化反应,生成中间体4-氯-5-甲酰基噻唑-2(3H)-酮(Ⅱ),产率86.7%...以硫脲和氯乙酸为原料,在无溶剂和350 W微波辐射4 m in条件下,缩合生成中间体2,4-噻唑烷二酮(Ⅰ)产率91.5%;随后在无溶剂和400 W微波辐射5 m in条件下,通过V ilsm e ier甲酰化反应,生成中间体4-氯-5-甲酰基噻唑-2(3H)-酮(Ⅱ),产率86.7%;最后以正丙醇为溶剂,450 W微波辐射7 m in条件下,成环得到5-氨基-噻唑[4,5-d]嘧啶-2(3H)-酮(Ⅲ),产率80.5%。反应总产率为63.9%。合成产物与中间体的结构经1HNMR,MS和元素分析确认。展开更多
DC Resistivity Tomography is a non-linear inversion problem. So far there are mainly two kinds of inversion methods, based on the finite-element method and alpha centers method. In this paper, the disadvantages of the...DC Resistivity Tomography is a non-linear inversion problem. So far there are mainly two kinds of inversion methods, based on the finite-element method and alpha centers method. In this paper, the disadvantages of these two kinds of methods were analysed,and a new method of forward modeling and inversion (Tomography) based on boundary integral equations was proposed. This scheme successfuly overcomes the difficulties of the two formarly methods. It isn’t necessary to use the linearization approximation and calculate the Jacobi matrix. Numerical modeling results given in this paper showed that the computation speed of our method is fast, and there is not any special requirement for initial model, and satisfying results of tomography can be obtained in the case of great contrast of conductivity. So it has wide applications.展开更多
文摘以硫脲和氯乙酸为原料,在无溶剂和350 W微波辐射4 m in条件下,缩合生成中间体2,4-噻唑烷二酮(Ⅰ)产率91.5%;随后在无溶剂和400 W微波辐射5 m in条件下,通过V ilsm e ier甲酰化反应,生成中间体4-氯-5-甲酰基噻唑-2(3H)-酮(Ⅱ),产率86.7%;最后以正丙醇为溶剂,450 W微波辐射7 m in条件下,成环得到5-氨基-噻唑[4,5-d]嘧啶-2(3H)-酮(Ⅲ),产率80.5%。反应总产率为63.9%。合成产物与中间体的结构经1HNMR,MS和元素分析确认。
文摘DC Resistivity Tomography is a non-linear inversion problem. So far there are mainly two kinds of inversion methods, based on the finite-element method and alpha centers method. In this paper, the disadvantages of these two kinds of methods were analysed,and a new method of forward modeling and inversion (Tomography) based on boundary integral equations was proposed. This scheme successfuly overcomes the difficulties of the two formarly methods. It isn’t necessary to use the linearization approximation and calculate the Jacobi matrix. Numerical modeling results given in this paper showed that the computation speed of our method is fast, and there is not any special requirement for initial model, and satisfying results of tomography can be obtained in the case of great contrast of conductivity. So it has wide applications.
