1,2-diiodo-3,3-dimethylbut-1-ene was synthesized used 3,3-dimethylbut-1-yne as the initial materials and Ce2(SO4)3 as catalyst in H2O.Then 5,5-dimethyl-1-(o-aminophenyl)-1,3-hexadiyne was synthesized from 1,2-diiodo-3...1,2-diiodo-3,3-dimethylbut-1-ene was synthesized used 3,3-dimethylbut-1-yne as the initial materials and Ce2(SO4)3 as catalyst in H2O.Then 5,5-dimethyl-1-(o-aminophenyl)-1,3-hexadiyne was synthesized from 1,2-diiodo-3,3-dimethylbut-1-ene and 2-ethynylaniline by cross-coupling rection in the presence of Pd(OAc)2 and CuI.The total yield was 68.7 %.The structure was characterized by NMR and MS spectrum.展开更多
The fused triazole derivatives,which is an important inhibitors of the dipeptidyl peptidase-Ⅳ enzyme(DPP-Ⅳ),can be used for the treatment or prevention of type 2 diabetes.A new fused triazole derivatives of 3-oxo-3-...The fused triazole derivatives,which is an important inhibitors of the dipeptidyl peptidase-Ⅳ enzyme(DPP-Ⅳ),can be used for the treatment or prevention of type 2 diabetes.A new fused triazole derivatives of 3-oxo-3-[3-trifluoromethyl-5,6-dihydro[1,2,4]-triazolo[4,3-a]pyrazin-7(8H)-yl]-1-phenylpropan-1-amine was synthesized from 2-chloropyrazine and benzaldehyde by hydrazinolysis,trifluoroacetylation,cyclization,hydrogenation,condensation and deprotection reaction.The structures of the compound and its intermediates were determined by IR,NMR,and MS.展开更多
基金2013年国家级大学生创新创业训练计划项目(201313256001)湖北师范学院硕士研究生创新科研基金项目(1051320130216)+1 种基金National Undergraduate Training Programs for Innovation and Entrepreneurship(201313256001)Postgraduate Innovation Scientific Research Foundation of Hubei Normal University(1051320130216)
文摘1,2-diiodo-3,3-dimethylbut-1-ene was synthesized used 3,3-dimethylbut-1-yne as the initial materials and Ce2(SO4)3 as catalyst in H2O.Then 5,5-dimethyl-1-(o-aminophenyl)-1,3-hexadiyne was synthesized from 1,2-diiodo-3,3-dimethylbut-1-ene and 2-ethynylaniline by cross-coupling rection in the presence of Pd(OAc)2 and CuI.The total yield was 68.7 %.The structure was characterized by NMR and MS spectrum.
文摘The fused triazole derivatives,which is an important inhibitors of the dipeptidyl peptidase-Ⅳ enzyme(DPP-Ⅳ),can be used for the treatment or prevention of type 2 diabetes.A new fused triazole derivatives of 3-oxo-3-[3-trifluoromethyl-5,6-dihydro[1,2,4]-triazolo[4,3-a]pyrazin-7(8H)-yl]-1-phenylpropan-1-amine was synthesized from 2-chloropyrazine and benzaldehyde by hydrazinolysis,trifluoroacetylation,cyclization,hydrogenation,condensation and deprotection reaction.The structures of the compound and its intermediates were determined by IR,NMR,and MS.
