1,2-diiodo-3,3-dimethylbut-1-ene was synthesized used 3,3-dimethylbut-1-yne as the initial materials and Ce2(SO4)3 as catalyst in H2O.Then 5,5-dimethyl-1-(o-aminophenyl)-1,3-hexadiyne was synthesized from 1,2-diiodo-3...1,2-diiodo-3,3-dimethylbut-1-ene was synthesized used 3,3-dimethylbut-1-yne as the initial materials and Ce2(SO4)3 as catalyst in H2O.Then 5,5-dimethyl-1-(o-aminophenyl)-1,3-hexadiyne was synthesized from 1,2-diiodo-3,3-dimethylbut-1-ene and 2-ethynylaniline by cross-coupling rection in the presence of Pd(OAc)2 and CuI.The total yield was 68.7 %.The structure was characterized by NMR and MS spectrum.展开更多
基金supported by the "111 Project" from the Ministry of Education of China and the State Administration of Foreign Expert Affairs of China(No.111-2-07)National Science and Technology Major Projects of China(No.2012ZX09103-101-030)and the Project Program of State Key Laboratory of Natural Medicines,China Pharmaceutical University(No.ZJ12009)
文摘1,2-diiodo-3,3-dimethylbut-1-ene was synthesized used 3,3-dimethylbut-1-yne as the initial materials and Ce2(SO4)3 as catalyst in H2O.Then 5,5-dimethyl-1-(o-aminophenyl)-1,3-hexadiyne was synthesized from 1,2-diiodo-3,3-dimethylbut-1-ene and 2-ethynylaniline by cross-coupling rection in the presence of Pd(OAc)2 and CuI.The total yield was 68.7 %.The structure was characterized by NMR and MS spectrum.
