The reaction of diketene and cinnamyl alcohol gave cinnamyl acetoacetate. Cinnamyl acetoacetate was ammoniatzed to give cinnamyl 3-aminocrotonate. Methyl acetoacetate condensed with 3-nitrobenzaldehyde to form methyl ...The reaction of diketene and cinnamyl alcohol gave cinnamyl acetoacetate. Cinnamyl acetoacetate was ammoniatzed to give cinnamyl 3-aminocrotonate. Methyl acetoacetate condensed with 3-nitrobenzaldehyde to form methyl 2-(3-nitrobenzylidene)acetoacetate which then via. Hantzsch cyclization with cinnamyl 3-aminocrotonate produced new calcicum antagonist pranidipine under mild conditions. The total yield was 69% based on cinnamyl alcohol. Pranidipine synthesized has been characterized by IR? 1H NMR? 13C NMR and MS spectral measurements.展开更多
文摘The reaction of diketene and cinnamyl alcohol gave cinnamyl acetoacetate. Cinnamyl acetoacetate was ammoniatzed to give cinnamyl 3-aminocrotonate. Methyl acetoacetate condensed with 3-nitrobenzaldehyde to form methyl 2-(3-nitrobenzylidene)acetoacetate which then via. Hantzsch cyclization with cinnamyl 3-aminocrotonate produced new calcicum antagonist pranidipine under mild conditions. The total yield was 69% based on cinnamyl alcohol. Pranidipine synthesized has been characterized by IR? 1H NMR? 13C NMR and MS spectral measurements.
