To search for more potent and less toxic antifungal agents,Four 2(2,4Diflurophenyl)1(4alkylpiperazine1yl)3(1,2,4triazole1yl)2propanols were designed and synthesized,and their antifungal activities in vitro were determ...To search for more potent and less toxic antifungal agents,Four 2(2,4Diflurophenyl)1(4alkylpiperazine1yl)3(1,2,4triazole1yl)2propanols were designed and synthesized,and their antifungal activities in vitro were determined.All title compounds exhibited mild activities against yeast.展开更多
The fused triazole derivatives,which is an important inhibitors of the dipeptidyl peptidase-Ⅳ enzyme(DPP-Ⅳ),can be used for the treatment or prevention of type 2 diabetes.A new fused triazole derivatives of 3-oxo-3-...The fused triazole derivatives,which is an important inhibitors of the dipeptidyl peptidase-Ⅳ enzyme(DPP-Ⅳ),can be used for the treatment or prevention of type 2 diabetes.A new fused triazole derivatives of 3-oxo-3-[3-trifluoromethyl-5,6-dihydro[1,2,4]-triazolo[4,3-a]pyrazin-7(8H)-yl]-1-phenylpropan-1-amine was synthesized from 2-chloropyrazine and benzaldehyde by hydrazinolysis,trifluoroacetylation,cyclization,hydrogenation,condensation and deprotection reaction.The structures of the compound and its intermediates were determined by IR,NMR,and MS.展开更多
文摘To search for more potent and less toxic antifungal agents,Four 2(2,4Diflurophenyl)1(4alkylpiperazine1yl)3(1,2,4triazole1yl)2propanols were designed and synthesized,and their antifungal activities in vitro were determined.All title compounds exhibited mild activities against yeast.
文摘The fused triazole derivatives,which is an important inhibitors of the dipeptidyl peptidase-Ⅳ enzyme(DPP-Ⅳ),can be used for the treatment or prevention of type 2 diabetes.A new fused triazole derivatives of 3-oxo-3-[3-trifluoromethyl-5,6-dihydro[1,2,4]-triazolo[4,3-a]pyrazin-7(8H)-yl]-1-phenylpropan-1-amine was synthesized from 2-chloropyrazine and benzaldehyde by hydrazinolysis,trifluoroacetylation,cyclization,hydrogenation,condensation and deprotection reaction.The structures of the compound and its intermediates were determined by IR,NMR,and MS.
