以二甲基亚砜为溶剂,1,4-对二氯苄和吡唑为反应物,微波辐射合成了1,4-二(吡唑基-1-亚甲基)苯。通过实验研究确定最佳合成条件为:微波输出功率为400W、间歇辐射时间为4min、n(吡唑)∶n(对二氯苄)=2.2∶1。最佳条件下产率可达79.6%。经元...以二甲基亚砜为溶剂,1,4-对二氯苄和吡唑为反应物,微波辐射合成了1,4-二(吡唑基-1-亚甲基)苯。通过实验研究确定最佳合成条件为:微波输出功率为400W、间歇辐射时间为4min、n(吡唑)∶n(对二氯苄)=2.2∶1。最佳条件下产率可达79.6%。经元素分析及IR、1 H NMR表征,确认了合成产物结构。展开更多
Eight derivatives of 1,3-dimethyl-5-methylthio-4-phenylhydrazonocarboxyl pyrazole were synthesized from 1,3-dimethyl-5-methylthio-4-hydrazinocarboxyl pyrazole. All compounds synthesized were identified by 1H NMR and e...Eight derivatives of 1,3-dimethyl-5-methylthio-4-phenylhydrazonocarboxyl pyrazole were synthesized from 1,3-dimethyl-5-methylthio-4-hydrazinocarboxyl pyrazole. All compounds synthesized were identified by 1H NMR and elemental analysis. Some of them exhibited certain growth inhibition action to Phoma asparagi, Alternaria solani, Gibberella zeae, Physalospora piricola, Colletotrichum lagenarium as tested in vitro at dosage of 50 mg/L.展开更多
以5,6-二甲氧基-2-(4-吡啶基)-亚甲基-1-茚酮(Ⅱ)和溴化苄(Ⅲ)为原料,合成盐酸多奈哌齐的关键中间体1-苄基-4-(5,6-二甲氧基-1-茚酮-2-亚甲基)-吡啶(Ⅰ).研究了主要因素对反应的影响,n(Ⅱ)∶n(Ⅲ)=1∶1.3,反应时间60 m in,收率为92.8%....以5,6-二甲氧基-2-(4-吡啶基)-亚甲基-1-茚酮(Ⅱ)和溴化苄(Ⅲ)为原料,合成盐酸多奈哌齐的关键中间体1-苄基-4-(5,6-二甲氧基-1-茚酮-2-亚甲基)-吡啶(Ⅰ).研究了主要因素对反应的影响,n(Ⅱ)∶n(Ⅲ)=1∶1.3,反应时间60 m in,收率为92.8%.经核磁共振谱图分析确认为目标产物.进一步讨论了反应的动力学过程,并建立了动力学方程.展开更多
The title compound N,N′ ditosyl 3 methoxyimino 1,5 diaza cyclooctane(4) has been prepared by two methods,the reactions of all steps are carried out under very moderate conditions and the overall yield is high.The str...The title compound N,N′ ditosyl 3 methoxyimino 1,5 diaza cyclooctane(4) has been prepared by two methods,the reactions of all steps are carried out under very moderate conditions and the overall yield is high.The structures of the new compounds 2,3,4 are characterized by elemental analysis,IR, 1H NMR and MS spectroscopy.展开更多
文摘以二甲基亚砜为溶剂,1,4-对二氯苄和吡唑为反应物,微波辐射合成了1,4-二(吡唑基-1-亚甲基)苯。通过实验研究确定最佳合成条件为:微波输出功率为400W、间歇辐射时间为4min、n(吡唑)∶n(对二氯苄)=2.2∶1。最佳条件下产率可达79.6%。经元素分析及IR、1 H NMR表征,确认了合成产物结构。
文摘Eight derivatives of 1,3-dimethyl-5-methylthio-4-phenylhydrazonocarboxyl pyrazole were synthesized from 1,3-dimethyl-5-methylthio-4-hydrazinocarboxyl pyrazole. All compounds synthesized were identified by 1H NMR and elemental analysis. Some of them exhibited certain growth inhibition action to Phoma asparagi, Alternaria solani, Gibberella zeae, Physalospora piricola, Colletotrichum lagenarium as tested in vitro at dosage of 50 mg/L.
文摘以5,6-二甲氧基-2-(4-吡啶基)-亚甲基-1-茚酮(Ⅱ)和溴化苄(Ⅲ)为原料,合成盐酸多奈哌齐的关键中间体1-苄基-4-(5,6-二甲氧基-1-茚酮-2-亚甲基)-吡啶(Ⅰ).研究了主要因素对反应的影响,n(Ⅱ)∶n(Ⅲ)=1∶1.3,反应时间60 m in,收率为92.8%.经核磁共振谱图分析确认为目标产物.进一步讨论了反应的动力学过程,并建立了动力学方程.
文摘The title compound N,N′ ditosyl 3 methoxyimino 1,5 diaza cyclooctane(4) has been prepared by two methods,the reactions of all steps are carried out under very moderate conditions and the overall yield is high.The structures of the new compounds 2,3,4 are characterized by elemental analysis,IR, 1H NMR and MS spectroscopy.
