4-Methylbenzaldehyde and 2-methylbenzaldehyde are oxidated by iodine in the mixture of THF and ammonia water at room temperature to give p-tolunitrile and o-tolunitrile in 87.1% and 82.0% yield respectively.p-Tolunitr...4-Methylbenzaldehyde and 2-methylbenzaldehyde are oxidated by iodine in the mixture of THF and ammonia water at room temperature to give p-tolunitrile and o-tolunitrile in 87.1% and 82.0% yield respectively.p-Tolunitrile is nitrated with fuming nitric acid in concentrated sulfuric acid below 0℃ to produce 4-methyl-3-nitrobenzonitrile in 88.4% yield,and for o-tolunitrile to afford 2-methyl-5-nitrobenzonitrile in 79.6% yield.Their structures are characterized by IR and 1H NMR spectra respectively.展开更多
以4-氨基-3-甲基苯甲酸为起始原料,经混酸硝化反应、正丁酸酐酰化反应和甲醇酯化反应等三步合成目标产物3-甲基-4-正丁酰氨基-5-硝基苯甲酸甲酯.其中间产物和目标产物的化学结构均经1 H NMR、13 C NMR、MS等方法进行了表征.实验过程中...以4-氨基-3-甲基苯甲酸为起始原料,经混酸硝化反应、正丁酸酐酰化反应和甲醇酯化反应等三步合成目标产物3-甲基-4-正丁酰氨基-5-硝基苯甲酸甲酯.其中间产物和目标产物的化学结构均经1 H NMR、13 C NMR、MS等方法进行了表征.实验过程中还对各步反应条件进行了优化,各步在最佳反应条件下总产率可达72.6%.该合成路线简单易行,容易实现工业化生产,具有很好的应用价值.展开更多
文摘4-Methylbenzaldehyde and 2-methylbenzaldehyde are oxidated by iodine in the mixture of THF and ammonia water at room temperature to give p-tolunitrile and o-tolunitrile in 87.1% and 82.0% yield respectively.p-Tolunitrile is nitrated with fuming nitric acid in concentrated sulfuric acid below 0℃ to produce 4-methyl-3-nitrobenzonitrile in 88.4% yield,and for o-tolunitrile to afford 2-methyl-5-nitrobenzonitrile in 79.6% yield.Their structures are characterized by IR and 1H NMR spectra respectively.
文摘以4-氨基-3-甲基苯甲酸为起始原料,经混酸硝化反应、正丁酸酐酰化反应和甲醇酯化反应等三步合成目标产物3-甲基-4-正丁酰氨基-5-硝基苯甲酸甲酯.其中间产物和目标产物的化学结构均经1 H NMR、13 C NMR、MS等方法进行了表征.实验过程中还对各步反应条件进行了优化,各步在最佳反应条件下总产率可达72.6%.该合成路线简单易行,容易实现工业化生产,具有很好的应用价值.
