2-溴甲基-3-羟基吡啶是合成常山酮的中间体,以3-羟基吡啶为起始原料,经胺甲基化、醋酐乙酰化、浓氢溴酸水解3步反应,合成2-溴甲基-3-羟基吡啶,总收率达56.79%。通过MS和1 H NMR对化合物结构进行表征。该方法原料是工业级,反应条件平和,...2-溴甲基-3-羟基吡啶是合成常山酮的中间体,以3-羟基吡啶为起始原料,经胺甲基化、醋酐乙酰化、浓氢溴酸水解3步反应,合成2-溴甲基-3-羟基吡啶,总收率达56.79%。通过MS和1 H NMR对化合物结构进行表征。该方法原料是工业级,反应条件平和,对设备的要求不高,可以满足工业化路线的要求。展开更多
In this paper, it was found that isopropylidene (1-hydroxy-3-oxo-butylidene) malonate 4 was a heat unstable compound and the one step convenient methods for preparation of 4-hydroxy-6-methyl-2-pyrone 1 and 3-carboxy-4...In this paper, it was found that isopropylidene (1-hydroxy-3-oxo-butylidene) malonate 4 was a heat unstable compound and the one step convenient methods for preparation of 4-hydroxy-6-methyl-2-pyrone 1 and 3-carboxy-4-hydroxy-6-methyl-2-pyrone 2 in good yields were reported. Isopropylidene malonate 3、diketen and triethylamine reacted in chloroform to give 2, and in the mixture of dichloromethane and chlorobenzene to offer 1.展开更多
文摘In this paper, it was found that isopropylidene (1-hydroxy-3-oxo-butylidene) malonate 4 was a heat unstable compound and the one step convenient methods for preparation of 4-hydroxy-6-methyl-2-pyrone 1 and 3-carboxy-4-hydroxy-6-methyl-2-pyrone 2 in good yields were reported. Isopropylidene malonate 3、diketen and triethylamine reacted in chloroform to give 2, and in the mixture of dichloromethane and chlorobenzene to offer 1.
