4substituted ethyl2methyl6,7methylenedioxy3quinolinecarboxylate was prepared from 3,4methylenedioxy-phenylketones Ⅳ,yield of Ⅳa-Ⅳd is 74～87%.The synthetic route consists of acylation,nitration,...4substituted ethyl2methyl6,7methylenedioxy3quinolinecarboxylate was prepared from 3,4methylenedioxy-phenylketones Ⅳ,yield of Ⅳa-Ⅳd is 74～87%.The synthetic route consists of acylation,nitration,reduction and condensation.Moleculor structures of Ⅳa～Ⅳd were determined by IR,1H NMR and MS.展开更多
The halogen substituted anthranilic acid(1) was condensed with acetic anhydride to give halogen substituted 3 methyl 1H 2,4 benoxazin 1 one(2), which was further condensed with hydrazide (3) to give twelve novel halog...The halogen substituted anthranilic acid(1) was condensed with acetic anhydride to give halogen substituted 3 methyl 1H 2,4 benoxazin 1 one(2), which was further condensed with hydrazide (3) to give twelve novel halogen substituted 2 (3 methyl 5 substitued 4H 1,2,4 triazol 4 yl) benzoic acid. All compounds synthesized were identified by 1H NMR and elemental analyses.展开更多
By taking 3 chloro 4 methyl aniline as raw material,two solvent mixtures of naphtha and petroleum ether in a certain proportion,and through sulfonation 2 amino 4 chloro 5 toluene sulfonic acid was synthesized.The yiel...By taking 3 chloro 4 methyl aniline as raw material,two solvent mixtures of naphtha and petroleum ether in a certain proportion,and through sulfonation 2 amino 4 chloro 5 toluene sulfonic acid was synthesized.The yield of product was about 90%,and the recovery of solvents was over 95%.展开更多
A compound ethyl(5S,6R)-2-(4-methylphenyl)-6-[(1R)-tert-butyldimethylsilyloxyethy]-penem-3-carboxylate was synthesized through displacement,acylation and Wittig cyclization reaction of optically active material(3R,4R)...A compound ethyl(5S,6R)-2-(4-methylphenyl)-6-[(1R)-tert-butyldimethylsilyloxyethy]-penem-3-carboxylate was synthesized through displacement,acylation and Wittig cyclization reaction of optically active material(3R,4R)-3-[(1R)-tert-butyldimethylsilyloxyethyl]-4-acetoxy-2-azetidi-none(4AA)upon thionocarboxlic acid.The intermediates and the target product were characterized by 1HNMR,IR,elementary analysis and MS.展开更多
文摘4substituted ethyl2methyl6,7methylenedioxy3quinolinecarboxylate was prepared from 3,4methylenedioxy-phenylketones Ⅳ,yield of Ⅳa-Ⅳd is 74～87%.The synthetic route consists of acylation,nitration,reduction and condensation.Moleculor structures of Ⅳa～Ⅳd were determined by IR,1H NMR and MS.
文摘The halogen substituted anthranilic acid(1) was condensed with acetic anhydride to give halogen substituted 3 methyl 1H 2,4 benoxazin 1 one(2), which was further condensed with hydrazide (3) to give twelve novel halogen substituted 2 (3 methyl 5 substitued 4H 1,2,4 triazol 4 yl) benzoic acid. All compounds synthesized were identified by 1H NMR and elemental analyses.
文摘By taking 3 chloro 4 methyl aniline as raw material,two solvent mixtures of naphtha and petroleum ether in a certain proportion,and through sulfonation 2 amino 4 chloro 5 toluene sulfonic acid was synthesized.The yield of product was about 90%,and the recovery of solvents was over 95%.
文摘A compound ethyl(5S,6R)-2-(4-methylphenyl)-6-[(1R)-tert-butyldimethylsilyloxyethy]-penem-3-carboxylate was synthesized through displacement,acylation and Wittig cyclization reaction of optically active material(3R,4R)-3-[(1R)-tert-butyldimethylsilyloxyethyl]-4-acetoxy-2-azetidi-none(4AA)upon thionocarboxlic acid.The intermediates and the target product were characterized by 1HNMR,IR,elementary analysis and MS.
