Thin layer chromatography was used to separate and analyze the samples in the process of preparation of β d glucopyranose 1 bromo 2 amino 2,3,4,6 tetra acetyl ester.The best developing solvent system is ethyl acetate...Thin layer chromatography was used to separate and analyze the samples in the process of preparation of β d glucopyranose 1 bromo 2 amino 2,3,4,6 tetra acetyl ester.The best developing solvent system is ethyl acetate∶methane alcohol∶water=6∶3∶0.5(V/V).The reactants, inter mediates and products could be separated effectively,thus indicated the reaction progression obviously.展开更多
2acetylamino3,4,6triacetate Dglucopyranose is an important imtermediate in the synthesis of Lipid A analogs.It was synthesized by the regioselective 1Odeacylation of fully acylated sugars.In this paper, ...2acetylamino3,4,6triacetate Dglucopyranose is an important imtermediate in the synthesis of Lipid A analogs.It was synthesized by the regioselective 1Odeacylation of fully acylated sugars.In this paper, the fully acylated aminoglucose was synthesized by a new method.In comparison with the old procedure,the reaction time was shorten ed,yet the yield was still higher.展开更多
2Amino1,2,3,4,6Opentaacetyl glucopyranose was synthesized from glucosamine hydrochloride,acetic hydride and triethylamine with thick sulfur acid as a catalyst.Under optimum reaction conditions,glucosamine hy...2Amino1,2,3,4,6Opentaacetyl glucopyranose was synthesized from glucosamine hydrochloride,acetic hydride and triethylamine with thick sulfur acid as a catalyst.Under optimum reaction conditions,glucosamine hydrochloride,acetic hydrideand triethylamine reacted in at 60°C for 3h to give the goal product in 852% yield.Its structure was confirmed by H1NMR and elemental analysis.展开更多
This paper reports that in the presence of cetyltrimethyl ammonium bromide as phase transfer catalyst,D-glucosamine hydrochloride reacts with 2,4-dinitrophenol to synthesize 1-O-(2’,4’-dinitrophenyl)-2-acetamido-β-...This paper reports that in the presence of cetyltrimethyl ammonium bromide as phase transfer catalyst,D-glucosamine hydrochloride reacts with 2,4-dinitrophenol to synthesize 1-O-(2’,4’-dinitrophenyl)-2-acetamido-β-D-glucoside.Chemical structure of the new compound was confirmed by elemental analysis,IR and UV.展开更多
以D-氨基葡萄糖盐酸盐、间硝基苯甲酸和对甲基苯甲酸为原料,先将氨基葡萄糖的羟基加以保护,然后以N,N-二环已基碳二亚胺(DCC)为脱水剂,合成N-硝基苯甲酰基-1,3,4,6-四-O-乙酰基-2-脱氧-β-D-氨基葡萄糖.产品结构经傅里叶变换红外光谱(FT...以D-氨基葡萄糖盐酸盐、间硝基苯甲酸和对甲基苯甲酸为原料,先将氨基葡萄糖的羟基加以保护,然后以N,N-二环已基碳二亚胺(DCC)为脱水剂,合成N-硝基苯甲酰基-1,3,4,6-四-O-乙酰基-2-脱氧-β-D-氨基葡萄糖.产品结构经傅里叶变换红外光谱(FT-IR)及核磁共振氢谱(1 H NMR)表征确认.研究表明:1,3,4,6-四-O-乙酰基-2-脱氧-β-D-氨基葡萄糖、DCC和间硝基苯甲酸/对甲基苯甲酸的摩尔比为1∶1.5∶1.5,反应温度为40℃,反应时间为4h为最佳反应条件.展开更多
A series of protected and deprotected 2 - deoxy -2 - aromatic acyl -β- D - glucopyranoses are prepared. Six of them are confirmed by IR,1H NMR,13C NMR and elementary analyses. The preliminary antibacterial activities...A series of protected and deprotected 2 - deoxy -2 - aromatic acyl -β- D - glucopyranoses are prepared. Six of them are confirmed by IR,1H NMR,13C NMR and elementary analyses. The preliminary antibacterial activities against staphylococcus albus and escherichia coli are studied. The result show that all the deprotected products has a good antibacterial ability to the two bacterias,while the products protected by acetyl show no activity.展开更多
文摘Thin layer chromatography was used to separate and analyze the samples in the process of preparation of β d glucopyranose 1 bromo 2 amino 2,3,4,6 tetra acetyl ester.The best developing solvent system is ethyl acetate∶methane alcohol∶water=6∶3∶0.5(V/V).The reactants, inter mediates and products could be separated effectively,thus indicated the reaction progression obviously.
文摘2acetylamino3,4,6triacetate Dglucopyranose is an important imtermediate in the synthesis of Lipid A analogs.It was synthesized by the regioselective 1Odeacylation of fully acylated sugars.In this paper, the fully acylated aminoglucose was synthesized by a new method.In comparison with the old procedure,the reaction time was shorten ed,yet the yield was still higher.
文摘2Amino1,2,3,4,6Opentaacetyl glucopyranose was synthesized from glucosamine hydrochloride,acetic hydride and triethylamine with thick sulfur acid as a catalyst.Under optimum reaction conditions,glucosamine hydrochloride,acetic hydrideand triethylamine reacted in at 60°C for 3h to give the goal product in 852% yield.Its structure was confirmed by H1NMR and elemental analysis.
文摘This paper reports that in the presence of cetyltrimethyl ammonium bromide as phase transfer catalyst,D-glucosamine hydrochloride reacts with 2,4-dinitrophenol to synthesize 1-O-(2’,4’-dinitrophenyl)-2-acetamido-β-D-glucoside.Chemical structure of the new compound was confirmed by elemental analysis,IR and UV.
文摘以D-氨基葡萄糖盐酸盐、间硝基苯甲酸和对甲基苯甲酸为原料,先将氨基葡萄糖的羟基加以保护,然后以N,N-二环已基碳二亚胺(DCC)为脱水剂,合成N-硝基苯甲酰基-1,3,4,6-四-O-乙酰基-2-脱氧-β-D-氨基葡萄糖.产品结构经傅里叶变换红外光谱(FT-IR)及核磁共振氢谱(1 H NMR)表征确认.研究表明:1,3,4,6-四-O-乙酰基-2-脱氧-β-D-氨基葡萄糖、DCC和间硝基苯甲酸/对甲基苯甲酸的摩尔比为1∶1.5∶1.5,反应温度为40℃,反应时间为4h为最佳反应条件.
文摘A series of protected and deprotected 2 - deoxy -2 - aromatic acyl -β- D - glucopyranoses are prepared. Six of them are confirmed by IR,1H NMR,13C NMR and elementary analyses. The preliminary antibacterial activities against staphylococcus albus and escherichia coli are studied. The result show that all the deprotected products has a good antibacterial ability to the two bacterias,while the products protected by acetyl show no activity.
