在催化剂过氧磷钨酸十二烷基吡啶盐(Cat-PW4)的作用下,α-蒎烯与H2O2反应生成主要产物(3R,4R)-4,7,7-三甲基-6-氧杂二环[3.2.1]辛烷-3,4-二醇。不同反应条件对反应转化率和选择性的实验结果表明,最佳反应条件为:12.8 mmolα-蒎烯、5 m ...在催化剂过氧磷钨酸十二烷基吡啶盐(Cat-PW4)的作用下,α-蒎烯与H2O2反应生成主要产物(3R,4R)-4,7,7-三甲基-6-氧杂二环[3.2.1]辛烷-3,4-二醇。不同反应条件对反应转化率和选择性的实验结果表明,最佳反应条件为:12.8 mmolα-蒎烯、5 m L溶剂三氯甲烷、0.2 g催化剂、3.3 m L 30%H2O2,反应温度40℃,反应时间3 h,α-蒎烯转化率和产物的选择性分别为94.7%和39.8%。反应结束后,该产物存在于水相和有机相中,通过萃取和重结晶分离提纯,得率11%,纯度达到98%;其分子结构通过红外光谱、紫外光谱、1H核磁共振谱、13C核磁共振谱、低分辨率质谱及高分辨率质谱确证。展开更多
Two metabolites(A and B) were isolated from a mangrove endophytic fungus Stysanus like sp.(#2492) from the South China Sea.Their structures were elucidated by spectral data as N-(2’-hydroxytetracosyl)-2-amino1,3,4-tr...Two metabolites(A and B) were isolated from a mangrove endophytic fungus Stysanus like sp.(#2492) from the South China Sea.Their structures were elucidated by spectral data as N-(2’-hydroxytetracosyl)-2-amino1,3,4-trihydroxyoctadecane(A) and γ-stearolactone(B).In the primary bioassay,compound B did not exhibit significant inhibitory activity to DNA topoisomerase hTOP Ⅰ,and also had no significant inhibitory activity to tumor cell lines Bel-7402 and NCIH-460.It was the first report that γ-stearolactone(B) isolated from marine fungus as natural product.展开更多
文摘在催化剂过氧磷钨酸十二烷基吡啶盐(Cat-PW4)的作用下,α-蒎烯与H2O2反应生成主要产物(3R,4R)-4,7,7-三甲基-6-氧杂二环[3.2.1]辛烷-3,4-二醇。不同反应条件对反应转化率和选择性的实验结果表明,最佳反应条件为:12.8 mmolα-蒎烯、5 m L溶剂三氯甲烷、0.2 g催化剂、3.3 m L 30%H2O2,反应温度40℃,反应时间3 h,α-蒎烯转化率和产物的选择性分别为94.7%和39.8%。反应结束后,该产物存在于水相和有机相中,通过萃取和重结晶分离提纯,得率11%,纯度达到98%;其分子结构通过红外光谱、紫外光谱、1H核磁共振谱、13C核磁共振谱、低分辨率质谱及高分辨率质谱确证。
文摘Two metabolites(A and B) were isolated from a mangrove endophytic fungus Stysanus like sp.(#2492) from the South China Sea.Their structures were elucidated by spectral data as N-(2’-hydroxytetracosyl)-2-amino1,3,4-trihydroxyoctadecane(A) and γ-stearolactone(B).In the primary bioassay,compound B did not exhibit significant inhibitory activity to DNA topoisomerase hTOP Ⅰ,and also had no significant inhibitory activity to tumor cell lines Bel-7402 and NCIH-460.It was the first report that γ-stearolactone(B) isolated from marine fungus as natural product.
